Atorvastatin treatment in a dog preclinical model of Alzheimer's disease leads to up-regulation of haem oxygenase-1 and is associated with reduced oxidative stress in brain

International Journal of Neuropsychopharmacology

Volumn 15, Issue 7, 2012, Pages 981-987

  Butterfield, D Allan ^a   Barone, Eugenio ^a,b   Di Domenico, Fabio ^a,c   Cenini, Giovanna ^a,d   Sultana, Rukhsana ^a   Murphy, Michael P ^d   Mancuso, Cesare ^b   Head, Elizabeth ^d  

^a UNIVERSITY OF KENTUCKY   (United States)

^b CATHOLIC UNIVERSITY   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Alzheimer's disease; atorvastatin; haem oxygenase 1; oxidative stress

Indexed keywords

3 NITROTYROSINE; 4 HYDROXYNONENAL; ATORVASTATIN; GLUTATHIONE; HEME OXYGENASE 1; HEME OXYGENASE 2; PLACEBO;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN LEVEL; CEREBELLUM; CONTROLLED STUDY; LEARNING; LIVER; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PARIETAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREATMENT DURATION; UPREGULATION;

ALDEHYDES; ALZHEIMER DISEASE; ANIMALS; ANTICHOLESTEREMIC AGENTS; BRAIN; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; DOGS; GLUTATHIONE; HEME OXYGENASE-1; HEPTANOIC ACIDS; KETOCHOLESTEROLS; LINEAR MODELS; LIVER; OXIDATIVE STRESS; PYRROLES; UP-REGULATION;

EID: 84864349775     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S1461145711001118     Document Type: Article

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