A simplified catalytic system for direct catalytic asymmetric aldol reaction of thioamides; Application to an enantioselective synthesis of atorvastatin

Tetrahedron

Volumn 67, Issue 35, 2011, Pages 6539-6546

  Kawato, Yuji ^a,b   Iwata, Mitsutaka ^a,b   Yazaki, Ryo ^a,b   Kumagai, Naoya ^a   Shibasaki, Masakatsu ^a  

^a INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Aldol reaction; Asymmetric catalysis; Atorvastatin; Mesitylcopper; Thioamide

Indexed keywords

ATORVASTATIN; BRONSTED BASE; COPPER; THIOAMIDE;

ALDOL REACTION; ARTICLE; ASYMMETRIC CATALYSIS; CONTROLLED STUDY; DRUG SYNTHESIS; ENANTIOSELECTIVITY; PRIORITY JOURNAL;

EID: 79960958490     PISSN: 00404020     EISSN: 14645416     Source Type: Journal    
DOI: 10.1016/j.tet.2011.05.109     Document Type: Article

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