Insulin glycation by methylglyoxal results in native-like aggregation and inhibition of fibril formation

BMC Biochemistry

Volumn 12, Issue 1, 2011, Pages

  Oliveira, Luis Ma ^a,b,c   Lages, Ana ^a   Gomes, Ricardo A ^a,d   Neves, Henrique ^a   Família, Carlos ^a   Coelho, Ana V ^d   Quintas, Alexandre ^a  

^a INSTITUTO SUPERIOR DE CIÊNCIAS DA SAÚDE EGAS MONIZ   (Portugal)

^b UNIVERSITY OF LISBON   (Portugal)

^c INSTITUTO POLITÉCNICO DE CASTELO BRANCO   (Portugal)

^d UNIVERSIDADE NOVA DE LISBOA   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; METHYLGLYOXAL;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DYNAMICS; FIBER; HORMONE INHIBITION; HORMONE STRUCTURE; HUMAN; INSULIN FIBRIL FORMATION; INSULIN GLYCATION; PROTEIN AGGREGATION; PROTEIN GLYCOSYLATION; PROTEIN STABILITY; AMINO ACID SEQUENCE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; GLYCOSYLATION; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN SECONDARY STRUCTURE;

AMINO ACID SEQUENCE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOSYLATION; HUMANS; INSULIN; PROTEIN MULTIMERIZATION; PROTEIN STABILITY; PROTEIN STRUCTURE, SECONDARY; PYRUVALDEHYDE;

EID: 79961123141     PISSN: None     EISSN: 14712091     Source Type: Journal    
DOI: 10.1186/1471-2091-12-41     Document Type: Article

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