3-Deazaadenosine, a S-adenosylhomocysteine hydrolase inhibitor, has dual effects on NF-κB regulation: Inhibition of NF-κB transcriptional activity and promotion of IκBα degradation

Journal of Biological Chemistry

Volumn 274, Issue 27, 1999, Pages 18981-18988

  Jeong, Seong Yun ^a   Ahn, Sang Gun ^a   Lee, Jeong Hwa ^a   Kim, Ho Shik ^a   Kim, Jin Woo ^a   Rhim, Hyangshuk ^a   Jeong, Seong Whan ^a   Kim, In Kyung ^a  

^a The Catholic University of Korea   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

3 DEAZAADENOSINE; 3 DEAZAARISTEROMYCIN; ADENOSYLHOMOCYSTEINASE INHIBITOR; BACTERIUM LIPOPOLYSACCHARIDE; HOMOCYSTEINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR PROTEIN; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; DNA BINDING; DRUG EFFECT; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION;

EID: 0033516464     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.27.18981     Document Type: Article

References (48)

1. Baeuerle, P. A., and Henkel, T. (1994) Annu. Rev. Immunol. 12, 141-179
2. Gilmore, T. D., Koedood, M., Piffat, K. A., and White, D. W. (1996) Oncogene 13, 1367-1378
3. Ghosh, S., May, M. J., and Kopp, E. B. (1998) Annu. Rev. Immunol. 16, 225-260
4. Verma, I. M., Stevenson, J. K., Schwarz, E. M., Antwerp, D. V., and Miyamoto, S. (1995) Genes Dev. 9, 2723-2735
5. Whiteside, S. T., Epinat, J.-C., Rice, N. R., and Israël, A. (1997) EMBO J. 16, 1413-1426
6. Baldwin, A. S., Jr. (1996) Annu. Rev. Immunol. 14, 649-681
7. Mercurio, F., Zhu, H., Murray, B. W., Schevchenko, A., Bennett, B. L., Li, J., Young, D. B., Barbosa, M., and Mann, M. (1997) Science 278, 860-866
8. Woronicz, J. D., Gao, X., Cao, Z., Rothe, M., and Goeddel, D. V. (1997) Science 278, 866-869
9. Zandi, E., Rothwarf, D. W., Delhase, M., Hayakawa, M., and Karin, M. (1997) Cell 91, 243-252
10. Schreck, R., Rieber, P., and Baeuerle, P. A. (1991) EMBO J. 10, 2247-2258
11. Kopp, E., and Ghosh, S. (1994) Science 265, 956-959
12. Schreck, R., Meier, B., Männel, D. N., Dröge, W., and Baeuerle, P. A. (1992) J. Exp. Med. 175, 1181-1194
13. Griscavage, J. M., Wilk, S., and Ignarro, L. J. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 3308-3312
14. Scheinman, R. I., Cogswell, P. C., Lofquist, A. K., and Baldwin, A. S., Jr. (1995) Science 270, 283-286
15. Auphan N., DiDonato, J. A., Rosette, C., Helmberg, A., and Krin, M. (1995) Science 270, 286-290
16. Wesselborg, S., Bauer, M. K. A., Vogt, M., Schmitz, M. L., and Schulze-Osthoff, K. (1997) J. Biol. Chem. 272, 12422-12429
17. Ollivier, V., Parry, G. C. N., Cobb, R. R., de Prost, D., and Mackman, N. (1996) J. Biol. Chem. 271, 20828-20835
18. Chiang, P. K., Richards, H. H., and Cantoni, G. L. (1977) Mol. Pharmacol. 13, 939-947
19. Aksamit, R. R., Falk, W., and Cantoni, G. L. (1982) J. Biol. Chem. 257, 621-625
20. Chiang, P. K., and Cantoni, G. L. (1979) Biochem. Pharmacol. 28, 1897-1902
21. Flexner, C. W., Hildreth, J. E., Kuncl, R. W., and Drachman, D. B. (1992) Lancet 339, 438
22. Mayers, D. L., Mikovits, J. A., Joshi, B., Hewlett, I. K., Estrada, J. S., Wolfe, A. D., Garcia, G. E., Doctor, B. P., Burke, D. S., Gordon, R. K., Lane, J. R., and Chiang, P. K. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 215-219
23. Medzihradsky, J. L., Zimmerman, T. P., Wolberg, G., and Elion, G. B. (1982) J. Immunopharmacol. 4, 29-41
24. Krenitsky, T. A., Rideout, J. L., Chao, E. Y., Koszalka, G. W., Gurney, F., Crouch, R. C., Cohn, N. K., Wolberg, G., and Vinegar, R. (1986) J. Med. Chem. 29, 138-143
25. Zimmerman, T. P., Wolberg, G., and Duncan, G. S. (1978) Proc. Natl. Acad. Sci. U. S. A. 75, 6220-6224
26. Jeong, S.-Y., Lee, J.-H., Kim, H.-S., Hong, S.-H., Cheong, C.-H., and Kim, I.-K. (1996) Immunology 89, 558-562
27. Jurgensen, C. H., Huber, B. E., Zimmerman, T. P., and Wolberg, G. (1990) J. Immunol. 144, 653-661
28. Shankar, R., de la Motte, C. A., and DiCorleto, P. E. (1992) J. Biol. Chem. 267, 9376-9382
29. Endresen, P. C., Eide, T. J., and Aarbakke, J. (1993) Biochem. Pharmacol. 46, 1893-1901
30. Kim, I.-K., Li, C.-C. H., Young, H. A., Lee, J.-H., Kim, H.-S., Pardhasaradhi, K., Garcia, G. E., and Chiang, P. K. (1997) J. Biomed. Sci. 4, 83-90
31. Chomczynski, P., and Sacchi, N. (1987) Anal. Biochem. 162, 156-159
32. Dignam, J. D., Lebovitz, R. M., and Roeder, R. G. (1983) Nucleic Acids Res. 11, 1475-1489
33. Lenardo, M. J., Fan, C.-H., Maniatis, T., and Baltimore, D. (1989) Cell 57, 287-294
34. DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., and Karin, M. (1997) Nature 388, 548-554
35. Shakhov, A. N., Collart, M. A., Vassalli, P., Nedospasov, S. A., and Jongeneel, C. V. (1990) J. Exp. Med. 171, 35-47
36. Chiao, P. J., Miyamoto, S., and Verma, I. M. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 28-32
37. Beg, A. A., Sha, W. C., Bronson, R. T., Ghosh, S., and Baltimore, D. (1995) Nature 376, 167-170
38. Beg, A. A., and Baltimore, D. (1996) Science 274, 782-784
39. Wang, C.-Y., Mayo, M. W., and Baldwin, A. S., Jr. (1996) Science 274, 784-787
40. Antwerp, D. J. V., Martin, S. J., Kafri, T., Green, D. R., and Verma, I. M. (1996) Science 274, 787-789
41. Liu, Z.-G., Hsu, H., Goeddel, D. V., and Karin, M. (1996) Cell 87, 565-576
42. Duyao, M. P., Buckler, A. J., and Sonenshein, G. E. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 4727-4731
43. Duerre, J. A., Buttz, H. R., and Ackerman, J. J. (1992) Biochem. Cell Biol. 70, 703-711
44. Loennechen, T., Moens, U., Kildalsen, H., Andersen, A., Rekvig, O. P., and Aarbakke, J. (1997) Pharmacol. Toxicol. 81, 199-204
45. Nabel, G., and Baltimore, D. (1987) Nature 326, 711-713
46. Naumann, M., and Scheidereit, C. (1994) EMBO J. 13, 4597-4607
47. Zhong, H., SuYang, H., Erdjument-Brommage, H., Tempst, P., and Ghosh, S. (1997) Cell 89, 413-424
48. Backlund, P. S., Jr., Carotti, D., and Cantoni, G. L. (1986) Eur. J. Biochem. 160, 245-251