Hypoxia/reoxygenation stress signals an increase in organic anion transporting polypeptide 1a4 (Oatp1a4) at the blood-brain barrier: Relevance to CNS drug delivery

Journal of Cerebral Blood Flow and Metabolism

Volumn 34, Issue 4, 2014, Pages 699-707

  Thompson, Brandon J ^a   Sanchez Covarrubias, Lucy ^a   Slosky, Lauren M ^a   Zhang, Yifeng ^a   Laracuente, Mei Li ^a   Ronaldson, Patrick T ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Blood brain barrier; Drug transport; Hypoxia reoxygenation; Oatp1a4; Statins; TGF signaling

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; ATORVASTATIN; BICARBONATE; CALPAIN; CASPASE 3; CASPASE 7; CATHEPSIN; ESTRONE SULFATE; FEXOFENADINE; GRANZYME; MATRIX METALLOPROTEINASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; OXYGEN; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1A4; TAUROCHOLIC ACID; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANION GAP; ARTICLE; BLOOD BRAIN BARRIER; BLOOD GAS; BRAIN CAPILLARY; BRAIN HYPOXIA; BRAIN PERFUSION; BRAIN PROTECTION; BRAIN TISSUE; CARBON DIOXIDE TENSION; CENTRAL NERVOUS SYSTEM; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG PENETRATION; DRUG TRANSPORT; DRUG UPTAKE; ERYTHROCYTE VOLUME; FEMALE; HEMATOCRIT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOXIA; IN VIVO STUDY; NERVOUS TISSUE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; OXYGEN TENSION; PERFUSION PRESSURE; PH; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; REOXYGENATION; REPERFUSION; SIGNAL TRANSDUCTION; TIME TO MAXIMUM PLASMA CONCENTRATION; VEIN BLOOD FLOW; WESTERN BLOTTING;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD GAS ANALYSIS; BLOOD-BRAIN BARRIER; BLOTTING, WESTERN; CARBON DIOXIDE; DRUG DELIVERY SYSTEMS; ELECTROLYTES; FEMALE; HEPTANOIC ACIDS; HYPOXIA, BRAIN; MICROVESSELS; NEUROPROTECTIVE AGENTS; ORGANIC ANION TRANSPORTERS; OXYGEN; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY;

EID: 84897570512     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2014.4     Document Type: Article

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