Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 40, 2008, Pages 15340-15345

  Reshetnyak, Yana K ^a   Andreev, Oleg A ^a   Segala, Michael ^a   Markin, Vladislav S ^b   Engelman, Donald M ^c  

^a UNIVERSITY OF RHODE ISLAND   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c YALE UNIVERSITY   (United States)

Author keywords

Drug delivery; Imaging; Membrane protein; Thermodynamics

Indexed keywords

CHOLINE DERIVATIVE; MEMBRANE PROTEIN; OLEOYLPALMITOYLLECITHIN; UNCLASSIFIED DRUG;

ARTICLE; ARTIFICIAL MEMBRANE; CYTOPLASM; ENERGY TRANSFER; FLUORESCENCE SPECTROSCOPY; ISOTHERMAL TITRATION CALORIMETRY; LIPID BILAYER; MATHEMATICAL ANALYSIS; PH LOW INSERTION PEPTIDE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN INTERACTION; THERMODYNAMICS;

BASE SEQUENCE; BINDING SITES; HYDROGEN-ION CONCENTRATION; KINETICS; LIPID BILAYERS; MEMBRANE FLUIDITY; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN FOLDING; SPECTROMETRY, FLUORESCENCE; THERMODYNAMICS;

EID: 55749112330     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0804746105     Document Type: Article

References (29)

1. Engelman DM, et al. (2003) Membrane protein folding: beyond the two stage model. FEBS Lett 555:122-125.
2. Osborne AR, Rapoport TA (2007) Protein translocation is mediated by oligomers of the SecY complex with one SecY copy forming the channel. Cell 129:97-110.
3. Brambillasca SM, Yabal M, Makarow M, Borgese N (2006) Unassisted translocation of large polypeptide domains across phospholipid bilayers. J Cell Biol 175:767-777.
4. Borgese N, Brambillasca S, Colombo S (2007) How tails guide tail-anchored proteins to their destinations. Curr Opin Cell Biol 19:368-375.
5. Engelman DM, Steitz TA (1981) The spontaneous insertion of proteins into and across membranes: The helical hairpin hypothesis. Cell 23:411-422.
6. Hunt JF, Rath P, Rothschild KJ, Engelman DM (1997) Spontaneous, pH-dependent membrane insertion of a transbilayer alpha-helix. Biochemistry 36:15177-151792.
7. Reshetnyak YK, Andreev OA, Lehnert U, Engelman DM (2006) Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix. Proc Natl Acad Sci USA 103:6460-6465.
8. Andreev OA, et al. (2007) Mechanism and uses of a peptide that targets tumors and other acidic tissues. Proc Natl Acad Sci USA 104:7893-7898.
9. Reshetnyak YK, Segala M, Andreev OA, Engelman DM (2007) A monomeric membrane peptide that lives in three worlds: In solution, attached to and inserted across lipid bilayers. Biophys J 93:2363-2672.
10. Nakamura S, Kidokoro S (2004) Isothermal acid-titration calorimetry for evaluating the pH dependence of protein stability. Biophys Chem 109:229-249.
11. Nakamura S, Kidokoro S (2005) Direct observation of the enthalpy change accompanying the native to molten-globule transition of cytochrome c by using isothermal acid-titration calorimetry. Biophys Chem 113:161-168.
12. Zoonens M, Reshetnyak YK, Engelman DM (2008). Bilayer interactions of pHLIP, a peptide that can deliver drugs and target tumors. Biophys J 95:225-235.
13. Reshetnyak YK, Koshevnik Yu, Burstein EA (2001) Decomposition of protein tryptophan fluorescence spectra into log-normal components: III. Correlation between fluorescence and microenvironment parameters of individual tryptophan residues. Biophys J 81:1735-1758.
14. Shen C, et al. (2008) The Protein Fluorescence And Structural Toolkit (PFAST): Database and programs for the analysis of protein fluorescence and structural data. Protein Struct Funct Bioinf 71:1744-1754.
15. Wieprecht T, Apostolov O, Beyermann M, Seelig J (2000) Interaction of a mitochondrial presequence with lipid membranes: Role of helix formation for membrane binding and perturbation. Biochemistry 39:15297-15305.
16. Andrushchenko VV, et al. (2008) Thermodynamics of the interactions of tryptophan-rich cathelicidin antimicrobial peptides with model and natural membranes. Biochim Biophys Acta 1778:1004-1014.
17. Wieprecht T, Beyermann M, Seelig J (1999) Binding of antibacterial magainin peptides to electrically neutral membranes: Thermodynamics and structure. Biochemistry 38:10377-10387.
18. Markin VS (1981) Lateral organization of membranes and cell shapes. Biophys J 36:1-19.
19. Bohinc K, et al. (2006) Shape variation of bilayer membrane daughter vesicles induced by anisotropic membrane inclusions. Cell Mol Biol Lett 11:90-101.
20. Engelman DM (2005) Membranes are more mosaic than fluid. Nature 438:578-580.
21. White SH (2007) Membrane protein insertion: The biology-physics nexus. J Gen Physiol 129:363-369.
22. Pacios LF (2001) Distinct molecular surfaces and hydrophobicity of amino acid residues in proteins. J Chem Inf Comput Sci 41:1427-1431.
23. Engelman DM (1969) Surface area per lipid molecule in the intact membrane of the human red cell. Nature 223:1279-1280.
24. Kucerka N, Kiselev MA, Balgavý, P., (2004) Determination of bilayer thickness and lipid surface area in unilamellar dimyristoylphosphatidylcholine vesicles from small-angle neutron scattering curves: A comparison of evaluation methods. Eur Biophys J 33:328-334.
25. Fernández-Vidal M, Jayasinghe S, Ladokhin AS, White SH (2007) Folding amphipathic helices into membranes: Amphiphilicity trumps hydrophobicity. Mol Biol 370:459-470.
26. Zemel A, Ben-Shaul A, May S (2005) Perturbation of a lipid membrane by amphipathic peptides and its role in pore formation. Eur Biophys J 34:230-242.
27. Tamm LK, Hong H, Liang B (2004) Folding and assembly of beta-barrel membrane proteins. Biochim Biophys Acta 1666:250-263.
28. Im W, Brooks CL (2005) Chemical theory and computation special feature: Interfacial folding and membrane insertion of designed peptides studied by molecular dynamics simulations. Proc Natl Acad Sci USA 102:6771-6776.
29. Kutay U, Hartmann E, Rapoport TA (1993) A class of membrane proteins with C-terminal anchor. Trends Cell Biol 3:72-75.