-
2
-
-
0016913421
-
-
A.G. Brown, T.C. Smale, T.J. King, R. Hasenkamp, R.H. Thompson, J. Chem. Soc. Perkin Trans. I (1976) 1165.
-
(1976)
J. Chem. Soc. Perkin Trans. I
, pp. 1165
-
-
Brown, A.G.1
Smale, T.C.2
King, T.J.3
Hasenkamp, R.4
Thompson, R.H.5
-
4
-
-
0030802435
-
-
(b) P.R. Hebert, J.M. Gaziano, K.S. Chan, C.H. Hennekens, JAMA 278 (1997) 4.
-
(1997)
JAMA
, vol.278
, pp. 4
-
-
Hebert, P.R.1
Gaziano, J.M.2
Chan, K.S.3
Hennekens, C.H.4
-
5
-
-
0345910029
-
-
(c) http://www.pharminfo.com/ pubs/msb/statins.html.
-
-
-
-
6
-
-
0347171430
-
-
Mevacor® is a trademark of Merck & Co
-
Mevacor® is a trademark of Merck & Co.
-
-
-
-
7
-
-
0346540632
-
-
Launched in the market (Merck & Co.) in 1988. FDA approved new dose ranges for Zocor® in 1998
-
Launched in the market (Merck & Co.) in 1988. FDA approved new dose ranges for Zocor® in 1998.
-
-
-
-
8
-
-
0345909561
-
-
Pravachol is a trademark of Bristol-Myers Squibb. FDA approved in 1996
-
Pravachol is a trademark of Bristol-Myers Squibb. FDA approved in 1996.
-
-
-
-
9
-
-
0347801444
-
-
FDA approved in 1996, Lipitor® is a trademark of Pfizer (Parke-Davis)
-
FDA approved in 1996, Lipitor® is a trademark of Pfizer (Parke-Davis).
-
-
-
-
10
-
-
0346541137
-
-
Launched in the market in 1995. Baycol® is a trademark of Bayer in the USA
-
Launched in the market in 1995. Baycol® is a trademark of Bayer in the USA.
-
-
-
-
11
-
-
0345910028
-
-
Lescol is a trademark of Novartis Pharma AG
-
Lescol is a trademark of Novartis Pharma AG.
-
-
-
-
12
-
-
0345910027
-
-
Statin drugs constituted ∼ 6% of the total annual sale of the top 200 drugs in 1999, worth $125 billion in the USA. Lipitor, $3.0b; Zocor, $2.3b; Pravacol, $1.18b; Mevacor, $389.5m; and Lescol, $268.1m. For a listing of the top 200 prescription drugs, see: http://www.rxlist.com and a listing of the top 200 drugs in sales, see: http://www.pharmacyline.com.
-
-
-
-
13
-
-
0347171431
-
-
Statin drugs constituted ∼ 6% of the total annual sale of the top 200 drugs in 1999, worth $125 billion in the USA. Lipitor, $3.0b; Zocor, $2.3b; Pravacol, $1.18b; Mevacor, $389.5m; and Lescol, $268.1m. For a listing of the top 200 prescription drugs, see: http://www.rxlist.com and a listing of the top 200 drugs in sales, see: http://www.pharmacyline.com.
-
-
-
-
14
-
-
0025000298
-
-
(a) S.Y. Sit, R.A. Parker, I. Motoc, W. Han, N. Balasubramanian, J.D. Catt, P.J. Brown, W.E. Harte, M.D. Thompson, J.J. Wright, J. Med. Chem. 33 (1990) 2982.
-
(1990)
J. Med. Chem.
, vol.33
, pp. 2982
-
-
Sit, S.Y.1
Parker, R.A.2
Motoc, I.3
Han, W.4
Balasubramanian, N.5
Catt, J.D.6
Brown, P.J.7
Harte, W.E.8
Thompson, M.D.9
Wright, J.J.10
-
15
-
-
0021997673
-
-
(b) G.E Stokker, W.F. Hoffman, A.W. Alberts, E.J. Cragoe Jr, A.A. Deana, J.L. Gilfillan, J.W. Huff, F.C. Novello, J.D. Purgh, R.L Smith, A.K. Willard, J. Med. Chem. 28 (1985) 347.
-
(1985)
J. Med. Chem.
, vol.28
, pp. 347
-
-
Stokker, G.E.1
Hoffman, W.F.2
Alberts, A.W.3
Cragoe E.J., Jr.4
Deana, A.A.5
Gilfillan, J.L.6
Huff, J.W.7
Novello, F.C.8
Purgh, J.D.9
Smith, R.L.10
Willard, A.K.11
-
16
-
-
0031020870
-
-
(a) T. Honda, S. Ono, H. Mizutani, K.O. Hallinan, Tetrahedron Asymm. 8 (1997) 181.
-
(1997)
Tetrahedron Asymm.
, vol.8
, pp. 181
-
-
Honda, T.1
Ono, S.2
Mizutani, H.3
Hallinan, K.O.4
-
18
-
-
0027288854
-
-
(c) C. Bonini, R. Racioppi, L. Viggiani, G. Righi, L. Rossi, Tetrahedron: Asymm. 4 (1993) 793.
-
(1993)
Tetrahedron: Asymm.
, vol.4
, pp. 793
-
-
Bonini, C.1
Racioppi, R.2
Viggiani, L.3
Righi, G.4
Rossi, L.5
-
19
-
-
0027398651
-
-
(d) C. Bonini, R. Racioppi, G. Righi, L. Viggiani, J. Org. Chem. 58 (1993) 802.
-
(1993)
J. Org. Chem.
, vol.58
, pp. 802
-
-
Bonini, C.1
Racioppi, R.2
Righi, G.3
Viggiani, L.4
-
22
-
-
0043248416
-
-
(f) A.D. Mico, G. Piancatelli, S. Cacurri, S. Lappa, Gazz. Chim. Ital. 122 (1992) 415.
-
(1992)
Gazz. Chim. Ital.
, vol.122
, pp. 415
-
-
Mico, A.D.1
Piancatelli, G.2
Cacurri, S.3
Lappa, S.4
-
23
-
-
33751500471
-
-
(g) S.D. Rychnovsky, G. Griesgraber, S. Zeller, D.J. Skalitzky, J. Org. Chem. 56 (1991) 5161.
-
(1991)
J. Org. Chem.
, vol.56
, pp. 5161
-
-
Rychnovsky, S.D.1
Griesgraber, G.2
Zeller, S.3
Skalitzky, D.J.4
-
25
-
-
0000659656
-
-
(i) F. Bonadies, R.D. Fabio, A. Gubbiotti, S. Melozzi, C. Bonini, Tetrahedron Lett. 28 (1987) 703.
-
(1987)
Tetrahedron Lett.
, vol.28
, pp. 703
-
-
Bonadies, F.1
Fabio, R.D.2
Gubbiotti, A.3
Melozzi, S.4
Bonini, C.5
-
28
-
-
0026637929
-
-
(a) S. Takano, T. Kamikubo, T. Sugihara, K. Ogasawara, Tetrahedron Asymm. 3 (1992) 853.
-
(1992)
Tetrahedron Asymm.
, vol.3
, pp. 853
-
-
Takano, S.1
Kamikubo, T.2
Sugihara, T.3
Ogasawara, K.4
-
30
-
-
0029055424
-
-
(c) T. Hiyama, G.B. Reddy, T. Minami, T. Hanamoto, Bull. Chem. Soc. Jpn. 68 (1995) 350.
-
(1995)
Bull. Chem. Soc. Jpn.
, vol.68
, pp. 350
-
-
Hiyama, T.1
Reddy, G.B.2
Minami, T.3
Hanamoto, T.4
-
35
-
-
0000659656
-
-
(h) F. Bonadies, R.D. Fabio, A. Gubbiotti, S. Mecozzi, C. Bonini, Tetrahedron Lett. 28 (1987) 703.
-
(1987)
Tetrahedron Lett.
, vol.28
, pp. 703
-
-
Bonadies, F.1
Fabio, R.D.2
Gubbiotti, A.3
Mecozzi, S.4
Bonini, C.5
-
37
-
-
0028278565
-
-
(j) M. Sato, S. Sunami, Y. Sugita, C. Kaneko, Chem. Pharm. Bull. 42 (1994) 839.
-
(1994)
Chem. Pharm. Bull.
, vol.42
, pp. 839
-
-
Sato, M.1
Sunami, S.2
Sugita, Y.3
Kaneko, C.4
-
38
-
-
0026079855
-
-
(k) G.B. Reddy, T. Minami, T. Hanamoto, T. Hiyama, J. Org. Chem. 56 (1991) 5752.
-
(1991)
J. Org. Chem.
, vol.56
, pp. 5752
-
-
Reddy, G.B.1
Minami, T.2
Hanamoto, T.3
Hiyama, T.4
-
41
-
-
0022643559
-
-
(n) W.F. Hoffman, A.W. Alberts, E.J. Cragoe Jr, A.A. Deana, B.E. Evans, J.C. Gifillan, N.P. Gould, J.W. Huff, F.C. Novello, J.D. Prugh, K.E. Rittle, R.I. Smith, G.E. Stokker, A.K. Willard, J. Med. Chem. 29 (1986) 159.
-
(1986)
J. Med. Chem.
, vol.29
, pp. 159
-
-
Hoffman, W.F.1
Alberts, A.W.2
Cragoe E.J., Jr.3
Deana, A.A.4
Evans, B.E.5
Gifillan, J.C.6
Gould, N.P.7
Huff, J.W.8
Novello, F.C.9
Prugh, J.D.10
Rittle, K.E.11
Smith, R.I.12
Stokker, G.E.13
Willard, A.K.14
-
50
-
-
0001290552
-
-
(i) M. Miyazawa, E. Matsuoka, S. Sasaki, S. Oonuma, K. Maruyama, M. Miyashita, Chem Lett. (1998) 109.
-
(1998)
Chem Lett.
, pp. 109
-
-
Miyazawa, M.1
Matsuoka, E.2
Sasaki, S.3
Oonuma, S.4
Maruyama, K.5
Miyashita, M.6
-
54
-
-
0001249486
-
-
(b) K.M. Chen, G.E. Hardmann, K. Prasad, O. Repic, M.J. Shapiro, Tetrahedron Lett. 28 (1987) 155.
-
(1987)
Tetrahedron Lett.
, vol.28
, pp. 155
-
-
Chen, K.M.1
Hardmann, G.E.2
Prasad, K.3
Repic, O.4
Shapiro, M.J.5
-
58
-
-
0347171418
-
-
1H-NMR spectroscopy
-
1H-NMR spectroscopy.
-
-
-
-
59
-
-
0345910019
-
-
Chiralcel® OD-H™ is a product of Chiral Technologies, Inc. Exton, PA
-
Chiralcel® OD-H™ is a product of Chiral Technologies, Inc. Exton, PA.
-
-
-
-
61
-
-
0032924763
-
-
and references cited therein
-
(b) Wright, D.L. Current Org. Chem. 3 (1999) 211 and references cited therein.
-
(1999)
Current Org. Chem.
, vol.3
, pp. 211
-
-
Wright, D.L.1
-
62
-
-
0030841601
-
-
M. Miyashita, T. Suzuki, M. Hoshino, A. Yoshikoshi, Tetrahedron 53 (1997) 12469.
-
(1997)
Tetrahedron
, vol.53
, pp. 12469
-
-
Miyashita, M.1
Suzuki, T.2
Hoshino, M.3
Yoshikoshi, A.4
-
72
-
-
0003726028
-
-
Wiley-Interscience, New York, 1975 Reprinted edition, Aldrich Chemical Co. Inc., Milwaukee, WI, Chapter 9
-
H.C. Brown, G.W. Kramer, A.B. Levy, M.M. Midland, Organic Syntheses via Boranes, Wiley-Interscience, New York, 1975 Reprinted edition, vol. 1. Aldrich Chemical Co. Inc., Milwaukee, WI, 1997, Chapter 9.
-
(1997)
Organic Syntheses Via Boranes
, vol.1
-
-
Brown, H.C.1
Kramer, G.W.2
Levy, A.B.3
Midland, M.M.4
|