Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner

Toxicology and Applied Pharmacology

Volumn 263, Issue 1, 2012, Pages 7-13

  Al Salman, Fadheela ^a   Plant, Nick ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

CAR; Drug metabolism; Gene expression; Nuclear receptor; PXR

Indexed keywords

CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 3A4; MULTIDRUG RESISTANCE PROTEIN 1; POLYCHLORINATED BIPHENYL; PREGNANE X RECEPTOR;

ARTICLE; CELL LINE; CHEMICAL STRUCTURE; GENE ACTIVATION; GENE EXPRESSION; GENE TARGETING; IN VITRO STUDY;

CACO-2 CELLS; CELL LINE; COLON; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; LIVER; LUNG; POLYCHLORINATED BIPHENYLS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID;

MAMMALIA;

EID: 84864124385     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.05.016     Document Type: Article

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