Cinnamoyl nitrogen mustard derivatives of pyrazole analogues of tallimustine modified at the amidino moiety: Design, synthesis, molecular modeling and antitumor activity studies

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 14, 2004, Pages 3911-3921

  Baraldi, Pier Giovanni ^a   Beria, Italo ^b   Cozzi, Paolo ^b   Geroni, Cristina ^b   Espinosa, Antonio ^c   Gallo, Miguel A ^c   Entrena, Antonio ^c   Bingham, John P ^d   Hartley, John A ^d   Romagnoli, Romeo ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b Tai Milano Spa   (Italy)

^c UNIVERSITY OF GRANADA   (Spain)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Antitumor activity; Cinnamoyl nitrogen mustard derivatives; Pyrazole amidino modified moiety; Tallimustine

Indexed keywords

3 [1 METHYL 3 [1 METHYL 3 [1 METHYL 4 [4 N,N BIS(2 CHLOROETHYL)AMINOCINNAMOYL]AMINOPYRROLE 2 CARBOXAMIDO]PYRAZOLE 5 CARBOXAMIDO]PYRAZOLE 5 CARBOXAMIDO]ETHYL 2 (4,5 DIHYDRO 1H IMIDAZOL 2 INE); 3 [1 METHYL 3 [1 METHYL 3 [1 METHYL 4 [4 N,N BIS(2 CHLOROETHYL)AMINOCINNAMOYL]AMINOPYRROLE 2 CARBOXAMIDO]PYRAZOLE 5 CARBOXAMIDO]PYRAZOLE 5 CARBOXAMIDO]PROPIONAMIDINE; 3 [1 METHYL 4 [1 METHYL 3 [1 METHYL 3 [4 N,N BIS(2 CHLOROETHYL)AMINOCINNAMOYL]AMINOPYRROLE 2 CARBOXAMIDO]PYRAZOLE 5 CARBOXAMIDO]PYRAZOLE 5 CARBAMOYL]ETHYLAMIDE; ANTINEOPLASTIC AGENT; CHLORMETHINE DERIVATIVE; N CYANO 3 [1 METHYL 3 [1 METHYL 3 [1 METHYL 4 [4 N,N BIS(2 CHLOROETHYL)AMINOCINNAMOYL]AMINOPYRROLE 2 CARBOXAMIDO]PYRAZOLE 5 CARBOXAMIDO]PYRAZOLE 5 CARBOXAMIDO]PROPIONAMIDINE; N HYDROXY 3 [1 METHYL 3 [1 METHYL 3 [1 METHYL 4 [4 N,N BIS(2 CHLOROETHYL)AMINOCINNAMOYL]AMINOPYRROLE 2 CARBOXAMIDO]PYRAZOLE 5 CARBOXAMIDO]PYRAZOLE 5 CARBOXAMIDO]PROPIONAMIDINE; N,N' DIMETHYL [3 [1 METHYL 3 [1 METHYL 4 [4 N,N BIS(2 CHLOROETHYL)AMINOCINNAMOYL]AMINOPYRROLE 2 CARBOXAMIDO]PYRAZOLE 5 CARBOXAMIDO]PYRAZOLE 5 CARBOXAMIDO]PROPIONAMIDINE; PYRAZOLE DERIVATIVE; TALLIMUSTINE; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOLECULAR MODEL; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; CELL DIVISION; CELL LINE, TUMOR; DISTAMYCINS; DNA; HUMANS; MICE; MODELS, MOLECULAR; NITROGEN MUSTARD COMPOUNDS; PYRAZOLES;

EID: 2942718672     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.04.045     Document Type: Article

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