Transcriptional activation of p21WAF1/CIP1 is mediated by increased DNA binding activity and increased interaction between p53 and Sp1 via phosphorylation during replicative senescence of human embryonic fibroblasts

Molecular Biology Reports

Volumn 41, Issue 4, 2014, Pages 2397-2408

  Kim, Hyun Seok ^b   Heo, Jee In ^a   Park, Seong Hoon ^c   Shin, Jong Yeon ^d   Kang, Hong Jun ^e   Kim, Min Ju ^a   Kim, Sung Chan ^a   Kim, Jaebong ^a   Park, Jae Bong ^a   Lee, Jae Yong ^a  

^a Hallym University   (South Korea)

^b Ewha Womans University   (South Korea)

^c NORTHWESTERN UNIVERSITY   (United States)

^d Seoul National University   (South Korea)

^e TULANE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

p21; p53; Senescence; Sp1

Indexed keywords

ALKALINE PHOSPHATASE; CYCLIN DEPENDENT KINASE INHIBITOR 1; PROTEIN P53; TRANSCRIPTION FACTOR SP1; CYCLIN DEPENDENT KINASE INHIBITOR 1A; PROTEIN BINDING;

ARTICLE; BINDING SITE; CELL DIVISION; CONTROLLED STUDY; DNA BINDING; EMBRYO CELL; ENZYME ACTIVITY; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOLECULAR DYNAMICS; PLASMID; POLYMERASE CHAIN REACTION; PROMOTER REGION; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SENESCENCE; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; UPREGULATION; CELL AGING; CELL CULTURE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHOSPHORYLATION;

BINDING SITES; CELL AGING; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P21; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTIONAL ACTIVATION; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 84897486652     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-014-3094-9     Document Type: Article

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