Lipopolysaccharide potentiates polychlorinated biphenyl-induced disruption of the blood-brain barrier via TLR4/IRF-3 signaling

Toxicology

Volumn 302, Issue 2-3, 2012, Pages 212-220

  Choi, Jeong June ^a   Choi, Yean Jung ^b   Chen, Lei ^c   Zhang, Bei ^a,b   Eum, Sung Yong ^a   Abreu, Maria T ^a   Toborek, Michal ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Blood brain barrier; Inflammation; Interferon regulatory factor 3; Polychlorinated biphenyls; Tight junctions; Toll like receptor 4

Indexed keywords

2,2',4,4',5,5' HEXACHLOROBIPHENYL; 3,3',4,4',5 PENTACHLOROBIPHENYL; INTERFERON REGULATORY FACTOR 3; LIPOPOLYSACCHARIDE; POLYCHLORINATED BIPHENYL; TIGHT JUNCTION PROTEIN; TOLL LIKE RECEPTOR 4; CYTOKINE; IRF3 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ARTICLE; BLOOD BRAIN BARRIER; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; EPITHELIUM CELL; IN VITRO STUDY; MALE; MICROVASCULATURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMALL INTESTINE; ANIMAL; BLOOD; C57BL MOUSE; CELL LINE; CELL MOTION; DRUG EFFECT; GENE SILENCING; GENETICS; HUMAN; METABOLISM; ORAL DRUG ADMINISTRATION;

MUS;

ADMINISTRATION, ORAL; ANIMALS; BLOOD-BRAIN BARRIER; CELL LINE; CELL MOVEMENT; CYTOKINES; ENDOTHELIAL CELLS; GENE SILENCING; HUMANS; INTERFERON REGULATORY FACTOR-3; LIPOPOLYSACCHARIDES; MALE; MICE; MICE, INBRED C57BL; POLYCHLORINATED BIPHENYLS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 84897121201     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.08.001     Document Type: Article

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