Implication of cytokines: Roles of tumor necrosis factor-α in liver injury

Hepatology Research

Volumn 38, Issue SUPPL. 1, 2008, Pages

  Nagaki, Masahito ^a   Moriwaki, Hisataka ^a  

^a GIFU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Acute liver failure; Apoptosis; Cell signaling; Flice inhibitory protein; Nuclear factor B; Superantigen

Indexed keywords

BACTERIAL ANTIGEN; BACTERIAL TOXIN; CHEMOKINE; CYTOKINE; DACTINOMYCIN; ENDOTOXIN; FAS ANTIGEN; GALACTOSAMINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LEFLUNOMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; SUPERANTIGEN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 1;

APOPTOSIS; CELL FATE; CELL PROLIFERATION; CELL PROTECTION; CONFERENCE PAPER; DEATH; GENE EXPRESSION; HUMAN; IMMUNE SYSTEM; IMMUNITY; IMMUNOREGULATION; INFLAMMATION; LEUKOCYTE; LIVER CELL; LIVER INJURY; LIVER RESECTION; MULTIPLE ORGAN FAILURE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; VIRUS;

EID: 58049112589     PISSN: 13866346     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2008.00422.x     Document Type: Conference Paper

References (55)

1. Leist M, Jaattela M. Four deaths and a funeral: From caspases to alternative mechanisms. Nat Rev Mol Cell Biol 2001; 2: 589-98.
2. Riordan SM, Williams R. Mechanisms of hepatocyte injury, multiorgan failure, and prognostic criteria in acute liver failure. Semin Liver Dis 2003; 23: 203-15.
3. Galanos C, Freudenberg MA, Reutter W. Galactosamine-induced sensitization to the lethal effects of endotoxin. Proc Natl Acad Sci USA 1979; 76: 5939-43.
4. Miethke T, Cahl C, Heeg K, Echtenacher B, Krammer PH, Wagner H. T cell-mediated lethal shock triggered in mice by superantigen staphylococcal enterotoxin B: Critical role of tumor necrosis factor. J Exp Med 1992; 175: 91-8.
5. Nagaki M, Muto Y, Ohnishi H et al. injury and lethal shock in galactosamine-sensitized mice induced by the superantigen staphylococcal enterotoxin B. Gastroenterology 1994; 106: 450-8.
6. Visvanathan K, Lewin SR. Immunopathogenesis: Role of innate and adaptive immune responses. Semin Liver Dis 2006; 26: 104-15.
7. Kimura K, Kakimi K, Wieland S, Guidotti LG, Chisari FV. Activated intrahepatic antigen-presenting cells inhibit hepatitis B virus replication in the liver of transgenic mice. J Immunol 2002; 169: 5188-95.
8. Nattermann J, Du X, Wei Y, Shevchenko D, Beutler B. Endotoxin-mimeric effect of antibodies against toll-like receptor 4. J Endotoxin Res 2000; 6: 257-64.
9. Yasuda S, Nagaki M, Moriwaki H. Staphylococcal enterotoxin B induces hepatic injury and lethal shock in endotoxin-resistant C3H/HeJ mice despite a deficient macrophage response. J Endotoxin Res 2002; 8: 253-61.
10. Calandra T, Baumgartner J, Verhoef J, Glauser MP, the Swiss-Dutch J5 Immuoglobulin Study Group. Prognostic values of tumor necrosis factor/ cachectin, interleukin-1, interferon-α, and interferon-γ in the serum of patients with septic shock. J Infect Dis 1990; 161: 982-7.
11. Muto Y, Nouri-Aria KT, Mearger A, Alexander GJM, Eddleston ALWF, Williams R. Enhanced tumor necrosis factor and interleukin-1 in fulminant hepatic failure. Lancet 1988; 2: 72-4.
12. Iwai H, Nagaki M, Naito T etal. Removal of endotoxin and cytokines by plasma exchange in patients with acute hepatic failure. Crit Care Med 1998; 26: 873-6.
13. Bone RC. Immunologic dissonance: A continuing evolution in our understanding of the systemic inflammatory response syndrome (SIRS) and the multiple organ dysfunction syndrome (MODS). Ann Interm Med 1996; 125: 680-7.
14. Van Zee KJ, Kohno T, Fischer E, Rock CS, Moldawer LL, Lowry SF. Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor a in vitro and in vivo. Proc Natl Acad Sci USA 1992; 89: 4845-9.
15. Girardin E, Roux-Lombard P, Grau GE, Suter P, Gallati H, Dayer J-M, the J5 Study Group. Imbalance between tumor necrosis factor-alpha and soluble TNF receptor concentrations in severe meningococcaemia. Immunology 1992; 76: 20-3.
16. Nagaki M, Iwai H, Naiki T, Ohnishi H, Muto Y, Moriwaki H. High levels of serum interleukin-10 and tumor necrosis factor-α are associated with fatality in fulminant hepatitis. J Infect Dis 2000; 182: 1103-8.
17. Chen X, Ding WX, Ni HM et al. Bid-independent mitochondrial activation in tumor necrosis factor alpha-induced apoptosis and liver injury. Mol Cell Biol 2007; 27: 541-53.
18. Scaffidi C, Fuluda S, Srinivasan A et al. Two CD95 (APO-1/Fas) signaling pathways. EMBO 1998; 17: 1675-87.
19. Rodriguez I, Matsuura K, Khatib K, Reed JC, Nagata S. Vassalli P. A Bcl-2 transgene expressed in hepatocytes protects mice from fulminant liver destruction but not from rapid death induced by anti-Fas antibody injection. J Exp Med 1996; 183: 1031-6.
20. Lacronique V, Mignon A, Fabre M et al. Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice. Nat Med 1996; 2: 80-6.
21. Yin XM, Wang K, Gross A et al. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature 1999; 400: 886-91.
22. Leist M, Gantner F, Nauman H et al. Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins. Gastroenterology 1997; 112: 923-34.
23. Ogasawara J, Watanabe-Fukunaga R, Adachi M et al. Lethal effect of the anti-Fas antibody in mice. Nature 1993; 364: 806-9.
24. Leist M, Gantner F, Kunstle G. The 55-kD tumor necrosis factor receptor and CD95 independently signal murine hepatocyte apoptosis and subsequent liver failure. Mol Med 1996; 2: 109-24.
25. Nagaki M, Sugiyama A, Osawa Y et al. Lethal hepatic apoptosis mediated by tumor necrosis factor receptor, unlike Fas-mediated apoptosis, requires hepatocyte sensitization in mice. J Hepatol 1999; 31: 997-1005.
26. Wong GHW, Goeddle DV. Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways. J Immunol 1995; 152: 1751-5.
27. Clement MV, Stamenkovic I. Fas and tumor necrosis factor receptor-mediated cell death; similarities and distinctions. J Exp Med 1994; 180: 557-67.
28. Imao M, Nagaki M, Imose M, Moriwaki H. Differential caspase-9-dependent signaling pathway between tumor necrosis factor receptor- and Fas-mediated hepatocyte apoptosis in mice. Liver Int 2006; 26: 137-46.
29. Beg AA, Baltimore D. An essential role for NF-κB in preventing TNF-α-induced cell death. sci 1996; 274: 782-4.
30. Karin M, Lin A. NF-κB at the crossroads of life and death. Nat Immunol 2002; 3: 221-7.
31. Beg A, Sha AW, Bronson R, Ghosh S, Baltimore D. Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB. Nature 1995; 376: 167-70.
32. Li Q, Van Antwarp D, Mercurio F, Lee KF, Verma IM. Sever liver degeneration in mice lacking the IKappaβ kinase 2 gene. Science 1999; 284: 321-5.
33. Makris C, Godfrey DV, Krahn-Senftleben G et al. Female mice heterozygous for IKK gamma/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti. Mol Cell 2000; 5: 969-79.
34. Chaisson ML, Brooling JT, Ladiges W, Tsai S, Fausto N. Hepatocyte-specific inhibition of NF-kapppaβ leads to apoptosis after TNF treatment, but not after partial hepatectomy. J Clin Invest 2002; 110: 193-202.
35. Maeda S, Chang L, Li ZW, Luo JL, Leffert H, Karin M. IKKbeta is required for prevention of apoptosis mediated by cell-bound but not by circulating TNFalpha. Immunity 2003; 19: 725-37.
36. Nagaki M, Naiki T, Brenner DA et al. Tumor necrosis factor α prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not Fas-mediated apoptosis: Role of nuclear factor-κB. Hepatology 2000; 32: 1272-9.
37. Madge LA, Pober JS. A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NF-κB in human endothelial cells. J Biol Chem 2000; 275: 15458-65.
38. Hatano E, Brenner DA. Akt protects mouse hepatocytes from TNF-α- and Fas-mediated apoptosis through NF-κB activation. Am J Physiol Gastrointest Liver Physiol 2002; 282: G1357-1368.
39. Osawa Y, Banno Y, Nagaki M et al. TNF-α-induced sphingosine 1-phosphate inhibits apoptosis through a phosphatidylinositol 3-kinase/ Akt pathway in human hepatocytes. J Immunol 2001; 167: 173-80.
40. Imose M, Nagaki M, Naiki T et al. Inhibition of nuclear factor κB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor α in mice. Liver Int 2003; 23: 386-96.
41. Osawa Y, Nagaki M, Banno Y et al. Tumor necrosis factor alpha-induced interleukin-8 production via phosphatidylinositol 3-kinase/Akt pathways inhibits cell apoptosis in human hepatocytes. Infect Immun 2002; 70: 6294-301.
42. Osawa Y, Nagaki M, Banno Y et al. Expression of the NF-κB target gene X-ray-inducible immediate early response factor-1 short enhances TNF-α-induced hepatocyte apoptosis by inhibiting Akt activation. J Immunol 2003; 170: 4053-60.
43. Deng Y, Ren X, Yang L, Lin Y, Wu X. A JNK-dependent pathway is required for TNFalpha-induced apoptosis. Cell 2003; 115: 61-70.
44. Tang G, Minemoto Y, Dibling B et al. Inhibition of JNK activation through NF-kappaB target genes. Nature 2001; 414: 313-7.
45. Wullaert A, Heyninck K, Beyaert R. Mechanisms of crosstalk between TNF-induced NF-κB and JNK activation in hepatocytes. Biochem Pharmacol 2006; 72: 1090-101.
46. Amanullah A, Azam N, Balliet A et al. Cell signaling: Cell survival and a Gadd45-factor deficiency. Nature 2003; 424: 741-2.
47. Kamada H, Honda S, Maeda S, Chang L, Hirata H, Karin M. Reactive oxygen species promote TNF-α-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 2005; 120: 649-61.
48. Pham CG, Bubici C, Zazzeroni F et al. Ferritin heavy chain upregulation by NF-kappaβ inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species. Cell 2004; 119: 529-42.
49. Tobiume K, Matsuzawa A, Takahashi T et al. ASK1 is required for sustained activation of JNK/p38 MAP kinases and apoptosis. EMBO Rep 2001; 2: 222-8.
50. Chang L, Kamata H, Solinas G et al. The E3 ubiquitin ligase Itch couples JNK activation to TNF-α-induced cell death by inducing c-FLIPL turnover. Cell 2006; 124: 601-13.
51. Micheau O, Tschopp J. Induction of TNF receptor 1-mediated apoptosis via two sequential signaling complexes. Cell 2003; 114: 181-90.
52. Imao M, Nagaki M, Moriwaki H. Dual effects of heat stress on tumor necrosis factor-α-induced hepatocyte apoptosis in mice. Lab Invest 2006; 86: 959-67.
53. Takai S, Nagaki M, Imao M, Kimura K, Kozawa O, Moriwaki H. Intrinsic resistance to TNF-α-induced hepatocyte apoptosis in ICR mice correlates with expression of a short form of c-FLIP. Lab Invest 2006; 87: 572-81.
54. Imose M, Nagaki M, Kimura K etal. Leflunomide protects from T-cell-mediated liver injury in mice through inhibition of nuclear factor κB. Hepatology 2004; 40: 1160-9.
55. Kimura K, Nagaki M, Takai S, Satake S, Moriwaki H. Pivotal role of nuclear factor κB signaling in anti-CD40-induced liver injury in mice. Hepatology 2004; 40: 1180-9.