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One recent example is Jacobsen's elucidation, through rigorous kinetic study, of an unexpected cooperative catalysis mechanism for the Co-Salen-catalyzed hydrolytic ring opening of epoxides, which involves simultaneous activation of both the nucleophile and the electrophile by two molecules of the catalyst. (a) Schaus, S. E.; Brandes, B. D.; Larrow, J. F.; Tokunaga, M.; Hansen, K. B.; Gould, A. E.; Furrow, M. E.; Jacobsen, E. N. J. Am. Chem. Soc. 2002, 124, 1307.
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Racemic and meso cyclic anhydrides should be interesting substrates for other asymmetric ring opening reactions. For recent examples see: (a) Ostendorf, M.; Romagnoli, R.; Cabeza Pereiro, I.; Roos, E. C.; Moolenaar, M. J.; Speckamp, W. N.; Hiemstra, H. Tetrahedron: Asymmetry 1997, 8, 1773.
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