All-trans retinoic acid inhibits mesangial cell proliferation by up-regulating p21Waf1/Cip1 and p27Kip1 and down-regulating Skp2

Journal of Nephrology

Volumn 25, Issue 6, 2012, Pages 1031-1040

  Su, Baofeng ^a   Chen, Xiaolan ^a   Zhong, Chonghui ^a   Guo, Naifeng ^a   He, Jianghong ^a   Fan, Yaping ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

All trans retinoic acid; Apoptosis; Mesangial cells; Proliferation

Indexed keywords

BETA ACTIN; CHOLECYSTOKININ OCTAPEPTIDE; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; DIMETHYL SULFOXIDE; MESSENGER RNA; RETINOIC ACID; S PHASE KINASE ASSOCIATED PROTEIN 2; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BETA ACTIN GENE; CELL ASSAY; CELL CYCLE G0 PHASE; CELL NUCLEUS; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYCLIN DEPENDENT KINASE INHIBITOR 1 GENE; CYCLIN DEPENDENT KINASE INHIBITOR 1B GENE; CYTOPLASM; DOWN REGULATION; DRUG EFFECT; G1 PHASE CELL CYCLE CHECKPOINT; GENE SEQUENCE; GROWTH INHIBITION; IMMUNOFLUORESCENCE MICROSCOPY; MESANGIUM CELL; MOLECULAR DYNAMICS; NICK END LABELING; NONHUMAN; PROTEIN LOCALIZATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; S PHASE KINASE ASSOCIATED PROTEIN 2 GENE; UPREGULATION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; G0 PHASE; G1 PHASE CELL CYCLE CHECKPOINTS; IN SITU NICK-END LABELING; MESANGIAL CELLS; MICROSCOPY, CONFOCAL; RATS; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; S-PHASE KINASE-ASSOCIATED PROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFORMING GROWTH FACTOR BETA1; TRETINOIN; UP-REGULATION;

EID: 84870591790     PISSN: 11218428     EISSN: 17246059     Source Type: Journal    
DOI: 10.5301/jn.5000090     Document Type: Article

References (44)

1. Wolfe RA, Port FK, Webb RL, et al. Introduction to the excerpts from the United States Renal Data System 1999 annual data report. Am J Kidney Dis. 1999;34(2)(Suppl 1):S1-S3.
2. Böttinger EP, Bitzer M. TGF-beta signaling in renal disease. J Am Soc Nephrol. 2002;13(10):2600-2610.
3. Isaka Y, Akagi Y, Ando Y, Tsujie M, Imai E. Cytokines and glomerulosclerosis. Nephrol Dial Transplant. 1999;14(90001) (Suppl 1):30-32.
4. Ziyadeh FN. Mediators of diabetic renal disease: the case for TGF-beta as the major mediator. J Am Soc Nephrol. 2004;15(90010)(Suppl 1):S55-S57.
5. Hengst L, Reed SI. Inhibitors of the Cip/Kip family. Curr Top Microbiol Immunol. 1998;227:25-41.
6. Sherr CJ, Roberts JM. Inhibitors of mammalian G1 cyclindependent kinases. Genes Dev. 1995;9(10):1149-1163.
7. Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 1999;13(12): 1501-1512.
8. Niculescu AB III, Chen X, Smeets M, Hengst L, Prives C, Reed SI. Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol. 1998;18(1):629-643.
9. Ogryzko VV, Wong P, Howard BH. WAF1 retards S-phase progression primarily by inhibition of cyclin-dependent kinases. Mol Cell Biol. 1997;17(8):4877-4882.
10. Radhakrishnan SK, Feliciano CS, Najmabadi F, et al. Constitutive expression of E2F-1 leads to p21-dependent cell cycle arrest in S phase of the cell cycle. Oncogene. 2004;23 (23):4173-4176.
11. el-Deiry WS, Tokino T, Velculescu VE, et al. WAF1, a potential mediator of p53 tumor suppression. Cell. 1993;75(4): 817-825.
12. Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 1993;75(4):805-816.
13. Xiong Y, Hannon GJ, Zhang H, Casso D, Kobayashi R, Beach D. p21 is a universal inhibitor of cyclin kinases. Nature. 1993; 366(6456):701-704.
14. LaBaer J, Garrett MD, Stevenson LF, et al. New functional activities for the p21 family of CDK inhibitors. Genes Dev. 1997; 11(7):847-862.
15. Shivji MK, Ferrari E, Ball K, Hübscher U, Wood RD. Resistance of human nucleotide excision repair synthesis in vitro to p21Cdn1. Oncogene. 1998;17(22):2827-2838.
16. Li Y, Jenkins CW, Nichols MA, Xiong Y. Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21. Oncogene. 1994;9(8):2261-2268.
17. Waga S, Hannon GJ, Beach D, Stillman B. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature. 1994;369(6481):574-578.
18. Slingerland J, Pagano M. Regulation of the CDK inhibitor p27 and its deregulation in cancer. J Cell Physiol. 2000;183(1): 10-17.
19. Bloom J, Pagano M. Deregulated degradation of the cdk inhibitor p27 and malignant transformation. Semin Cancer Biol. 2003;13(1):41-47.
20. Viglietto G, Motti ML, Fusco A. Understanding p27(kip1) deregulation in cancer: down-regulation or mislocalization. Cell Cycle. 2002;1(6):394-400.
21. Coqueret O. New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment? Trends Cell Biol. 2003;13(2):65-70.
22. Borriello A, Cucciolla V, Criscuolo M, et al. Retinoic acid induces p27Kip1 nuclear accumulation by modulating its phosphorylation. Cancer Res. 2006;66(8):4240-4248.
23. Radu M, Soprano DR, Soprano KJ. S10 phosphorylation of p27 mediates at RA induced growth arrest in ovarian carcinoma cell lines. J Cell Physiol. 2008;217(2):558-568.
24. Morath C, Dechow C, Lehrke I, et al. Effects of retinoids on the TGF-beta system and extracellular matrix in experimental glomerulonephritis. J Am Soc Nephrol. 2001;12(11): 2300-2309.
25. Schaier M, Liebler S, Schade K, et al. Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat. J Mol Med (Berl). 2004;82(2):116-125.
26. Moreno-Manzano V, Ishikawa Y, Lucio-Cazana J, Kitamura M. Suppression of apoptosis by all-trans-retinoic acid: dual intervention in the c-Jun n-terminal kinase-AP-1 pathway. J Biol Chem. 1999;274(29):20251-20258.
27. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C (T)) method. Methods. 2001;25(4):402-408.
28. Vaughan MR, Pippin JW, Griffin SV, et al. ATRA induces podocyte differentiation and alters nephrin and podocin expression in vitro and in vivo. Kidney Int. 2005;68(1):133-144.
29. Woo KT, Lau YK, Wong KS, Chiang GS. ACEI/ATRA therapy decreases proteinuria by improving glomerular permselectivity in IgA nephritis. Kidney Int. 2000;58(6):2485-2491.
30. Shima Y, Iwano M, Yoshizaki K, Tanaka T, Kawase I, Nishimoto N. All-trans-retinoic acid inhibits the development of mesangial proliferative glomerulonephritis in interleukin-6 transgenic mice. Nephron Exp Nephrol. 2005;100(1):e54-e62.
31. Guo NF, Chen XL, Fan YP, et al. The effects of all-trans retinoic acid on expression of cox-2, Smad3, Smad7 signal pathway in rat glomerular mesangial cell treated by TGF-β1. J Nephrol Dial Transplant. 2009;18:542-549.
32. Daniel C, Duffield J, Brunner T, Steinmann-Niggli K, Lods N, Marti HP. Matrix metalloproteinase inhibitors cause cell cycle arrest and apoptosis in glomerular mesangial cells. J Pharmacol Exp Ther. 2001;297(1):57-68.
33. Fan YP, Weiss RH. Exogenous attenuation of p21(Waf1/Cip1) decreases mesangial cell hypertrophy as a result of hyperglycemia and IGF-1. J Am Soc Nephrol. 2004;15(3):575-584.
34. Nagata D, Suzuki E, Nishimatsu H, et al. Cyclin A downregulation and p21(cip1) upregulation correlate with GATA-6-induced growth arrest in glomerular mesangial cells. Circ Res. 2000;87(8):699-704.
35. Liu M, Iavarone A, Freedman LP. Transcriptional activation of the human p21(WAF1/CIP1) gene by retinoic acid receptor: correlation with retinoid induction of U937 cell differentiation. J Biol Chem. 1996;271(49):31723-31728.
36. Zhang H, Kobayashi R, Galaktionov K, Beach D. p19Skp1 and p45Skp2 are essential elements of the cyclin A-CDK2 S phase kinase. Cell. 1995;82(6):915-925.
37. Servant MJ, Coulombe P, Turgeon B, Meloche S. Differential regulation of p27(Kip1) expression by mitogenic and hypertrophic factors: involvement of transcriptional and posttranscriptional mechanisms. J Cell Biol. 2000;148(3):543-556.
38. Agrawal D, Hauser P, McPherson F, Dong F, Garcia A, Pledger WJ. Repression of p27kip1 synthesis by platelet-derived growth factor in BALB/c 3T3 cells. Mol Cell Biol. 1996;16(8): 4327-4336.
39. Millard SS, Yan JS, Nguyen H, Pagano M, Kiyokawa H, Koff A. Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest. J Biol Chem. 1997;272(11):7093-7098.
40. Pagano M, Tam SW, Theodoras AM, et al. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science. 1995;269(5224): 682-685.
41. Dow R, Hendley J, Pirkmaier A, Musgrove EA, Germain D. Retinoic acid-mediated growth arrest requires ubiquitylation and degradation of the F-box protein Skp2. J Biol Chem. 2001;276(49):45945-45951.
42. Yu Z, Han J, Lin J, Xiao Y, Zhang X, Li Y. Apoptosis induced by atRA in MEPM cells is mediated through activation of caspase and RAR. Toxicol Sci. 2006;89(2):504-509.
43. Sumantran VN, Zhang R, Lee DS, Wicha MS. Differential regulation of apoptosis in normal versus transformed mammary epithelium by lutein and retinoic acid. Cancer Epidemiol Biomarkers Prev. 2000;9(3):257-263.
44. Ou H, Haendeler J, Aebly MR, et al. Retinoic acid-induced tissue transglutaminase and apoptosis in vascular smooth muscle cells. Circ Res. 2000;87(10):881-887.