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Volumn 74, Issue 7, 2014, Pages 2038-2049

Tumor-infiltrating myeloid cells activate Dll4/Notch/TGF-β signaling to drive malignant progression

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1; MONOCYTE CHEMOTACTIC PROTEIN 1; NOTCH RECEPTOR; PEPTIDES AND PROTEINS; PROTEIN DLL4; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 84897442586     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-13-3118     Document Type: Article
Times cited : (34)

References (50)
  • 1
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: Functions of cells recruited to the tumor microenvironment
    • Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell 2012;21: 309-22.
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 4
    • 84866784798 scopus 로고    scopus 로고
    • Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy
    • DeNardo DG, Brennan DJ, Rexhepaj E, Ruffell B, Shiao SL, Madden SF, et al. Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discov 2011;1:54-67.
    • (2011) Cancer Discov , vol.1 , pp. 54-67
    • DeNardo, D.G.1    Brennan, D.J.2    Rexhepaj, E.3    Ruffell, B.4    Shiao, S.L.5    Madden, S.F.6
  • 5
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature. 2005;438:967-74.
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 6
    • 80054725681 scopus 로고    scopus 로고
    • Macrophage binding to receptor vcam-1 transmits survival signals in breast cancer cells that invade the lungs
    • Chen Q, Zhang XH, Massague J. Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs. Cancer Cell 2011;20:538-49.
    • (2011) Cancer Cell , vol.20 , pp. 538-549
    • Chen, Q.1    Zhang, X.H.2    Massague, J.3
  • 8
    • 33749017931 scopus 로고    scopus 로고
    • Cysteine cathepsins: Multifunctional enzymes in cancer
    • Mohamed MM, Sloane BF. Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer 2006;6:764-75.
    • (2006) Nat Rev Cancer , vol.6 , pp. 764-775
    • Mohamed, M.M.1    Sloane, B.F.2
  • 9
    • 84866985855 scopus 로고    scopus 로고
    • Targeting the tgf-β signalling pathway in disease
    • Akhurst RJ, Hata A. Targeting the TGF-β signalling pathway in disease. Nat Rev Drug Discov 2012;11:790-811.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 790-811
    • Akhurst, R.J.1    Hata, A.2
  • 11
    • 33644545381 scopus 로고    scopus 로고
    • Tumour microenvironment -Opinion: Validating matrix metalloproteinases as drug targets and anti-Targets for cancer therapy
    • Overall CM, Kleifeld O. Tumour microenvironment -opinion: validating matrix metalloproteinases as drug targets and anti-Targets for cancer therapy. Nat Rev Cancer 2006;6:227-39.
    • (2006) Nat Rev Cancer , vol.6 , pp. 227-239
    • Overall, C.M.1    Kleifeld, O.2
  • 12
    • 0037244284 scopus 로고    scopus 로고
    • Intrinsic requirement for zinc finger transcription factor gfi-1 in neutrophil differentiation
    • Hock H, Hamblen MJ, Rooke HM, Traver D, Bronson RT, Cameron S, et al. Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity 2003;18:109-20.
    • (2003) Immunity , vol.18 , pp. 109-120
    • Hock, H.1    Hamblen, M.J.2    Rooke, H.M.3    Traver, D.4    Bronson, R.T.5    Cameron, S.6
  • 13
    • 0036510161 scopus 로고    scopus 로고
    • Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor gfi1
    • Karsunky H, Zeng H, Schmidt T, Zevnik B, Kluge R, Schmid KW, et al. Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1. Nat Genet 2002;30: 295-300.
    • (2002) Nat Genet , vol.30 , pp. 295-300
    • Karsunky, H.1    Zeng, H.2    Schmidt, T.3    Zevnik, B.4    Kluge, R.5    Schmid, K.W.6
  • 14
    • 0345166971 scopus 로고    scopus 로고
    • Cross-Talk between the notch and tgf-β signaling pathways mediated by interaction of the notch intracellular domain with smad3
    • Blokzijl A, Dahlqvist C, Reissmann E, Falk A, Moliner A, Lendahl U, et al. Cross-Talk between the Notch and TGF-β signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. J Cell Biol 2003;163:723-8.
    • (2003) J Cell Biol , vol.163 , pp. 723-728
    • Blokzijl, A.1    Dahlqvist, C.2    Reissmann, E.3    Falk, A.4    Moliner, A.5    Lendahl, U.6
  • 15
    • 10744231139 scopus 로고    scopus 로고
    • Synergy and antagonism between notch and bmp receptor signaling pathways in endothelial cells
    • Itoh F, Itoh S, Goumans MJ, Valdimarsdottir G, Iso T, Dotto GP, et al. Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells. Embo J 2004;23:541-51.
    • (2004) Embo J , vol.23 , pp. 541-551
    • Itoh, F.1    Itoh, S.2    Goumans, M.J.3    Valdimarsdottir, G.4    Iso, T.5    Dotto, G.P.6
  • 16
    • 84858286273 scopus 로고    scopus 로고
    • Stalk cell phenotype depends on integration of notch and smad1/5 signaling cascades
    • Moya IM, Umans L, Maas E, Pereira PN, Beets K, Francis A, et al. Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades. Dev Cell 2012;22:501-14.
    • (2012) Dev Cell , vol.22 , pp. 501-514
    • Moya, I.M.1    Umans, L.2    Maas, E.3    Pereira, P.N.4    Beets, K.5    Francis, A.6
  • 17
    • 34948890061 scopus 로고    scopus 로고
    • Transcription factor gfi-1 induced by g-csf is a negative regulator of cxcr4 in myeloid cells
    • De La Luz Sierra M, Gasperini P, McCormick PJ, Zhu J, Tosato G. Transcription factor Gfi-1 induced by G-CSF is a negative regulator of CXCR4 in myeloid cells. Blood 2007;110:2276-85.
    • (2007) Blood , vol.110 , pp. 2276-2285
    • De La Luz Sierra, M.1    Gasperini, P.2    McCormick, P.J.3    Zhu, J.4    Tosato, G.5
  • 19
    • 84868626633 scopus 로고    scopus 로고
    • Semaphorin 6a regulates angiogenesis by modulating vegf signaling
    • Segarra M, Ohnuki H, Maric D, Salvucci O, Hou X, Kumar A, et al. Semaphorin 6A regulates angiogenesis by modulating VEGF signaling. Blood 2012;120:4104-15.
    • (2012) Blood , vol.120 , pp. 4104-4115
    • Segarra, M.1    Ohnuki, H.2    Maric, D.3    Salvucci, O.4    Hou, X.5    Kumar, A.6
  • 21
    • 0346996709 scopus 로고    scopus 로고
    • Granulocytemacrophage colony-stimulating factor is a chemoattractant cytokine for human neutrophils: Involvement of the ribosomal p70 s6 kinase signaling pathway
    • Gomez-Cambronero J, Horn J, Paul CC, Baumann MA. Granulocytemacrophage colony-stimulating factor is a chemoattractant cytokine for human neutrophils: involvement of the ribosomal p70 S6 kinase signaling pathway. J Immunol 2003;171:6846-55.
    • (2003) J Immunol , vol.171 , pp. 6846-6855
    • Gomez-Cambronero, J.1    Horn, J.2    Paul, C.C.3    Baumann, M.A.4
  • 23
    • 0029147796 scopus 로고
    • Transforming growth factor beta 1 inhibits mouse keratinocytes late in g1 independent of effects on gene transcription
    • Alexandrow MG,Moses HL. Transforming growth factor beta 1 inhibits mouse keratinocytes late in G1 independent of effects on gene transcription. Cancer Res 1995;55:3928-32.
    • (1995) Cancer Res , vol.55 , pp. 3928-3932
    • Alexandrow, M.G.1    Moses, H.L.2
  • 24
    • 0037067653 scopus 로고    scopus 로고
    • E2f4/5 and p107 as smad cofactors linking the tgf-β receptor to c-myc repression
    • Chen CR, Kang Y, Siegel PM, Massague J. E2F4/5 and p107 as Smad cofactors linking the TGF-β receptor to c-myc repression. Cell 2002;110:19-32.
    • (2002) Cell , vol.110 , pp. 19-32
    • Chen, C.R.1    Kang, Y.2    Siegel, P.M.3    Massague, J.4
  • 25
    • 9144246932 scopus 로고    scopus 로고
    • Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation
    • Timmerman LA, Grego-Bessa J, Raya A, Bertran E, Perez-Pomares JM, Diez J, et al. Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev 2004;18:99-115.
    • (2004) Genes Dev , vol.18 , pp. 99-115
    • Timmerman, L.A.1    Grego-Bessa, J.2    Raya, A.3    Bertran, E.4    Perez-Pomares, J.M.5    Diez, J.6
  • 26
    • 84859171807 scopus 로고    scopus 로고
    • Myc on the path to cancer
    • Dang CV. MYC on the path to cancer. Cell 2012;149:22-35.
    • (2012) Cell , vol.149 , pp. 22-35
    • Dang, C.V.1
  • 27
    • 40349098612 scopus 로고    scopus 로고
    • Migratory neighbors and distant invaders: Tumor-Associated niche cells
    • Wels J, Kaplan RN, Rafii S, Lyden D. Migratory neighbors and distant invaders: tumor-Associated niche cells. Genes Dev 2008;22:559-74.
    • (2008) Genes Dev , vol.22 , pp. 559-574
    • Wels, J.1    Kaplan, R.N.2    Rafii, S.3    Lyden, D.4
  • 28
    • 75749146306 scopus 로고    scopus 로고
    • Plasticity of cell migration: A multiscale tuning model
    • Friedl P, Wolf K. Plasticity of cell migration: a multiscale tuning model. J Cell Biol 2010;188:11-9.
    • (2010) J Cell Biol , vol.188 , pp. 11-19
    • Friedl, P.1    Wolf, K.2
  • 29
    • 0034729760 scopus 로고    scopus 로고
    • Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cdna arrays
    • Leethanakul C, Patel V, Gillespie J, Pallente M, Ensley JF, Koontongkaew S, et al. Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays. Oncogene 2000;19:3220-4.
    • (2000) Oncogene , vol.19 , pp. 3220-3224
    • Leethanakul, C.1    Patel, V.2    Gillespie, J.3    Pallente, M.4    Ensley, J.F.5    Koontongkaew, S.6
  • 30
    • 10044298473 scopus 로고    scopus 로고
    • Prognostic factors in oral cavity and oropharyngeal squamous cell carcinoma
    • Marcus B, Arenberg D, Lee J, Kleer C, Chepeha DB, Schmalbach CE, et al. Prognostic factors in oral cavity and oropharyngeal squamous cell carcinoma. Cancer 2004;101:2779-87.
    • (2004) Cancer , vol.101 , pp. 2779-2787
    • Marcus, B.1    Arenberg, D.2    Lee, J.3    Kleer, C.4    Chepeha, D.B.5    Schmalbach, C.E.6
  • 31
    • 84861805678 scopus 로고    scopus 로고
    • The molecular pathogenesis of head and neck squamous cell carcinoma
    • Rothenberg SM, Ellisen LW. The molecular pathogenesis of head and neck squamous cell carcinoma. J Clin Invest 2012;122:1951-7.
    • (2012) J Clin Invest , vol.122 , pp. 7
    • Rothenberg, S.M.1    Ellisen, L.W.2
  • 32
    • 84871181384 scopus 로고    scopus 로고
    • Alterations of smad expression and activation in defining 2 subtypes of human head and neck squamous cell carcinoma
    • Xie W, Aisner S, Baredes S, Sreepada G, Shah R, Reiss M. Alterations of Smad expression and activation in defining 2 subtypes of human head and neck squamous cell carcinoma. Head Neck 2013;35:76-85.
    • (2013) Head Neck , vol.35 , pp. 76-85
    • Xie, W.1    Aisner, S.2    Baredes, S.3    Sreepada, G.4    Shah, R.5    Reiss, M.6
  • 33
    • 84866742560 scopus 로고    scopus 로고
    • Tgf-β signalling in context
    • Massague J. TGF-β signalling in context. Nat Rev Mol Cell Biol 2012;13:616-30.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 616-630
    • Massague, J.1
  • 34
    • 77953023274 scopus 로고    scopus 로고
    • Tgf-β and immune cells: An important regulatory axis in the tumor microenvironment and progression
    • Yang L, Pang Y, Moses HL. TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression. Trends Immunol 2010;31:220-7.
    • (2010) Trends Immunol , vol.31 , pp. 220-227
    • Yang, L.1    Pang, Y.2    Moses, H.L.3
  • 35
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
    • Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 2008;14: 818-29.
    • (2008) Dev Cell , vol.14 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 36
    • 27144433568 scopus 로고    scopus 로고
    • Notch in the pathway: The roles of notch signaling in neural crest development
    • Cornell RA, Eisen JS.Notch in the pathway: the roles of Notch signaling in neural crest development. Semin Cell Dev Biol 2005;16:663-72.
    • (2005) Semin Cell Dev Biol , vol.16 , pp. 663-672
    • Cornell, R.A.1    Eisen, J.S.2
  • 37
    • 84856309973 scopus 로고    scopus 로고
    • The notch and tgf-β signaling pathways contribute to the aggressiveness of clear cell renal cell carcinoma
    • Sjolund J, Bostrom AK, Lindgren D, Manna S, Moustakas A, Ljungberg B, et al. The notch and TGF-β signaling pathways contribute to the aggressiveness of clear cell renal cell carcinoma. PLoS One 2011;6: e23057.
    • (2011) PLoS One , vol.6
    • Sjolund, J.1    Bostrom, A.K.2    Lindgren, D.3    Manna, S.4    Moustakas, A.5    Ljungberg, B.6
  • 38
    • 1842524153 scopus 로고    scopus 로고
    • Integration of tgfbeta/ smad and jagged1/notch signalling in epithelial-To-mesenchymal transition
    • Zavadil J, Cermak L, Soto-Nieves N, Bottinger EP. Integration of TGFbeta/ Smad and Jagged1/Notch signalling in epithelial-To-mesenchymal transition. Embo J 2004;23:1155-65.
    • (2004) Embo J , vol.23 , pp. 1155-1165
    • Zavadil, J.1    Cermak, L.2    Soto-Nieves, N.3    Bottinger, E.P.4
  • 39
    • 0347519180 scopus 로고    scopus 로고
    • Functional notch signaling is required for bmp4-induced inhibition of myogenic differentiation
    • Dahlqvist C, Blokzijl A, Chapman G, Falk A, Dannaeus K, Ibanez CF, et al. Functional Notch signaling is required for BMP4-induced inhibition of myogenic differentiation. Development 2003;130:6089-99.
    • (2003) Development , vol.130 , pp. 6089-6099
    • Dahlqvist, C.1    Blokzijl, A.2    Chapman, G.3    Falk, A.4    Dannaeus, K.5    Ibanez, C.F.6
  • 40
    • 77950950894 scopus 로고    scopus 로고
    • Macrophage diversity enhances tumor progression and metastasis
    • Qian BZ, Pollard JW. Macrophage diversity enhances tumor progression and metastasis. Cell 2010;141:39-51.
    • (2010) Cell , vol.141 , pp. 39-51
    • Qian, B.Z.1    Pollard, J.W.2
  • 43
    • 84879422834 scopus 로고    scopus 로고
    • Notch inhibitors for cancer treatment
    • Espinoza I, Miele L. Notch inhibitors for cancer treatment. Pharmacol Ther 2013;139:95-110.
    • (2013) Pharmacol Ther , vol.139 , pp. 95-110
    • Espinoza, I.1    Miele, L.2
  • 44
    • 80053344442 scopus 로고    scopus 로고
    • Resuscitating cancer immunosurveillance: Selective stimulation of dll1-notch signaling in t cells rescues t-cell function and inhibits tumor growth
    • Huang Y, Lin L, Shanker A, Malhotra A, Yang L, Dikov MM, et al. Resuscitating cancer immunosurveillance: selective stimulation of DLL1-Notch signaling in T cells rescues T-cell function and inhibits tumor growth. Cancer Res 2011;71:6122-31.
    • (2011) Cancer Res , vol.71 , pp. 6122-6131
    • Huang, Y.1    Lin, L.2    Shanker, A.3    Malhotra, A.4    Yang, L.5    Dikov, M.M.6
  • 47
    • 0030054646 scopus 로고    scopus 로고
    • Notch4/int-3, a mammary proto-oncogene, is an endothelial cellspecific mammalian notch gene
    • Uyttendaele H, Marazzi G, Wu G, Yan Q, Sassoon D, Kitajewski J. Notch4/int-3, a mammary proto-oncogene, is an endothelial cellspecific mammalian Notch gene. Development 1996;122:2251-9.
    • (1996) Development , vol.122 , pp. 2251-2259
    • Uyttendaele, H.1    Marazzi, G.2    Wu, G.3    Yan, Q.4    Sassoon, D.5    Kitajewski, J.6
  • 48
    • 84861398396 scopus 로고    scopus 로고
    • Lunatic fringe deficiency cooperates with the met/caveolin gene amplicon to induce basal-like breast cancer
    • Xu K, Usary J, Kousis PC, Prat A, Wang DY, Adams JR, et al. Lunatic fringe deficiency cooperates with the Met/Caveolin gene amplicon to induce basal-like breast cancer. Cancer Cell 2012;21:626-41.
    • (2012) Cancer Cell , vol.21 , pp. 626-641
    • Xu, K.1    Usary, J.2    Kousis, P.C.3    Prat, A.4    Wang, D.Y.5    Adams, J.R.6
  • 50
    • 84857692141 scopus 로고    scopus 로고
    • Differential macrophage programming in the tumor microenvironment
    • Ruffell B, Affara NI, Coussens LM. Differential macrophage programming in the tumor microenvironment. Trends Immunol 2012;33:119-26.
    • (2012) Trends Immunol , vol.33 , pp. 119-126
    • Ruffell, B.1    Affara, N.I.2    Coussens, L.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.