Ethanol feeding of micropigs alters methionine metabolism and increases hepatocellular apoptosis and proliferation

Hepatology

Volumn 23, Issue 3, 1996, Pages 497-505

  Halsted, Charles H ^a,d   Villanueva, Jesus ^a   Chandler, Carol J ^a   Stabler, Sally P ^b   Allen, Robert H ^b   Muskhelishvili, Levan ^c   James, S Jill ^c   Poirier, Lionel ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^c NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CYCLINE; DEOXYURIDINE TRIPHOSPHATE PYROPHOSPHATASE; METHIONINE; METHIONINE SYNTHASE; S ADENOSYLHOMOCYSTEINE; S ADENOSYLMETHIONINE; THYMIDINE TRIPHOSPHATE;

ALCOHOL CONSUMPTION; ALCOHOLISM; AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER RISK; CELL DEATH; CELL PROLIFERATION; CELL REGENERATION; CONTROLLED STUDY; ENZYME ACTIVITY; LIVER CARCINOGENESIS; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; SWINE;

EID: 0029918034     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510230314     Document Type: Article

References (9)

1. 12. JAMA 1988;259:1525-1530.
2. Butterworth CE, Hatch KDS, Gore H, Meuller H, Krumdieck CL. Improvement in cervical dysplasia with folic acid therapy in users of oral contraceptives. Am J Clin Nutr 1982;35:73-82.
3. Lashner BA, Heidenreich PA, Su GL, Kane SV, Hanauer SB. Effect of folate supplementation on the incidence of dysplasia and cancer in chronic ulcerative colitis. Gastroenterology 1989;97:255-259.
4. Cravo ML, Mason JB, Dayal Y, Hutchinson M, Smith D, Selhub J, Rosenberg IH. Folate deficiency enhances the development of colonic neoplasia in dimethylhydrazine-treated rats. Cancer Res 1992;52:5002-5006.
5. Seitz HK, Simanowski UA, Garzon FT, Rideout JM, Peters TJ, Koch A, Berger MR, et al. Possible role of acetaldehyde in ethanol-related rectal carcinogenesis in the rat. Gastroenterology 1990;98:406-413.
6. Doll R, Forman D, La Vecchia C, Woutersen R. Alcoholic beverages and cancers of the digestive tract and larynx. In: Verschuren PM, ed. Health issues related to alcohol consumption Washington: ILSI Press, 1993:125-166.
7. Freudenheim JL, Graham S, Marshall JR, Haughey BP, Cholewinski S, Wilkinson G. Folate intake and carcinogenesis of the colon and rectum. Int J Epidemiol 1991;20:368-374.
8. Giovannucci E, Stampfer MJ, Colditz GA, Rimm EB, Trichopoulos D, Rosner BA, Speizer FE, et al. Folate, methionine, and alcohol intake and risk of colorectal adenoma. J Natl Cancer Inst 1993;85:875-884.
9. Halsted CH. Alcohol and folate interactions: clinical implications. In: Bailey LB, ed. Folate in health and disease. New York: Marcel Dekker, 1995:313-328.