Adiponectin offers protection against L166P mutant DJ-1-induced neuronal cytotoxicity mediated by APPL1-dependent AMPK activation

International Journal of Neuroscience

Volumn 124, Issue 5, 2014, Pages 350-361

  Li, Xuemei ^a   Geng, Jianhong ^a   Liu, Junling ^b  

^a AFFILIATED HOSPITAL OF WEIFANG MEDICAL UNIVERSITY   (China)

^b WEIFANG MEDICAL UNIVERSITY   (China)

Author keywords

Adiponectin; AMPK; DJ 1; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; ADAPTOR PROTEIN; ADAPTOR PROTEIN WITH PHOSPHOTYROSINE BINDING PLECKSTRIN HOMOLOGY DOMAINS AND LEUCINE ZIPPER MOTIF; ADIPONECTIN; ADIPONECTIN RECEPTOR 1; ADIPONECTIN RECEPTOR 2; CELL SURFACE RECEPTOR; DJ 1 PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; NITRIC OXIDE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ARTICLE; ATTENUATION; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MUTANT; NEUROPROTECTION; NEUROTOXICITY; OXIDATIVE STRESS; PARKINSON DISEASE; PROTEIN EXPRESSION; RNA INTERFERENCE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADIPONECTIN; AMP-ACTIVATED PROTEIN KINASES; CELL LINE, TUMOR; CELL SURVIVAL; ENZYME ACTIVATION; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MUTATION; NITRIC OXIDE; ONCOGENE PROTEINS; REACTIVE OXYGEN SPECIES; RECEPTORS, ADIPONECTIN; TRANSFECTION;

EID: 84897986995     PISSN: 00207454     EISSN: 15635279     Source Type: Journal    
DOI: 10.3109/00207454.2013.846340     Document Type: Article

References (48)

1. Lees AJ, Hardy J, Revesz T. Parkinson's disease. Lancet 2009;373:2055-66.
2. Leverenz JB, Umar I, Wang Q, et al. Proteomic identifca-tion of novel proteins in cortical Lewy bodies. Brain Pathol 2007;17:139-145. (Pubitemid 46466133)
3. Spillantini MG, Schmidt ML, Lee VM, et al. Alpha-synuclein in Lewy bodies. Nature 1997;388:839-40.
4. Meulener M, Whitworth AJ, Armstrong-Gold CE, et al. Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. Curr Biol 2005;15:1572-77. (Pubitemid 41219597)
5. Canet-Aviles RM, Wilson MA, Miller DW, et al. The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfnic acid-driven mitochondrial localization. Proc Natl Acad Sci USA 2004;101:9103-8. (Pubitemid 38781618)
6. Bretaud S, Allen C, Ingham PW, Bandmann O. p53-dependent neuronal cell death in a DJ-1-defcient zebrafsh model of Parkinson's disease. J Neurochem 2007;100:1626-35. (Pubitemid 46376201)
7. Cookson MR. DJ-1, PINK1, and their effects on mitochondrial pathways. Mov Disord 2010;25(Suppl 1):S44-8.
8. Bonifati V, Rizzu P, van Baren MJ, et al. Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinson-ism. Science 2003;299:256-59. (Pubitemid 36131051)
9. Cookson MR. Parkinsonism due to mutations in PINK1, parkin, and DJ-1 and oxidative stress and mitochondrial pathways. Cold Spring Harb Perspect Med 2012;2(9):a009 415.
10. Deeg S, Gralle M, Sroka K, et al. BAG1 restores formation of functional DJ-1 L166P dimers and DJ-1 chaperone activity. J Cell Biol 2010;188:505-13.
11. Wang Y, Lam KS, Yau MH, et al. Post-translational modifca-tions of adiponectin: mechanisms and functional implications. Biochem J 2008;409:623-33. (Pubitemid 351214189)
12. Yamauchi T, Kamon J, Minokoshi Y, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 2002;8:1288-95. (Pubitemid 35373562)
13. Nishimura M, Izumiya Y, Higuchi A, et al. Adiponectin prevents cerebral ischemic injury through endothelial nitric oxide synthase dependent mechanisms. Circulation 2008;117:216-23.
14. Jeon BT, Shin HJ, Kim JB, et al. Adiponectin protects hip-pocampal neurons against kainic acid-induced excitotoxicity. Brain Res Rev 2009;61:81-8.
15. Jung TW, Lee JY, Shim WS, et al. Adiponectin protects human neuroblastoma SH-SY5Y cells against acetaldehyde-induced cytotoxicity. Biochem Pharmacol 2006;72(5):616-23. (Pubitemid 44163296)
16. Song W, Huo T, Guo F, et al. Globular adiponectin elicits neu-roprotection by inhibiting NADPH oxidase-mediated oxida-tive damage in ischemic stroke. Neuroscience 2013;248C:136-44.
17. Qiu G, Wan R, Hu J, et al. Adiponectin protects rat hippocampal neurons against excitotoxicity. Age (Dordr) 2011;33(2):155-65.
18. Cassani E, Cancello R, Cavanna F, et al. Serum adiponectin levels in advanced-stage Parkinson's disease patients. Parkinsons Dis 2011:624764.
19. Mao X, Kikani CK, Riojas RA, et al. APPL1 binds to adiponectin receptors and mediates adiponectin signaling and function. Nat Cell Biol 2006;8(5):516-23.
20. Deepa SS, Dong LQ. APPL1: role in adiponectin signaling and beyond. Am J Physiol Endocrinol Metab 2009;296:E22-36.
21. Ouchi N, Kihara S, Arita Y, et al. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation 2000;102(11):1296-301.
22. Chan KH, Lam KS, Cheng OY, et al. Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity. PLoS One 2012;7(12):e52354.
23. Sheng B, Gong K, Niu Y, et al. Inhibition of gamma-secretase activity reduces Abeta production, reduces oxidative stress, increases mitochondrial activity and leads to reduced vulnerability to apoptosis: Implications for the treatment of Alzheimer's disease. Free Radic Biol Med 2009;46(10):1362-75.
24. Sheng B, Wang X, Su B, et al. Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer's disease. J Neurochem 2012;120(3):419-29.
25. He Y, Chang G, Zhan S, et al. Soluble tissue factor has unique angiogenic activities that selectively promote migration and differentiation but not proliferation of endothelial cells. Biochem Biophys Res Commun 2008;370(3):489-94.
26. Yamauchi T, Kadowaki T. Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases. Int J Obes (Lond) 2008;32(Suppl 7):S13-8.
27. Giaime E, Sunyach C, Druon C, et al. Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6. Cell Death Differ Cell Death Differ 2010;17(1):158-69.
28. Kumar H, Lim HW, More SV, et al. The role of free radicals in the aging brain and Parkinson's disease: convergence and parallelism. Int J Mol Sci 2012;13(8):10478-504.
29. Parker WD Jr., Parks JK, Swerdlow RH. Complex I def-ciency in Parkinson's disease frontal cortex. Brain Res 2008; 1189:215-218. (Pubitemid 351842538)
30. Bender A, Krishnan KJ, Morris CM et al. High levels of mito-chondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease. Nat Genet 2006;38:515-17.
31. Canet-Aviles RM, Wilson MA, Miller DW, et al. The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfnic acid-driven mitochondrial localization. Proc Natl Acad Sci USA 2004;101:9103-108. (Pubitemid 38781618)
32. Irrcher I, Aleyasin H, Seifert EL, et al. Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics. Hum Mol Genet 2010;19:3734-46.
33. Wang X, Petrie TG, Liu Y, et al. Parkinson's disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction. J Neurochem 2012;121:830-39.
34. Ren H, Fu K, Mu C, et al. L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL. Mol Neurodegener 2012;7:40.
35. Vasseur S, Afzal S, Tardivel-Lacombe J, et al. DJ-1/PARK7 is an important mediator of hypoxia-induced cellular responses. Proc Natl Acad Sci USA 2009;106:1111-6.
36. McCullough LD, Zeng Z, Li H, et al. Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke. J Biol Chem 2005;280(21):20493-502. (Pubitemid 40776749)
37. Mart́inez de Morentin PB, González CR, et al. AMP-activated protein kinase: 'a cup of tea' against cholesterol-induced neuro-toxicity. J Pathol 2010;222(4):329-34.
38. Blázquez C, Geelen MJ, Velasco G, et al. The AMP-activated protein kinase prevents ceramide synthesis de novo and apopto-sis in astrocytes. FEBS Lett 2001;489(2-3):149-53. (Pubitemid 32126399)
39. Culmsee C, Monnig J, Kemp BE, et al. AMP-activated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation. J Mol Neurosci 2001;17(1):45-58. (Pubitemid 32928285)
40. Jung TW, Lee JY, Shim WS, et al. Adiponectin protects human neuroblastoma SH-SY5Y cells against MPP+-induced cytotox-icity. Biochem Biophys Res Commun 2006;343(2):564-70.
41. Nishimura M, Izumiya Y, Higuchi A, et al. Adiponectin prevents cerebral ischemic injury through endothelial nitric oxide synthase dependent mechanisms. Circulation 2008;117: 216-23.
42. Chen B, Liao WQ, Xu N, et al. Adiponectin protects against cerebral ischemia-reperfusion injury through anti-infammatory action. Brain Res 2009;1273:129-37.
43. Sonmez FM, Zaman D, Aksoy A, et al. The effects of topira-mate and valproate therapy on insulin, c-peptide, leptin, neu-ropeptide Y, adiponectin, visfatin, and resistin levels in children with epilepsy. Seizure 2013;pii:S1059-1311(13)00200-8.
44. Osuka K, Watanabe Y, Yasuda M, et al. Adiponectin activates endothelial nitric oxide synthase through AMPK signaling after subarachnoid hemorrhage. Neurosci Lett 2012;514(1):2-5.
45. Lu DY, Chen JH, Tan TW, et al. Resistin protects against 6-hydroxydopamine-induced cell death in dopaminergic-like MES23.5 cells. J Cell Physiol 2013 Mar;228(3):563-71.
46. Ho PW, Liu HF, Ho JW, et al. Mitochondrial uncoupling protein-2 (UCP2) mediates leptin protection against MPP+ toxicity in neuronal cells. Neurotox Res 2010;17(4):332-43.
47. Giaime E, Sunyach C, Druon C, et al. Loss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6. Cell Death Differ 2010;17:158-69.
48. Qiu G, Wan R, Hu J, et al. Adiponectin protects rat hippocam-pal neurons against excitotoxicity. Age (Dordr) 2011;33(2): 155-65.