Neuroprotective effect of atorvastatin in an experimental model of nerve crush injury

Neurosurgery

Volumn 67, Issue 2, 2010, Pages 376-388

  Pan, Hung Chuan ^a,b,c   Yang, Dar Yu ^d   Ou, Yen Chuan ^a   Ho, Shu Peng ^c   Cheng, Fu Chou ^c   Chen, Chun Jung ^c  

^a TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

^c NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^d Chang Bing Show Chwan Hospital   (Taiwan)

Author keywords

Degeneration; Neuroprotection; Regeneration; Sciatic nerve; Statin

Indexed keywords

ATORVASTATIN; BETA TUBULIN; CD68 ANTIGEN; CILIARY NEUROTROPHIC FACTOR; COLLAGEN; INTERLEUKIN 1BETA; L SELECTIN; MITOGEN ACTIVATED PROTEIN KINASE; MYELIN BASIC PROTEIN; NEUROMODULIN; PROTEIN KINASE B; RNA; SMAD2 PROTEIN; SMAD3 PROTEIN; SODIUM CHLORIDE; STAT1 PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATTENUATION; BEHAVIOR; BIOCHEMISTRY; BLOOD SAMPLING; COGNITION; CONTROLLED STUDY; DRUG EFFECT; DRUG MEGADOSE; ELECTROPHYSIOLOGY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL MODEL; HISTOLOGY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROPHAGE; MALE; MICROMORPHOLOGY; MONOCYTE; NERVE CRUSH; NERVE DEGENERATION; NERVE REGENERATION; NEUROPROTECTION; NEUTROPHIL; NONHUMAN; OXIDATIVE STRESS; PERIPHERAL NERVE INJURY; POLYMERASE CHAIN REACTION; PREMEDICATION; PRIORITY JOURNAL; PROTECTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SCIATIC NERVE; SHORT COURSE THERAPY; TREATMENT DURATION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CASPASES; CELL MEMBRANE PERMEABILITY; COLLAGEN; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEPTANOIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LIPID PEROXIDATION; MALE; NERVE CRUSH; NERVE DEGENERATION; NERVE REGENERATION; NEUROPROTECTIVE AGENTS; PEROXIDASE; PYRROLES; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SCIATIC NERVE; SIGNAL TRANSDUCTION;

EID: 77955013827     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/01.NEU.0000371729.47895.A0     Document Type: Article

References (66)

1. Al-Majed AA, Neumann CM, Brushart TM, Gordon T. Brief electrical stimulation promotes the speed and accuracy of motor axonal regeneration. J Neurosci. 2000;20(7):2602-2608.
2. Boyd JG, Gordon T. Neurotrophic factors and their receptors in axonal regeneration and functional recovery after peripheral nerve injury. Mol Neurobiol. 2003;27(3):277-324.
3. Chen CJ, Ou YC, Liao SL, et al. Transplantation of bone marrow stromal cells for peripheral nerve repair. Exp Neurol. 2007;204(1):443-453.
4. Eto M, Sumi H, Fujimura H, Yoshikawa H, Sakoda S. Pioglitazone promotes peripheral nerve remyelination after crush injury through CD36 upregulation. J Peripher Nerv Syst. 2008;13(3):242-248.
5. Labrador RO, Buti M, Navarro X. Influence of collagen and laminin gels concentration on nerve regeneration after resection and tube repair. Exp Neurol. 1998;149 (1):243-252.
6. Pan HC, Chen CJ, Cheng FC, et al. Combination of G-CSF administration and human amniotic fluid mesenchymal stem cells transplantation promotes peripheral nerve regeneration. Neurochem Res. 2008;34(3):518-527.
7. Pan HC, Cheng FC, Chen CJ, et al. Post-injury regeneration in rat sciatic nerve facilitated by neurotrophic factors secreted by amniotic fluid mesenchymal stem cells. J Clin Neurosci. 2007;14(11):1089-1098.
8. Pan HC, Yang DY, Chiu YT, et al. Enhanced regeneration in injured sciatic nerve by human amniotic mesenchymal stem cells. J Clin Neurosci. 2006;13(5):570-575.
9. Roglio I, Bianchi R, Gotti S, et al. Neuroprotective effects of dihydroprogesterone and progesterone in an experimental model of nerve crush injury. Neuroscience. 2008;155(3):673-685.
10. Goldstein JL, Brown MS. Regulation of the mevalonate pathway. Nature. 1990;343(6257):425-430.
11. Rader DJ. Therapy to reduce the risk of coronary heart disease. Clin Cardiol. 2003;26(1):2-8.
12. Stein EA. Management of dyslipidemia in the high-risk patient. Am Heart J. 2002;144(suppl 6):S43-S50.
13. Weitz-Schmidt G. Statins as anti-inflammatory agents. Trends Pharmacol Sci. 2002;23(10):482-486.
14. Wong WW, Tan MM, Xia Z, Dimitroulakos J, Minden MD, Penn LZ. Cerivastatin triggers tumor-specific apoptosis with higher efficacy than lovastatin. Clin Cancer Res. 2001;7(7):2067-2075.
15. Chen SF, Hung TH, Chen CC, et al. Lovastatin improves histological and functional outcomes and reduces inflammation after experimental traumatic brain injury. Life Sci. 2007;81(4):288-298.
16. Endres M, Laufs U, Huang Z, et al. Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 1998;95(15):8880-8885.
17. Hernández-Romero MC, Argelles S, Villarán RF, et al. Simvastatin prevents the inflammatory process and the dopaminergic degeneration induced by the intranigral injection of lipopolysaccharide. J Neurochem. 2008;105(2):445-459.
18. Kirsch C, Eckert GP, Koudinov AR, Muller WE. Brain cholesterol, statins and Alzheimer's disease. Pharmacopsychiatry. 2003;36(suppl 2):S113-S119. (Pubitemid 37346641)
19. Lee JK, Won JS, Singh AK, Singh I. Statin inhibits kainic acid-induced seizure and associated inflammation and hippocampal cell death. Neurosci Lett. 2008;440(3):260-264.
20. Luccarini I, Ballerini C, Biagioli T, et al. Combined treatment with atorvastatin and minocyline suppresses severity of EAE. Exp Neurol. 2008;211(1):214-226.
21. Pennu R, Barbosa E, Singh AK, Singh I. Attenuation of acute inflammatory response by atorvastatin after spinal cord injury in rats. J Neurosci Res. 2005;79(3):340-350.
22. Wang H, Lynch JR, Song P, et al. Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury. Exp Neurol. 2007;206(1):59-69.
23. Cohen-Boulakia FE, Tarhzaoui K, Valensi PE, Lestrade RA, Albertini JP, Behar A. Effect of cerivastatin on peripheral capillary permeability to albumin and peripheral nerve function in diabetic rats. Diabetes Metab. 2007;33(3):189-196.
24. Gholami MR, Abolhassani F, Pasbakhsh P, et al. The effects of simvastatin on ischemia-reperfusion injury of sciatic nerve in adult rats. Eur J Pharmacol. 2008;590 (1-3):111-114.
25. Ii M, Nishimura H, Kusano KF, et al. Neuronal nitric oxide synthase mediates statin-induced restoration of vasa nervorum and reversal of diabetic neuropathy. Circulation. 2005;112(1):93-102.
26. Sarkey JP, Richards MP, Stubbs EB. Lovastatin attenuates nerve injury in an animal model of Guillain-Barré syndrome. J Neurochem. 2007;100(5):1265-1277.
27. Omura K, Ohbayashi M, Sano M, Omura T, Hasegawa T, Nagano A. The recovery of blood-nerve barrier in nerve crush injury-a quantitative analysis utilizing immunohistochemistry. Brain Res. 2004;1001(1-2):13-21.
28. Torigoe K, Tanaka HF, Takahashi A, Awaya A, Hashimoto K. Basic behavior of migratory Schwann cells in peripheral nerve regeneration. Exp Neurol. 1996;137 (2):301-308.
29. Yang DY, Pan HC, Yen YJ, et al. Detrimental effects of post-treatment with fatty acids on brain injury in ischemic rats. Neurotoxicology. 2007;28(6):1220-1229.
30. Chen CJ, Ou YC, Lin SY, Liao SL, Chen SY, Chen JH. Manganese modulates proinflammatory gene expression in activated glia. Neurochem Int. 2006;49(1):62-71.
31. Wang JP, Tsao LT, Raung SL, Hsu MF, Kuo SC. Investigation of the inhibition by acetylshikonin of the respiratory burst in rat neutrophils. Br J Pharmacol. 1997;121(3): 409-416.
32. Chen CJ, Chen JH, Chen SY, Liao SL, Raung SL. Upregulation of RANTES gene expression in neuroglia by Japanese encephalitis virus infection. J Virol. 2004; 78(22):12107-12119.
33. Bain JR, Mackinnon SE, Hunter DA. Functional evaluation of complete sciatic, peroneal, and posterior tibia nerve lesions in the rat. Plast Reconstr Surg. 1989;83(1):129-138.
34. Rosen JM, Pham HN, Hentz VR. Fascicular tubulization: a comparison of nerve experimental nerve repair techniques in the cat. Ann Plast Surg. 1989;22(6):467-478.
35. Aminoff MJ. Electrodiagnosis in Clinical Neurology. 4th ed. New York, NY: Churchill Livingstone; 1999:257-263.
36. Anton ES, Sandrock AW Jr, Matthew WD. Merosin promotes neurite growth and Schwann cell migration in vitro and nerve regeneration in vivo: evidence using an antibody to merosin, ARM-1. Dev Biol. 1994;164(1):133-146.
37. Baeuerle P, Henkel T. Function and activation of NF-κB in the immune system. Annu Rev Immunol. 1994;12:141-179.
38. Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol. 2002;4(5):E131-E136.
39. Casals-Díaz L, Vivó M, Navarro X. Nociceptive response and spinal plastic changes of afferent C-fibers in three neuropathic pain models induced by sciatic nerve injury in the rat. Exp Neurol. 2009;217(1):84-95.
40. Dinh P, Hazel A, Palispis W, Suryadevara S, Gupta R. Functional assessment after sciatic nerve injury in a rat model. Microsurgery. 2009;29(8):644-649.
41. Gegg ME, Harry R, Hankey D, et al. Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction. J Immunol. 2005;174(4):2327-2335.
42. Shubayev VI, Angert M, Dolkas J, Campana WM, Palenscar K, Myers RR. TNFalphainduced MMP-9 promotes macrophage recruitment into injured peripheral nerve. Mol Cell Neurosci. 2006;31(3):407-415.
43. Valsecchi AE, Franchi S, Panerai AE, Sacerdote P, Trovato AE, Colleoni M. Genistein, a natural phytoestrogen from soy, relieves neuropathic pain following chronic constriction sciatic nerve injury in mice: anti-inflammatory and antioxidant activity. J Neurochem. 2008;107(1):230-240.
44. Wang Y, Schmeichel AM, Iida H, Schmelzer JD, Low PA. Ischemia-reperfusion injury causes oxidative stress and apoptosis of Schwann cells in acute and chronic experimental diabetic neuropathy. Antioxid Redox Signal. 2005;7(11-12):1513-1520.
45. Wang Y, Schmeichel AM, Iida H, Schmelzer JD, Low PA. Enhanced inflammatory response via activation of NF-kappaB in acute experimental diabetic neuropathy subjected to ischemia-reperfusion injury. J Neurol Sci. 2006;247(1):47-52.
46. Prasad R, Giri S, Nath N, Singh I, Singh AK. Inhibition of phosphoinositide 3 kinase-Akt (protein kinase B)-nuclear factor-kappa B pathway by lovastatin limits endothelial-monocyte cell interaction. J Neurochem. 2005;94(1):204-214.
47. Rezaie-Majd A, Maca T, Bucek RA, et al. Simvastatin reduces expression of cytokines interleukin-6, interleukin-8, and monocyte chemoattractant protein-1 in circulat ing monocytes from hypercholesterolemic patients. Arterioscler Thromb Vasc Biol. 2002;22(7):1194-1199.
48. Liem RK, Hutchison SB. Purification of individual components of the neurofilament triplet: filament assembly from the 70000-Dalton subunit. Biochemistry. 1982;21(13):3221-3226.
49. Xu QG, Midha R, Martinez JA, Guo GF, Zochodne DW. Facilitated sprouting in a peripheral nerve injury. Neuroscience. 2008;152(4):877-887.
50. Pedraza L, Fidler L, Staugaitis SM, Colman DR. The active transport of myelin basic protein into the nucleus suggests a regulatory role in myelination. Neuron. 1997;18(4):579-589.
51. Chen YS, Hsieh CL, Tsai CC, et al. Peripheral nerve regeneration using silicone rubber chambers filled with collagen, laminin and fibronectin. Biomaterials. 2000;21(15):1541-1547.
52. Chen ZY, Chai YF, Cao L, Lu L, He C. Glial cell line-derived neurotrophic factor enhances axonal regeneration following sciatic nerve transection in adult rats. Brain Res. 2001;902(2):272-276.
53. Lee AC, Yu VM, Lowe JB, et al. Controlled release of nerve growth factor enhances sciatic nerve regeneration. Exp Neurol. 2003;184(1):295-303.
54. Marcol W, Kotulska K, Swiech-Sabuda E, et al. Regeneration of sciatic nerves of adult rats induced by extracts from distal stumps of pre-degenerated peripheral nerves. J Neurosci Res. 2003;72(3):417-424.
55. Hwang SY, Jung JS, Lim SJ, et al. LY294002 inhibits interferon-gamma- stimulated inducible nitric oxide synthase expression in BV2 microglial cells. Biochem Biophys Res Commun. 2004;318(3):691-697.
56. Kim HY, Park EJ, Joe EH, Jou I. Curcumin suppresses Janus kinase-STAT inflammatory signaling through activation of Src homology 2 domain-containing tyrosine phosphatase 2 in brain microglia. J Immunol. 2003;171(11):6072-6079.
57. Moro T, Shimoyama Y, Kushida M, et al. Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis. Life Sci. 2008;83(15-16):531-539.
58. Nagao H, Matsuoka I, Kurihara K. Effects of phorbol ester on expression of CNTFmRNA in cultured astrocytes from rat olfactory bulb. Brain Res. 1996;719(1-2):23-28.
59. Liu Q, Mao H, Nie J, et al. Transforming growth factor β-1 induces epithelialmesenchymal transition by activating the JNK-Smad3 pathway in rat peritoneal mesothelial cells. Perit Dial Int. 2008;28(suppl 3):S88-S95.
60. Zou T, Ling C, Xiao Y, et al. Exogenous tissue-plasminogen activator (tPA) enhances peripheral nerve regeneration and functional recovery after injury in adult mice. J Neuropathol Exp Neurol. 2006;65(1):78-86.
61. Kieseier BC, Seifert T, Giovannoni G, Hartung HP. Matrix metalloproteinases in inflammatory demyelination: targets for treatment. Neurology. 1999;53(1):20-25.
62. Siebert H, Dippel N, Mader M, Weber F, Bruck W. Matrix metalloproteinase expression and inhibition after sciatic nerve axotomy. J Neuropathol Exp Neurol. 2001;60(1):85-93.
63. La Fleur M, Underwood JL, Rappolee DA, Werb Z. Basement membrane and repair of injury to peripheral nerve: defining a potential role for macrophages, matrix metalloproteinases, and tissue inhibitor of metalloproteinase-1. J Exp Med. 1996;184(6):2311-2326.
64. Shubayev VI, Myers RR. Endoneurial remodeling by TNFalpha- and TNFalphareleasing proteases: a spatial and temporal colocalization study in painful neuropathy. J Peripher Nerv Syst. 2002;7(1):28-36.
65. Chen G, Zhang S, Shi J, Ai J, Qi M, Hang C. Simvastatin reduces secondary brain injury caused by cortical contusion in rats: possible involvement of TLR4/NF-κB pathway. Exp Neurol. 2009;216(2):398-406.
66. Dold S, Laschke MW, Lavasani S, Menger MD, Jeppsson B, Thorlacius H. Simvastatin protects against cholestasis-induced liver injury. Br J Pharmacol. 2009;156(3):466-474.