Sequential aldol condensation catalyzed by DERA mutant Ser238Asp and a formal total synthesis of atorvastatin

Tetrahedron Letters

Volumn 45, Issue 11, 2004, Pages 2439-2441

  Liu, Junjie ^a   Hsu, Che Chang ^a   Wong, Chi Huey ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; ATORVASTATIN; FRUCTOSE BISPHOSPHATE ALDOLASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PEPTIDE DERIVATIVE; SCHIFF BASE; SERINE;

ALDOL REACTION; ARTICLE; CATALYSIS; CHIRALITY; DRUG SYNTHESIS; ENZYME ACTIVITY; REACTION ANALYSIS; STRUCTURE ANALYSIS;

EID: 1242331787     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2004.01.110     Document Type: Article

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15. 3 OD) δ 4.33 (m, 1H), 4.09 (m, 1H), 3.03 (m, 2H), 2.38 (dd, J=4.8 , 15.4 Hz, 1H), 2.31 (dd, J=7.9 , 14.9 Hz, 1H), 1.74 (m, 2H), 1.60 (dt, J=2.6 , 12.7 Hz, 1H), 1.48 (s, 3H), 1.45 (s, 9H), 1.33 (s, 3H), 1.21 (m, 1H).