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Volumn 38, Issue 4, 2014, Pages 889-896

S-Adenosylhomocysteine Inhibits NF-κB-Mediated Gene Expression in Hepatocytes and Confers Sensitivity to TNF Cytotoxicity

Author keywords

Alcoholic Liver Disease; NF kappaB; S Adenosylhomocysteine; Sensitization; Tumor Necrosis Factor alpha

Indexed keywords

ADENOSINE; CASPASE 8; HOMOCYSTEINE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MESSENGER RNA; S ADENOSYLHOMOCYSTEINE; SERINE; TUMOR NECROSIS FACTOR ALPHA; CYTOTOXIN;

EID: 84898040722     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/acer.12315     Document Type: Article
Times cited : (7)

References (43)
  • 2
    • 0029976817 scopus 로고    scopus 로고
    • An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
    • Beg AA, Baltimore D (1996) An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science 274:782-784.
    • (1996) Science , vol.274 , pp. 782-784
    • Beg, A.A.1    Baltimore, D.2
  • 3
    • 84861325324 scopus 로고    scopus 로고
    • A20 ubiquitin ligase-mediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastoma
    • Bellail AC, Olson JJ, Yang X, Chen ZJ, Hao C (2012) A20 ubiquitin ligase-mediated polyubiquitination of RIP1 inhibits caspase-8 cleavage and TRAIL-induced apoptosis in glioblastoma. Cancer Discov 2:140-155.
    • (2012) Cancer Discov , vol.2 , pp. 140-155
    • Bellail, A.C.1    Olson, J.J.2    Yang, X.3    Chen, Z.J.4    Hao, C.5
  • 4
    • 0028037617 scopus 로고
    • Adenosine and homocysteine together enhance TNF-mediated cytotoxicity but do not alter activation of nuclear factor-kappa B in L929 cells
    • Bergmann S, Shatrov V, Ratter F, Schiemann S, Schulze-Osthoff K, Lehmann V (1994) Adenosine and homocysteine together enhance TNF-mediated cytotoxicity but do not alter activation of nuclear factor-kappa B in L929 cells. J Immunol 153:1736-1743.
    • (1994) J Immunol , vol.153 , pp. 1736-1743
    • Bergmann, S.1    Shatrov, V.2    Ratter, F.3    Schiemann, S.4    Schulze-Osthoff, K.5    Lehmann, V.6
  • 8
    • 18144426719 scopus 로고    scopus 로고
    • NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4
    • Fagerlund R, Kinnunen L, Kohler M, Julkunen I, Melen K (2005) NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4. J Biol Chem 280:15942-15951.
    • (2005) J Biol Chem , vol.280 , pp. 15942-15951
    • Fagerlund, R.1    Kinnunen, L.2    Kohler, M.3    Julkunen, I.4    Melen, K.5
  • 9
    • 0031865753 scopus 로고    scopus 로고
    • Negative regulation of the rat glutathione S-transferase A2 gene by glucocorticoids involves a canonical glucocorticoid consensus sequence
    • Falkner KC, Rushmore TH, Linder MW, Prough RA (1998) Negative regulation of the rat glutathione S-transferase A2 gene by glucocorticoids involves a canonical glucocorticoid consensus sequence. Mol Pharmacol 53:1016-1026.
    • (1998) Mol Pharmacol , vol.53 , pp. 1016-1026
    • Falkner, K.C.1    Rushmore, T.H.2    Linder, M.W.3    Prough, R.A.4
  • 12
    • 0000352873 scopus 로고
    • Galactosamine-induced sensitization to the lethal effects of endotoxin
    • Galanos C, Freudenberg MA, Reutter W (1979) Galactosamine-induced sensitization to the lethal effects of endotoxin. Proc Natl Acad Sci U S A 76:5939-5943.
    • (1979) Proc Natl Acad Sci U S A , vol.76 , pp. 5939-5943
    • Galanos, C.1    Freudenberg, M.A.2    Reutter, W.3
  • 14
    • 57349120536 scopus 로고    scopus 로고
    • Enhanced PDE4B expression augments LPS-inducible TNF expression in ethanol-primed monocytes: relevance to alcoholic liver disease
    • Gobejishvili L, Barve S, Joshi-Barve S, McClain C (2008) Enhanced PDE4B expression augments LPS-inducible TNF expression in ethanol-primed monocytes: relevance to alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol 295:G718-G724.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.295
    • Gobejishvili, L.1    Barve, S.2    Joshi-Barve, S.3    McClain, C.4
  • 16
    • 80052711668 scopus 로고    scopus 로고
    • Transactivation of gene expression by NF-kappaB is dependent on thioredoxin reductase activity
    • Heilman JM, Burke TJ, McClain CJ, Watson WH (2011) Transactivation of gene expression by NF-kappaB is dependent on thioredoxin reductase activity. Free Radic Biol Med 51:1533-1542.
    • (2011) Free Radic Biol Med , vol.51 , pp. 1533-1542
    • Heilman, J.M.1    Burke, T.J.2    McClain, C.J.3    Watson, W.H.4
  • 17
    • 0033407588 scopus 로고    scopus 로고
    • Antioxidants attenuate nuclear factor-kappa B activation and tumor necrosis factor-alpha production in alcoholic hepatitis patient monocytes and rat Kupffer cells, in vitro
    • Hill DB, Devalaraja R, Joshi-Barve S, Barve S, McClain CJ (1999) Antioxidants attenuate nuclear factor-kappa B activation and tumor necrosis factor-alpha production in alcoholic hepatitis patient monocytes and rat Kupffer cells, in vitro. Clin Biochem 32:563-570.
    • (1999) Clin Biochem , vol.32 , pp. 563-570
    • Hill, D.B.1    Devalaraja, R.2    Joshi-Barve, S.3    Barve, S.4    McClain, C.J.5
  • 19
    • 0026493715 scopus 로고
    • Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats
    • Hirano T, Kaplowitz N, Tsukamoto H, Kamimura S, Fernandez-Checa JC (1992) Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats. Hepatology 16:1423-1427.
    • (1992) Hepatology , vol.16 , pp. 1423-1427
    • Hirano, T.1    Kaplowitz, N.2    Tsukamoto, H.3    Kamimura, S.4    Fernandez-Checa, J.C.5
  • 20
    • 0030716183 scopus 로고    scopus 로고
    • Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat
    • Iimuro Y, Gallucci RM, Luster MI, Kono H, Thurman RG (1997) Antibodies to tumor necrosis factor alfa attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. Hepatology 26:1530-1537.
    • (1997) Hepatology , vol.26 , pp. 1530-1537
    • Iimuro, Y.1    Gallucci, R.M.2    Luster, M.I.3    Kono, H.4    Thurman, R.G.5
  • 21
    • 0033516464 scopus 로고    scopus 로고
    • 3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation
    • Jeong SY, Ahn SG, Lee JH, Kim HS, Kim JW, Rhim H, Jeong SW, Kim IK (1999) 3-deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-kappaB regulation. Inhibition of NF-kappaB transcriptional activity and promotion of IkappaBalpha degradation. J Biol Chem 274:18981-18988.
    • (1999) J Biol Chem , vol.274 , pp. 18981-18988
    • Jeong, S.Y.1    Ahn, S.G.2    Lee, J.H.3    Kim, H.S.4    Kim, J.W.5    Rhim, H.6    Jeong, S.W.7    Kim, I.K.8
  • 22
    • 0030914902 scopus 로고    scopus 로고
    • Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1
    • Koop DR, Klopfenstein B, Iimuro Y, Thurman RG (1997) Gadolinium chloride blocks alcohol-dependent liver toxicity in rats treated chronically with intragastric alcohol despite the induction of CYP2E1. Mol Pharmacol 51:944-950.
    • (1997) Mol Pharmacol , vol.51 , pp. 944-950
    • Koop, D.R.1    Klopfenstein, B.2    Iimuro, Y.3    Thurman, R.G.4
  • 23
    • 0026699666 scopus 로고
    • Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements
    • Krikos A, Laherty CD, Dixit VM (1992) Transcriptional activation of the tumor necrosis factor alpha-inducible zinc finger protein, A20, is mediated by kappa B elements. J Biol Chem 267:17971-17976.
    • (1992) J Biol Chem , vol.267 , pp. 17971-17976
    • Krikos, A.1    Laherty, C.D.2    Dixit, V.M.3
  • 24
    • 0034730713 scopus 로고    scopus 로고
    • Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice
    • Lee EG, Boone DL, Chai S, Libby SL, Chien M, Lodolce JP, Ma A (2000) Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science 289:2350-2354.
    • (2000) Science , vol.289 , pp. 2350-2354
    • Lee, E.G.1    Boone, D.L.2    Chai, S.3    Libby, S.L.4    Chien, M.5    Lodolce, J.P.6    Ma, A.7
  • 29
    • 33751325327 scopus 로고    scopus 로고
    • A histone methylation-dependent DNA methylation pathway is uniquely impaired by deficiency in Arabidopsis S-adenosylhomocysteine hydrolase
    • Mull L, Ebbs ML, Bender J (2006) A histone methylation-dependent DNA methylation pathway is uniquely impaired by deficiency in Arabidopsis S-adenosylhomocysteine hydrolase. Genetics 174:1161-1171.
    • (2006) Genetics , vol.174 , pp. 1161-1171
    • Mull, L.1    Ebbs, M.L.2    Bender, J.3
  • 30
    • 58049112589 scopus 로고    scopus 로고
    • Implication of cytokines: roles of tumor necrosis factor-alpha in liver injury
    • Nagaki M, Moriwaki H (2008) Implication of cytokines: roles of tumor necrosis factor-alpha in liver injury. Hepatol Res 38(Suppl 1):S19-S28.
    • (2008) Hepatol Res , vol.38 , Issue.SUPPL. 1
    • Nagaki, M.1    Moriwaki, H.2
  • 31
    • 34548487143 scopus 로고    scopus 로고
    • Beyond IkappaBs: alternative regulation of NF-kappaB activity
    • Neumann M, Naumann M (2007) Beyond IkappaBs: alternative regulation of NF-kappaB activity. FASEB J 21:2642-2654.
    • (2007) FASEB J , vol.21 , pp. 2642-2654
    • Neumann, M.1    Naumann, M.2
  • 32
    • 0026691240 scopus 로고
    • The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity
    • Opipari AW Jr, Hu HM, Yabkowitz R, Dixit VM (1992) The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity. J Biol Chem 267:12424-12427.
    • (1992) J Biol Chem , vol.267 , pp. 12424-12427
    • Opipari Jr, A.W.1    Hu, H.M.2    Yabkowitz, R.3    Dixit, V.M.4
  • 33
    • 0035399943 scopus 로고    scopus 로고
    • TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes
    • Osawa Y, Banno Y, Nagaki M, Brenner DA, Naiki T, Nozawa Y, Nakashima S, Moriwaki H (2001) TNF-alpha-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/Akt pathway in human hepatocytes. J Immunol 167:173-180.
    • (2001) J Immunol , vol.167 , pp. 173-180
    • Osawa, Y.1    Banno, Y.2    Nagaki, M.3    Brenner, D.A.4    Naiki, T.5    Nozawa, Y.6    Nakashima, S.7    Moriwaki, H.8
  • 34
    • 0344609754 scopus 로고    scopus 로고
    • Modulation of tumor necrosis factor-alpha-mediated cytotoxicity by changes of the cellular methylation state: mechanism and in vivo relevance
    • Ratter F, Gassner C, Shatrov V, Lehmann V (1999) Modulation of tumor necrosis factor-alpha-mediated cytotoxicity by changes of the cellular methylation state: mechanism and in vivo relevance. Int Immunol 11:519-527.
    • (1999) Int Immunol , vol.11 , pp. 519-527
    • Ratter, F.1    Gassner, C.2    Shatrov, V.3    Lehmann, V.4
  • 35
    • 84858120447 scopus 로고    scopus 로고
    • Regulation of NF-kappaB signaling by the A20 deubiquitinase
    • Shembade N, Harhaj EW (2012) Regulation of NF-kappaB signaling by the A20 deubiquitinase. Cell Mol Immunol 9:123-130.
    • (2012) Cell Mol Immunol , vol.9 , pp. 123-130
    • Shembade, N.1    Harhaj, E.W.2
  • 36
    • 34250782784 scopus 로고    scopus 로고
    • Alcohol-induced S-adenosylhomocysteine accumulation in the liver sensitizes to TNF hepatotoxicity: possible involvement of mitochondrial S-adenosylmethionine transport
    • Song Z, Zhou Z, Song M, Uriarte S, Chen T, Deaciuc I, McClain CJ (2007) Alcohol-induced S-adenosylhomocysteine accumulation in the liver sensitizes to TNF hepatotoxicity: possible involvement of mitochondrial S-adenosylmethionine transport. Biochem Pharmacol 74:521-531.
    • (2007) Biochem Pharmacol , vol.74 , pp. 521-531
    • Song, Z.1    Zhou, Z.2    Song, M.3    Uriarte, S.4    Chen, T.5    Deaciuc, I.6    McClain, C.J.7
  • 37
    • 4644248469 scopus 로고    scopus 로고
    • S-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver disease
    • Song Z, Zhou Z, Uriarte S, Wang L, Kang YJ, Chen T, Barve S, McClain CJ (2004) S-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver disease. Hepatology 40:989-997.
    • (2004) Hepatology , vol.40 , pp. 989-997
    • Song, Z.1    Zhou, Z.2    Uriarte, S.3    Wang, L.4    Kang, Y.J.5    Chen, T.6    Barve, S.7    McClain, C.J.8
  • 38
    • 0027168447 scopus 로고
    • NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway
    • Sun SC, Ganchi PA, Ballard DW, Greene WC (1993) NF-kappa B controls expression of inhibitor I kappa B alpha: evidence for an inducible autoregulatory pathway. Science 259:1912-1915.
    • (1993) Science , vol.259 , pp. 1912-1915
    • Sun, S.C.1    Ganchi, P.A.2    Ballard, D.W.3    Greene, W.C.4
  • 41
    • 0029858387 scopus 로고    scopus 로고
    • TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB
    • Wang CY, Mayo MW, Baldwin AS Jr (1996) TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science 274:784-787.
    • (1996) Science , vol.274 , pp. 784-787
    • Wang, C.Y.1    Mayo, M.W.2    Baldwin Jr, A.S.3
  • 42
    • 79952704984 scopus 로고    scopus 로고
    • Ethanol exposure modulates hepatic S-adenosylmethionine and S-adenosylhomocysteine levels in the isolated perfused rat liver through changes in the redox state of the NADH/NAD(+) system
    • Watson WH, Song Z, Kirpich IA, Deaciuc IV, Chen T, McClain CJ (2011) Ethanol exposure modulates hepatic S-adenosylmethionine and S-adenosylhomocysteine levels in the isolated perfused rat liver through changes in the redox state of the NADH/NAD(+) system. Biochim Biophys Acta 1812:613-618.
    • (2011) Biochim Biophys Acta , vol.1812 , pp. 613-618
    • Watson, W.H.1    Song, Z.2    Kirpich, I.A.3    Deaciuc, I.V.4    Chen, T.5    McClain, C.J.6


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