Deoxysphingolipids, novel biomarkers for type 2 diabetes, are cytotoxic for insulin-producing cells

Diabetes

Volumn 63, Issue 4, 2014, Pages 1326-1339

  Zuellig, Richard A ^a   Hornemann, Thorsten ^a,b,c   Othman, Alaa ^a,c   Hehl, Adrian B ^b   Bode, Heiko ^a,b   Güntert, Tanja ^b   Ogunshola, Omolara O ^b   Saponara, Enrica ^a   Grabliauskaite, Kamile ^a   Jang, Jae Hwi ^a   Ungethuem, Udo ^a   Wei, Yu ^a,b,c   Von Eckardstein, Arnold ^a,b,c   Graf, Rolf ^a   Sonda, Sabrina ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c Competence Centre for Systems Physiology and Metabolic Diseases ^*  (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

1 DEOXY DIHYDROCERAMIDE; 1 DEOXYSPHINGANINE; ACTIN; CERAMIDE; DEOXYSPHINGOLIPID; GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE P38; P21 ACTIVATED KINASE; RAC1 PROTEIN; SPHINGANINE; SPHINGOLIPID; STRESS ACTIVATED PROTEIN KINASE; SYNTHETASE; UNCLASSIFIED DRUG;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL DEATH; CELL MIGRATION; CELL VIABILITY; CONTROLLED STUDY; CYTOSKELETON; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; INSULIN METABOLISM; INSULIN PRODUCING CELL; INSULIN RELEASE; LIPOGENESIS; MALE; METABOLITE; MOUSE; NECROSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENESCENCE; UPREGULATION;

ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; BLOOD GLUCOSE; CELL AGING; CELL SURVIVAL; CELLS, CULTURED; CYTOSKELETON; HUMANS; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; MICE; RATS; SIGNAL TRANSDUCTION; SPHINGOSINE;

EID: 84897850177     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-1042     Document Type: Article

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