Opsin localization and rhodopsin photochemistry in a transgenic mouse model of retinitis pigmentosa

Neuroscience

Volumn 87, Issue 3, 1998, Pages 709-717

  Wu, T H ^a   Ting, T D ^a   Okajima, T I L ^a   Pepperberg, D R ^a   Ho, Y K ^a   Ripps, H ^a   Naash, M I ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Autosomal dominant retinitis pigmentosa; Opsin; Rhodopsin; Rod photoreceptor; Transgenic mice

Indexed keywords

APOPROTEIN; OPSIN; RHODOPSIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CONTROLLED STUDY; MOUSE; NONHUMAN; PHOTORECEPTOR; POINT MUTATION; PRIORITY JOURNAL; RETINA ROD OUTER SEGMENT; RETINITIS PIGMENTOSA; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; GENES, DOMINANT; MICE; MICE, TRANSGENIC; PHOTOCHEMISTRY; RETINITIS PIGMENTOSA; RHODOPSIN; RODS (RETINA); SPECTROPHOTOMETRY; VISION;

EID: 0032483063     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(98)00173-0     Document Type: Article

References (31)

1. Al-Ubaidi M. R., Pittler S. J., Champagne M. S., Triantafyllos J. T., McGinnis J. F., Baehr W. Mouse opsin: gene structure and molecular basis of multiple transcripts. J. biol. Chem. 265:1990;20563-20569.
2. Baehr W., Falk J. D., Bugra K., Triantafyllos J. T., McGinnis J. F. Isolation and analysis of the mouse opsin gene. Fedn Eur. biochem. Socs Lett. 238:1988;253-256.
3. Berson E. L. Retinitis pigmentosa. Invest. Ophthal. vis. Sci. 34:1993;1659-1676.
4. Cheng T., Naash M. I. Quantitative analysis of mRNA levels of the transgenic and endogenous opsin genes in retinas of transgenic mice. (Abstract). Invest. Ophthal. vis. Sci. 36:1995;S273.
5. Crouch R. K., Chader G. J., Wiggert B., Pepperberg D. R. Retinoids and the visual process. Photochem. Photobiol. 64:1996;613-621.
6. Cusanovich M. A. (1982) Kinetics and mechanism of rhodopsin regeneration with 11-cis-retinal. In Methods In Enzymology - Biomembranes Part H (ed. Packer L.), Vol. 81, pp. 443-447. Academic, New York and London.
7. Dryja T. P., McGee T. L., Reichel E., Hahn L. B., Cowley G. S., Yandell D. W., Sandberg M. A., Berson E. L. A point mutation of the rhodopsin gene in one form of retinitis pigmentosa. Nature. 343:1990;364-366.
8. Farrar G. J., McWillam P., Bradley D. G., Kenna P., Lawler M., Sharp E. M., Humphries M. M., Eiberg H., Conneally P. M., Trofatter J. A., Humphries P. Autosomal dominant retinitis pigmentosa: linkage to rhodopsin and evidence for genetic heterogeneity. Genomics. 8:1990;35-40.
9. Fung B. K.-K. Characterization of transducin from bovine retinal rod outer segments. I. Separation and reconstitution of the subunits. J. biol. Chem. 258:1983;10495-10502.
10. Gal A., Apfelstedt-Sylla E., Janecke A. R., Zrenner E. Rhodopsin mutations in inherited retinal dystrophies and dysfunctions. Prog. Ret. Res. 16:1997;51-79.
11. Goto Y., Peachey N. S., Ripps H., Naash M. I. Functional abnormalities in transgenic mice expressing a mutant rhodopsin gene. Invest. Ophthal. vis. Sci. 36:1995;62-71.
12. Goto Y., Peachey N. S., Ziroli N. E., Seiple W. H., Gryczan C., Pepperberg D. R., Naash M. I. Rod phototransduction in transgenic mice expressing a mutant opsin gene. J. Opt. Soc. Am. A. 13:1996;577-585.
13. Hubbard R., Brown P. K. and Bownds D. (1971) Methodology of vitamin A and visual pigments. In Methods In Enzymology - Vitamins and Coenzymes (eds McCormick D. B and Wright L. D.), Vol. 18, pp. 615-653. Academic, New York and London.
14. Jin J., Heth C. A., Roof D. J. P23H mutant human opsin in transgenic murine retina; truncation of N-terminus and lack of glycosylation. (Abstract). Invest. Ophthal. vis. Sci. 36:1995;S424.
15. Kemp C. M., Jacobson S. G., Roman A. J., Sung C., Nathans J. Abnormal rod dark adaptation in autosomal dominant retinitis pigmentosa with proline-23-histidine rhodopsin mutation. Am. J. Ophthal. 113:1992;165-174.
16. Lowry D. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the folin phenol reagent. J. biol. Chem. 193:1951;267-275.
17. Liu X., Wu T.-H., Stowe S., Matsushita A., Arikawa K., Naash M. I., Williams D. S. Defective phototransductive disk membrane morphogenesis in transgenic mice expressing opsin with a mutated N-terminal domain. J. Cell Sci. 110:1997;2589-2597.
18. Molday R. S., Mackenzie D. Monoclonal antibodies to rhodopsin: characterization, cross-reactivity, and application as structural probes. Biochemistry. 22:1983;653-660.
19. Naash M. I., Al-Ubaidi M. R., Hollyfield J. G. and Baehr W. (1993) Simulation of autosomal dominant retinitis pigmentosa in transgenic mice. In Retinal Degeneration (eds Hollyfield J. G., Anderson R. E and LaVail M. M.), pp. 202-210. Plenum, New York.
20. Naash M. I., Hollyfield J. G., Al-Ubaidi M. R., Baehr W. Simulation of human autosomal dominant retinitis pigmentosa in transgenic mice expressing a mutated murine opsin gene. Proc. natn. Acad. Sci. U.S.A. 90:1993;5499-5503.
21. Naash M. I., Peachey N. S., Li Z.-Y., Gryczan C. C., Goto Y., Blanks J., Milam A. H., Ripps H. Light-induced acceleration of photoreceptor degeneration in transgenic mice expressing mutant rhodopsin. Invest. Ophthal. vis. Sci. 37:1996;775-782.
22. Olsson J. E., Gordon J. W., Pawlyk B. S., Roof D., Hayes A., Molday R. S., Mukai S., Cowley G. S., Berson E. L., Dryja T. P. Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal retinitis pigmentosa. Neuron. 9:1992;815-830.
23. Ripps H. Night blindness revisited: from man to molecules. Invest. Ophthal. vis. Sci. 23:1982;588-609.
24. Roof D. J., Adamian M., Hayes A. Rhodopsin accumulation at abnormal sites in retinas of mice with a human P23H rhodopsin transgene. (Abstract). Invest. Ophthal. vis. Sci. 35:1994;4049-4062.
25. Sung C., Davenport C. M., Hennessey J. C., Maumenee I. H., Jacobson S. G., Heckenlively J. R., Nowakowski R., Fishman G., Gouras P., Nathans J. Rhodopsin mutations in autosomal dominant retinitis pigmentosa. Proc. natn. Acad. Sci. U.S.A. 88:1991;6481-6485.
26. Sung C., Schneider B. G., Agarwal N., Papermaster D. S., Nathans J. Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa. Proc. natn. Acad. Sci. U.S.A. 88:1991;8840-8844.
27. Switzer R. C. III, Merril C. R., Shifrin S. A highly sensitive stain for detecting proteins and peptides in polyacrylamide gels. Analyt. Biochem. 98:1979;231-235.
28. Wald G., Brown P. K. The molar extinction of rhodopsin. J. gen. Physiol. 37:1954;189-200.
29. Wu T., Li S., Kogut P., Peachey N. S., Naash M. I. Expression of P23H mutation in transgenic mice as a model for one form of human autosomal dominant retinitis pigmentosa. (Abstract). Invest. Ophthal. vis. Sci. 37:1996;S999.
30. Young R. W. The renewal of photoreceptor cell outer segments. J. Cell Biol. 33:1967;61-72.
31. Young R. W., Bok D. Participation of the retinal pigment epithelium in the rod outer segment renewal process. J. Cell Biol. 42:1969;392-403.