Natural diterpenoid compound elevates expression of bim protein, which interacts with antiapoptotic protein Bcl-2, converting it to proapoptotic bax-like molecule

Journal of Biological Chemistry

Volumn 287, Issue 2, 2012, Pages 1054-1065

  Zhao, Lixia ^a,b   He, Feng ^c   Liu, Haiyang ^d   Zhu, Yushan ^a,b   Tian, Weili ^a,b   Gao, Ping ^a,b   He, Hongping ^d   Yue, Wen ^a,b   Lei, Xiaobo ^a,b   Ni, Biyun ^a,b   Wang, Xiaohui ^a,b   Jin, Haijing ^a,b   Hao, Xiaojiang ^d   Lin, Jialing ^c   Chen, Quan ^a,b  

^a INSTITUTE OF ZOOLOGY   (China)

^b NANKAI UNIVERSITY   (China)

^c UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^d KUNMING INSTITUTE OF BOTANY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-APOPTOTIC PROTEIN; ANTI-CANCER THERAPEUTICS; BCL-2 FAMILY PROTEINS; CANCER DEVELOPMENT; CASPASE ACTIVATION; CYTOCHROME C; INDUCED APOPTOSIS; KNOCK OUTS; MURINE EMBRYONIC FIBROBLASTS; OUTER MEMBRANE; TUMOR GROWTH;

CELL CULTURE; CELL DEATH; LIPIDS; MITOCHONDRIA; OLIGOMERIZATION; OLIGOMERS;

PROTEINS;

BIM PROTEIN; CYTOCHROME C; DITERPENOID; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL MIGRATION; CELL PERMEABILIZATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME RELEASE; FIBROBLAST; MITOCHONDRION; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; TUMOR CELL;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2-ASSOCIATED X PROTEIN; CELL LINE, TRANSFORMED; CYTOCHROMES C; DITERPENES; GENE EXPRESSION REGULATION; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MITOCHONDRIAL MEMBRANES; PERMEABILITY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2;

MURINAE; MUS;

EID: 84862917028     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.264481     Document Type: Article

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