Novel 1H-pyrazole-3-carboxamide derivatives: Synthesis, anticancer evaluation and identification of their DNA-binding interaction

Chemical and Pharmaceutical Bulletin

Volumn 62, Issue 3, 2014, Pages 238-246

  Lu, Yi ^a   Ran, Ting ^a   Lin, Guowu ^b   Jin, Qiaomei ^a   Jin, Jianling ^a   Li, Hongmei ^a   Guo, Hao ^a   Lu, Tao ^a   Wang, Yue ^a,c  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c NANJING UNIVERSITY   (China)

Author keywords

DNA interaction; Molecular docking; Pyrazole derivative; Spectroscopy; Synthesis

Indexed keywords

5 (3 CYCLOPROPYLUREIDO) N [4 ((4 METHYLPIPERAZIN 1 YL)METHYL)PHENYL] 1 H PYRAZOLE 3 CARBOXAMIDE; AMIDE; ANTINEOPLASTIC AGENT; ETHIDIUM BROMIDE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; CALF THYMUS DNA; DNA;

ABSORPTION SPECTROSCOPY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; DNA BINDING; DNA CLEAVAGE; DNA CONFORMATION; DNA DETERMINATION; DRUG SYNTHESIS; DRUG TARGETING; FLUORESCENCE; HUMAN; HUMAN CELL; MOLECULAR MODEL; PLASMID; THYMUS; VISCOMETRY; ANIMAL; BOVINAE; CHEMISTRY; DRUG SCREENING; SYNTHESIS; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; CELL LINE, TUMOR; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PYRAZOLES;

EID: 84897129892     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.c13-00676     Document Type: Article

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