Asymmetric synthesis of the HMG-CoA reductase inhibitor atorvastatin calcium: An organocatalytic anhydride desymmetrization and cyanide-free side chain elongation approach

Journal of Organic Chemistry

Volumn 79, Issue 6, 2014, Pages 2723-2728

  Chen, Xiaofei ^a   Xiong, Fangjun ^a   Chen, Wenxue ^a   He, Qiuqin ^a   Chen, Fener ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CYANIDES;

ASYMMETRIC SYNTHESIS; ATORVASTATIN CALCIUMS; DESYM-METRIZATION; ENANTIOSELECTIVE; HMG-COA REDUCTASE INHIBITOR; ORGANOCATALYTIC; SIDE-CHAINS;

CHAINS;

ACID ANHYDRIDE; ATORVASTATIN; CYANIDE; GLUTARIC ACID DERIVATIVE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ARTICLE; ASYMMETRIC SYNTHESIS; BIOTRANSFORMATION; CATALYSIS; CATALYST; ENANTIOSELECTIVITY; REACTION ANALYSIS;

ANHYDRIDES; CALCIUM; CYANIDES; GLUTARATES; HEPTANOIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; PYRROLES;

EID: 84896971085     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo402829b     Document Type: Article

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