Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-Δ12,14-prostaglandin J2

Biochemical and Biophysical Research Communications

Volumn 395, Issue 1, 2010, Pages 17-24

  Mishra, Nandita ^a   Kar, Rekha ^a   Singha, Prajjal K ^a   Venkatachalam, Manjeri A ^a   McEwen, Donald G ^a   Saikumar, Pothana ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

15d PGJ2; Drp1; GTPase effector domain; Mitochondrial fission; Mitochondrial fusion; Protein oligomerization

Indexed keywords

15 DEOXY DELTA12,14 PROSTAGLANDIN J2; ALANINE; CYSTEINE; DYNAMIN; DYNAMIN RELATED PROTEIN 1; ELECTROPHILE; GUANOSINE TRIPHOSPHATASE; OLIGOMER; UNCLASSIFIED DRUG; 15 DEOXY DELTA(12,14) PROSTAGLANDIN J2; 15-DEOXY-DELTA(12,14)-PROSTAGLANDIN J2; DNM1L PROTEIN, HUMAN; DRP1 PROTEIN, RAT; DRUG DERIVATIVE; MICROTUBULE ASSOCIATED PROTEIN; MITOCHONDRIAL PROTEIN; PROSTAGLANDIN D2;

ANIMAL CELL; ARTICLE; CELL ELONGATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE MUTATION; HUMAN; HUMAN CELL; MITOCHONDRION; MITOSIS INHIBITION; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RAT; ANIMAL; CELL LINE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HELA CELL; METABOLISM; MUTATION; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ANIMALS; CELL LINE; CYSTEINE; DYNAMINS; GTP PHOSPHOHYDROLASES; HELA CELLS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; MUTATION; PROSTAGLANDIN D2; PROTEIN STRUCTURE, TERTIARY; RATS;

EID: 77951905953     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.03.093     Document Type: Article

References (18)

1. S. Hoppins, L. Lackner, J. Nunnari, The machines that divide and fuse mitochondria, Ann. Rev. Biochem. 76 (2007) 751-780.
2. G.J. Praefcke, H.T. McMahon, The dynamin superfamily: universal membrane tubulation and fission molecules?, Nat Rev. 5 (2004) 133-147.
3. E. Smirnova, L. Griparic, D.L. Shurland, A.M. van der Bliek, Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells, Mol. Biol. Cell 12 (2001) 2245-2256.
4. E. Ingerman, E.M. Perkins, M. Marino, J.A. Mears, J.M. McCaffery, J.E. Hinshaw, J. Nunnari, Dnm1 forms spirals that are structurally tailored to fit mitochondria, J. Cell Biol. 170 (2005) 1021-1027.
5. A. Santel, S. Frank, Shaping mitochondria: the complex posttranslational regulation of the mitochondrial fission protein DRP1, IUBMB Life 60 (2008) 448-455.
6. R. Rajakariar, M. Hilliard, T. Lawrence, S. Trivedi, P. Colville-Nash, G. Bellingan, D. Fitzgerald, M.M. Yaqoob, D.W. Gilroy, Hematopoietic prostaglandin D2 synthase controls the onset and resolution of acute inflammation through PGD2 and 15-deoxyDelta12 14 PGJ2, Proc. Natl. Acad. Sci. USA 104 (2007) 20979-20984.
7. S. Offenbacher, B.M. Odle, T.E. Van Dyke, The use of crevicular fluid prostaglandin E2 levels as a predictor of periodontal attachment loss, J. Periodontal Res. 21 (1986) 101-112.
8. J.M. Weinberg, P. Saikumar, Mitochondrial function, Methods Mol. Med. 86 (2003) 351-371.
9. I. Wittig, H.P. Braun, H. Schagger, Blue native PAGE, Nat. Protoc. 1 (2006) 418-428.
10. P.P. Zhu, A. Patterson, B. Lavoie, J. Stadler, M. Shoeb, R. Patel, C. Blackstone, Cellular localization, oligomerization, and membrane association of the hereditary spastic paraplegia 3A (SPG3A) protein atlastin, J. Biol. Chem. 278 (2003) 49063-49071.
11. E. Ingerman, J. Nunnari, A continuous, regenerative coupled GTPase assay for dynamin-related proteins, Methods Enzymol. 404 (2005) 611-619.
12. J.Y. Oh, N. Giles, A. Landar, V. Darley-Usmar, Accumulation of 15-deoxydelta(12,14)-prostaglandin J2 adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defence induction, Biochem. J. 411 (2008) 297-306.
13. P.A. Parone, S. Da Cruz, D. Tondera, Y. Mattenberger, D.I. James, P. Maechler, F. Barja, J.C. Martinou, Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA, PLoS One 3 (2008) e3257.
14. M.K. Dennehy, K.A. Richards, G.R. Wernke, Y. Shyr, D.C. Liebler, Cytosolic and nuclear protein targets of thiol-reactive electrophiles, Chem. Res. Toxicol. 19 (2006) 20-29.
15. P.P. Zhu, A. Patterson, J. Stadler, D.P. Seeburg, M. Sheng, C. Blackstone, Intraand intermolecular domain interactions of the C-terminal GTPase effector domain of the multimeric dynamin-like GTPase Drp1, J. Biol. Chem. 279 (2004) 35967-35974.
16. Y. Yoon, K.R. Pitts, M.A. McNiven, Mammalian dynamin-like protein DLP1 tubulates membranes, Mol. Biol. Cell 12 (2001) 2894-2905.
17. J.S. Chappie, S. Acharya, Y.W. Liu, M. Leonard, T.J. Pucadyil, S.L. Schmid, An intramolecular signaling element that modulates dynamin function in vitro and in vivo, Mol. Biol. Cell 20 (2009) 3561-3571.
18. A. Roux, B. Antonny, The long and short of membrane fission, Cell 135 (2008) 1163-1165.