메뉴 건너뛰기




Volumn 5 MAR, Issue , 2014, Pages

Targeting diseased tissues by pHLIP insertion at low cell surface pH

Author keywords

Drug delivery; Imaging; Nanotechnology; Universal health test

Indexed keywords

AMANITIN; CARRIER PROTEIN; CELL PENETRATING PEPTIDE; GOLD NANOPARTICLE; GRAMICIDIN; LIPOSOME; MEMBRANE PROTEIN; NANOCARRIER; NANOPARTICLE; PH LOW INSERTION PEPTIDE; PHALLOIDIN; UNCLASSIFIED DRUG;

EID: 84897930823     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2014.00097     Document Type: Review
Times cited : (80)

References (52)
  • 1
    • 78650553199 scopus 로고    scopus 로고
    • pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation
    • doi: 10.1073/pnas.1014403107
    • An, M., Wijesinghe, D., Andreev, O. A., Reshetnyak, Y. K., and Engelman, D. M. (2010). pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation. Proc. Natl. Acad. Sci. U.S.A. 107, 20246-20250. doi: 10.1073/pnas.1014403107.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 20246-20250
    • An, M.1    Wijesinghe, D.2    Andreev, O.A.3    Reshetnyak, Y.K.4    Engelman, D.M.5
  • 2
    • 34249949775 scopus 로고    scopus 로고
    • Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo
    • doi: 10.1073/pnas.0702439104
    • Andreev, O. A., Dupuy, A. D., Segala, M., Sandugu, S., Serra, D. A., Chichester, C. O., et al. (2007). Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo. Proc. Natl. Acad. Sci. U.S.A. 104, 7893-7898. doi: 10.1073/pnas.0702439104.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 7893-7898
    • Andreev, O.A.1    Dupuy, A.D.2    Segala, M.3    Sandugu, S.4    Serra, D.A.5    Chichester, C.O.6
  • 3
    • 77749313553 scopus 로고    scopus 로고
    • Targeting acidic diseased tissue: new technology based on use of the pH (Low) Insertion Peptide (pHLIP)
    • Andreev, O. A., Engelman, D. M., and Reshetnyak, Y. K. (2009). Targeting acidic diseased tissue: new technology based on use of the pH (Low) Insertion Peptide (pHLIP). Chim. Oggi 27, 34-37.
    • (2009) Chim. Oggi , vol.27 , pp. 34-37
    • Andreev, O.A.1    Engelman, D.M.2    Reshetnyak, Y.K.3
  • 4
    • 78049333901 scopus 로고    scopus 로고
    • pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents
    • doi: 10.3109/09687688.2010.509285
    • Andreev, O. A., Engelman, D. M., and Reshetnyak, Y. K. (2010a). pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents. Mol. Membr. Biol. 27, 341-352. doi: 10.3109/09687688.2010.509285.
    • (2010) Mol. Membr. Biol. , vol.27 , pp. 341-352
    • Andreev, O.A.1    Engelman, D.M.2    Reshetnyak, Y.K.3
  • 5
    • 77749233798 scopus 로고    scopus 로고
    • pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path
    • doi: 10.1073/pnas.0914330107
    • Andreev, O. A., Karabadzhak, A. G., Weerakkody, D., Andreev, G. O., Engelman, D. M., and Reshetnyak, Y. K. (2010b). pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path. Proc. Natl. Acad. Sci. U.S.A. 107, 4081-4086. doi: 10.1073/pnas.0914330107.
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 4081-4086
    • Andreev, O.A.1    Karabadzhak, A.G.2    Weerakkody, D.3    Andreev, G.O.4    Engelman, D.M.5    Reshetnyak, Y.K.6
  • 6
    • 80054741747 scopus 로고    scopus 로고
    • Roles of carboxyl groups in the transmembrane insertion of peptides
    • doi: 10.1016/j.jmb.2011.08.010
    • Barrera, F. N., Weerakkody, D., Anderson, M., Andreev, O. A., Reshetnyak, Y. K., and Engelman, D. M. (2011). Roles of carboxyl groups in the transmembrane insertion of peptides. J. Mol. Biol. 413, 359-371. doi: 10.1016/j.jmb.2011.08.010.
    • (2011) J. Mol. Biol. , vol.413 , pp. 359-371
    • Barrera, F.N.1    Weerakkody, D.2    Anderson, M.3    Andreev, O.A.4    Reshetnyak, Y.K.5    Engelman, D.M.6
  • 7
    • 84878782419 scopus 로고    scopus 로고
    • Cell-penetrating peptides: 20 years later, where do we stand?
    • doi: 10.1016/j.febslet.2013.04.031
    • Bechara, C., and Sagan, S. (2013). Cell-penetrating peptides: 20 years later, where do we stand? FEBS Lett. 587, 1693-1702. doi: 10.1016/j.febslet.2013.04.031.
    • (2013) FEBS Lett. , vol.587 , pp. 1693-1702
    • Bechara, C.1    Sagan, S.2
  • 8
    • 19444382074 scopus 로고    scopus 로고
    • The engineering of membrane-permeable peptides
    • doi: 10.1016/j.ab.2005.03.026
    • Carrigan, C. N., and Imperiali, B. (2005). The engineering of membrane-permeable peptides. Anal. Biochem. 341, 290-298. doi: 10.1016/j.ab.2005.03.026.
    • (2005) Anal. Biochem. , vol.341 , pp. 290-298
    • Carrigan, C.N.1    Imperiali, B.2
  • 9
    • 33748988741 scopus 로고    scopus 로고
    • Tryptophan-and arginine-rich antimicrobial peptides: structures and mechanisms of action
    • doi: 10.1016/j.bbamem.2006.04.006
    • Chan, D. I., Prenner, E. J., and Vogel, H. J. (2006). Tryptophan-and arginine-rich antimicrobial peptides: structures and mechanisms of action. Biochim. Biophys. Acta 1758, 1184-1202. doi: 10.1016/j.bbamem.2006.04.006.
    • (2006) Biochim. Biophys. Acta , vol.1758 , pp. 1184-1202
    • Chan, D.I.1    Prenner, E.J.2    Vogel, H.J.3
  • 10
    • 84869103855 scopus 로고    scopus 로고
    • Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilities
    • doi: 10.1126/science.1226338
    • Cheng, Z., Al Zaki, A., Hui, J. Z., Muzykantov, V. R., and Tsourkas, A. (2012). Multifunctional nanoparticles: cost versus benefit of adding targeting and imaging capabilities. Science 338, 903-910. doi: 10.1126/science.1226338.
    • (2012) Science , vol.338 , pp. 903-910
    • Cheng, Z.1    Al Zaki, A.2    Hui, J.Z.3    Muzykantov, V.R.4    Tsourkas, A.5
  • 11
    • 77953935500 scopus 로고    scopus 로고
    • Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer
    • doi: 10.1111/j.1582-4934.2009.00994.x
    • Chiche, J., Brahimi-Horn, M. C., and Pouyssegur, J. (2010). Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer. J. Cell. Mol. Med. 14, 771-794. doi: 10.1111/j.1582-4934.2009.00994.x.
    • (2010) J. Cell. Mol. Med. , vol.14 , pp. 771-794
    • Chiche, J.1    Brahimi-Horn, M.C.2    Pouyssegur, J.3
  • 12
    • 84865125806 scopus 로고    scopus 로고
    • Efficient (18)F-labeling of large 37-amino-acid pHLIP peptide analogues and their biological evaluation
    • doi: 10.1021/bc3000222
    • Daumar, P., Wanger-Baumann, C. A., Pillarsetty, N., Fabrizio, L., Carlin, S. D., Andreev, O. A., et al. (2012). Efficient (18)F-labeling of large 37-amino-acid pHLIP peptide analogues and their biological evaluation. Bioconjug. Chem. 23, 1557-1566. doi: 10.1021/bc3000222.
    • (2012) Bioconjug. Chem. , vol.23 , pp. 1557-1566
    • Daumar, P.1    Wanger-Baumann, C.A.2    Pillarsetty, N.3    Fabrizio, L.4    Carlin, S.D.5    Andreev, O.A.6
  • 13
    • 84857134071 scopus 로고    scopus 로고
    • pH-controlled delivery of luminescent europium coated nanoparticles into platelets
    • doi: 10.1073/pnas.1112132109
    • Davies, A., Lewis, D. J., Watson, S. P., Thomas, S. G., and Pikramenou, Z. (2012). pH-controlled delivery of luminescent europium coated nanoparticles into platelets. Proc. Natl. Acad. Sci. U.S.A. 109, 1862-1867. doi: 10.1073/pnas.1112132109.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 1862-1867
    • Davies, A.1    Lewis, D.J.2    Watson, S.P.3    Thomas, S.G.4    Pikramenou, Z.5
  • 14
    • 51049090204 scopus 로고    scopus 로고
    • Nanoparticle therapeutics: an emerging treatment modality for cancer
    • doi: 10.1038/nrd2614
    • Davis, M. E., Chen, Z. G., and Shin, D. M. (2008). Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat. Rev. Drug Discov. 7, 771-782. doi: 10.1038/nrd2614.
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 771-782
    • Davis, M.E.1    Chen, Z.G.2    Shin, D.M.3
  • 15
    • 14644439267 scopus 로고    scopus 로고
    • Cancer nanotechnology: opportunities and challenges
    • doi: 10.1038/nrc1566
    • Ferrari, M. (2005). Cancer nanotechnology: opportunities and challenges. Nat. Rev. Cancer 5, 161-171. doi: 10.1038/nrc1566.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 161-171
    • Ferrari, M.1
  • 16
    • 34447094919 scopus 로고    scopus 로고
    • Glycolysis in cancer: a potential target for therapy
    • doi: 10.1016/j.biocel.2007.03.021
    • Gatenby, R. A., and Gillies, R. J. (2007). Glycolysis in cancer: a potential target for therapy. Int. J. Biochem. Cell Biol. 39, 1358-1366. doi: 10.1016/j.biocel.2007.03.021.
    • (2007) Int. J. Biochem. Cell Biol. , vol.39 , pp. 1358-1366
    • Gatenby, R.A.1    Gillies, R.J.2
  • 17
    • 0029971428 scopus 로고    scopus 로고
    • Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer
    • Gerweck, L. E., and Seetharaman, K. (1996). Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer. Cancer Res. 56, 1194-1198.
    • (1996) Cancer Res. , vol.56 , pp. 1194-1198
    • Gerweck, L.E.1    Seetharaman, K.2
  • 18
    • 84862757952 scopus 로고    scopus 로고
    • Evolutionary dynamics of carcinogenesis and why targeted therapy does not work
    • doi: 10.1038/nrc3298
    • Gillies, R. J., Verduzco, D., and Gatenby, R. A. (2012). Evolutionary dynamics of carcinogenesis and why targeted therapy does not work. Nat. Rev. Cancer 12, 487-493. doi: 10.1038/nrc3298.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 487-493
    • Gillies, R.J.1    Verduzco, D.2    Gatenby, R.A.3
  • 19
    • 68149163521 scopus 로고    scopus 로고
    • Multifunctional nanoparticles for imaging, delivery and targeting in cancer therapy
    • doi: 10.1517/17425240902932908
    • Gindy, M. E., and Prud'homme, R. K. (2009). Multifunctional nanoparticles for imaging, delivery and targeting in cancer therapy. Expert Opin. Drug Deliv. 6, 865-878. doi: 10.1517/17425240902932908.
    • (2009) Expert Opin. Drug Deliv. , vol.6 , pp. 865-878
    • Gindy, M.E.1    Prud'homme, R.K.2
  • 20
    • 77953599629 scopus 로고    scopus 로고
    • Heterogeneous diffusion of a membrane-bound pHLIP peptide
    • doi: 10.1016/j.bpj.2010.03.050
    • Guo, L., and Gai, F. (2010). Heterogeneous diffusion of a membrane-bound pHLIP peptide. Biophys. J. 98, 2914-2922. doi: 10.1016/j.bpj.2010.03.050.
    • (2010) Biophys. J. , vol.98 , pp. 2914-2922
    • Guo, L.1    Gai, F.2
  • 21
    • 84887210246 scopus 로고    scopus 로고
    • pH-controlled delivery of nanoparticles into tumor cells
    • doi: 10.1002/adhm.201300013
    • Han, L., Ma, H., Guo, Y., Kuang, Y., He, X., and Jiang, C. (2013). pH-controlled delivery of nanoparticles into tumor cells. Adv. Healthc. Mater. 2, 1435-1439. doi: 10.1002/adhm.201300013.
    • (2013) Adv. Healthc. Mater. , vol.2 , pp. 1435-1439
    • Han, L.1    Ma, H.2    Guo, Y.3    Kuang, Y.4    He, X.5    Jiang, C.6
  • 22
    • 0036001159 scopus 로고    scopus 로고
    • Structural basis of perturbed pKa values of catalytic groups in enzyme active sites
    • doi: 10.1080/15216540211468
    • Harris, T. K., and Turner, G. J. (2002). Structural basis of perturbed pKa values of catalytic groups in enzyme active sites. IUBMB Life 53, 85-98. doi: 10.1080/15216540211468.
    • (2002) IUBMB Life , vol.53 , pp. 85-98
    • Harris, T.K.1    Turner, G.J.2
  • 24
    • 0030708557 scopus 로고    scopus 로고
    • A biophysical study of integral membrane protein folding
    • doi: 10.1021/bi970146j
    • Hunt, J. F., Earnest, T. N., Bousche, O., Kalghatgi, K., Reilly, K., Horvath, C., et al. (1997). A biophysical study of integral membrane protein folding. Biochemistry 36, 15156-15176. doi: 10.1021/bi970146j.
    • (1997) Biochemistry , vol.36 , pp. 15156-15176
    • Hunt, J.F.1    Earnest, T.N.2    Bousche, O.3    Kalghatgi, K.4    Reilly, K.5    Horvath, C.6
  • 25
    • 84859901776 scopus 로고    scopus 로고
    • Modulation of the pHLIP transmembrane helix insertion pathway
    • doi: 10.1016/j.bpj.2012.03.021
    • Karabadzhak, A. G., Weerakkody, D., Wijesinghe, D., Thakur, M. S., Engelman, D. M., Andreev, O. A., et al. (2012). Modulation of the pHLIP transmembrane helix insertion pathway. Biophys. J. 102, 1846-1855. doi: 10.1016/j.bpj.2012.03.021.
    • (2012) Biophys. J. , vol.102 , pp. 1846-1855
    • Karabadzhak, A.G.1    Weerakkody, D.2    Wijesinghe, D.3    Thakur, M.S.4    Engelman, D.M.5    Andreev, O.A.6
  • 26
    • 84873333450 scopus 로고    scopus 로고
    • Peptide targeting and imaging of damaged lung tissue in influenza-infected mice
    • doi: 10.2217/fmb.12.134
    • Li, N., Yin, L., Thevenin, D., Yamada, Y., Limmon, G., Chen, J., et al. (2013). Peptide targeting and imaging of damaged lung tissue in influenza-infected mice. Future Microbiol. 8, 257-269. doi: 10.2217/fmb.12.134.
    • (2013) Future Microbiol. , vol.8 , pp. 257-269
    • Li, N.1    Yin, L.2    Thevenin, D.3    Yamada, Y.4    Limmon, G.5    Chen, J.6
  • 27
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • doi: 10.1016/S0169-409X(00)00129-0
    • Lipinski, C. A., Lombardo, F., Dominy, B. W., and Feeney, P. J. (2001). Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 46, 3-26. doi: 10.1016/S0169-409X(00)00129-0.
    • (2001) Adv. Drug Deliv. Rev. , vol.46 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 28
    • 84873088126 scopus 로고    scopus 로고
    • Optical molecular imaging detects changes in extracellular pH with the development of head and neck cancer
    • doi: 10.1002/ijc.27837
    • Loja, M. N., Luo, Z., Greg Farwell, D., Luu, Q. C., Donald, P. J., Amott, D., et al. (2013). Optical molecular imaging detects changes in extracellular pH with the development of head and neck cancer. Int. J. Cancer 132, 1613-1623. doi: 10.1002/ijc.27837.
    • (2013) Int. J. Cancer , vol.132 , pp. 1613-1623
    • Loja, M.N.1    Luo, Z.2    Greg Farwell, D.3    Luu, Q.C.4    Donald, P.J.5    Amott, D.6
  • 31
    • 84860142832 scopus 로고    scopus 로고
    • Therapeutic potential of amanitin-conjugated anti-epithelial cell adhesion molecule monoclonal antibody against pancreatic carcinoma
    • doi: 10.1093/jnci/djs140
    • Moldenhauer, G., Salnikov, A. V., Luttgau, S., Herr, I., Anderl, J., and Faulstich, H. (2012). Therapeutic potential of amanitin-conjugated anti-epithelial cell adhesion molecule monoclonal antibody against pancreatic carcinoma. J. Natl. Cancer Inst. 104, 622-634. doi: 10.1093/jnci/djs140.
    • (2012) J. Natl. Cancer Inst. , vol.104 , pp. 622-634
    • Moldenhauer, G.1    Salnikov, A.V.2    Luttgau, S.3    Herr, I.4    Anderl, J.5    Faulstich, H.6
  • 32
    • 84874056993 scopus 로고    scopus 로고
    • Antiproliferative effect of pHLIP-amanitin
    • doi: 10.1021/bi301647y
    • Moshnikova, A., Moshnikova, V., Andreev, O. A., and Reshetnyak, Y. K. (2013). Antiproliferative effect of pHLIP-amanitin. Biochemistry 52, 1171-1178. doi: 10.1021/bi301647y.
    • (2013) Biochemistry , vol.52 , pp. 1171-1178
    • Moshnikova, A.1    Moshnikova, V.2    Andreev, O.A.3    Reshetnyak, Y.K.4
  • 34
    • 27844485836 scopus 로고    scopus 로고
    • Protein translocation by the Sec61/SecY channel
    • doi: 10.1146/annurev.cellbio.21.012704.133214
    • Osborne, A. R., Rapoport, T. A., and Van Den Berg, B. (2005). Protein translocation by the Sec61/SecY channel. Annu. Rev. Cell Dev. Biol. 21, 529-550. doi: 10.1146/annurev.cellbio.21.012704.133214.
    • (2005) Annu. Rev. Cell Dev. Biol. , vol.21 , pp. 529-550
    • Osborne, A.R.1    Rapoport, T.A.2    Van Den Berg, B.3
  • 35
    • 0032927078 scopus 로고    scopus 로고
    • Plasmalemmal pH-gradients in drug-sensitive and drug-resistant MCF-7 human breast carcinoma xenografts measured by 31P magnetic resonance spectroscopy
    • doi: 10.1016/S0006-2952(98)00306-2
    • Raghunand, N., Altbach, M. I., Van Sluis, R., Baggett, B., Taylor, C. W., Bhujwalla, Z. M., et al. (1999). Plasmalemmal pH-gradients in drug-sensitive and drug-resistant MCF-7 human breast carcinoma xenografts measured by 31P magnetic resonance spectroscopy. Biochem. Pharmacol. 57, 309-312. doi: 10.1016/S0006-2952(98)00306-2.
    • (1999) Biochem. Pharmacol. , vol.57 , pp. 309-312
    • Raghunand, N.1    Altbach, M.I.2    Van Sluis, R.3    Baggett, B.4    Taylor, C.W.5    Bhujwalla, Z.M.6
  • 36
    • 33646272211 scopus 로고    scopus 로고
    • Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix
    • doi: 10.1073/pnas.0601463103
    • Reshetnyak, Y. K., Andreev, O. A., Lehnert, U., and Engelman, D. M. (2006). Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix. Proc. Natl. Acad. Sci. U.S.A. 103, 6460-6465. doi: 10.1073/pnas.0601463103.
    • (2006) Proc. Natl. Acad. Sci. U.S.A. , vol.103 , pp. 6460-6465
    • Reshetnyak, Y.K.1    Andreev, O.A.2    Lehnert, U.3    Engelman, D.M.4
  • 37
    • 55749112330 scopus 로고    scopus 로고
    • Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane
    • doi: 10.1073/pnas.0804746105
    • Reshetnyak, Y. K., Andreev, O. A., Segala, M., Markin, V. S., and Engelman, D. M. (2008). Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane. Proc. Natl. Acad. Sci. U.S.A. 105, 15340-15345. doi: 10.1073/pnas.0804746105.
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 15340-15345
    • Reshetnyak, Y.K.1    Andreev, O.A.2    Segala, M.3    Markin, V.S.4    Engelman, D.M.5
  • 38
    • 34848885103 scopus 로고    scopus 로고
    • A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers
    • doi: 10.1529/biophysj.107.109967
    • Reshetnyak, Y. K., Segala, M., Andreev, O. A., and Engelman, D. M. (2007). A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers. Biophys. J. 93, 2363-2372. doi: 10.1529/biophysj.107.109967.
    • (2007) Biophys. J. , vol.93 , pp. 2363-2372
    • Reshetnyak, Y.K.1    Segala, M.2    Andreev, O.A.3    Engelman, D.M.4
  • 39
    • 84855683946 scopus 로고    scopus 로고
    • Measuring tumor aggressiveness and targeting metastatic lesions with fluorescent pHLIP
    • doi: 10.1007/s11307-010-0457-z
    • Reshetnyak, Y. K., Yao, L., Zheng, S., Kuznetsov, S., Engelman, D. M., and Andreev, O. A. (2011). Measuring tumor aggressiveness and targeting metastatic lesions with fluorescent pHLIP. Mol. Imaging Biol. 13, 1146-1156. doi: 10.1007/s11307-010-0457-z.
    • (2011) Mol. Imaging Biol. , vol.13 , pp. 1146-1156
    • Reshetnyak, Y.K.1    Yao, L.2    Zheng, S.3    Kuznetsov, S.4    Engelman, D.M.5    Andreev, O.A.6
  • 40
  • 41
    • 69549108017 scopus 로고    scopus 로고
    • Accurate analysis of tumor margins using a fluorescent ph low insertion peptide (pHLIP)
    • doi: 10.3390/ijms10083478
    • Segala, J., Engelman, D. M., Reshetnyak, Y. K., and Andreev, O. A. (2009). Accurate analysis of tumor margins using a fluorescent ph low insertion peptide (pHLIP). Int. J. Mol. Sci. 10, 3478-3487. doi: 10.3390/ijms10083478.
    • (2009) Int. J. Mol. Sci. , vol.10 , pp. 3478-3487
    • Segala, J.1    Engelman, D.M.2    Reshetnyak, Y.K.3    Andreev, O.A.4
  • 43
    • 67749115965 scopus 로고    scopus 로고
    • Enhanced intracellular delivery using arginine-rich peptides by the addition of penetration accelerating sequences (Pas)
    • doi: 10.1016/j.jconrel.2009.05.019
    • Takayama, K., Nakase, I., Michiue, H., Takeuchi, T., Tomizawa, K., Matsui, H., et al. (2009). Enhanced intracellular delivery using arginine-rich peptides by the addition of penetration accelerating sequences (Pas). J. Control. Release 138, 128-133. doi: 10.1016/j.jconrel.2009.05.019.
    • (2009) J. Control. Release , vol.138 , pp. 128-133
    • Takayama, K.1    Nakase, I.2    Michiue, H.3    Takeuchi, T.4    Tomizawa, K.5    Matsui, H.6
  • 44
    • 67651095995 scopus 로고    scopus 로고
    • pHLIP-mediated translocation of membrane-impermeable molecules into cells
    • doi: 10.1016/j.chembiol.2009.06.006
    • Thevenin, D., An, M., and Engelman, D. M. (2009). pHLIP-mediated translocation of membrane-impermeable molecules into cells. Chem. Biol. 16, 754-762. doi: 10.1016/j.chembiol.2009.06.006.
    • (2009) Chem. Biol. , vol.16 , pp. 754-762
    • Thevenin, D.1    An, M.2    Engelman, D.M.3
  • 46
    • 66249099231 scopus 로고    scopus 로고
    • A novel technology for the imaging of acidic prostate tumors by positron emission tomography
    • doi: 10.1158/0008-5472.CAN-08-3781
    • Vavere, A. L., Biddlecombe, G. B., Spees, W. M., Garbow, J. R., Wijesinghe, D., Andreev, O. A., et al. (2009). A novel technology for the imaging of acidic prostate tumors by positron emission tomography. Cancer Res. 69, 4510-4516. doi: 10.1158/0008-5472.CAN-08-3781.
    • (2009) Cancer Res. , vol.69 , pp. 4510-4516
    • Vavere, A.L.1    Biddlecombe, G.B.2    Spees, W.M.3    Garbow, J.R.4    Wijesinghe, D.5    Andreev, O.A.6
  • 48
    • 4143101547 scopus 로고    scopus 로고
    • The machinery of membrane protein assembly
    • doi: 10.1016/j.sbi.2004.07.003
    • White, S. H., and Von Heijne, G. (2004). The machinery of membrane protein assembly. Curr. Opin. Struct. Biol. 14, 397-404. doi: 10.1016/j.sbi.2004.07.003.
    • (2004) Curr. Opin. Struct. Biol. , vol.14 , pp. 397-404
    • White, S.H.1    Von Heijne, G.2
  • 49
    • 84890936296 scopus 로고    scopus 로고
    • pH dependent transfer of nano-pores into membrane of cancer cells to induce apoptosis
    • doi: 10.1038/srep03560
    • Wijesinghe, D., Arachchige, M. C., Lu, A., Reshetnyak, Y. K., and Andreev, O. A. (2013). pH dependent transfer of nano-pores into membrane of cancer cells to induce apoptosis. Sci. Rep. 3:3560. doi: 10.1038/srep03560.
    • (2013) Sci. Rep. , vol.3 , pp. 3560
    • Wijesinghe, D.1    Arachchige, M.C.2    Lu, A.3    Reshetnyak, Y.K.4    Andreev, O.A.5
  • 50
    • 81855190867 scopus 로고    scopus 로고
    • Tuning a polar molecule for selective cytoplasmic delivery by a pH (Low) insertion peptide
    • doi: 10.1021/bi2009773
    • Wijesinghe, D., Engelman, D. M., Andreev, O. A., and Reshetnyak, Y. K. (2011). Tuning a polar molecule for selective cytoplasmic delivery by a pH (Low) insertion peptide. Biochemistry 50, 10215-10222. doi: 10.1021/bi2009773.
    • (2011) Biochemistry , vol.50 , pp. 10215-10222
    • Wijesinghe, D.1    Engelman, D.M.2    Andreev, O.A.3    Reshetnyak, Y.K.4
  • 52
    • 84874933955 scopus 로고    scopus 로고
    • pHLIP(R)-mediated delivery of PEGylated liposomes to cancer cells
    • doi: 10.1016/j.jconrel.2013.01.037
    • Yao, L., Daniels, J., Wijesinghe, D., Andreev, O. A., and Reshetnyak, Y. K. (2013b). pHLIP(R)-mediated delivery of PEGylated liposomes to cancer cells. J. Control. Release 167, 228-237. doi: 10.1016/j.jconrel.2013.01.037.
    • (2013) J. Control. Release , vol.167 , pp. 228-237
    • Yao, L.1    Daniels, J.2    Wijesinghe, D.3    Andreev, O.A.4    Reshetnyak, Y.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.