Accurate analysis of tumor margins using a fluorescent pH Low Insertion Peptide (pHLIP)

International Journal of Molecular Sciences

Volumn 10, Issue 8, 2009, Pages 3478-3487

  Segala, James ^a,c   Engelman, Donald M ^b   Reshetnyak, Yana K ^a   Andreev, Oleg A ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

^b YALE UNIVERSITY   (United States)

^c RHODE ISLAND HOSPITAL   (United States)

Author keywords

Computational algorithm; Fluorescence guided surgery; pHLIP; Tumor border; Tumor targeting

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FLUORESCENCE IMAGING; HELA CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NEAR INFRARED SPECTROSCOPY; NONHUMAN; PH MEASUREMENT; TUMOR LOCALIZATION; TUMOR VOLUME;

COMPUTATIONAL ALGORITHM; FLUORESCENCE-GUIDED SURGERY; PHLIP; TUMOR BORDER; TUMOR TARGETING;

ALGORITHMS; ANIMALS; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; MEMBRANE PROTEINS; MICE; MICE, NUDE; NEOPLASMS; PEPTIDES; SPECTROSCOPY, NEAR-INFRARED; TRANSPLANTATION, HETEROLOGOUS;

EID: 69549108017     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms10083478     Document Type: Article

References (18)

1. de Grand, A.M.; Frangioni, J.V. An operational near-infrared fluorescence imaging system prototype for large animal surgery. Technol. Cancer Res. Treat. 2003, 2, 553-562.
2. Frangioni, J.V. In vivo near-infrared fluorescence imaging. Curr. Opin. Chem. Biol. 2003, 7, 626-634.
3. Tanaka, E.; Choi, H.S.; Fujii, H.; Bawendi, M.G.; Frangioni, J.V. Image-guided oncologic surgery using invisible light: Completed pre-clinical development for sentinel lymph node mapping. Ann. Surg. Oncol. 2006, 13, 1671-1681.
4. Frangioni, J.V. New technologies for human cancer imaging. J. Clin. Oncol. 2008, 26, 4012-4021.
5. Kusano, M.; Tajima, Y.; Yamazaki, K.; Kato, M.; Watanabe, M.; Miwa, M. Sentinel node mapping guided by indocyanine green fluorescence imaging: A new method for sentinel node navigation surgery in gastrointestinal cancer. Dig. Surg. 2008, 25, 103-108. (Pubitemid 351748763)
6. Tajima, Y.; Yamazaki, K.; Masuda, Y.; Kato, M.; Yasuda, D.; Aoki, T.; Kato, T.; Murakami, M.; Miwa, M.; Kusano, M. Sentinel node mapping guided by indocyanine green fluorescence imaging in gastric cancer. Ann. Surg. 2009, 249, 58-62.
7. Srinivas, P.R.; Kramer, B.S.; Srivastava, S. Trends in biomarker research for cancer detection. Lancet Oncol. 2001, 2, 698-704. (Pubitemid 33085816)
8. Hanke, J.H.; Webster, K.R.; Ronco, L.V. Protein biomarkers and drug design for cancer treatments. Eur. J. Cancer Prev. 2004, 13, 297-305. (Pubitemid 39096083)
9. Kennedy, T.C.; Hirsch, F.R. Using molecular markers in sputum for the early detection of lung cancer, a review. Lung Cancer. 2004, 45, S21-S27. (Pubitemid 39488167)
10. Jeffrey, S.S.; Lonning, P.E.; Hillner, B.E. Genomics-based prognosis and therapeutic prediction in breast cancer. J. Natl. Compr. Canc. Netw. 2005, 3, 291-300. (Pubitemid 44265435)
11. Fransvea, E.; Paradiso, A.; Antonaci, S.; Giannelli, G. HCC heterogeneity: Molecular pathogenesis and clinical implications. Cell Oncol. 2009, 31, 227-233.
12. Bild, A.H.; Yao, G.; Chang, J.T.; Wang, Q.; Potti, A.; Chasse, D.; Joshi, M.B.; Harpole, D.; Lancaster, J.M.; Berchuck, A.; Olson, J.A., Jr.; Marks, J.R.; Dressman, H.K.; West, M.; Nevins, J.R. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 2006, 439, 353-357.
13. Trédan, O.; Galmarini, C.M.; Patel, K.; Tannock, I.F. Drug resistance and the solid tumor microenvironment. J. Natl. Cancer Inst. 2007, 99, 1441-1454.
14. Andreev, O.A.; Engelman, D.M.; Reshetnyak, Y.K. Targeting acidic diseased tissue. New technology based on use of the pH (Low) Insertion Peptide (pHLIP). Chem. Today 2009, 27, 10-13.
15. Vāvere, A.L.; Biddlecombe, G.B.; Spees, W.M.; Garbow, J.R.; Wijesinghe, D.; Andreev, O.A.; Engelman, D.M.; Reshetnyak, Y.K.; Lewis, J.S. A novel technology for the imaging of acidic prostate tumors by positron emission tomography. Cancer Res. 2009, 69, 4510-4516.
16. Andreev, O.A.; Dupuy, A.D.; Segala, M.; Sandugu, S.; Serra, D.A.; Chichester, C.O.; Engelman, D.M.; Reshetnyak, Y.K. Mechanism and uses of a peptide that targets tumors and other acidic tissue in vivo. Proc. Natl. Acad. Sci. USA 2007, 104, 7893-7898.
17. Reshetnyak, Y.K.; Andreev, O.A.; Lehnert, U.; Engelman, D.M. Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix. Proc. Natl. Acad. Sci. USA 2006, 103, 6460-6465.
18. Otsu, N. A threshold selection method from gray-level histograms. IEEE Trans. Sys., Man., Cyber. 1979, 9, 62-66. (Pubitemid 9413341)