Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke

Journal of Biological Chemistry

Volumn 280, Issue 21, 2005, Pages 20493-20502

  McCullough, Louise D ^a   Zeng, Zhiyuan ^a   Li, Hong ^c   Landree, Leslie E ^c   McFadden, Jill ^b   Ronnett, Gabriele V ^c  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

^b FASgen Inc   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CHEMICAL REACTIONS; ENZYME INHIBITION; GLUCOSE; METABOLISM; NEUROLOGY; OXYGEN; PHARMACODYNAMICS;

AMP-ACTIVATED PROTEIN KINASE (AMPK); PHARMACOLOGY; PHOSPHORYLATION; PROTEIN KINASE;

ENZYMES;

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; C 75; CENTRAL NERVOUS SYSTEM AGENTS; COMPOUND C; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CELL HYPOXIA; CELL SURVIVAL; CONTROLLED STUDY; ENERGY BALANCE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HIPPOCAMPUS; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRESS; STROKE;

4-BUTYROLACTONE; AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; BRAIN ISCHEMIA; CEREBRAL CORTEX; CEREBROVASCULAR ACCIDENT; CONSTRICTION; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; ENZYME ACTIVATION; ENZYME INHIBITORS; FATTY ACID SYNTHETASE COMPLEX; GLUCOSE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MIDDLE CEREBRAL ARTERY; MULTIENZYME COMPLEXES; NERVE TISSUE PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; OXYGEN; PROTEIN-SERINE-THREONINE KINASES; RATS; RIBONUCLEOTIDES;

EID: 20144368904     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M409985200     Document Type: Article

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