Inherent instability of the retinitis pigmentosa P23H mutant opsin

Journal of Biological Chemistry

Volumn 289, Issue 13, 2014, Pages 9288-9303

  Chen, Yuanyuan ^a   Jastrzebska, Beata ^a   Cao, Pengxiu ^a   Zhang, Jianye ^a   Wang, Benlian ^a   Sun, Wenyu ^b   Yuan, Yiyuan ^a   Feng, Zhaoyang ^a   Palczewski, Krzysztof ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Polgenix Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COVALENT BONDS; OPHTHALMOLOGY;

AUTOSOMAL DOMINANT RETINITIS PIGMENTOSA; CAENORHABDITIS ELEGANS; INHERENT INSTABILITY; MOLECULAR MECHANISM; PROTEIN DEGRADATION; REDUCED SENSITIVITY; RETINAL DEGENERATIONS; RETINITIS PIGMENTOSA;

CHROMOPHORES;

9 CIS RETINAL; CHAPERONE; ISORHODOPSIN; MUTANT PROTEIN; OPSIN; SCOTOPSIN; UNCLASSIFIED DRUG; DISULFIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CAENORHABDITIS ELEGANS; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CHROMATOPHORE; CONTROLLED STUDY; DISULFIDE BOND; IN VITRO STUDY; LOCOMOTION; MOLECULAR PATHOLOGY; MOLECULAR SIZE; NERVOUS SYSTEM; NONHUMAN; PHOTORECEPTOR; PHOTOTRANSDUCTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN GLYCOSYLATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; RETINITIS PIGMENTOSA; RNA TRANSLATION; THERMOSTABILITY; WILD TYPE; AMINO ACID SEQUENCE; ANIMAL; BOVINAE; CELL DEATH; CHEMISTRY; GENETICS; LIGHT; METABOLISM; MOLECULAR GENETICS; MUTATION; PATHOLOGY; PHOTORECEPTOR CELL; TRANSGENIC ANIMAL;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; CAENORHABDITIS ELEGANS; CATTLE; CELL DEATH; DISULFIDES; LIGHT; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION; PHOTORECEPTOR CELLS; PROTEIN STABILITY; RETINITIS PIGMENTOSA; ROD OPSINS;

EID: 84897414068     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.551713     Document Type: Article

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