pH (low) insertion peptide (pHLIP) targets ischemic myocardium

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 1, 2013, Pages 82-86

  Sosunov, Eugene A ^a   Anyukhovsky, Evgeny P ^a   Sosunov, Alexander A ^a   Moshnikova, Anna ^b   Wijesinghe, Dayanjali ^b   Engelman, Donald M ^c   Reshetnyak, Yana K ^b   Andreev, Oleg A ^b  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b UNIVERSITY OF RHODE ISLAND   (United States)

^c YALE UNIVERSITY   (United States)

Author keywords

Acidity; Cardiac; Fluorescence imaging; Targeted delivery

Indexed keywords

LIPOSOME; PEPTIDES AND PROTEINS; PH (LOW) INSERTION PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; GENE INSERTION; HEART INFARCTION; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; ISOLATED HEART; MALE; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN TARGETING;

ANIMALS; DRUG DELIVERY SYSTEMS; FLUORESCENCE; HYDROGEN-ION CONCENTRATION; LIPOSOMES; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MYOCARDIAL ISCHEMIA; MYOCARDIUM;

MURINAE;

EID: 84871966458     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1220038110     Document Type: Article

References (40)

1. Andreev OA, Engelman DM, Reshetnyak YK (2010) pH-sensitive membrane peptides (pHLIPs) as a novel class of delivery agents. Mol Membr Biol 27(7):341-352.
2. Hunt JF, Rath P, Rothschild KJ, Engelman DM (1997) Spontaneous, pH-dependent membrane insertion of a transbilayer alpha-helix. Biochemistry 36(49):15177-15192. (Pubitemid 27527982)
3. Reshetnyak YK, Andreev OA, Lehnert U, Engelman DM (2006) Translocation of molecules into cells by pH-dependent insertion of a transmembrane helix. Proc Natl Acad Sci USA 103(17):6460-6465.
4. Reshetnyak YK, Segala M, Andreev OA, Engelman DM (2007) A monomeric membrane peptide that lives in three worlds: In solution, attached to, and inserted across lipid bilayers. Biophys J 93(7):2363-2372. (Pubitemid 47511136)
5. Andreev OA, Reshetnyak YK (2007) Mechanism of formation of actomyosin interface. J Mol Biol 365(3):551-554. (Pubitemid 44960352)
6. Karabadzhak AG, et al. (2012) Modulation of the pHLIP transmembrane helix insertion pathway. Biophys J 102(8):1846-1855.
7. Andreev OA, et al. (2007) Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo. Proc Natl Acad Sci USA 104(19):7893-7898. (Pubitemid 47185847)
8. Vāvere AL, et al. (2009) A novel technology for the imaging of acidic prostate tumors by positron emission tomography. Cancer Res 69(10):4510-4516.
9. Reshetnyak YK, et al. (2011) Measuring tumor aggressiveness and targeting metastatic lesions with fluorescent pHLIP. Mol Imaging Biol 13(6):1146-1156.
10. Daumar P, et al. (2012) Efficient (18)F-labeling of large 37-amino-acid pHLIP peptide analogues and their biological evaluation. Bioconjug Chem 23(8):1557-1566.
11. Macholl S, et al. (2012) In vivo pH imaging with (99m)Tc-pHLIP. Mol Imaging Biol 14(6):725-734.
12. An M, Wijesinghe D, Andreev OA, Reshetnyak YK, Engelman DM (2010) pH-(low)-insertion-peptide (pHLIP) translocation of membrane impermeable phalloidin toxin inhibits cancer cell proliferation. Proc Natl Acad Sci USA 107(47):20246-20250.
13. Wijesinghe D, Engelman DM, Andreev OA, Reshetnyak YK (2011) Tuning a polar molecule for selective cytoplasmic delivery by a pH (low) insertion peptide. Biochemistry 50(47):10215-10222.
14. Roger et al. (2011) Heart disease and stroke statistics - 2011 update: a report from the American Heart Association. Circulation 123(4):e18-e209.
15. Fox K, et al.; Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology; ESC Committee for Practice Guidelines (CPG) (2006) Guidelines on the management of stable angina pectoris: Executive summary: The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology. Eur Heart J 27(11):1341-1381. (Pubitemid 43998110)
16. Cobbe SM, Poole-Wilson PA (1980) The time of onset and severity of acidosis in myocardial ischaemia. J Mol Cell Cardiol 12(8):745-760. (Pubitemid 10056516)
17. + increase and noradrenaline release as possible cause of early arrhythmias following acute coronary artery occlusion in pigs. J Mol Cell Cardiol 12(6):579-593.
18. Cobbe SM, Poole-Wilson PA (1982) Continuous coronary sinus and arterial pH monitoring during pacing-induced ischaemia in coronary artery disease. Br Heart J 47(4):369-374. (Pubitemid 12145368)
19. Galagudza MM, et al. (2010) Targeted drug delivery into reversibly injured myocardium with silica nanoparticles: Surface functionalization, natural biodistribution, and acute toxicity. Int J Nanomedicine 5:231-237.
20. Scott RC, Crabbe D, Krynska B, Ansari R, Kiani MF (2008) Aiming for the heart: Targeted delivery of drugs to diseased cardiac tissue. Expert Opin Drug Deliv 5(4):459-470. (Pubitemid 351721724)
21. Wang AZ, et al. (2008) Biofunctionalized targeted nanoparticles for therapeutic applications. Expert Opin Biol Ther 8(8):1063-1070.
22. Caride VJ, Zaret BL (1977) Liposome accumulation in regions of experimental myocardial infarction. Science 198(4318):735-738. (Pubitemid 8225019)
23. Palmer TN, Caride VJ, Caldecourt MA, Twickler J, Abdullah V (1984) The mechanism of liposome accumulation in infarction. Biochim Biophys Acta 797(3):363-368. (Pubitemid 14194902)
24. Torchilin VP, et al. (1992) Targeted accumulation of polyethylene glycol-coated immunoliposomes in infarcted rabbit myocardium. FASEB J 6(9):2716-2719.
25. Vance JE, Steenbergen R (2005) Metabolism and functions of phosphatidylserine. Prog Lipid Res 44(4):207-234. (Pubitemid 40973811)
26. Khaw BA, DaSilva J, Hartner WC (2007) Cytoskeletal-antigen specific immunoliposome-targeted in vivo preservation of myocardial viability. J Control Release 120(1-2):35-40. (Pubitemid 46876742)
27. Khaw BA, Torchilin VP, Vural I, Narula J (1995) Plug and seal: Prevention of hypoxic cardiocyte death by sealing membrane lesions with antimyosin-liposomes. Nat Med 1(11):1195-1198.
28. Scott RC, et al. (2007) Targeted delivery of antibody conjugated liposomal drug carriers to rat myocardial infarction. Biotechnol Bioeng 96(4):795-802. (Pubitemid 46395947)
29. 99mTc-pHLIP. Mol Imaging Biol 14:725-734.
30. Zoonens M, Reshetnyak YK, Engelman DM (2008) Bilayer interactions of pHLIP, a peptide that can deliver drugs and target tumors. Biophys J 95(1):225-235.
31. Gu Q, Lee L-Y (2010) Acid-sensing ion channels and pain. Pharmaceuticals (Ott) 3(5):1411-1425.
32. Pan HL, Longhurst JC, Eisenach JC, Chen SR (1999) Role of protons in activation of cardiac sympathetic C-fibre afferents during ischaemia in cats. J Physiol 518(Pt 3):857-866. (Pubitemid 29387253)
33. Benson CJ, Eckert SP, McCleskey EW (1999) Acid-evoked currents in cardiac sensory neurons: A possible mediator of myocardial ischemic sensation. Circ Res 84(8):921-928. (Pubitemid 29196737)
34. Sutherland SP, Benson CJ, Adelman JP, McCleskey EW (2001) Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons. Proc Natl Acad Sci USA 98(2):711-716. (Pubitemid 32105108)
35. Yagi J, Wenk HN, Naves LA, McCleskey EW (2006) Sustained currents through ASIC3 ion channels at the modest pH changes that occur during myocardial ischemia. Circ Res 99(5):501-509. (Pubitemid 44337822)
36. Naves LA, McCleskey EW (2005) An acid-sensing ion channel that detects ischemic pain. Braz J Med Biol Res 38(11):1561-1569. (Pubitemid 41671740)
37. Gazit AZ, Avari JN, Balzer DT, Rhee EK (2007) Electrocardiographic diagnosis of myocardial ischemia in children: Is a diagnostic electrocardiogram always diagnostic? Pediatrics 120(2):440-444. (Pubitemid 47219518)
38. Committee on Care and Use of Laboratory Animals (1996) Guide for the Care and Use of Laboratory Animals., (Natl Inst Health, Bethesda), DHHS Publ No (NIH) 85-23.
39. Anyukhovsky EP, et al. (2011) Expression of skeletal muscle sodium channel (Nav1.4) or connexin32 prevents reperfusion arrhythmias in murine heart. Cardiovasc Res 89(1):41-50.
40. Sosunov EA, Anyukhovsky EP, Rosen MR (2008) Altered ventricular stretch contributes to initiation of cardiac memory. Heart Rhythm 5(1):106-113.