The marine sphingolipid-derived compound ES 285 triggers an atypical cell death pathway

Apoptosis

Volumn 12, Issue 2, 2007, Pages 395-409

  Salcedo, M ^a   Cuevas, C ^b   Alonso, J L ^b   Otero, G ^b   Faircloth, G ^b   Fernandez Sousa, J M ^b   Avila, J ^a   Wandosell, F ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b PHARMAMAR S A   (Spain)

Author keywords

Apoptosis; Marine derived compounds anti tumoral drugs; Sphingolipid derivatives

Indexed keywords

ES 285; MARCKS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE C; SPHINGOLIPID; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; MICROFILAMENT; MICROTUBULE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ALKANES; ANIMALS; CASPASES; CELL DEATH; CELL EXTRACTS; CYTOCHROMES C; DIGLYCERIDES; ENZYME ACTIVATION; ENZYME INHIBITORS; FLOW CYTOMETRY; LETHAL DOSE 50; LIPIDS; MICE; MITOCHONDRIA; NIH 3T3 CELLS; PROTEIN KINASE C; PROTEIN TRANSPORT; SPHINGOLIPIDS; SUBCELLULAR FRACTIONS; TUMOR SUPPRESSOR PROTEIN P53;

BIVALVIA; MACTROMERIS;

EID: 33846514589     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-006-0573-z     Document Type: Article

References (62)

1. Aune GJ, Furuta T, Pommier Y (2002) Ecteinascidin 743: a novel anticancer drug with a unique mechanism of action. Anticancer Drugs 13:545-555
2. Cuadros R, Montejo de Garcini E, Wandosell F, Faircloth G, Fernandez-Sousa JM, Avila J (2000) The marine compound spisulosine, an inhibitor of cell proliferation, promotes the disassembly of actin stress fibers. Cancer Lett 152:23-29
3. Spiegel S, Kolesnick R (2002) Sphingosine 1-phosphate as a therapeutic agent. Leukemia 16:1596-1602
4. Brindley DN, English D, Pilquil C, Buri K, Ling ZC (2002) Lipid phosphate phosphatases regulate signal transduction through glycerolipids and sphingolipids. Biochim Biophys Acta 1582:33-44
5. Moolenaar WH (1999) Bioactive lysophospholipids and their G protein-coupled receptors. Exp Cell Res 253:230-238
6. Lynch KR, Macdonald TL (2002) Structure-activity relationships of lysophosphatidic acid analogs. Biochim Biophys Acta 1582:289-294
7. Payne SG, Milstien S, Spiegel S (2002) Sphingosine-1-phosphate: dual messenger functions. FEBS Lett 531:54-57
8. van Corven EJ, Groenink A, Jalink K, Eichholtz T, Moolenaar WH (1989) Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins. Cell 59:45-54
9. Hooks SB, Santos WL, Im DS, Heise CE, Macdonald TL, Lynch KR (2001) Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-receptor independent. J Biol Chem 276:4611-4621
10. Weiner JA, Chun J (1999) Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid. Proc Natl Acad Sci USA 96:5233-5238
11. Hisano N, Yatomi Y, Satoh K et al (1999) Induction and suppression of endothelial cell apoptosis by sphingolipids: a possible in vitro model for cell-cell interactions between platelets and endothelial cells. Blood 93:4293-4299
12. Tigyi G, Fischer DJ, Sebok A, Marshall F, Dyer DL, Miledi R (1996) Lysophosphatidic acid-induced neurite retraction in PC12 cells: neurite- protective effects of cyclic AMP signaling. J Neurochem 66:549-558
13. Fukushima N, Weiner JA, Kaushal Det al (2002) Lysophosphatidic acid influences the morphology and motility of young, postmitotic cortical neurons. Mol Cell Neurosci 20:271-282
14. Kranenburg O, Poland M, Gebbink M, Oomen L, Moolenaar WH (1997) Dissociation of LPA-induced cytoskeletal contraction from stress fiber formation by differential localization of RhoA. J Cell Sci 110:2417-2427
15. Zhang Q, Peyruchaud O, French KJ, Magnusson MK, Mosher DF (1999) Sphingosine 1-phosphate stimulates fibronectin matrix assembly through a Rho-dependent signal pathway. Blood 93:2984-2990
16. Postma FR, Jalink K, Hengeveld T et al (1996) Serum-induced membrane depolarization in quiescent fibroblasts: activation of a chloride conductance through the G protein-coupled LPA receptor. Embo J 15:63-72
17. Sakakura C, Sweeney EA, Shirahama T et al (1998) Selectivity of sphingosine-induced apoptosis. Lack of activity of DL- erythyrodihydrosphingosine. Biochem Biophys Res Commun 246:827-830
18. Hofmann J (2001) Modulation of protein kinase C in antitumor treatment. Rev Physiol Biochem Pharmacol 142:1-96
19. Caponigro F, French RC, Kaye SB (1997) Protein kinase C: a worthwhile target for anticancer drugs? Anticancer Drugs 8:26-33
20. Schwartz GK, Jiang J, Kelsen D, Albino AP (1993) Protein kinase C: a novel target for inhibiting gastric cancer cell invasion. J Natl Cancer Inst 85:402-407
21. Marks F, Gschwendt M (1995) Protein kinase C and skin tumor promotion. Mutat Res 333:161-172
22. Ohno S, Nishizuka Y (2002) Protein kinase C isotypes and their specific functions: prologue. J Biochem (Tokyo) 132:509-511
23. Saito N, Shirai Y (2002) Protein kinase C gamma (PKC gamma): function of neuron specific isotype. J Biochem (Tokyo) 132:683-687
24. Nakashima S (2002) Protein kinase C alpha (PKC alpha): regulation and biological function. J Biochem (Tokyo) 132:669-675
25. da Rocha AB, Mans DR, Regner A, Schwartsmann G (2002) Targeting protein kinase C: new therapeutic opportunities against high-grade malignant gliomas? Oncologist 7:17-33
26. Brose N, Rosenmund C (2002) Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters. J Cell Sci 115:4399-4411
27. Fishman DD, Segal S, Livneh E (1998) The role of protein kinase C in G1 and G2/M phases of the cell cycle (review). Int J Oncol 12:181-186
28. Brodie C, Blumberg PM (2003) Regulation of cell apoptosis by protein kinase c delta. Apoptosis 8:19-27
29. Ganong BR, Loomis CR, Hannun YA, Bell RM (1986) Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols. Proc Natl Acad Sci USA 83:1184-1188
30. Kanoh H, Yamada K, Sakane F (2002) Diacylglycerol kinases: emerging downstream regulators in cell signaling systems. J Biochem (Tokyo) 131:629-633
31. Ron D, Kazanietz MG (1999) New insights into the regulation of protein kinase C and novel phorbol ester receptors. Faseb J 13:1658-1676
32. Ohmori S, Sakai N, Shirai Y et al (2000) Importance of protein kinase C targeting for the phosphorylation of its substrate, myristoylated alanine-rich C-kinase substrate. J Biol Chem 275:26449-26457
33. Hannun YA, Bell RM (1986) Phorbol ester binding and activation of protein kinase C on triton X-100 mixed micelles containing phosphatidylserine. J Biol Chem 261:9341-9347
34. 2+-dependent protein phosphorylation system in various types of leukemic cells from human patients and in human leukemic cell lines HL60 and K562, and its inhibition by alkyl-lysophospholipid. Cancer Res 43:2955-2961
35. 2+-dependent protein kinase and phosphorylation of leukemic cell proteins by CP-46,665-1, a novel antineoplastic lipoidal amine. Biochem Biophys Res Commun 127:590-595
36. Hannun YA, Loomis CR, Merrill AH, Jr, Bell RM (1986) Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets. J Biol Chem 261:12604-12609
37. Sachs CW, Safa AR, Harrison SD, Fine RL (1995) Partial inhibition of multidrug resistance by safingol is independent of modulation of P-glycoprotein substrate activities and correlated with inhibition of protein kinase C. J Biol Chem 270:26639-26648
38. Bit RA, Davis PD, Elliott LH et al (1993) Inhibitors of protein kinase C. 3. Potent and highly selective bisindolylmaleimides by conformational restriction. J Med Chem 36:21-29
39. Toullec D, Pianetti P, Coste H et al (1991) The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 266:15771-15781
40. Spiegel S, Kolesnick R (2002) Sphingosine 1-phosphate as a therapeutic agent. Leukemia 16:1596-1602
41. Brindley DN, English D, Pilquil C, Buri K, Ling ZC (2002) Lipid phosphate phosphatases regulate signal transduction through glycerolipids and sphingolipids. Biochim Biophys Acta 1582:33-44
42. Tigyi G (2001) Selective ligands for lysophosphatidic acid receptor subtypes: gaining control over the endothelial differentiation gene family. Mol Pharmacol 60:1161-1164
43. Zhao Y, Neltner BS, Davis HW (2000) Role of MARCKS in regulating endothelial cell proliferation. Am J Physiol Cell Physiol 279:C1611-1620
44. Aderem A (1992) The MARCKS brothers: a family of protein kinase C substrates. Cell 71:713-716
45. Blackshear PJ (1993) The MARCKS family of cellular protein kinase C substrates. J Biol Chem 268:1501-1504
46. Agopyan N, Agopyan I (1991) Effects of protein kinase C activators and inhibitors on membrane properties, synaptic responses, and cholinergic actions in CA1 subfield of rat hippocampus in situ and in vitro. Synapse 7:193-206
47. Goetzl EJ (2001) Pleiotypic mechanisms of cellular responses to biologically active lysophospholipids. Prostaglandins 64:11-20
48. Fukushima N, Chun J (2001) The LPA receptors. Prostaglandins 64:21-32
49. Kazanietz MG (2002) Novel "nonkinase" phorbol ester receptors: the C1 domain connection. Mol Pharmacol 61:759-767
50. Blatt NB, Glick GD (2001) Signaling pathways and effector mechanisms pre-programmed cell death. Bioorg Med Chem 9:1371-1384
51. Herr I, Debatin KM (2001) Cellular stress response and apoptosis in cancer therapy. Blood 98:2603-2614
52. Datta SR, Dudek H, Tao X et al (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91:231-241
53. Dudek H, Datta SR, Franke TF et al (1997) Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275:661-665
54. Haupt S, Berger M, Goldberg Z, Haupt Y (2003) Apoptosis - the p53 network. J Cell Sci 116:4077-4085
55. Earnshaw WC, Martins LM, Kaufmann SH (1999) Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem 68:383-424
56. Cuadros R, Montejo de Garcini E, Wandosell F, Faircloth G, Fernandez-Sousa JM, Avila J (2000) The marine compound spisulosine, an inhibitor of cell proliferation, promotes the disassembly of actin stress fibers. Cancer Lett 152:23-29
57. Wilson E, Rice WG, Kinkade JM, Jr., Merrill AH, Jr., Arnold RR, Lambeth JD (1987) Protein kinase C inhibition by sphingoid long-chain bases: effects on secretion in human neutrophils. Arch Biochem Biophys 259:204-214
58. Rao RV, Ellerby HM, Bredesen DE (2004) Coupling endoplasmic reticulum stress to the cell death program. Cell Death Differ 11:372-380
59. Szegezdi E, Fitzgerald U, Samali A (2003) Caspase-12 and ER-stress-mediated apoptosis: the story so far. Ann NY Acad Sci 1010:186-194
60. Hitomi J, Katayama T, Taniguchi M, Honda A, Imaizumi K, Tohyama M (2004) Apoptosis induced by endoplasmic reticulum stress depends on activation of caspase-3 via caspase-12. Neurosci Lett 357:127-130
61. Park MT, Kang JA, Choi JA et al (2003) Phytosphingosine induces apoptotic cell death via caspase 8 activation and Bax translocation in human cancer cells. Clin Cancer Res 9:878-885
62. Suzuki E, Handa K, Toledo MS, Hakomori S (2004) Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert. Proc Natl Acad Sci USA 101:14788-14793