Reducing methylglyoxal as a therapeutic target for diabetic heart disease

Biochemical Society Transactions

Volumn 42, Issue 2, 2014, Pages 523-527

  Vulesevic, Branka ^a   Milne, Ross W ^a   Suuronen, Erik J ^a  

^a UNIVERSITY OF OTTAWA HEART INSTITUTE   (Canada)

Author keywords

Cardiovascular disease; Diabetes; Endothelial dysfunction; Glyoxalase; Methylglyoxal

Indexed keywords

ACETYLCYSTEINE; ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCATION END PRODUCT RECEPTOR; ANTIOXIDANT; CARBONYL DERIVATIVE; CONNECTIVE TISSUE GROWTH FACTOR; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GLUCOSE; GLUCOSE TRANSPORTER 1; GLYOXALASE; INSULIN; INTERCELLULAR ADHESION MOLECULE 1; METHYLGLYOXAL; NITRIC OXIDE; PROTEIN KINASE C BETA; REACTIVE OXYGEN METABOLITE; SCAVENGER; VASCULAR CELL ADHESION MOLECULE 1;

ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; DIABETES MELLITUS; DIABETIC CARDIOMYOPATHY; DIABETIC MICROANGIOPATHY; DIABETIC NEPHROPATHY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; GLUCOSE BLOOD LEVEL; GLYCOLYSIS; HEART FAILURE; HEART FUNCTION; HEART MITOCHONDRION; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HUMAN; INSULIN RESISTANCE; METABOLIC DISORDER; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; STREPTOZOTOCIN-INDUCED DIABETES MELLITUS; SYSTOLIC HYPERTENSION; VASCULAR SMOOTH MUSCLE; ANIMAL; METABOLISM;

ANIMALS; CARDIOVASCULAR DISEASES; DIABETES MELLITUS; GLYCOSYLATION END PRODUCTS, ADVANCED; HUMANS; PYRUVALDEHYDE;

EID: 84896945904     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20130254     Document Type: Review

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