Synthesis and cytotoxic evaluation of 6-(3-pyrazolylpropyl) derivatives of 1,4-naphthohydroquinone-1,4-diacetate

Archiv der Pharmazie

Volumn 342, Issue 10, 2009, Pages 591-599

  Molinari, Aurora ^a   Oliva, Alfonso ^a   Ojeda, Claudia ^a   Miguel Del Corral, José M ^b   Castro, M Angeles ^b   Cuevas, Carmen ^c   San Feliciano, Arturo ^b  

^a PONTIFICIA UNIVERSIDAD CATÓLICA DE VALPARAÍSO   (Chile)

^b UNIVERSITY OF SALAMANCA   (Spain)

^c PHARMAMAR S A   (Spain)

Author keywords

myrcene; 1,4 Naphthohydroquinone; Antineoplastic cytotoxicity; Pyrazole

Indexed keywords

6 (3 BROMOPROPYL) 1,4 NAPHTHOHYDROQUINONE DIACETIC ACID; 6 (3 BROMOPROPYL) 5,6,7,8 TETRAHYDRO 1,4 NAPHTHOHYDROQUINONE DIACETIC ACID; 6 (3 BROMOPROPYL) 5,8 DIHYDRO 1,4 NAPHTHOHYDROQUINONE DIACETIC ACID; 6 (3 HYDROXYPROPYL) 1,4 NAPHTHOHYDROQUINONE DIACETIC ACID; 6 (3 HYDROXYPROPYL) 5,6,7,8 TETRAHYDRO 1,4 NAPHTHOQUINONE DIACETIC ACID; 6 (3 HYDROXYPROPYL) 5,8 DIHYDRO 1,4 NAPHTHOQUINONE DIACETIC ACID; 6 [3 (3 METHYL 1 PHENYLPYRAZOLYL 5 OXY)PROPYL] 1,4 NAPHTHOHYDROQUINONE DIACETIC ACID; 6 [3 (3 METHYL 1 PHENYLPYRAZOLYL 5 OXY)PROPYL] 5,6,7,8 TETRAHYDRO 1,4 NAPHTHOHYDROQUINONE DIACETIC ACID; 6 [3 (3 METHYL 1 PHENYLPYRAZOLYL 5 OXY)PROPYL] 5,8 DIHYDRO 1,4 NAPHTHOHYDROQUINONE DIACETIC ACID; 6 [3 (4 TOSYLOXY)PROPYL] 1,4 NAPHTHOHYDROQUINONE; 6 [3 (4 TOSYLOXY)PROPYL] 5,6,7,8 TETRAHYDRO 1,4 NAPHTHOHYDROQUINONE; 6 [3 (4 TOSYLOXY)PROPYL] 5,8 DIHYDRO 1,4 NAPHTHOHYDROQUINONE; 6 [3 (5 HYDROXY 3 METHYL 1 PHENYLPYRAZOLYL 4 DITHIOCARBONYLOXY)PROPYL] 1,4 NAPHTHOHYDROQUINONE DIACETIC ACID; 6 [3 (5 HYDROXY 3 METHYL 1 PHENYLPYRAZOLYL 4 DITHIOCARBONYLOXY)PROPYL] 5,6,7,8 TETRAHYDRO 1,4 NAPHTHOHYDROQUINONE DIACETIC ACID; 6 [3 (5 HYDROXY 3 METHYL 1 PHENYLPYRAZOLYL 4 DITHIOCARBONYLOXY)PROPYL] 5,8 DIHYDROQUINONE 1,4 NAPHTHOHYDROQUINONE DIACETIC ACID; 6 [3 (5 HYDROXY 3 METHYLPYRAZOLYL 4 DITHIOCARBONYLOXY)PROPYL] 1,4 NAPHTHOHYDROQUINONE DIACETIC ACID; 6 [3 (5 HYDROXY 3 METHYLPYRAZOLYL 4 DITHIOCARBONYLOXY)PROPYL] 5,6,7,8 TETRAHYDROQUINONE DIACETIC ACID; 6 [3 (5 HYDROXY 3 METHYLPYRAZOLYL 4 DITHIOCARBONYLOXY)PROPYL] 5,8 DIHYDRO 1,4 NAPHTHOHYDROQUINONE DIACETIC ACID; ANTINEOPLASTIC AGENT; DOXORUBICIN; HYDROQUINONE DERIVATIVE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST ADENOCARCINOMA; CANCER CELL CULTURE; CELL STRAIN HT29; CONTROLLED STUDY; CYTOTOXICITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LUNG CARCINOMA; PRIORITY JOURNAL;

ACETATES; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HT29 CELLS; HUMANS; HYDROQUINONES; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 70349642299     PISSN: 03656233     EISSN: 15214184     Source Type: Journal    
DOI: 10.1002/ardp.200900041     Document Type: Article

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