S-adenosylmethionine decreases lipopolysaccharide-induced phosphodiesterase 4B2 and attenuates tumor necrosis factor expression via cAMP/protein kinase a pathway

Journal of Pharmacology and Experimental Therapeutics

Volumn 337, Issue 2, 2011, Pages 433-443

  Gobejishvili, Leila ^a,b   Avila, Diana V ^a,b   Barker, David F ^a,b   Ghare, Smita ^a,b   Henderson, David ^c   Brock, Guy N ^a   Kirpich, Irina A ^a,b   Joshi Barve, Swati ^a,b   Mokshagundam, Sri Prakash L ^a   McClain, Craig J ^a,b,d   Barve, Shirish ^a,b  

^a UNIVERSITY OF LOUISVILLE HOSPITAL   (United States)

^b UNIVERSITY OF LOUISVILLE   (United States)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; HISTONE H3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; LYSINE; MESSENGER RNA; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IVB2; S ADENOSYLMETHIONINE; SYNAPTOTAGMIN I; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL LEVEL; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; INTRON; METHYLATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; ANTIGENS, CD14; BETA-GALACTOSIDASE; BLOTTING, WESTERN; CELL NUCLEUS; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; CYTOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIPOPOLYSACCHARIDES; LUCIFERASES; MACROPHAGES; MICE; MONOCYTES; NF-KAPPA B; PHOSPHODIESTERASE INHIBITORS; PLASMIDS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; S-ADENOSYLMETHIONINE; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79955043463     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.174268     Document Type: Article

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