Chemo-Enzymatic Approach to Statin Side-Chain Building Blocks

Advanced Synthesis and Catalysis

Volumn 345, Issue 6-7, 2003, Pages 713-715

  Ohrlein R ^a   Baisch, Gabriele ^a  

^a CIBA GEIGY LTD   (Switzerland)

Author keywords

Atorvastatin; Aza Wittig reaction; Enzymatic desymmetrisation; Statin side chain

Indexed keywords

ATORVASTATIN; CARBON; CHLORINE DERIVATIVE; GLUTARIC ACID DERIVATIVE;

ATOM; DRUG SYNTHESIS; ENZYME MECHANISM; ENZYME PURIFICATION; PROTEIN DETERMINATION; QUANTUM YIELD; REACTION ANALYSIS; REVIEW;

EID: 0242607602     PISSN: 16154150     EISSN: None     Source Type: Journal    
DOI: 10.1002/adsc.200303028     Document Type: Review

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11. [10] R. Öhrlein, G. Baisch, HL/5-22584/EP; for aza-Witig-reactions see also: Y. G. Golobov, Tetrahedron 1992, 48, 1353; H. Warmhoff, et al., Advances in Heterocyclic Chemistry, Vol. 64, Academic Press, New York, 1995. However, the synthesis of pentasubstituted pyrroles is novel.
12. R. Öhrlein, G. Baisch, HL/5-22584/EP; for aza-Witig-reactions see also: Y. G. Golobov, Tetrahedron 1992, 48, 1353; H. Warmhoff, et al., Advances in Heterocyclic Chemistry, Vol. 64, Academic Press, New York, 1995. However, the synthesis of pentasubstituted pyrroles is novel.
13. R. Öhrlein, G. Baisch, HL/5-22584/EP; for aza-Witig-reactions see also: Y. G. Golobov, Tetrahedron 1992, 48, 1353; H. Warmhoff, et al., Advances in Heterocyclic Chemistry, Vol. 64, Academic Press, New York, 1995. However, the synthesis of pentasubstituted pyrroles is novel.