Tuning the insertion properties of pHLIP

Biochimica et Biophysica Acta - Biomembranes

Volumn 1798, Issue 6, 2010, Pages 1041-1046

  Musial Siwek, Monika ^a   Karabadzhak, Alexander ^b   Andreev, Oleg A ^b   Reshetnyak, Yana K ^b   Engelman, Donald M ^a  

^a YALE UNIVERSITY   (United States)

^b UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

Helix formation; Membrane insertion; PHLIP; Transmembrane helix

Indexed keywords

ALANINE; ASPARTIC ACID; GLUTAMIC ACID; PEPTIDE; PH LOW INSERTION PEPTIDE; UNCLASSIFIED DRUG;

ACIDITY; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AQUEOUS SOLUTION; ARTICLE; MEMBRANE STRUCTURE; PH; PRIORITY JOURNAL; PROTEIN STRUCTURE; SOLUBILITY;

ANIMALS; CELL MEMBRANE; DRUG DELIVERY SYSTEMS; HUMANS; HYDROGEN-ION CONCENTRATION; MEMBRANE PROTEINS; NEOPLASMS; PROTEIN STRUCTURE, SECONDARY;

EID: 77952530942     PISSN: 00052736     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamem.2009.08.023     Document Type: Article

References (28)

1. Hunt J.F., Rath P., Rothschild K.J., Engelman D.M. Spontaneous, pH-dependent membrane insertion of a transbilayer alpha-helix. Biochemistry 1997, 36:15177-15192.
2. Reshetnyak Y.K., Segala M., Andreev O.A., Engelman D.M. A monomeric membrane peptide that lives in three worlds: in solution, attached to, and inserted across lipid bilayers. Biophys. J. 2007, 93:2363-2372.
3. Reshetnyak Y.K., Andreev O.A., Lehnert U., Engelman D.M. Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:6460-6465.
4. Andreev O.A., Dupuy A.D., Segala M., Sandugu S., Serra D.A., Chichester C.O., Engelman D.M., Reshetnyak Y.K. Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:7893-7898.
5. Koukourakis M.I., Pitiakoudis M., Giatromanolaki A., Tsarouha A., Polychronidis A., Sivridis E., Simopoulos C. Oxygen and glucose consumption in gastrointestinal adenocarcinomas: correlation with markers of hypoxia, acidity and anaerobic glycolysis. Cancer Sci. 2006, 97:1056-1060.
6. Swietach P., Vaughan-Jones R.D., Harris A.L. Regulation of tumor pH and the role of carbonic anhydrase 9. Cancer Metastasis Rev. 2007, 26:299-310.
7. Yeagle P.L., Bennett M., Lemaitre V., Watts A. Transmembrane helices of membrane proteins may flex to satisfy hydrophobic mismatch. Biochim. Biophys. Acta 2007, 1768:530-537.
8. Jayasinghe S., Hristova K., White S.H. Energetics, stability, and prediction of transmembrane helices. J. Mol. Biol. 2001, 312:927-934.
9. Krishnakumar S.S., London E. Effect of sequence hydrophobicity and bilayer width upon the minimum length required for the formation of transmembrane helices in membranes. J. Mol. Biol. 2007, 374:671-687.
10. Rath A., Johnson R.M., Deber C.M. Peptides as transmembrane segments: decrypting the determinants for helix-helix interactions in membrane proteins. Biopolymers 2007, 88:217-232.
11. Wimley W.C., White S.H. Designing transmembrane alpha-helices that insert spontaneously. Biochemistry 2000, 39:4432-4442.
12. Killian J.A. Synthetic peptides as models for intrinsic membrane proteins. FEBS Lett. 2003, 555:134-138.
13. White S.H., von Heijne G. Transmembrane helices before, during, and after insertion. Curr. Opin. Struct. Biol. 2005, 15:378-386.
14. White S.H., von Heijne G. How translocons select transmembrane helices. Annu. Rev. Biophys. 2008, 37:23-42.
15. Bormann B.J., Engelman D.M. Intramembrane helix-helix association in oligomerization and transmembrane signaling. Annu. Rev. Biophys. Biomol. Struct. 1992, 21:223-242.
16. Hunt J.F., Earnest T.N., Bousche O., Kalghatgi K., Reilly K., Horvath C., Rothschild K.J., Engelman D.M. A biophysical study of integral membrane protein folding. Biochemistry 1997, 36:15156-15176.
17. Engelman D.M., Chen Y., Chin C.N., Curran A.R., Dixon A.M., Dupuy A.D., Lee A.S., Lehnert U., Matthews E.E., Reshetnyak Y.K., Senes A., Popot J.L. Membrane protein folding: beyond the two stage model. FEBS Lett. 2003, 555:122-125.
18. Popot J.L., Engelman D.M. Membrane protein folding and oligomerization: the two-stage model. Biochemistry 1990, 29:4031-4037.
19. Popot J.L., Engelman D.M. Helical membrane protein folding, stability, and evolution. Annu. Rev. Biochem. 2000, 69:881-922.
20. Reshetnyak Y.K., Andreev O.A., Segala M., Markin V.S., Engelman D.M. Energetics of peptide (pHLIP) binding to and folding across a lipid bilayer membrane. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:15340-15345.
21. Zoonens M., Reshetnyak Y.K., Engelman D.M. Bilayer interactions of pHLIP, a peptide that can deliver drugs and target tumors. Biophys. J. 2008, 95:225-235.
22. MacDonald R.C., MacDonald R.I., Menco B.P., Takeshita K., Subbarao N.K., Hu L.R. Small-volume extrusion apparatus for preparation of large, unilamellar vesicles. Biochim. Biophys. Acta 1991, 1061:297-303.
23. Hessa T., Kim H., Bihlmaier K., Lundin C., Boekel J., Andersson H., Nilsson I., White S.H., von Heijne G. Recognition of transmembrane helices by the endoplasmic reticulum translocon. Nature 2005, 433:377-381.
24. Hessa T., Meindl-Beinker N.M., Bernsel A., Kim H., Sato Y., Lerch-Bader M., Nilsson I., White S.H., von Heijne G. Molecular code for transmembrane-helix recognition by the Sec61 translocon. Nature 2007, 450:1026-1030.
25. Reshetnyak Y.K., Segala M., Andreev O.A., Engelman D.M. A monomeric membrane peptide that lives in three worlds: in solution, attached to and inserted across lipid bilayers. Biophys. J. 2007, 93:2363-2372.
26. Burstein E.A., Abornev S.M., Reshetnyak Y.K. Decomposition of protein tryptophan fluorescence spectra into log-normal components: I. Decomposition algorithms. Biophys. J. 2001, 81:1699-1709.
27. Kumar S., Bansal M. Dissecting alpha-helices: position-specific analysis of alpha-helices in globular proteins. Proteins 1998, 31:460-476.
28. Heller H., Schaefer M., Schulten K. Molecular dynamics simulation of a bilayer of 200 lipids in the gel and in the liquid-crystal phases. J. Phys. Chem. 1993, 97:8343-8360.