메뉴 건너뛰기




Volumn 63, Issue 8, 2011, Pages 983-998

Statins therapy: A review on conventional and novel formulation approaches

Author keywords

Conventional drug delivery systems; Novel drug delivery systems; Statins

Indexed keywords

ATORVASTATIN; CYCLODEXTRIN; CYCLOSPORIN A; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPOSOME; MACROGOL 6000; MEVINOLIN; NANOBEAD; OMEGA 3 FATTY ACID ESTER; POLYMER; PRAVASTATIN; ROSUVASTATIN; SIMVASTATIN; SOLID LIPID NANOPARTICLE; STARSTAT; UNCLASSIFIED DRUG;

EID: 79959908456     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2011.01273.x     Document Type: Review
Times cited : (53)

References (101)
  • 2
    • 3242792734 scopus 로고    scopus 로고
    • Role of statin therapy in the coronary bypass patient
    • Lazer HL. Role of statin therapy in the coronary bypass patient. Ann Thorac Surg 2009; 78: 730-740.
    • (2009) Ann Thorac Surg , vol.78 , pp. 730-740
    • Lazer, H.L.1
  • 3
    • 27744593677 scopus 로고    scopus 로고
    • Antihyperlipidemic statins: A self-contained, clinically relevant medicinal chemistry lesson
    • 77
    • Roche VF. Antihyperlipidemic statins: a self-contained, clinically relevant medicinal chemistry lesson. Am J Pharm Edu 2005; 69: 546-560. (Pubitemid 41602665)
    • (2005) American Journal of Pharmaceutical Education , vol.69 , Issue.4 , pp. 546-560
    • Roche, V.F.1
  • 6
    • 51249095156 scopus 로고    scopus 로고
    • Hypercholesterolaemia and management
    • Bhatnagar D et al. Hypercholesterolaemia and management. BMJ 2008; 337: 993.
    • (2008) BMJ , vol.337 , pp. 993
    • Bhatnagar, D.1
  • 7
    • 73649134029 scopus 로고    scopus 로고
    • HDL biogenesis and functions: Role of HDL quality and quantity in atherosclerosis
    • Tsompanidi EM et al. HDL biogenesis and functions: role of HDL quality and quantity in atherosclerosis. Atherosclerosis 2010; 208: 3-9.
    • (2010) Atherosclerosis , vol.208 , pp. 3-9
    • Tsompanidi, E.M.1
  • 8
    • 18744404250 scopus 로고    scopus 로고
    • Management of mixed hyperlipidemia
    • Stalenhoef AFH. Management of mixed hyperlipidemia. Eur Heart J 2005; 26: 856-857.
    • (2005) Eur Heart J , vol.26 , pp. 856-857
    • Stalenhoef, A.F.H.1
  • 10
    • 79551516177 scopus 로고    scopus 로고
    • The anti-ischemic and antianginal properties of statins
    • DOI: 10.1007/s11883-010-0147-y
    • Lardizable JA, Deedwania PC. The anti-ischemic and antianginal properties of statins. Curr Atheroscler Rep 2010; DOI: 10.1007/s11883-010-0147-y.
    • (2010) Curr Atheroscler Rep
    • Lardizable, J.A.1    Deedwania, P.C.2
  • 11
    • 78649618892 scopus 로고    scopus 로고
    • Similarities, differences and agonisms of pleiotropic effects of statins and omega-3 fatty acids
    • Villalobos ME et al. Similarities, differences and agonisms of pleiotropic effects of statins and omega-3 fatty acids. Nutr Hosp 2010; 25: 889-909.
    • (2010) Nutr Hosp , vol.25 , pp. 889-909
    • Villalobos, M.E.1
  • 12
    • 28844474981 scopus 로고    scopus 로고
    • Statin therapy in the treatment of Alzheimer disease: What is the rationale?
    • DeKosky ST. Statin therapy in the treatment of Alzheimer disease: what is the rationale? Am J Med 2005; 118 (Suppl. 12A): 48-53.
    • (2005) Am J Med , vol.118 , Issue.SUPPL. 12A , pp. 48-53
    • DeKosky, S.T.1
  • 13
    • 0037490080 scopus 로고    scopus 로고
    • Quantifying effects of statins on low density lipoprotein cholesterol, ischemic heart disease and stroke: Systemic review and met analysis
    • Law MR et al. Quantifying effects of statins on low density lipoprotein cholesterol, ischemic heart disease and stroke: systemic review and met analysis. BMJ 2003; 326: 1423.
    • (2003) BMJ , vol.326 , pp. 1423
    • Law, M.R.1
  • 14
    • 66449122174 scopus 로고    scopus 로고
    • Synergism of simvastatin with losartan prevents angiotensin II-induced cardiomyocyte apoptosis in vitro
    • Xu J et al. Synergism of simvastatin with losartan prevents angiotensin II-induced cardiomyocyte apoptosis in vitro. J Pharm Pharmacol 2009; 61: 503-510.
    • (2009) J Pharm Pharmacol , vol.61 , pp. 503-510
    • Xu, J.1
  • 15
    • 68849097104 scopus 로고    scopus 로고
    • Hypercholesterolaemia induces early renal lesions characterized by upregulation of MMP-9 and iNOS and ETAR: Alleviated by a dual endothelin receptor antagonist CPU0213 and simvastatin
    • Luo L et al. Hypercholesterolaemia induces early renal lesions characterized by upregulation of MMP-9 and iNOS and ETAR: alleviated by a dual endothelin receptor antagonist CPU0213 and simvastatin. J Pharm Pharmacol 2009; 61: 775-780.
    • (2009) J Pharm Pharmacol , vol.61 , pp. 775-780
    • Luo, L.1
  • 16
    • 0033831429 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of cerivastatin
    • Muck W. Clinical pharmacokinetics of cerivastatin. Clin Pharmacokinet 2000; 39: 99-116.
    • (2000) Clin Pharmacokinet , vol.39 , pp. 99-116
    • Muck, W.1
  • 17
    • 0037278559 scopus 로고    scopus 로고
    • Cerivastatin: A cellular and molecular drug for the future?
    • Siegel-Axel DI. Cerivastatin: a cellular and molecular drug for the future? Cell Mol Life Sci 2003; 60: 1144-1164.
    • (2003) Cell Mol Life Sci , vol.60 , pp. 1144-1164
    • Siegel-Axel, D.I.1
  • 18
    • 35748962429 scopus 로고    scopus 로고
    • The safety of statins in clinical practice
    • DOI 10.1016/S0140-6736(07)60716-8, PII S0140673607607168
    • Armitage J. The safety of statins in clinical practice. Lancet 2007; 370: 1781-1790. (Pubitemid 350137473)
    • (2007) Lancet , vol.370 , Issue.9601 , pp. 1781-1790
    • Armitage, J.1
  • 20
    • 79961175431 scopus 로고    scopus 로고
    • Cerivastatin and reports of fatal rhabdomylosis
    • Staffa JA et al. Cerivastatin and reports of fatal rhabdomylosis. N Engl J Med 2002; 346: 539-540.
    • (2002) N Engl J Med , vol.346 , pp. 539-540
    • Staffa, J.A.1
  • 21
    • 85047684673 scopus 로고    scopus 로고
    • Synergistic action of statins and nitrogen-containing bisphosphonates in the development of rhabdomyolysis in L6 rat skeletal myoblasts
    • Matzno S et al. Synergistic action of statins and nitrogen-containing bisphosphonates in the development of rhabdomyolysis in L6 rat skeletal myoblasts. J Pharm Pharmacol 2009; 61: 781-788.
    • (2009) J Pharm Pharmacol , vol.61 , pp. 781-788
    • Matzno, S.1
  • 22
    • 0036708020 scopus 로고    scopus 로고
    • A review of the pharmacologic and pharmacokinetic aspects of rosuvastatin
    • White CM. A review of the pharmacologic and pharmacokinetic aspects of rosuvastatin. J Clin Pharmacol 2002; 42: 963-970. (Pubitemid 34920793)
    • (2002) Journal of Clinical Pharmacology , vol.42 , Issue.9 , pp. 963-970
    • White, C.M.1
  • 24
    • 79959887998 scopus 로고    scopus 로고
    • Oral pharmaceutical composition containing a statin derivative
    • United States patent US 20040235935. Nov 25
    • Vandebist F et al. Inventors; Oral pharmaceutical composition containing a statin derivative United States patent US 20040235935. 2004 Nov 25.
    • (2004)
    • Vandebist, F.1
  • 25
    • 0035082566 scopus 로고    scopus 로고
    • Efficacy and tolerability of fluvastatin extended-release delivery system: A pooled analysis
    • Ballantyne CM et al. Efficacy and tolerability of fluvastatin extended-release delivery system: a pooled analysis. Clin Ther 2001; 23: 177-192.
    • (2001) Clin Ther , vol.23 , pp. 177-192
    • Ballantyne, C.M.1
  • 26
    • 39049128727 scopus 로고    scopus 로고
    • Preparation, characterization, and dissolution behavior of a solid dispersion of simvastatin with polyethylene glycol 4000 and polyvinylpyrrolidone K30
    • Patel R, Patel M. Preparation, characterization, and dissolution behavior of a solid dispersion of simvastatin with polyethylene glycol 4000 and polyvinylpyrrolidone K30. J Disper Sci Tech 2008; 29: 193-194.
    • (2008) J Disper Sci Tech , vol.29 , pp. 193-194
    • Patel, R.1    Patel, M.2
  • 27
    • 34047232844 scopus 로고    scopus 로고
    • Preparation, characterization, and in vitro and in vivo evaluation of lovastatin solid lipid nanoparticles
    • Suresh G et al. Preparation, characterization, and in vitro and in vivo evaluation of lovastatin solid lipid nanoparticles. AAPS PharmSciTech 2007; 8: E1-E9.
    • (2007) AAPS PharmSciTech , vol.8
    • Suresh, G.1
  • 29
    • 79953785891 scopus 로고    scopus 로고
    • Oral solid Compitrol 888 ATO nanosuspension of simvastatin: Optimization and biodistribution studies
    • posted online 3 Dec doi:10.3109/03639045.2010.527983 (epub ahead of print)
    • Shah M et al. Oral solid Compitrol 888 ATO nanosuspension of simvastatin: optimization and biodistribution studies. Drug Dev Ind Pharm. posted online 3 Dec 2010; doi:10.3109/03639045.2010.527983 (epub ahead of print).
    • (2010) Drug Dev Ind Pharm
    • Shah, M.1
  • 30
    • 70449536503 scopus 로고    scopus 로고
    • Glyceryl monooleate/poloxamer 407 cubic nanoparticles as oral drug delivery systems: I. In vitro evaluation and enhanced oral bioavailability of the poorly water-soluble drug simvastatin
    • Lai J et al. Glyceryl monooleate/poloxamer 407 cubic nanoparticles as oral drug delivery systems: I. In vitro evaluation and enhanced oral bioavailability of the poorly water-soluble drug simvastatin. AAPS PharmSciTech 2009; 10: 960-966.
    • (2009) AAPS PharmSciTech , vol.10 , pp. 960-966
    • Lai, J.1
  • 31
    • 33750853746 scopus 로고    scopus 로고
    • Design and in vitro evaluation of polymeric formulae of simvastatin for local bone induction
    • Ismail FA. Design and in vitro evaluation of polymeric formulae of simvastatin for local bone induction. Drug Dev Ind Pharm 2006; 32: 1199-1106.
    • (2006) Drug Dev Ind Pharm , vol.32 , pp. 1199-11106
    • Ismail, F.A.1
  • 33
    • 49149110227 scopus 로고    scopus 로고
    • Injectable simvastatin in periodontal defects and alveolar ridges: Pilot studies
    • Morris S et al. Injectable simvastatin in periodontal defects and alveolar ridges: pilot studies. J Periodontol 2009; 79: 1465-1473.
    • (2009) J Periodontol , vol.79 , pp. 1465-1473
    • Morris, S.1
  • 34
    • 79959906236 scopus 로고    scopus 로고
    • Pharmaceutical composition containing statin encapsulated nanoparticle
    • United States patent US 20100086602. Apr 8
    • Egashira K. Inventor; Pharmaceutical composition containing statin encapsulated nanoparticle. United States patent US 20100086602. 2010 Apr 8.
    • (2010)
    • Egashira, K.1
  • 36
    • 33748805769 scopus 로고    scopus 로고
    • Synthesis and characterization of a fluvastatin-releasing hydrogel delivery system to modulate hMSC differentiation and function for bone regeneration
    • DOI 10.1016/j.biomaterials.2006.06.031, PII S0142961206005862, Biomaterials and Stem Cells
    • Benoit DS et al. Synthesis and characterization of a fluvastatin- releasing hydrogel delivery system to modulate hMSC differentiation and function for bone regeneration. Biomaterials 2006; 36: 6102-6110. (Pubitemid 44414974)
    • (2006) Biomaterials , vol.27 , Issue.36 , pp. 6102-6110
    • Benoit, D.S.W.1    Nuttelman, C.R.2    Collins, S.D.3    Anseth, K.S.4
  • 37
    • 34447284555 scopus 로고    scopus 로고
    • Bioerodible devices for intermittent release of simvastatin acid
    • DOI 10.1016/j.ijpharm.2007.03.007, PII S0378517307002396
    • Jeon JH et al. Bioerodible devices for intermittent release of simvastatin acid. Int J Pharm 2007; 340: 6-12. (Pubitemid 47043348)
    • (2007) International Journal of Pharmaceutics , vol.340 , Issue.1-2 , pp. 6-12
    • Jeon, J.H.1    Thomas, M.V.2    Puleo, D.A.3
  • 38
    • 33750855443 scopus 로고    scopus 로고
    • Arterial heparin deposition: Role of diffusion, convection and extravascular space
    • Lovich MA et al. Arterial heparin deposition: role of diffusion, convection and extravascular space. Am J Physiol Heart Circ Physiol 1998; 275: 2236-2242.
    • (1998) Am J Physiol Heart Circ Physiol , vol.275 , pp. 2236-2242
    • Lovich, M.A.1
  • 39
    • 79959873735 scopus 로고    scopus 로고
    • Intravascular stent
    • United States patent US 6152957. Nov 28
    • Jang GD. Inventor; Intravascular stent. United States patent US 6152957. 2000; Nov 28.
    • (2000)
    • Jang, G.D.1
  • 40
    • 40949102636 scopus 로고    scopus 로고
    • Solid dispersion of meloxicam: Factorially designed dosage form for geriatric population
    • DOI 10.2478/v10007-007-0048-y, PII V7652218J93G124W
    • Pathak D et al. Solid dispersion of meloxicam: factorially designed dosage form for geriatric population. Acta Pharm 2008; 58: 99-110. (Pubitemid 351415844)
    • (2008) Acta Pharmaceutica , vol.58 , Issue.1 , pp. 99-110
    • Pathak, D.1    Dahiya, S.2    Pathak, K.3
  • 41
    • 0034601240 scopus 로고    scopus 로고
    • Improving drug solubility for oral delivery using solid dispersions
    • DOI 10.1016/S0939-6411(00)00076-X, PII S093964110000076X
    • Leuner C, Dressman J. Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm 2000; 50: 47-60. (Pubitemid 30326688)
    • (2000) European Journal of Pharmaceutics and Biopharmaceutics , vol.50 , Issue.1 , pp. 47-60
    • Leuner, C.1    Dressman, J.2
  • 42
    • 36549042006 scopus 로고    scopus 로고
    • Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs
    • DOI 10.1016/j.drudis.2007.09.005, PII S1359644607003753
    • Vasconcelos T. Solid dispersions as strategy to improve oral bioavailability of poor water soluble drugs. Drug Discov Today 2007; 12: 1068-1075. (Pubitemid 350186132)
    • (2007) Drug Discovery Today , vol.12 , Issue.23-24 , pp. 1068-1075
    • Vasconcelos, T.1    Sarmento, B.2    Costa, P.3
  • 43
    • 77956921300 scopus 로고    scopus 로고
    • Preparation and characterization of solid dispersion of simvastatin
    • Silva TD et al. Preparation and characterization of solid dispersion of simvastatin. Drug Dev Ind Pharm 2010; 36: 1348-1355.
    • (2010) Drug Dev Ind Pharm , vol.36 , pp. 1348-1355
    • Silva, T.D.1
  • 44
    • 33845573098 scopus 로고    scopus 로고
    • Cyclodextrins and their pharmaceutical applications
    • DOI 10.1016/j.ijpharm.2006.10.044, PII S0378517306009665
    • Loftsson T, Duchene D. Cyclodextrins and their pharmaceutical applications. Int J Pharm 2007; 329: 1-11. (Pubitemid 44937538)
    • (2007) International Journal of Pharmaceutics , vol.329 , Issue.1-2 , pp. 1-11
    • Loftsson, T.1    Duchene, D.2
  • 45
    • 16344364096 scopus 로고    scopus 로고
    • Design and evaluation of cyclodextrin-based drug formulation
    • DOI 10.1248/cpb.52.900
    • Uekama K. Design and evaluation of cyclodextrin based drug formulation. Chem Pharm Bull 2004; 52: 900-915. (Pubitemid 41701863)
    • (2004) Chemical and Pharmaceutical Bulletin , vol.52 , Issue.8 , pp. 900-915
    • Uekama, K.1
  • 46
    • 27744547950 scopus 로고    scopus 로고
    • Diclofenac-b-cyclodextrin binary systems: Physicochemical characterization and in vitro dissolution and diffusion studies
    • Manca ML et al. Diclofenac-b-cyclodextrin binary systems: physicochemical characterization and in vitro dissolution and diffusion studies. AAPS PharmSciTech 2005; 6: 464-472.
    • (2005) AAPS PharmSciTech , vol.6 , pp. 464-472
    • Manca, M.L.1
  • 47
    • 0033106029 scopus 로고    scopus 로고
    • Mechanisms of drug release from cyclodextrin complexes
    • DOI 10.1016/S0169-409X(98)00052-0, PII S0169409X98000520
    • Stella VJ et al. Mechanisms of drug release from cyclodextrin complexes. Adv Drug Deliv Rev 1999; 36: 3-16. (Pubitemid 29074473)
    • (1999) Advanced Drug Delivery Reviews , vol.36 , Issue.1 , pp. 3-16
    • Stella, V.J.1    Rao, V.M.2    Zannou, E.A.3    Zia, V.4
  • 48
    • 77950917310 scopus 로고    scopus 로고
    • Effects of auxiliary substances on complexation efficiency and intrinsic dissolution rate of gemfibrozil-beta-CD complexes
    • Sami F et al. Effects of auxiliary substances on complexation efficiency and intrinsic dissolution rate of gemfibrozil-beta-CD complexes. AAPS PharmSciTech 2010; 11: 27-35.
    • (2010) AAPS PharmSciTech , vol.11 , pp. 27-35
    • Sami, F.1
  • 49
    • 35549013203 scopus 로고    scopus 로고
    • Controlled release of simvastatin acid using cyclodextrin inclusion system
    • Yoshinari M et al. Controlled release of simvastatin acid using cyclodextrin inclusion system. Dent Mater J 2007; 26: 451-456.
    • (2007) Dent Mater J , vol.26 , pp. 451-456
    • Yoshinari, M.1
  • 51
    • 79959907708 scopus 로고    scopus 로고
    • HMG CoA reductase inhibiting composition, method for competitively inhibiting HMG CoA reductase using such composition
    • United States patent US 20030162827. Aug 28
    • Venkataram S et al. inventors; HMG CoA reductase inhibiting composition, method for competitively inhibiting HMG CoA reductase using such composition. United States patent US 20030162827. 2003 Aug 28.
    • (2003)
    • Venkataram, S.1
  • 52
    • 79959890391 scopus 로고    scopus 로고
    • Novel statin pharmaceutical compositions and related methods of treatment
    • United States patent US 20060034815. Feb 16
    • Gujman H et al. inventors; Novel statin pharmaceutical compositions and related methods of treatment. United States patent US 20060034815. 2006 Feb 16.
    • (2006)
    • Gujman, H.1
  • 53
    • 79959879389 scopus 로고    scopus 로고
    • Pharmaceutical composition comprising microcapsules of statins suspended in alkyl esters of poly unsaturated fatty acids (PUFA)
    • United States patent US 20090196920. Aug 6
    • Carminati P, Duena AP. inventors; Pharmaceutical composition comprising microcapsules of statins suspended in alkyl esters of poly unsaturated fatty acids (PUFA). United States patent US 20090196920. 2009 Aug 6.
    • (2009)
    • Carminati, P.1    Duena, A.P.2
  • 54
    • 77949894367 scopus 로고    scopus 로고
    • Self emulsifying drug delivery system: A review
    • Patel PA et al. Self emulsifying drug delivery system: a review. Res J Pharm Technol 2008; 1: 313-323.
    • (2008) Res J Pharm Technol , vol.1 , pp. 313-323
    • Patel, P.A.1
  • 55
    • 0011379669 scopus 로고
    • Entropy-induced dispersion of bulk liquids
    • Reiss H. Entropy-induced dispersion of bulk liquids. J Colloid Interface Sci 1975; 53: 61-70.
    • (1975) J Colloid Interface Sci , vol.53 , pp. 61-70
    • Reiss, H.1
  • 56
    • 33748290093 scopus 로고    scopus 로고
    • Preparation and evaluation of self-microemulsifying drug delivery systems (SMEDDS) containing atorvastatin
    • DOI 10.1211/jpp.58.9.0004
    • Shen H, Zhong M. Preparation and evaluation of self-microemulsifying drug delivery systems (SMEDDS) containing atorvastatin. J Pharm Pharmacol 2006; 58: 1183-1191. (Pubitemid 44329099)
    • (2006) Journal of Pharmacy and Pharmacology , vol.58 , Issue.9 , pp. 1183-1191
    • Shen, H.1    Zhong, M.2
  • 58
  • 59
    • 79959881912 scopus 로고    scopus 로고
    • Oral bioavailability of simvastatin novel formulation in albino rats
    • Singla N et al. Oral bioavailability of simvastatin novel formulation in albino rats. J Pharm Sci Techol 2009; 1: 84-87.
    • (2009) J Pharm Sci Techol , vol.1 , pp. 84-87
    • Singla, N.1
  • 60
    • 33847665647 scopus 로고    scopus 로고
    • Formulation of a self-emulsifying system for oral delivery of simvastatin: In vitro and in vivo evaluation
    • DOI 10.2478/v10007-007-0009-5
    • Patil P et al. Formulation of a self-emulsifying system for oral delivery of simvastatin: in vitro and in vivo evaluation. Acta Pharm 2007; 57: 111-122. (Pubitemid 46361952)
    • (2007) Acta Pharmaceutica , vol.57 , Issue.1 , pp. 111-122
    • Patil, P.1    Patil, V.2    Paradkar, A.3
  • 61
    • 76849116015 scopus 로고    scopus 로고
    • Development and characterization of a lovastatin-loaded self-microemulsifying drug delivery system
    • Singh SK et al. Development and characterization of a lovastatin-loaded self-microemulsifying drug delivery system. Pharm Dev Technol 2009; 14: S1097-S9867.
    • (2009) Pharm Dev Technol , vol.14
    • Singh, S.K.1
  • 62
    • 34547864243 scopus 로고    scopus 로고
    • Drug delivery strategies for poorly water-soluble drugs
    • DOI 10.1517/17425247.4.4.403
    • Fahr A, Liu X. Drug delivery strategies for poorly water-soluble drugs. Expert Opin Drug Deliv 2007; 4: 403-416. (Pubitemid 47249138)
    • (2007) Expert Opinion on Drug Delivery , vol.4 , Issue.4 , pp. 403-416
    • Fahr, A.1    Liu, X.2
  • 63
    • 57349119914 scopus 로고    scopus 로고
    • Formulation and in vivo evaluation of self-nanoemulsifying granules for oral delivery of a combination of ezetimibe and simvastatin
    • Dixit RP, Nagarsenker MS. Formulation and in vivo evaluation of self-nanoemulsifying granules for oral delivery of a combination of ezetimibe and simvastatin. Drug Dev Ind Pharm 2008; 34: 1285-1296.
    • (2008) Drug Dev Ind Pharm , vol.34 , pp. 1285-1296
    • Dixit, R.P.1    Nagarsenker, M.S.2
  • 64
    • 0028845589 scopus 로고
    • pH-sensitive drug delivery system using o/w emulsion
    • Yuk SH et al. pH-sensitive drug delivery system using o/w emulsion. J Control Release 1995; 37: 69-74.
    • (1995) J Control Release , vol.37 , pp. 69-74
    • Yuk, S.H.1
  • 66
    • 0034595218 scopus 로고    scopus 로고
    • Vitamin A loaded solid lipid nanoparticles for topical use: Occlusive properties and drug targeting to the upper skin
    • DOI 10.1016/S0939-6411(99)00075-2, PII S0939641199000752
    • Jenning V et al. Vitamin A-loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin. Eur J Pharm Biopharm 2000; 49: 211-218. (Pubitemid 30229868)
    • (2000) European Journal of Pharmaceutics and Biopharmaceutics , vol.49 , Issue.3 , pp. 211-218
    • Jenning, V.1    Gysler, A.2    Schafer-Korting, M.3    Gohla, S.H.4
  • 68
    • 23844466230 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for application of ascorbyl palmitate
    • Uner M et al. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for application of ascorbyl palmitate. Pharmazie 2005; 60: 577-582. (Pubitemid 41153420)
    • (2005) Pharmazie , vol.60 , Issue.8 , pp. 577-582
    • Uner, M.1    Wissing, S.A.2    Yener, G.3    Muller, R.H.4
  • 70
    • 0037422347 scopus 로고    scopus 로고
    • Para-acyl-calix-arene based solid lipid nanoparticles (SLNs): A detailed study of preparation and stability parameters
    • DOI 10.1016/S0378-5173(02)00639-7
    • Shahgaldian P et al. Para-acyl-calix-arene based solid lipid nanoparticles (SLNs): a detailed study of preparation and stability parameters. Int J Pharm 2003; 253: 23-38. (Pubitemid 36197828)
    • (2003) International Journal of Pharmaceutics , vol.253 , Issue.1-2 , pp. 23-38
    • Shahgaldian, P.1    Da, S.E.2    Coleman, A.W.3    Rather, B.4    Zaworotko, M.J.5
  • 72
    • 0037240251 scopus 로고    scopus 로고
    • Solvent injection as a new approach for manufacturing lipid nanoparticles - Evaluation of the method and process parameters
    • DOI 10.1016/S0939-6411(02)00130-3
    • Schubert MA, Muller-Goyman CC. Solvent injection as a new approach for manufacturing lipid nanoparticles-evaluation of the method and process parameters. Eur J Pharm Biopharm 2003; 55: 125-131. (Pubitemid 36120504)
    • (2003) European Journal of Pharmaceutics and Biopharmaceutics , vol.55 , Issue.1 , pp. 125-131
    • Schubert, M.A.1    Muller-Goymann, C.C.2
  • 73
    • 0035966519 scopus 로고    scopus 로고
    • Improved skin oxygenation after benzyl nicotinate application in different carriers as measured by EPR oximetry in vivo
    • DOI 10.1016/S0168-3659(00)00351-5, PII S0168365900003515
    • Krzic M et al. Improved skin oxygenation after benzyl nicotinate application in different carriers as measured by EPR oximetry in vivo. J Control Release 2001; 70: 203-211. (Pubitemid 32144804)
    • (2001) Journal of Controlled Release , vol.70 , Issue.1-2 , pp. 203-211
    • Krzic, M.1    Sentjurc, M.2    Kristl, J.3
  • 74
    • 22044434130 scopus 로고    scopus 로고
    • A new healthy sunscreen system for human: Solid lipid nannoparticles as carrier for 3,4,5-trimethoxybenzoylchitin and the improvement by adding Vitamin E
    • DOI 10.1016/j.ijbiomac.2005.05.003, PII S0141813005000826
    • Song C, Liu S. A new healthy sunscreen system for human: solid lipid nanoparticles as carrier for 3, 4, 5-trimethoxybenzoylchitin and the improvement by adding Vitamin E. Int J Biol Macromol 2005; 36: 116-119. (Pubitemid 40966964)
    • (2005) International Journal of Biological Macromolecules , vol.36 , Issue.1-2 , pp. 116-119
    • Song, C.1    Liu, S.2
  • 75
    • 26944493750 scopus 로고    scopus 로고
    • Preparation of solid lipid nanoparticles using a membrane contactor
    • DOI 10.1016/j.jconrel.2005.07.023, PII S0168365905003366
    • Charcosset C et al. Preparation of solid lipid nanoparticles using a membrane contactor. J Control Release 2005; 108: 112-120. (Pubitemid 41476679)
    • (2005) Journal of Controlled Release , vol.108 , Issue.1 , pp. 112-120
    • Charcosset, C.1    El-Harati, A.2    Fessi, H.3
  • 76
    • 4544275025 scopus 로고    scopus 로고
    • Challenges and solutions for the delivery of biotech drugs - A review of drug nanocrystal technology and lipid nanoparticles
    • DOI 10.1016/j.jbiotec.2004.06.007, PII S0168165604003128
    • Muller RH, Keck CM. Challenges and solutions for the delivery of biotech drugs - a review of drug nanocrystal technology and lipid nanoparticles. J Biotechnol 2004; 113: 151-170. (Pubitemid 39237077)
    • (2004) Journal of Biotechnology , vol.113 , Issue.1-3 , pp. 151-170
    • Muller, R.H.1    Keck, C.M.2
  • 77
    • 0038032150 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) for controlled drug delivery - A review of the state of the art
    • DOI 10.1016/S0939-6411(00)00087-4, PII S0939641100000874
    • Muller RH et al. Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art. Eur J Pharm Biopharm 2000; 50: 161-177. (Pubitemid 30326695)
    • (2000) European Journal of Pharmaceutics and Biopharmaceutics , vol.50 , Issue.1 , pp. 161-177
    • Muller, R.H.1    Mader, K.2    Gohla, S.3
  • 78
    • 0037151496 scopus 로고    scopus 로고
    • Nanostructured lipid matrices for improved microencapsulation of drugs
    • Muller RH et al. Nanostructured lipid matrices for improved microencapsulation of drugs. Int J Pharm 2002; 242: 121-128.
    • (2002) Int J Pharm , vol.242 , pp. 121-128
    • Muller, R.H.1
  • 79
    • 77649184038 scopus 로고    scopus 로고
    • Effects of lipophilic emulsifiers on the oral administration of lovastatin from nanostructured lipid carriers: Physicochemical characterization and pharmacokinetics
    • Chen CC et al. Effects of lipophilic emulsifiers on the oral administration of lovastatin from nanostructured lipid carriers: physicochemical characterization and pharmacokinetics. Eur J Pharm Biopharm 2010; 74: 474-482.
    • (2010) Eur J Pharm Biopharm , vol.74 , pp. 474-482
    • Chen, C.C.1
  • 80
    • 34248396463 scopus 로고    scopus 로고
    • Preparation of tablets rapidly disintegrating in saliva containing bitter taste-masked granules by compression method
    • Bhatti S et al. Preparation of tablets rapidly disintegrating in saliva containing bitter taste-masked granules by compression method. Ind J Pharm Sci 2007; 69: 80-84.
    • (2007) Ind J Pharm Sci , vol.69 , pp. 80-84
    • Bhatti, S.1
  • 81
    • 44849092904 scopus 로고    scopus 로고
    • Modified polysaccharides as fast disintegrating excipients for orodispersible tablets of roxithromycin
    • Sharma V et al. Modified polysaccharides as fast disintegrating excipients for orodispersible tablets of roxithromycin. AAPS PharmSciTech 2008; 9: 87-94.
    • (2008) AAPS PharmSciTech , vol.9 , pp. 87-94
    • Sharma, V.1
  • 82
    • 78650025523 scopus 로고    scopus 로고
    • Orally disintegratable simvastatin tablets
    • United States patent US 20070087050. Apr 19
    • Jansen KA. Inventor; Orally disintegratable simvastatin tablets, United States patent US 20070087050. 2007 Apr 19.
    • (2007)
    • Jansen, K.A.1
  • 83
    • 79959887598 scopus 로고    scopus 로고
    • Pharmaceutical formulations and methods for modified release of statin drugs
    • United States patent US 20040132802. Jul 8
    • Butler J et al. Inventors; Pharmaceutical formulations and methods for modified release of statin drugs. United States patent US 20040132802. 2004 Jul 8.
    • (2004)
    • Butler, J.1
  • 85
    • 77954593961 scopus 로고    scopus 로고
    • Polymers in mucoadhesive buccal drug delivery system - A review
    • Punitha S, Girish Y. Polymers in mucoadhesive buccal drug delivery system - a review. Int J Res Pharm Sci 2010; 1: 170-186.
    • (2010) Int J Res Pharm Sci , vol.1 , pp. 170-186
    • Punitha, S.1    Girish, Y.2
  • 86
    • 77950868739 scopus 로고    scopus 로고
    • Buccal drug delivery of pravastatin sodium
    • Shidhaye SS et al. Buccal drug delivery of pravastatin sodium. AAPS PharmSciTech 2010; 11: 416-424.
    • (2010) AAPS PharmSciTech , vol.11 , pp. 416-424
    • Shidhaye, S.S.1
  • 87
    • 77649223503 scopus 로고    scopus 로고
    • Clinical effect of subgingivally delivered simvastatin in the treatment of patients with chronic periodontitis: A randomized clinical trial
    • Pradeep AR, Thorat MS. Clinical effect of subgingivally delivered simvastatin in the treatment of patients with chronic periodontitis: a randomized clinical trial. J Periodontol 2010; 81: 214-222.
    • (2010) J Periodontol , vol.81 , pp. 214-222
    • Pradeep, A.R.1    Thorat, M.S.2
  • 88
    • 0032584177 scopus 로고    scopus 로고
    • Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors
    • Laufs U et al. Upregulation of endothelial nitric oxide synthase by HMG CoAreductase inhibitors. Circulation 1998; 97: 1129-1135. (Pubitemid 28152885)
    • (1998) Circulation , vol.97 , Issue.12 , pp. 1129-1135
    • Laufs, U.1    La, F.V.2    Plutzky, J.3    Liao, J.K.4
  • 89
    • 0033826581 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
    • Kureishi Y et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med 2000; 6: 1004-1010.
    • (2000) Nat Med , vol.6 , pp. 1004-1010
    • Kureishi, Y.1
  • 91
    • 79959884332 scopus 로고    scopus 로고
    • Transdemal delivery system for statin combination therapy
    • Fairfield Clinical Trials LLC., assignee. United States patent US 20050281868. Dec 22
    • Lane EM. inventor; Fairfield Clinical Trials LLC., assignee. Transdemal delivery system for statin combination therapy. United States patent US 20050281868. 2005 Dec 22.
    • (2005)
    • Lane, E.M.1
  • 92
    • 17844373273 scopus 로고    scopus 로고
    • Transdermal drug delivery: Penetration enhancement techniques
    • DOI 10.2174/1567201052772915
    • Benson HAE. Transdermal drug delivery: penetration enhancement techniques. Curr Drug Deliv 2005; 2: 23-33. (Pubitemid 40590918)
    • (2005) Current Drug Delivery , vol.2 , Issue.1 , pp. 23-33
    • Benson, H.A.E.1
  • 93
    • 79959912994 scopus 로고    scopus 로고
    • Sustained-release preparation of statin drug
    • Pficker Pharmaceuticals Ltd., assignee. United States patent US 20090196910. Aug 6
    • Yie H et al. inventors; Pficker Pharmaceuticals Ltd., assignee. Sustained-release preparation of statin drug. United States patent US 20090196910. 2009; Aug 6.
    • (2009)
    • Yie, H.1
  • 94
    • 39649089565 scopus 로고    scopus 로고
    • The effect of local simvastatin delivery strategies on mandibular bone formation in vivo
    • Lee Y et al. The effect of local simvastatin delivery strategies on mandibular bone formation in vivo. Biomaterials 2008; 29: 1940-1949.
    • (2008) Biomaterials , vol.29 , pp. 1940-1949
    • Lee, Y.1
  • 95
    • 0027426454 scopus 로고
    • 5-Fluorouracil: Various kinds of loaded liposomes: Encapsulation efficiency, storage stability and fusogenic properties
    • DOI 10.1016/0378-5173(93)90356-K
    • Fresta M et al. 5-Fluorouracil - various kinds of loaded liposomes- encapsulation efficiency, storage stability and fusogenic properties. Int J Pharm 1993; 99: 145-156. (Pubitemid 23312030)
    • (1993) International Journal of Pharmaceutics , vol.99 , Issue.2-3 , pp. 145-156
    • Fresta, M.1    Villari, A.2    Puglisi, G.3    Cavallaro, G.4
  • 96
    • 39349090619 scopus 로고    scopus 로고
    • Intravenous rosuvastatin for acute stroke treatment
    • Prinz VP et al. Intravenous rosuvastatin for acute stroke treatment. Stroke 2008; 39: 433-438.
    • (2008) Stroke , vol.39 , pp. 433-438
    • Prinz, V.P.1
  • 99
    • 34547292379 scopus 로고    scopus 로고
    • Plum-pudding gels as a platform for drug delivery: Understanding the effects of the different components on the diffusion behavior of solutes
    • DOI 10.1021/jp069051u
    • Salvati A et al. Plum-pudding gels as a platform for drug delivery: understanding the effects of the different components on the diffusion behavior of solutes. J Phys Chem B Mater Surf Interfaces Biophys 2007; 111: 7367-7376. (Pubitemid 47152525)
    • (2007) Journal of Physical Chemistry B , vol.111 , Issue.25 , pp. 7367-7376
    • Salvati, A.1    Soderman, O.2    Lynch, I.3
  • 100
    • 4043170064 scopus 로고    scopus 로고
    • Release of model compounds from plumpudding- type gels composed of microgel particles randomly dispersed in a gel matrix
    • Lynch I, Dawson KA. Release of model compounds from plumpudding- type gels composed of microgel particles randomly dispersed in a gel matrix. J Phys Chem B Mater Surf Interfaces Biophys 2004; 108: 19893-19898.
    • (2004) J Phys Chem B Mater Surf Interfaces Biophys , vol.108 , pp. 19893-19898
    • Lynch, I.1    Dawson, K.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.