COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats

Neuropharmacology

Volumn 58, Issue 2, 2010, Pages 404-412

  van Vliet, Erwin A ^a,b   Zibell, Guido ^c   Pekcec, Anton ^c   Schlichtiger, Juli ^c   Edelbroek, Peter M ^a   Holtman, Linda ^b   Aronica, Eleonora ^a,d   Gorter, Jan A ^a,b   Potschka, Heidrun ^c  

^a STICHTING EPILEPSIE INSTELLINGEN NEDERLAND SEIN   (Netherlands)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c UNIVERSITY OF MUNICH   (Germany)

^d ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Blood brain barrier; COX 2; Cyclooxygenase; Epilepsy; NS 398; P glycoprotein; SC 58236; Seizure

Indexed keywords

4 [5 (4 CHLOROPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; CYCLOOXYGENASE 2; GLYCOPROTEIN P; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PHENYTOIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CEREBELLUM; CONTROLLED STUDY; DOSAGE SCHEDULE COMPARISON; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EFFICACY; DRUG PENETRATION; DRUG POTENTIATION; DRUG TRANSPORT; ENZYME INHIBITION; EPILEPTIC STATE; FEMALE; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SUBICULUM;

ANIMALS; ANTICONVULSANTS; BLOOD-BRAIN BARRIER; BRAIN; CHRONIC DISEASE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; DISEASE MODELS, ANIMAL; EPILEPSY; FEMALE; MALE; NITROBENZENES; P-GLYCOPROTEIN; PHENYTOIN; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; SEIZURES; SIGNAL TRANSDUCTION; STATUS EPILEPTICUS; SULFONAMIDES;

EID: 72049093471     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2009.09.012     Document Type: Article

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