Modulation of the pHLIP transmembrane helix insertion pathway

Biophysical Journal

Volumn 102, Issue 8, 2012, Pages 1846-1855

  Karabadzhak, Alexander G ^a   Weerakkody, Dhammika ^a   Wijesinghe, Dayanjali ^a   Thakur, Mak S ^a   Engelman, Donald M ^b   Andreev, Oleg A ^a   Markin, Vladislav S ^c   Reshetnyak, Yana K ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

^b YALE UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1-PALMITOYL-2-OLEOYLPHOSPHATIDYLCHOLINE; 2 OLEOYL 1 PALMITOYLPHOSPHATIDYLCHOLINE; LIPOSOME; MEMBRANE PROTEIN; PHLIP PROTEIN; PHOSPHATIDYLCHOLINE;

AMINO ACID SEQUENCE; ARTICLE; CELL MEMBRANE; CHEMICAL STRUCTURE; CHEMISTRY; KINETICS; LIPID BILAYER; METABOLISM; MOLECULAR GENETICS; PH; PROTEIN SECONDARY STRUCTURE; PROTEIN UNFOLDING; TEMPERATURE; THERMODYNAMICS;

AMINO ACID SEQUENCE; CELL MEMBRANE; HYDROGEN-ION CONCENTRATION; KINETICS; LIPID BILAYERS; LIPOSOMES; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHATIDYLCHOLINES; PROTEIN STRUCTURE, SECONDARY; PROTEIN UNFOLDING; TEMPERATURE; THERMODYNAMICS;

EID: 84859901776     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2012.03.021     Document Type: Article

References (29)

1. B. Van den Berg, and W.M. Clemons Jr. T.A. Rapoport X-ray structure of a protein-conducting channel Nature 427 2004 36 44 (Pubitemid 38094813)
2. A.R. Osborne, T.A. Rapoport, and B. van den Berg Protein translocation by the Sec61/SecY channel Annu. Rev. Cell Dev. Biol. 21 2005 529 550 (Pubitemid 41740645)
3. P.J. Simpson, and B. Schwappach R.L. Isaacson Structures of Get3, Get4, and Get5 provide new models for TA membrane protein targeting Structure 18 2010 897 902
4. S. Brambillasca, and M. Yabal N. Borgese Unassisted translocation of large polypeptide domains across phospholipid bilayers J. Cell Biol. 175 2006 767 777 (Pubitemid 44878509)
5. R. Renthal Helix insertion into bilayers and the evolution of membrane proteins Cell. Mol. Life Sci. 67 2010 1077 1088
6. S.H. White, and W.C. Wimley Membrane protein folding and stability: physical principles Annu. Rev. Biophys. Biomol. Struct. 28 1999 319 365 (Pubitemid 29319262)
7. D.M. Engelman, and Y. Chen J.L. Popot Membrane protein folding: beyond the two stage model FEBS Lett. 555 2003 122 125 (Pubitemid 37431108)
8. C.A. Minetti, and D.P. Remeta Energetics of membrane protein folding and stability Arch. Biochem. Biophys. 453 2006 32 53
9. S. Urban Taking the plunge: integrating structural, enzymatic and computational insights into a unified model for membrane-immersed rhomboid proteolysis Biochem. J. 425 2010 501 512
10. A.S. Ladokhin, and S.H. White Interfacial folding and membrane insertion of a designed helical peptide Biochemistry 43 2004 5782 5791 (Pubitemid 38623612)
11. Y.K. Reshetnyak, and M. Segala D.M. Engelman A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers Biophys. J. 93 2007 2363 2372 (Pubitemid 47511136)
12. Y.K. Reshetnyak, and O.A. Andreev D.M. Engelman Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane Proc. Natl. Acad. Sci. USA 105 2008 15340 15345
13. O.A. Andreev, and A.D. Dupuy Y.K. Reshetnyak Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo Proc. Natl. Acad. Sci. USA 104 2007 7893 7898 (Pubitemid 47185847)
14. M. Musial-Siwek, and A. Karabadzhak D.M. Engelman Tuning the insertion properties of pHLIP Biochim. Biophys. Acta 1798 2010 1041 1046
15. Y.K. Reshetnyak, and O.A. Andreev D.M. Engelman Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix Proc. Natl. Acad. Sci. USA 103 2006 6460 6465
16. M. An, and D. Wijesinghe D.M. Engelman pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation Proc. Natl. Acad. Sci. USA 107 2010 20246 20250
17. D. Wijesinghe, and D.M. Engelman Y.K. Reshetnyak Tuning a polar molecule for selective cytoplasmic delivery by a pH (low) insertion peptide Biochemistry 50 2011 10215 10222
18. Reference deleted in proof.
19. O.A. Andreev, D.M. Engelman, and Y.K. Reshetnyak pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents Mol. Membr. Biol. 27 2010 341 352
20. A.L. Vvere, and G.B. Biddlecombe J.S. Lewis A novel technology for the imaging of acidic prostate tumors by positron emission tomography Cancer Res. 69 2009 4510 4516
21. Y.K. Reshetnyak, and L. Yao O.A. Andreev Measuring tumor aggressiveness and targeting metastatic lesions with fluorescent pHLIP Mol. Imaging Biol. 13 2011 1146 1156
22. O.A. Andreev, and A.G. Karabadzhak Y.K. Reshetnyak pH (low) insertion peptide (pHLIP) inserts across a lipid bilayer as a helix and exits by a different path Proc. Natl. Acad. Sci. USA 107 2010 4081 4086
23. F.N. Barrera, and D. Weerakkody D.M. Engelman Roles of carboxyl groups in the transmembrane insertion of peptides J. Mol. Biol. 413 2011 359 371
24. - diffusion across phosphatidic acid bilayers Biochim. Biophys. Acta 727 1983 22 30
25. C.L. Kuyper, and J.S. Kuo D.T. Chiu Proton permeation into single vesicles occurs via a sequential two-step mechanism and is heterogeneous J. Am. Chem. Soc. 128 2006 3233 3240
26. A.T. Petkova, and J.G. Hu J. Herzfeld Arginine activity in the proton-motive photocycle of bacteriorhodopsin: solid-state NMR studies of the wild-type and D85N proteins Biochemistry 38 1999 1562 1572
27. T.K. Harris, and G.J. Turner Structural basis of perturbed pKa values of catalytic groups in enzyme active sites IUBMB Life 53 2002 85 98 (Pubitemid 34553129)
28. 13C NMR Biochemistry 39 2000 14472 14480
29. K. Bohinc, and D. Lombardo A. Iglic Shape variation of bilayer membrane daughter vesicles induced by anisotropic membrane inclusions Cell. Mol. Biol. Lett. 11 2006 90 101 (Pubitemid 44504049)