메뉴 건너뛰기




Volumn 120, Issue 8, 2014, Pages 1134-1144

Genomic tools in acute myeloid leukemia: From the bench to the bedside

Author keywords

acute myeloid leukemia; epigenomics; gene expression profiling; genomics; high throughput nucleotide sequencing

Indexed keywords

DNA METHYLTRANSFERASE 3A; ISOCITRATE DEHYDROGENASE 1; ISOCITRATE DEHYDROGENASE 2; TRANSCRIPTOME;

EID: 84898045456     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/cncr.28552     Document Type: Review
Times cited : (21)

References (111)
  • 1
    • 84863393263 scopus 로고    scopus 로고
    • Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
    • Patel JP, Gonen M, Figueroa ME, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med. 2012; 366: 1079-1089.
    • (2012) N Engl J Med , vol.366 , pp. 1079-1089
    • Patel, J.P.1    Gonen, M.2    Figueroa, M.E.3
  • 2
    • 55549101623 scopus 로고    scopus 로고
    • DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
    • Ley TJ, Mardis ER, Ding L, et al. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature. 2008; 456: 66-72.
    • (2008) Nature , vol.456 , pp. 66-72
    • Ley, T.J.1    Mardis, E.R.2    Ding, L.3
  • 3
    • 79951475133 scopus 로고    scopus 로고
    • A decade's perspective on DNA sequencing technology
    • Mardis ER,. A decade's perspective on DNA sequencing technology. Nature. 2011; 470: 198-203.
    • (2011) Nature , vol.470 , pp. 198-203
    • Mardis, E.R.1
  • 4
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Ley TJ, Ding L, Walter MJ, et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med. 2010; 363: 2424-2433.
    • (2010) N Engl J Med , vol.363 , pp. 2424-2433
    • Ley, T.J.1    Ding, L.2    Walter, M.J.3
  • 5
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • Mardis ER, Ding L, Dooling DJ, et al. Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med. 2009; 361: 1058-1066.
    • (2009) N Engl J Med , vol.361 , pp. 1058-1066
    • Mardis, E.R.1    Ding, L.2    Dooling, D.J.3
  • 6
    • 84878372012 scopus 로고    scopus 로고
    • Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia
    • Cancer Genome Atlas Research Network
    • Cancer Genome Atlas Research Network. Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med. 2013; 368: 2059-2074.
    • (2013) N Engl J Med , vol.368 , pp. 2059-2074
  • 8
    • 84878754014 scopus 로고    scopus 로고
    • Are results of targeted gene sequencing ready to be used for clinical decision making for patients with acute myelogenous leukemia?
    • Rao AV, Smith BD,. Are results of targeted gene sequencing ready to be used for clinical decision making for patients with acute myelogenous leukemia? Curr Hematol Malig Rep. 2013; 8: 149-155.
    • (2013) Curr Hematol Malig Rep , vol.8 , pp. 149-155
    • Rao, A.V.1    Smith, B.D.2
  • 9
    • 83755188042 scopus 로고    scopus 로고
    • Genomics of acute myeloid leukemia
    • Graubert TA, Mardis ER,. Genomics of acute myeloid leukemia. Cancer J. 2011; 17: 487-491.
    • (2011) Cancer J , vol.17 , pp. 487-491
    • Graubert, T.A.1    Mardis, E.R.2
  • 10
  • 11
    • 84859398686 scopus 로고    scopus 로고
    • Genomics of AML: Clinical applications of next-generation sequencing
    • 2011
    • Welch JS, Link DC,. Genomics of AML: clinical applications of next-generation sequencing. Hematol Am Soc Hematol Educ Program. 2011;2011: 30-35.
    • (2011) Hematol Am Soc Hematol Educ Program , pp. 30-35
    • Welch, J.S.1    Link, D.C.2
  • 12
    • 84993699133 scopus 로고    scopus 로고
    • Next-generation sequencing in hematologic malignancies: What will be the dividends?
    • Merker JD, Valouev A, Gotlib J,. Next-generation sequencing in hematologic malignancies: what will be the dividends? Ther Adv Hematol. 2012; 3: 333-339.
    • (2012) Ther Adv Hematol , vol.3 , pp. 333-339
    • Merker, J.D.1    Valouev, A.2    Gotlib, J.3
  • 13
    • 84880900798 scopus 로고    scopus 로고
    • Lessons from next-generation sequencing analysis in hematological malignancies [serial online]
    • Braggio E, Egan JB, Fonseca R, Stewart AK,. Lessons from next-generation sequencing analysis in hematological malignancies [serial online]. Blood Cancer J. 2013; 3: e127.
    • (2013) Blood Cancer J , vol.3
    • Braggio, E.1    Egan, J.B.2    Fonseca, R.3    Stewart, A.K.4
  • 14
    • 84874865318 scopus 로고    scopus 로고
    • Next generation sequencing in cancer research and clinical application [serial online]
    • Shyr D, Liu Q,. Next generation sequencing in cancer research and clinical application [serial online]. Biol Proced Online. 2013; 15: 4.
    • (2013) Biol Proced Online , vol.15 , pp. 4
    • Shyr, D.1    Liu, Q.2
  • 15
    • 68149176840 scopus 로고    scopus 로고
    • Chimeric transcript discovery by paired-end transcriptome sequencing
    • Maher CA, Palanisamy N, Brenner JC, et al. Chimeric transcript discovery by paired-end transcriptome sequencing. Proc Natl Acad Sci U S A. 2009; 106: 12353-12358.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 12353-12358
    • Maher, C.A.1    Palanisamy, N.2    Brenner, J.C.3
  • 16
    • 80052830541 scopus 로고    scopus 로고
    • Comparison of solution-based exome capture methods for next generation sequencing [serial online]
    • Sulonen AM, Ellonen P, Almusa H, et al. Comparison of solution-based exome capture methods for next generation sequencing [serial online]. Genome Biol. 2011; 12: R94.
    • (2011) Genome Biol , vol.12
    • Sulonen, A.M.1    Ellonen, P.2    Almusa, H.3
  • 17
    • 80054757012 scopus 로고    scopus 로고
    • Performance comparison of exome DNA sequencing technologies
    • Clark MJ, Chen R, Lam HY, et al. Performance comparison of exome DNA sequencing technologies. Nat Biotechnol. 2011; 29: 908-914.
    • (2011) Nat Biotechnol , vol.29 , pp. 908-914
    • Clark, M.J.1    Chen, R.2    Lam, H.Y.3
  • 18
    • 79953176952 scopus 로고    scopus 로고
    • Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
    • Yan XJ, Xu J, Gu ZH, et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet. 2011; 43: 309-315.
    • (2011) Nat Genet , vol.43 , pp. 309-315
    • Yan, X.J.1    Xu, J.2    Gu, Z.H.3
  • 19
    • 83055161507 scopus 로고    scopus 로고
    • Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype
    • Grossmann V, Tiacci E, Holmes AB, et al. Whole-exome sequencing identifies somatic mutations of BCOR in acute myeloid leukemia with normal karyotype. Blood. 2011; 118: 6153-6163.
    • (2011) Blood , vol.118 , pp. 6153-6163
    • Grossmann, V.1    Tiacci, E.2    Holmes, A.B.3
  • 20
    • 84864054209 scopus 로고    scopus 로고
    • GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia
    • Greif PA, Dufour A, Konstandin NP, et al. GATA2 zinc finger 1 mutations associated with biallelic CEBPA mutations define a unique genetic entity of acute myeloid leukemia. Blood. 2012; 120: 395-403.
    • (2012) Blood , vol.120 , pp. 395-403
    • Greif, P.A.1    Dufour, A.2    Konstandin, N.P.3
  • 21
    • 84868148842 scopus 로고    scopus 로고
    • Splicing factor mutations in myelodysplasia
    • Ogawa S,. Splicing factor mutations in myelodysplasia. Int J Hematol. 2012; 96: 438-442.
    • (2012) Int J Hematol , vol.96 , pp. 438-442
    • Ogawa, S.1
  • 22
    • 78751570979 scopus 로고    scopus 로고
    • RNA sequencing: Advances, challenges and opportunities
    • Ozsolak F, Milos PM,. RNA sequencing: advances, challenges and opportunities. Nat Rev Genet. 2011; 12: 87-98.
    • (2011) Nat Rev Genet , vol.12 , pp. 87-98
    • Ozsolak, F.1    Milos, P.M.2
  • 23
    • 28444453994 scopus 로고    scopus 로고
    • Spliceosome-mediated RNA trans-splicing
    • Yang Y, Walsh CE,. Spliceosome-mediated RNA trans-splicing. Mol Ther. 2005; 12: 1006-1012.
    • (2005) Mol Ther , vol.12 , pp. 1006-1012
    • Yang, Y.1    Walsh, C.E.2
  • 24
    • 84867850145 scopus 로고    scopus 로고
    • NMD: A multifaceted response to premature translational termination
    • Kervestin S, Jacobson A,. NMD: a multifaceted response to premature translational termination. Nat Rev Mol Cell Biol. 2012; 13: 700-712.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 700-712
    • Kervestin, S.1    Jacobson, A.2
  • 25
    • 57749195712 scopus 로고    scopus 로고
    • RNA-Seq: A revolutionary tool for transcriptomics
    • Wang Z, Gerstein M, Snyder M,. RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet. 2009; 10: 57-63.
    • (2009) Nat Rev Genet , vol.10 , pp. 57-63
    • Wang, Z.1    Gerstein, M.2    Snyder, M.3
  • 26
    • 79955854144 scopus 로고    scopus 로고
    • Identification of recurring tumor-specific somatic mutations in acute myeloid leukemia by transcriptome sequencing
    • Greif PA, Eck SH, Konstandin NP, et al. Identification of recurring tumor-specific somatic mutations in acute myeloid leukemia by transcriptome sequencing. Leukemia. 2011; 25: 821-827.
    • (2011) Leukemia , vol.25 , pp. 821-827
    • Greif, P.A.1    Eck, S.H.2    Konstandin, N.P.3
  • 27
    • 84873579853 scopus 로고    scopus 로고
    • CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia
    • McNerney ME, Brown CD, Wang X, et al. CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia. Blood. 2013; 121: 975-983.
    • (2013) Blood , vol.121 , pp. 975-983
    • McNerney, M.E.1    Brown, C.D.2    Wang, X.3
  • 28
    • 84871256210 scopus 로고    scopus 로고
    • New fusion transcripts identified in normal karyotype acute myeloid leukemia [serial online]
    • Wen H, Li Y, Malek SN, et al. New fusion transcripts identified in normal karyotype acute myeloid leukemia [serial online]. PLoS One. 2012; 7: e51203.
    • (2012) PLoS One , vol.7
    • Wen, H.1    Li, Y.2    Malek, S.N.3
  • 29
    • 84879397326 scopus 로고    scopus 로고
    • CBFA2T3-GLIS2 fusion transcript is a novel common feature in pediatric, cytogenetically normal AML, not restricted to FAB M7 subtype
    • Masetti R, Pigazzi M, Togni M, et al. CBFA2T3-GLIS2 fusion transcript is a novel common feature in pediatric, cytogenetically normal AML, not restricted to FAB M7 subtype. Blood. 2013; 121: 3469-3472.
    • (2013) Blood , vol.121 , pp. 3469-3472
    • Masetti, R.1    Pigazzi, M.2    Togni, M.3
  • 30
    • 84880787596 scopus 로고    scopus 로고
    • Significance of expression of ITGA5 and its splice variants in acute myeloid leukemia: A report from the Children's Oncology Group
    • Walter RB, Laszlo GS, Alonzo TA, et al. Significance of expression of ITGA5 and its splice variants in acute myeloid leukemia: a report from the Children's Oncology Group. Am J Hematol. 2013; 88: 694-702.
    • (2013) Am J Hematol , vol.88 , pp. 694-702
    • Walter, R.B.1    Laszlo, G.S.2    Alonzo, T.A.3
  • 31
    • 78650046221 scopus 로고    scopus 로고
    • Complete characterization of the microRNAome in a patient with acute myeloid leukemia
    • Ramsingh G, Koboldt DC, Trissal M, et al. Complete characterization of the microRNAome in a patient with acute myeloid leukemia. Blood. 2010; 116: 5316-5326.
    • (2010) Blood , vol.116 , pp. 5316-5326
    • Ramsingh, G.1    Koboldt, D.C.2    Trissal, M.3
  • 32
    • 84874268409 scopus 로고    scopus 로고
    • Identification of circulating microRNAs as potential biomarkers for detecting acute myeloid leukemia [serial online]
    • Zhi F, Cao X, Xie X, et al. Identification of circulating microRNAs as potential biomarkers for detecting acute myeloid leukemia [serial online]. PLoS One. 2013; 8: e56718.
    • (2013) PLoS One , vol.8
    • Zhi, F.1    Cao, X.2    Xie, X.3
  • 33
    • 78751557893 scopus 로고    scopus 로고
    • Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations
    • Starczynowski DT, Morin R, McPherson A, et al. Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations. Blood. 2011; 117: 595-607.
    • (2011) Blood , vol.117 , pp. 595-607
    • Starczynowski, D.T.1    Morin, R.2    McPherson, A.3
  • 34
    • 84862776906 scopus 로고    scopus 로고
    • Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing
    • Ding L, Ley TJ, Larson DE, et al. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature. 2012; 481: 506-510.
    • (2012) Nature , vol.481 , pp. 506-510
    • Ding, L.1    Ley, T.J.2    Larson, D.E.3
  • 35
    • 84864255882 scopus 로고    scopus 로고
    • The origin and evolution of mutations in acute myeloid leukemia
    • Welch JS, Ley TJ, Link DC, et al. The origin and evolution of mutations in acute myeloid leukemia. Cell. 2012; 150: 264-278.
    • (2012) Cell , vol.150 , pp. 264-278
    • Welch, J.S.1    Ley, T.J.2    Link, D.C.3
  • 36
    • 78149454504 scopus 로고    scopus 로고
    • Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value
    • Smith AE, Mohamedali AM, Kulasekararaj A, et al. Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value. Blood. 2010; 116: 3923-3932.
    • (2010) Blood , vol.116 , pp. 3923-3932
    • Smith, A.E.1    Mohamedali, A.M.2    Kulasekararaj, A.3
  • 37
    • 83555174295 scopus 로고    scopus 로고
    • TET2 deletions are a recurrent but rare phenomenon in myeloid malignancies and are frequently accompanied by TET2 mutations on the remaining allele
    • Bacher U, Weissmann S, Kohlmann A, et al. TET2 deletions are a recurrent but rare phenomenon in myeloid malignancies and are frequently accompanied by TET2 mutations on the remaining allele. Br J Haematol. 2012; 156: 67-75.
    • (2012) Br J Haematol , vol.156 , pp. 67-75
    • Bacher, U.1    Weissmann, S.2    Kohlmann, A.3
  • 38
    • 84860703461 scopus 로고    scopus 로고
    • Landscape of TET2 mutations in acute myeloid leukemia
    • Weissmann S, Alpermann T, Grossmann V, et al. Landscape of TET2 mutations in acute myeloid leukemia. Leukemia. 2012; 26: 934-942.
    • (2012) Leukemia , vol.26 , pp. 934-942
    • Weissmann, S.1    Alpermann, T.2    Grossmann, V.3
  • 39
    • 80052303426 scopus 로고    scopus 로고
    • TET family proteins and their role in stem cell differentiation and transformation
    • Cimmino L, Abdel-Wahab O, Levine RL, Aifantis I,. TET family proteins and their role in stem cell differentiation and transformation. Cell Stem Cell. 2011; 9: 193-204.
    • (2011) Cell Stem Cell , vol.9 , pp. 193-204
    • Cimmino, L.1    Abdel-Wahab, O.2    Levine, R.L.3    Aifantis, I.4
  • 40
    • 81255170304 scopus 로고    scopus 로고
    • Clinical implications of novel mutations in epigenetic modifiers in AML
    • Abdel-Wahab O, Patel J, Levine RL,. Clinical implications of novel mutations in epigenetic modifiers in AML. Hematol Oncol Clin North Am. 2011; 25: 1119-1133.
    • (2011) Hematol Oncol Clin North Am , vol.25 , pp. 1119-1133
    • Abdel-Wahab, O.1    Patel, J.2    Levine, R.L.3
  • 41
    • 80053900941 scopus 로고    scopus 로고
    • Frequent pathway mutations of splicing machinery in myelodysplasia
    • Yoshida K, Sanada M, Shiraishi Y, et al. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature. 2011; 478: 64-69.
    • (2011) Nature , vol.478 , pp. 64-69
    • Yoshida, K.1    Sanada, M.2    Shiraishi, Y.3
  • 42
    • 80054010617 scopus 로고    scopus 로고
    • Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts
    • Papaemmanuil E, Cazzola M, Boultwood J, et al. Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts. N Engl J Med. 2011; 365: 1384-1395.
    • (2011) N Engl J Med , vol.365 , pp. 1384-1395
    • Papaemmanuil, E.1    Cazzola, M.2    Boultwood, J.3
  • 43
    • 83455234787 scopus 로고    scopus 로고
    • Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms
    • Malcovati L, Papaemmanuil E, Bowen DT, et al. Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/ myeloproliferative neoplasms. Blood. 2011; 118: 6239-6246.
    • (2011) Blood , vol.118 , pp. 6239-6246
    • Malcovati, L.1    Papaemmanuil, E.2    Bowen, D.T.3
  • 44
    • 84879565619 scopus 로고    scopus 로고
    • Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome
    • Mian SA, Smith AE, Kulasekararaj AG, et al. Spliceosome mutations exhibit specific associations with epigenetic modifiers and proto-oncogenes mutated in myelodysplastic syndrome. Haematologica. 2013; 98: 1058-1066.
    • (2013) Haematologica , vol.98 , pp. 1058-1066
    • Mian, S.A.1    Smith, A.E.2    Kulasekararaj, A.G.3
  • 45
    • 84857734093 scopus 로고    scopus 로고
    • TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome
    • Rucker FG, Schlenk RF, Bullinger L, et al. TP53 alterations in acute myeloid leukemia with complex karyotype correlate with specific copy number alterations, monosomal karyotype, and dismal outcome. Blood. 2012; 119: 2114-2121.
    • (2012) Blood , vol.119 , pp. 2114-2121
    • Rucker, F.G.1    Schlenk, R.F.2    Bullinger, L.3
  • 46
    • 84866378702 scopus 로고    scopus 로고
    • The role of mutations in epigenetic regulators in myeloid malignancies
    • Shih AH, Abdel-Wahab O, Patel JP, Levine RL,. The role of mutations in epigenetic regulators in myeloid malignancies. Nat Rev Cancer. 2012; 12: 599-612.
    • (2012) Nat Rev Cancer , vol.12 , pp. 599-612
    • Shih, A.H.1    Abdel-Wahab, O.2    Patel, J.P.3    Levine, R.L.4
  • 47
    • 0141465061 scopus 로고    scopus 로고
    • The role of FLT3 in haematopoietic malignancies
    • Stirewalt DL, Radich JP,. The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer. 2003; 3: 650-665.
    • (2003) Nat Rev Cancer , vol.3 , pp. 650-665
    • Stirewalt, D.L.1    Radich, J.P.2
  • 48
    • 84886804684 scopus 로고    scopus 로고
    • DNMT3A mutation is a poor prognosis biomarker in AML: Results of a meta-analysis of 4500 AML patients
    • Shivarov V, Gueorguieva R, Stoimenov A, Tiu R,. DNMT3A mutation is a poor prognosis biomarker in AML: results of a meta-analysis of 4500 AML patients. Leuk Res. 2013; 37: 1445-1450.
    • (2013) Leuk Res , vol.37 , pp. 1445-1450
    • Shivarov, V.1    Gueorguieva, R.2    Stoimenov, A.3    Tiu, R.4
  • 49
    • 84862502902 scopus 로고    scopus 로고
    • Mutant DNMT3A: A marker of poor prognosis in acute myeloid leukemia
    • Ribeiro AF, Pratcorona M, Erpelinck-Verschueren C, et al. Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia. Blood. 2012; 119: 5824-5831.
    • (2012) Blood , vol.119 , pp. 5824-5831
    • Ribeiro, A.F.1    Pratcorona, M.2    Erpelinck-Verschueren, C.3
  • 50
    • 84863116398 scopus 로고    scopus 로고
    • Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia
    • Marcucci G, Metzeler KH, Schwind S, et al. Age-related prognostic impact of different types of DNMT3A mutations in adults with primary cytogenetically normal acute myeloid leukemia. J Clin Oncol. 2012; 30: 742-750.
    • (2012) J Clin Oncol , vol.30 , pp. 742-750
    • Marcucci, G.1    Metzeler, K.H.2    Schwind, S.3
  • 51
    • 84862007674 scopus 로고    scopus 로고
    • Prognostic significance of DNA methyltransferase 3A mutations in cytogenetically normal acute myeloid leukemia: A study by the Acute Leukemia French Association
    • Renneville A, Boissel N, Nibourel O, et al. Prognostic significance of DNA methyltransferase 3A mutations in cytogenetically normal acute myeloid leukemia: a study by the Acute Leukemia French Association. Leukemia. 2012; 26: 1247-1254.
    • (2012) Leukemia , vol.26 , pp. 1247-1254
    • Renneville, A.1    Boissel, N.2    Nibourel, O.3
  • 52
    • 84873570255 scopus 로고    scopus 로고
    • Mutations in the DNMT3A exon 23 independently predict poor outcome in older patients with acute myeloid leukemia: A SWOG report
    • Ostronoff F, Othus M, Ho PA, et al. Mutations in the DNMT3A exon 23 independently predict poor outcome in older patients with acute myeloid leukemia: a SWOG report. Leukemia. 2013; 27: 238-241.
    • (2013) Leukemia , vol.27 , pp. 238-241
    • Ostronoff, F.1    Othus, M.2    Ho, P.A.3
  • 53
    • 84881051116 scopus 로고    scopus 로고
    • Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: Results of the AML Study Group (AMLSG)
    • Gaidzik VI, Schlenk RF, Paschka P, et al. Clinical impact of DNMT3A mutations in younger adult patients with acute myeloid leukemia: results of the AML Study Group (AMLSG). Blood. 2013; 121: 4769-4777.
    • (2013) Blood , vol.121 , pp. 4769-4777
    • Gaidzik, V.I.1    Schlenk, R.F.2    Paschka, P.3
  • 54
    • 84255176496 scopus 로고    scopus 로고
    • ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN favorable genetic category
    • Metzeler KH, Becker H, Maharry K, et al. ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN favorable genetic category. Blood. 2011; 118: 6920-6929.
    • (2011) Blood , vol.118 , pp. 6920-6929
    • Metzeler, K.H.1    Becker, H.2    Maharry, K.3
  • 55
    • 84873568769 scopus 로고    scopus 로고
    • ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse outcome
    • Schnittger S, Eder C, Jeromin S, et al. ASXL1 exon 12 mutations are frequent in AML with intermediate risk karyotype and are independently associated with an adverse outcome. Leukemia. 2013; 27: 82-91.
    • (2013) Leukemia. , vol.27 , pp. 82-91
    • Schnittger, S.1    Eder, C.2    Jeromin, S.3
  • 56
    • 84866749552 scopus 로고    scopus 로고
    • Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes
    • Bejar R, Stevenson KE, Caughey BA, et al. Validation of a prognostic model and the impact of mutations in patients with lower-risk myelodysplastic syndromes. J Clin Oncol. 2012; 30: 3376-3382.
    • (2012) J Clin Oncol , vol.30 , pp. 3376-3382
    • Bejar, R.1    Stevenson, K.E.2    Caughey, B.A.3
  • 57
    • 84860767817 scopus 로고    scopus 로고
    • SF3B1 mutations in myelodysplastic syndromes: Clinical associations and prognostic implications
    • Damm F, Thol F, Kosmider O, et al. SF3B1 mutations in myelodysplastic syndromes: clinical associations and prognostic implications. Leukemia. 2012; 26: 1137-1140.
    • (2012) Leukemia , vol.26 , pp. 1137-1140
    • Damm, F.1    Thol, F.2    Kosmider, O.3
  • 58
    • 84864598664 scopus 로고    scopus 로고
    • MuSiC: Identifying mutational significance in cancer genomes
    • Dees ND, Zhang Q, Kandoth C, et al. MuSiC: identifying mutational significance in cancer genomes. Genome Res. 2012; 22: 1589-1598.
    • (2012) Genome Res , vol.22 , pp. 1589-1598
    • Dees, N.D.1    Zhang, Q.2    Kandoth, C.3
  • 59
    • 34548679336 scopus 로고    scopus 로고
    • Comment on "the consensus coding sequences of human breast and colorectal cancers" [serial online]
    • Getz G, Hofling H, Mesirov JP, et al. Comment on "The consensus coding sequences of human breast and colorectal cancers" [serial online]. Science. 2007; 317: 1500.
    • (2007) Science , vol.317 , pp. 1500
    • Getz, G.1    Hofling, H.2    Mesirov, J.P.3
  • 60
    • 79958127503 scopus 로고    scopus 로고
    • PathScan: A tool for discerning mutational significance in groups of putative cancer genes
    • Wendl MC, Wallis JW, Lin L, et al. PathScan: a tool for discerning mutational significance in groups of putative cancer genes. Bioinformatics. 2011; 27: 1595-1602.
    • (2011) Bioinformatics , vol.27 , pp. 1595-1602
    • Wendl, M.C.1    Wallis, J.W.2    Lin, L.3
  • 61
    • 84856535081 scopus 로고    scopus 로고
    • Mutual exclusivity analysis identifies oncogenic network modules
    • Ciriello G, Cerami E, Sander C, Schultz N,. Mutual exclusivity analysis identifies oncogenic network modules. Genome Res. 2012; 22: 398-406.
    • (2012) Genome Res , vol.22 , pp. 398-406
    • Ciriello, G.1    Cerami, E.2    Sander, C.3    Schultz, N.4
  • 62
    • 79952389826 scopus 로고    scopus 로고
    • Algorithms for detecting significantly mutated pathways in cancer
    • Vandin F, Upfal E, Raphael BJ,. Algorithms for detecting significantly mutated pathways in cancer. J Comput Biol. 2011; 18: 507-522.
    • (2011) J Comput Biol , vol.18 , pp. 507-522
    • Vandin, F.1    Upfal, E.2    Raphael, B.J.3
  • 63
    • 77954195272 scopus 로고    scopus 로고
    • Inference of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM [serial online]
    • Vaske CJ, Benz SC, Sanborn JZ, et al. Inference of patient-specific pathway activities from multi-dimensional cancer genomics data using PARADIGM [serial online]. Bioinformatics. 2010; 26: i237-i245.
    • (2010) Bioinformatics , vol.26
    • Vaske, C.J.1    Benz, S.C.2    Sanborn, J.Z.3
  • 64
    • 78651330430 scopus 로고    scopus 로고
    • COSMIC: Mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer
    • 2011
    • Forbes SA, Bindal N, Bamford S, et al. COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer. Nucleic Acids Res. 2011; 39 (Database issue): D945-D950, 2011.
    • (2011) Nucleic Acids Res , vol.39 DATABASE ISSUE
    • Forbes, S.A.1    Bindal, N.2    Bamford, S.3
  • 65
    • 84874724662 scopus 로고    scopus 로고
    • Update on activities at the Universal Protein Resource (UniProt) in 2013
    • UniProt Consortium. (Database issue)
    • UniProt Consortium. Update on activities at the Universal Protein Resource (UniProt) in 2013. Nucleic Acids Res. 2013; 41 (Database issue): D43-D47.
    • (2013) Nucleic Acids Res , vol.41
  • 66
    • 23744458086 scopus 로고    scopus 로고
    • Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes
    • Siepel A, Bejerano G, Pedersen JS, et al. Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. Genome Res. 2005; 15: 1034-1050.
    • (2005) Genome Res , vol.15 , pp. 1034-1050
    • Siepel, A.1    Bejerano, G.2    Pedersen, J.S.3
  • 67
    • 68149165614 scopus 로고    scopus 로고
    • Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm
    • Kumar P, Henikoff S, Ng PC,. Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm. Nat Protoc. 2009; 4: 1073-1081.
    • (2009) Nat Protoc , vol.4 , pp. 1073-1081
    • Kumar, P.1    Henikoff, S.2    Ng, P.C.3
  • 68
    • 84866002291 scopus 로고    scopus 로고
    • The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data
    • Cerami E, Gao J, Dogrusoz U, et al. The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2012; 2: 401-404.
    • (2012) Cancer Discov , vol.2 , pp. 401-404
    • Cerami, E.1    Gao, J.2    Dogrusoz, U.3
  • 69
    • 84859595800 scopus 로고    scopus 로고
    • Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes
    • Damm F, Kosmider O, Gelsi-Boyer V, et al. Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes. Blood. 2012; 119: 3211-3218.
    • (2012) Blood , vol.119 , pp. 3211-3218
    • Damm, F.1    Kosmider, O.2    Gelsi-Boyer, V.3
  • 70
    • 84255160977 scopus 로고    scopus 로고
    • Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: Association with progression and fludarabine-refractoriness
    • Rossi D, Bruscaggin A, Spina V, et al. Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness. Blood. 2011; 118: 6904-6908.
    • (2011) Blood , vol.118 , pp. 6904-6908
    • Rossi, D.1    Bruscaggin, A.2    Spina, V.3
  • 71
    • 84868554484 scopus 로고    scopus 로고
    • Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing [serial online]
    • Dolnik A, Engelmann JC, Scharfenberger-Schmeer M, et al. Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing [serial online]. Blood. 2012; 120: e83-e92.
    • (2012) Blood , vol.120
    • Dolnik, A.1    Engelmann, J.C.2    Scharfenberger-Schmeer, M.3
  • 72
    • 84863621527 scopus 로고    scopus 로고
    • Cancer epigenetics: From mechanism to therapy
    • Dawson MA, Kouzarides T,. Cancer epigenetics: from mechanism to therapy. Cell. 2012; 150: 12-27.
    • (2012) Cell , vol.150 , pp. 12-27
    • Dawson, M.A.1    Kouzarides, T.2
  • 74
    • 80053545678 scopus 로고    scopus 로고
    • Mutations in epigenetic modifiers in myeloid malignancies and the prospect of novel epigenetic-targeted therapy [serial online]
    • 2012
    • Fathi AT, Abdel-Wahab O,. Mutations in epigenetic modifiers in myeloid malignancies and the prospect of novel epigenetic-targeted therapy [serial online]. Adv Hematol 2012: 469592, 2012.
    • (2012) Adv Hematol , pp. 469592
    • Fathi, A.T.1    Abdel-Wahab, O.2
  • 75
    • 77649305610 scopus 로고    scopus 로고
    • The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
    • Ward PS, Patel J, Wise DR, et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell. 2010; 17: 225-234.
    • (2010) Cancer Cell , vol.17 , pp. 225-234
    • Ward, P.S.1    Patel, J.2    Wise, D.R.3
  • 76
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • Figueroa ME, Abdel-Wahab O, Lu C, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer Cell. 2010; 18: 553-567.
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3
  • 77
    • 84891476446 scopus 로고    scopus 로고
    • Cancer epigenetics: New therapies and new challenges [serial online]
    • 2013
    • Hatzimichael E, Crook T,. Cancer epigenetics: new therapies and new challenges [serial online]. J Drug Deliv 2013: 529312, 2013.
    • (2013) J Drug Deliv , pp. 529312
    • Hatzimichael, E.1    Crook, T.2
  • 78
    • 84865849117 scopus 로고    scopus 로고
    • A critical appraisal of tools available for monitoring epigenetic changes in clinical samples from patients with myeloid malignancies
    • Gronbaek K, Muller-Tidow C, Perini G, et al. A critical appraisal of tools available for monitoring epigenetic changes in clinical samples from patients with myeloid malignancies. Haematologica. 2012; 97: 1380-1388.
    • (2012) Haematologica , vol.97 , pp. 1380-1388
    • Gronbaek, K.1    Muller-Tidow, C.2    Perini, G.3
  • 79
    • 84870733829 scopus 로고    scopus 로고
    • Conserved DNA methylation patterns in healthy blood cells and extensive changes in leukemia measured by a new quantitative technique
    • Jelinek J, Liang S, Lu Y, et al. Conserved DNA methylation patterns in healthy blood cells and extensive changes in leukemia measured by a new quantitative technique. Epigenetics. 2012; 7: 1368-1378.
    • (2012) Epigenetics , vol.7 , pp. 1368-1378
    • Jelinek, J.1    Liang, S.2    Lu, Y.3
  • 80
    • 49649125042 scopus 로고    scopus 로고
    • Genome-scale DNA methylation maps of pluripotent and differentiated cells
    • Meissner A, Mikkelsen TS, Gu H, et al. Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature. 2008; 454: 766-770.
    • (2008) Nature , vol.454 , pp. 766-770
    • Meissner, A.1    Mikkelsen, T.S.2    Gu, H.3
  • 81
    • 46949098742 scopus 로고    scopus 로고
    • A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis
    • Down TA, Rakyan VK, Turner DJ, et al. A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol. 2008; 26: 779-785.
    • (2008) Nat Biotechnol , vol.26 , pp. 779-785
    • Down, T.A.1    Rakyan, V.K.2    Turner, D.J.3
  • 82
    • 84866551964 scopus 로고    scopus 로고
    • Genome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia
    • Yan P, Frankhouser D, Murphy M, et al. Genome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia. Blood. 2012; 120: 2466-2474.
    • (2012) Blood , vol.120 , pp. 2466-2474
    • Yan, P.1    Frankhouser, D.2    Murphy, M.3
  • 83
    • 84859083304 scopus 로고    scopus 로고
    • Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats [serial online]
    • Saied MH, Marzec J, Khalid S, et al. Genome wide analysis of acute myeloid leukemia reveal leukemia specific methylome and subtype specific hypomethylation of repeats [serial online]. PLoS One. 2012; 7: e33213.
    • (2012) PLoS One , vol.7
    • Saied, M.H.1    Marzec, J.2    Khalid, S.3
  • 84
    • 84898048405 scopus 로고    scopus 로고
    • Loss of de novo DNA methylation causes expansion of the mouse hematopoietic stem cell pool
    • Challen GA, Berg JS, Goodell MA,. Loss of de novo DNA methylation causes expansion of the mouse hematopoietic stem cell pool. Blood. 2010; 116: 364-364.
    • (2010) Blood , vol.116 , pp. 364-364
    • Challen, G.A.1    Berg, J.S.2    Goodell, M.A.3
  • 85
    • 84864031521 scopus 로고    scopus 로고
    • Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia [serial online]
    • Akalin A, Garrett-Bakelman FE, Kormaksson M, et al. Base-pair resolution DNA methylation sequencing reveals profoundly divergent epigenetic landscapes in acute myeloid leukemia [serial online]. PLoS Genet. 2012; 8: e1002781.
    • (2012) PLoS Genet , vol.8
    • Akalin, A.1    Garrett-Bakelman, F.E.2    Kormaksson, M.3
  • 86
    • 84865152223 scopus 로고    scopus 로고
    • ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
    • Abdel-Wahab O, Adli M, LaFave LM, et al. ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer Cell. 2012; 22: 180-193.
    • (2012) Cancer Cell , vol.22 , pp. 180-193
    • Abdel-Wahab, O.1    Adli, M.2    Lafave, L.M.3
  • 87
    • 84867800489 scopus 로고    scopus 로고
    • Chromatin accessibility, p300, and histone acetylation define PML-RARalpha and AML1-ETO binding sites in acute myeloid leukemia
    • Saeed S, Logie C, Francoijs KJ, et al. Chromatin accessibility, p300, and histone acetylation define PML-RARalpha and AML1-ETO binding sites in acute myeloid leukemia. Blood. 2012; 120: 3058-3068.
    • (2012) Blood , vol.120 , pp. 3058-3068
    • Saeed, S.1    Logie, C.2    Francoijs, K.J.3
  • 88
    • 84555192302 scopus 로고    scopus 로고
    • Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes
    • Graubert TA, Shen D, Ding L, et al. Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes. Nat Genet. 2012; 44: 53-57.
    • (2012) Nat Genet , vol.44 , pp. 53-57
    • Graubert, T.A.1    Shen, D.2    Ding, L.3
  • 89
    • 84859597590 scopus 로고    scopus 로고
    • Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis
    • Makishima H, Visconte V, Sakaguchi H, et al. Mutations in the spliceosome machinery, a novel and ubiquitous pathway in leukemogenesis. Blood. 2012; 119: 3203-3210.
    • (2012) Blood , vol.119 , pp. 3203-3210
    • Makishima, H.1    Visconte, V.2    Sakaguchi, H.3
  • 90
    • 84886905271 scopus 로고    scopus 로고
    • Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms
    • Przychodzen B, Jerez A, Guinta K, et al. Patterns of missplicing due to somatic U2AF1 mutations in myeloid neoplasms. Blood. 2013; 122: 999-1006.
    • (2013) Blood , vol.122 , pp. 999-1006
    • Przychodzen, B.1    Jerez, A.2    Guinta, K.3
  • 91
    • 84868091622 scopus 로고    scopus 로고
    • SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes
    • Visconte V, Rogers HJ, Singh J, et al. SF3B1 haploinsufficiency leads to formation of ring sideroblasts in myelodysplastic syndromes. Blood. 2012; 120: 3173-3186.
    • (2012) Blood , vol.120 , pp. 3173-3186
    • Visconte, V.1    Rogers, H.J.2    Singh, J.3
  • 92
    • 84863337617 scopus 로고    scopus 로고
    • Clonal architecture of secondary acute myeloid leukemia
    • Walter MJ, Shen D, Ding L, et al. Clonal architecture of secondary acute myeloid leukemia. N Engl J Med. 2012; 366: 1090-1098.
    • (2012) N Engl J Med , vol.366 , pp. 1090-1098
    • Walter, M.J.1    Shen, D.2    Ding, L.3
  • 93
    • 84878900540 scopus 로고    scopus 로고
    • Clonal diversity of recurrently mutated genes in myelodysplastic syndromes
    • Walter MJ, Shen D, Shao J, et al. Clonal diversity of recurrently mutated genes in myelodysplastic syndromes. Leukemia. 2013; 27: 1275-1282.
    • (2013) Leukemia , vol.27 , pp. 1275-1282
    • Walter, M.J.1    Shen, D.2    Shao, J.3
  • 94
    • 84865827060 scopus 로고    scopus 로고
    • Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia [serial online]
    • Jan M, Snyder TM, Corces-Zimmerman MR, et al. Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia [serial online]. Sci Transl Med. 2012; 4: 149ra18.
    • (2012) Sci Transl Med , vol.4
    • Jan, M.1    Snyder, T.M.2    Corces-Zimmerman, M.R.3
  • 95
    • 84874102335 scopus 로고    scopus 로고
    • Evolution and impact of subclonal mutations in chronic lymphocytic leukemia
    • Landau DA, Carter SL, Stojanov P, et al. Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell. 2013; 152: 714-726.
    • (2013) Cell , vol.152 , pp. 714-726
    • Landau, D.A.1    Carter, S.L.2    Stojanov, P.3
  • 96
    • 84883743375 scopus 로고    scopus 로고
    • Detailed molecular characterisation of acute myeloid leukaemia with a normal karyotype using targeted DNA capture
    • Conte N, Varela I, Grove C, et al. Detailed molecular characterisation of acute myeloid leukaemia with a normal karyotype using targeted DNA capture. Leukemia. 2013; 27: 1820-1825.
    • (2013) Leukemia , vol.27 , pp. 1820-1825
    • Conte, N.1    Varela, I.2    Grove, C.3
  • 97
    • 84861813715 scopus 로고    scopus 로고
    • Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia
    • Beekman R, Valkhof MG, Sanders MA, et al. Sequential gain of mutations in severe congenital neutropenia progressing to acute myeloid leukemia. Blood. 2012; 119: 5071-5077.
    • (2012) Blood , vol.119 , pp. 5071-5077
    • Beekman, R.1    Valkhof, M.G.2    Sanders, M.A.3
  • 98
    • 84887610979 scopus 로고    scopus 로고
    • Advances for studying clonal evolution in cancer
    • Ding L, Raphael BJ, Chen F, Wendl MC,. Advances for studying clonal evolution in cancer. Cancer Lett. 2013; 340: 212-219.
    • (2013) Cancer Lett , vol.340 , pp. 212-219
    • Ding, L.1    Raphael, B.J.2    Chen, F.3    Wendl, M.C.4
  • 99
    • 84875211731 scopus 로고    scopus 로고
    • Cancer heterogeneity: Implications for targeted therapeutics
    • Fisher R, Pusztai L, Swanton C,. Cancer heterogeneity: implications for targeted therapeutics. Br J Cancer. 2013; 108: 479-485.
    • (2013) Br J Cancer , vol.108 , pp. 479-485
    • Fisher, R.1    Pusztai, L.2    Swanton, C.3
  • 101
    • 84859742518 scopus 로고    scopus 로고
    • Molecular genetics of acute myeloid leukemia: Clinical implications and opportunities for integrating genomics into clinical practice
    • Abdel-Wahab O,. Molecular genetics of acute myeloid leukemia: clinical implications and opportunities for integrating genomics into clinical practice. Hematology. 2012; 17 (suppl 1): S39-S42.
    • (2012) Hematology , vol.17 , Issue.SUPPL. 1
    • Abdel-Wahab, O.1
  • 102
    • 61849150985 scopus 로고    scopus 로고
    • High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients
    • Tyner JW, Erickson H, Deininger MW, et al. High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients. Blood. 2009; 113: 1749-1755.
    • (2009) Blood , vol.113 , pp. 1749-1755
    • Tyner, J.W.1    Erickson, H.2    Deininger, M.W.3
  • 103
    • 84861866139 scopus 로고    scopus 로고
    • Targeted next generation sequencing of clinically significant gene mutations and translocations in leukemia
    • Duncavage EJ, Abel HJ, Szankasi P, Kelley TW, Pfeifer JD,. Targeted next generation sequencing of clinically significant gene mutations and translocations in leukemia. Mod Pathol. 2012; 25: 795-804.
    • (2012) Mod Pathol , vol.25 , pp. 795-804
    • Duncavage, E.J.1    Abel, H.J.2    Szankasi, P.3    Kelley, T.W.4    Pfeifer, J.D.5
  • 104
    • 84860675045 scopus 로고    scopus 로고
    • Next-generation sequencing for minimal residual disease monitoring in acute myeloid leukemia patients with FLT3-ITD or NPM1 mutations
    • Thol F, Kolking B, Damm F, et al. Next-generation sequencing for minimal residual disease monitoring in acute myeloid leukemia patients with FLT3-ITD or NPM1 mutations. Genes Chromosomes Cancer. 2012; 51: 689-695.
    • (2012) Genes Chromosomes Cancer , vol.51 , pp. 689-695
    • Thol, F.1    Kolking, B.2    Damm, F.3
  • 105
    • 79952254129 scopus 로고    scopus 로고
    • Strategy for robust detection of insertions, deletions, and point mutations in CEBPA, a GC-rich content gene, using 454 next-generation deep-sequencing technology
    • Grossmann V, Schnittger S, Schindela S, et al. Strategy for robust detection of insertions, deletions, and point mutations in CEBPA, a GC-rich content gene, using 454 next-generation deep-sequencing technology. J Mol Diagn. 2011; 13: 129-136.
    • (2011) J Mol Diagn , vol.13 , pp. 129-136
    • Grossmann, V.1    Schnittger, S.2    Schindela, S.3
  • 106
    • 84880884037 scopus 로고    scopus 로고
    • Genotyping of 25 leukemia-associated genes in a single work flow by next-generation sequencing technology with low amounts of input template DNA
    • Rinke J, Schafer V, Schmidt M, et al. Genotyping of 25 leukemia-associated genes in a single work flow by next-generation sequencing technology with low amounts of input template DNA. Clin Chem. 2013; 59: 1238-1250.
    • (2013) Clin Chem , vol.59 , pp. 1238-1250
    • Rinke, J.1    Schafer, V.2    Schmidt, M.3
  • 107
    • 84873658498 scopus 로고    scopus 로고
    • Detection of FLT3 internal tandem duplication in targeted, short-read-length, next-generation sequencing data
    • Spencer DH, Abel HJ, Lockwood CM, et al. Detection of FLT3 internal tandem duplication in targeted, short-read-length, next-generation sequencing data. J Mol Diagn. 2013; 15: 81-93.
    • (2013) J Mol Diagn , vol.15 , pp. 81-93
    • Spencer, D.H.1    Abel, H.J.2    Lockwood, C.M.3
  • 108
    • 84857232194 scopus 로고    scopus 로고
    • Next generation sequencing has lower sequence coverage and poorer SNP-detection capability in the regulatory regions [serial online]
    • Wang W, Wei Z, Lam TW, Wang J,. Next generation sequencing has lower sequence coverage and poorer SNP-detection capability in the regulatory regions [serial online]. Sci Rep. 2011; 1: 55.
    • (2011) Sci Rep , vol.1 , pp. 55
    • Wang, W.1    Wei, Z.2    Lam, T.W.3    Wang, J.4
  • 109
    • 79955016374 scopus 로고    scopus 로고
    • Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML
    • Link DC, Schuettpelz LG, Shen D, et al. Identification of a novel TP53 cancer susceptibility mutation through whole-genome sequencing of a patient with therapy-related AML. JAMA. 2011; 305: 1568-1576.
    • (2011) JAMA , vol.305 , pp. 1568-1576
    • Link, D.C.1    Schuettpelz, L.G.2    Shen, D.3
  • 110
    • 79955038968 scopus 로고    scopus 로고
    • Use of whole-genome sequencing to diagnose a cryptic fusion oncogene
    • Welch JS, Westervelt P, Ding L, et al. Use of whole-genome sequencing to diagnose a cryptic fusion oncogene. JAMA. 2011; 305: 1577-1584.
    • (2011) JAMA , vol.305 , pp. 1577-1584
    • Welch, J.S.1    Westervelt, P.2    Ding, L.3
  • 111
    • 84888862866 scopus 로고    scopus 로고
    • DGIdb: Mining the druggable genome
    • Dec doi: 10.1038/nmeth.2689. Epub 2013 Oct 13
    • Griffith M, Griffith OL, Coffman AC, Weible JV, McMichael JF, Spies NC, Koval J, Das I, Callaway MB, Eldred JM, Miller CA, Subramanian J, Govindan R, Kumar RD, Bose R, Ding L, Walker JR, Larson DE, Dooling DJ, Smith SM, Ley TJ, Mardis ER, Wilson RK,. DGIdb: mining the druggable genome. Nat Methods. 2013 Dec;10(12):1209-1210. doi: 10.1038/nmeth.2689. Epub 2013 Oct 13.
    • (2013) Nat Methods , vol.10 , Issue.12 , pp. 1209-1210
    • Ol, G.1    Ac, C.2    Jv, W.3    Jf, M.4    Nc, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.