p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's disease

Journal of Neurochemistry

Volumn 100, Issue 6, 2007, Pages 1626-1635

  Bretaud, Sandrine ^a,b   Allen, Claire ^a   Ingham, Phillip W ^a   Bandmann, Oliver ^a,b  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Apoptosis; DJ 1; p53; Parkinson's disease; Zebrafish

Indexed keywords

BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; PROTEASOME; PROTEIN BAX; PROTEIN P53; TOXIN;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DISEASE MODEL; DOPAMINERGIC NERVE CELL; EMBRYO; GENE INACTIVATION; GENETIC DISORDER; NERVE CELL NECROSIS; NEUROMODULATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS REGULATION; ZEBRA FISH;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BCL-2-ASSOCIATED X PROTEIN; CELL DEATH; DISEASE MODELS, ANIMAL; EMBRYO; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; HYDROGEN PEROXIDE; IN SITU HYBRIDIZATION; IN SITU NICK-END LABELING; LEUPEPTINS; NERVE TISSUE PROTEINS; NEURONS; NEUROTOXINS; PARKINSON DISEASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEIN P53; TYROSINE 3-MONOOXYGENASE; ZEBRAFISH; ZEBRAFISH PROTEINS;

ANIMALIA; DANIO RERIO;

EID: 33847723997     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04291.x     Document Type: Article

References (44)

1. Abeliovich A. and Beal M. F. (2006) Parkinsonism genes: culprits and clues. J. Neurochem. (published online ahead of print).
2. Annesi G., Savettieri G., Pugliese P. et al. (2005) DJ-1 mutations and parkinsonism-dementia-amyotrophic lateral sclerosis complex. Ann. Neurol. 58, 803-807.
3. Bae B. I., Xu H., Igarashi S. et al. (2005) p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease. Neuron 47, 29-41.
4. Beal F. and Lang A. (2006) The proteasomal inhibition model of Parkinson's disease: 'Boon or bust'? Ann. Neurol. 60, 158-161.
5. Biswas S. C., Ryu E., Park C., Malagelada C. and Greene L. A. (2005) Puma and p53 play required roles in death evoked in a cellular model of Parkinson's disease. Neurochem. Res. 30, 839-845.
6. Bladen C. L., Udayakumar D., Takeda Y. and Dynan W. S. (2005) Identification of the polypyrimidine tract binding protein-associated splicing factor.p54 (nrb) complex as a candidate DNA doublestrand break rejoining factor. J. Biol. Chem. 280, 5205-5210.
7. Bretaud S., Lee S. and Guo S. (2004) Sensitivity of zebrafish to environmental toxins implicated in Parkinson's disease. Neurotoxicol. Teratol. 26, 857-864.
8. Campbell W. A., Yang H., Zetterberg H., Baulac S., Sears J. A., Liu T., Wong S. T., Zhong T. P. and Xia W. (2006) Zebrafish lacking Alzheimer presenilin enhancer 2 (Pen-2) demonstrate excessive p53-dependent apoptosis and neuronal loss. J. Neurochem. 96, 1423-1440.
9. Chen L., Cagniard B., Mathews T., Jones S., Koh H. C., Ding Y., Carvey P. M., Ling Z., Kang U. J. and Zhuang X. (2005) Age-dependent motor deficits and dopaminergic dysfunction in DJ-1 null mice. J. Biol. Chem. 280, 21 418-21 426.
10. Dawson T. M. and Dawson V. L. (2003) Molecular pathways of neurodegeneration in Parkinson's disease. Science 302, 819-822
11. Dietrich P., Rideout H. J., Wang Q. and Stefanis L. (2003) Lack of p53 delays apoptosis, but increases ubiquitinated inclusions, in proteasomal inhibitor-treated cultured cortical neurons. Mol. Cell Neurosci. 24, 430-441.
12. Duan W., Zhu X., Ladenheim B., Yu Q. S., Guo Z., Oyler J., Cutler R. G., Cadet J. L., Greig N. H. and Mattson M. P. (2002) p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism. Ann. Neurol. 52, 597-606.
13. Ekker S. C. and Larson J. D. (2001) Morphant technology in model developmental systems. Genesis 30, 89-93.
14. Goldberg M. S., Pisani A., Haburcak M. et al. (2005) Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron 45, 489-496.
15. Guo S., Brush J., Teraoka H., Goddard A., Wilson S. W., Mullins M. C. and Rosenthal A. (1999) Development of noradrenergic neurons in the zebrafish hindbrain requires BMP, FGF8, and the homeodomain protein soulless/Phox2a. Neuron 24, 555-566.
16. Hartmann A., Michel P. P., Troadec J. D., Mouatt-Prigent A., Faucheux B. A., Ruberg M., Agid Y. and Hirsch E. C. (2001) Is Bax a mitochondrial mediator in apoptotic death of dopaminergic neurons in Parkinson's disease? J. Neurochem. 76, 1785-1793.
17. Heasman J. (2002) Morpholino oligos: making sense of antisense? Dev. Biol. 243, 209-214.
18. Holzschuh J., Ryu S., Aberger F. and Driever W. (2001) Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo. Mech. Dev. 101, 237-243.
19. Junn E., Taniguchi H., Jeong B. S., Zhao X., Ichijo H. and Mouradian M. M. (2005) Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. Proc. Natl Acad. Sci. USA 102, 9691-9696.
20. Kim R. H., Smith P. D., Aleyasin H. et al. (2005) Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc. Natl Acad. Sci. USA 102, 5215-5220.
21. Kirby J., Halligan E., Baptista M. J. et al. (2005) Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS. Brain 128, 1686-1706.
22. Langheinrich U., Hennen E., Stott G. and Vacun G. (2002) Zebrafish as a model organism for the identification and characterization of drugs and genes affecting p53 signaling. Curr. Biol. 12, 2023-2028.
23. de Lau L. M. and Breteler M. M. (2006) Epidemiology of Parkinson's disease. Lancet Neurol. 5, 525-535.
24. Li H. M., Niki T., Taira T., Iguchi-Ariga S. M. and Ariga H. (2005) Association of DJ-1 with chaperones and enhanced association and colocalization with mitochondrial Hsp70 by oxidative stress. Free Radic. Res. 39, 1091-1099.
25. Ma P. M. and Lopez M. (2003) Consistency in the number of dopaminergic paraventricular organ-accompanying neurons in the posterior tuberculum of the zebrafish brain. Brain Res. 967, 267-272.
26. McNaught K. S., Belizaire R., Isacson O., Jenner P. and Olanow C. W. (2003) Altered proteasomal function in sporadic Parkinson's disease. Exp. Neurol. 179, 38-46.
27. McNaught K. S., Perl D. P., Brownell A. L. and Olanow C. W. (2004) Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease. Ann. Neurol. 56, 149-162.
28. Meulener M., Whitworth A. J., Armstrong-Gold C. E., Rizzu P., Heutink P., Wes P. D., Pallanck L. J. and Bonini N. M. (2005) Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. Curr. Biol. 15, 1572-1577.
29. de la Monte S. M., Sohn Y. K., Ganju N. and Wands J. R. (1998) P53-and CD95-associated apoptosis in neurodegenerative diseases. Lab. Invest. 78, 401-411.
30. Nair V. D. (2006) Activation of p53 signaling initiates apoptotic death in a cellular model of Parkinson's disease. Apoptosis 11, 955-966.
31. Nakaso K., Yoshimoto Y., Yano H., Takeshima T. and Nakashima K. (2004) p53-mediated mitochondrial dysfunction by proteasome inhibition in dopaminergic SH-SY5Y cells. Neurosci. Lett. 354, 213-216.
32. Petrucelli L., O'Farrell C., Lockhart P. J. et al. (2002) Parkin protects against the toxicity associated with mutant α-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons. Neuron 36, 1007-1019.
33. Rink E. and Wullimann M. F. (2001) The teleostean (zebrafish) dopaminergic system ascending to the subpallium (striatum) is located in the basal diencephalon (posterior tuberculum). Brain Res. 889, 316-330.
34. Rink E. and Wullimann M. F. (2002) Connections of the ventral telencephalon and tyrosine hydroxylase distribution in the zebrafish brain (Danio rerio) lead to identification of an ascending dopaminergic system in a teleost. Brain Res. Bull. 57, 385-387.
35. Shendelman S., Jonason A., Martinat C., Leete T. and Abeliovich A. (2004) DJ-1 is a redox-dependent molecular chaperone that inhibits α-synuclein aggregate formation. PLoS Biol. 2, e362.
36. Shin J. T. and Fishman M. C. (2002) From Zebrafish to human: modular medical models. Annu. Rev. Genomics Hum. Genet. 3, 311-340.
37. Taira T., Saito Y., Niki T., Iguchi-Ariga S. M., Takahashi K. and Ariga H. (2004) DJ-1 has a role in antioxidative stress to prevent cell death. EMBO Report 5, 213-218.
38. Tatton W. G., Chalmers-Redman R., Brown D. and Tatton N. (2003) Apoptosis in Parkinson's disease: signals for neuronal degradation. Ann. Neurol. 53, S61-S72.
39. Vila M. and Przedborski S. (2004) Genetic clues to the pathogenesis of Parkinson's disease. Nat. Med. 10, S58-S62.
40. Wagenfeld A., Gromoll J. and Cooper T. G. (1998) Molecular cloning and expression of rat contraception associated protein 1 (CAP1), a protein putatively involved in fertilization. Biochem. Biophys. Res. Commun. 251, 545-549.
41. Warner T. T. and Schapira A. H. (2003) Genetic and environmental factors in the cause of Parkinson's disease. Ann. Neurol. 53, S16-S25.
42. Xu J., Zhong N., Wang H., Elias J. E., Kim C. Y., Woldman I., Pifl C., Gygi S. P., Geula C. and Yankner B. A. (2005) The Parkinson's disease-associated DJ-1 protein is a transcriptional co-activator that protects against neuronal apoptosis. Hum. Mol. Genet. 14, 1231-1241.
43. Yang Y., Gehrke S., Haque M. E. et al. (2005) Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proc. Natl Acad. Sci. USA 102, 13 670-13 675.
44. Yokota T., Sugawara K., Ito K., Takahashi R., Ariga H. and Mizusawa H. (2003) Down-regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition. Biochem. Biophys. Res. Commun. 312, 1342-1348.