Electronegative low-density lipoprotein induces cardiomyocyte apoptosis indirectly through endothelial cell-released chemokines

Apoptosis

Volumn 17, Issue 9, 2012, Pages 1009-1018

  Lee, An Sheng ^a,b   Wang, Guei Jane ^a,b   Chan, Hua Chen ^a   Chen, Fang Yu ^a,c   Chang, Chia Ming ^a   Yang, Chao Yuh ^a,b,d,e   Lee, Yuan Teh ^a,b,f   Chang, Kuan Cheng ^a,b   Chen, Chu Huang ^a,b,d,e  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d TEXAS HEART INSTITUTE   (United States)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

^f NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Apoptosis; Cardiomyocyte; Chemokine; Electronegative LDL

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CXCR2 ANTAGONIST; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN 1; LOW DENSITY LIPOPROTEIN 5; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; ATHEROGENESIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; HEART FAILURE; HEART MUSCLE CELL; HUMAN; HUMAN CELL; LIPOPROTEIN BLOOD LEVEL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; APOPTOSIS; CELLS, CULTURED; CHEMOKINE CXCL5; CHEMOKINES; CULTURE MEDIA, CONDITIONED; ENDOTHELIAL CELLS; HEART FAILURE; INTERLEUKIN-1BETA; INTERLEUKIN-8; LIPOPROTEINS, LDL; MALE; MYOCYTES, CARDIAC; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASE; PROTEIN TRANSPORT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, INTERLEUKIN-8B; SCAVENGER RECEPTORS, CLASS E; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 84865107478     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-012-0726-1     Document Type: Article

References (31)

1. Olivetti G, Abbi R, Quaini F et al (1997) Apoptosis in the failing human heart. N Engl J Med 336:1131-1141 (Pubitemid 27374695)
2. Sarkar S, Leaman DW, Gupta S et al (2004) Cardiac overexpression of myotrophin triggers myocardial hypertrophy and heart failure in transgenic mice. J Biol Chem 279:20422-20434 (Pubitemid 38623489)
3. Beltrami AP, Urbanek K, Kajstura J et al (2001) Evidence that human cardiac myocytes divide after myocardial infarction. N Engl J Med 344:1750-1757 (Pubitemid 32497029)
4. Kang BY, Wang W, Palade P, Sharma SG, Mehta JL (2009) Cardiac hypertrophy during hypercholesterolemia and its amelioration with rosuvastatin and amlodipine. J Cardiovasc Pharmacol 54:327-334
5. Lipinski MJ, Cauthen CA, Biondi-Zoccai GG et al (2009) Meta-analysis of randomized controlled trials of statins versus placebo in patients with heart failure. Am J Cardiol 104:1708-1716
6. Iwai-Kanai E, Hasegawa K, Sawamura T et al (2001) Activation of lectin-like oxidized low-density lipoprotein receptor-1 induces apoptosis in cultured neonatal rat cardiac myocytes. Circulation 104:2948-2954 (Pubitemid 33139108)
7. Chen CH, Jiang T, Yang JH et al (2003) Low-density lipoprotein in hypercholesterolemic human plasma induces vascular endothelial cell apoptosis by inhibiting fibroblast growth factor 2 transcription. Circulation 107:2102-2108 (Pubitemid 36532191)
8. Chen HH, Hosken BD, Huang M et al (2007) Electronegative LDLs from familial hypercholesterolemic patients are physicochemically heterogeneous but uniformly proapoptotic. J Lipid Res 48:177-184 (Pubitemid 46052909)
9. Yang CY, Raya JL, Chen HH et al (2003) Isolation, characterization, and functional assessment of oxidatively modified subfractions of circulating low-density lipoproteins. Arterioscler Thromb Vasc Biol 23:1083-1090 (Pubitemid 36713565)
10. Lu J, Jiang W, Yang JH et al (2008) Electronegative LDL impairs vascular endothelial cell integrity in diabetes by disrupting fibroblast growth factor 2 (FGF2) autoregulation. Diabetes 57:158-166
11. Tang D, Lu J, Walterscheid JP et al (2008) Electronegative LDL circulating in smokers impairs endothelial progenitor cell differentiation by inhibiting Akt phosphorylation via LOX-1. J Lipid Res 49:33-47
12. Lu J, Yang JH, Burns AR et al (2009) Mediation of electronegative low-density lipoprotein signaling by LOX-1: a possible mechanism of endothelial apoptosis. Circ Res 104:619-627
13. Tai MH, Kuo SM, Liang HT et al (2006) Modulation of angiogenic processes in cultured endothelial cells by low density lipoproteins subfractions from patients with familial hypercholesterolemia. Atherosclerosis 186:448-457
14. Kelly RA, Smith TW (1997) Cytokines and cardiac contractile function. Circulation 95:778-781 (Pubitemid 27091510)
15. Opie LH (1998) The heart: physiology, from cell to circulation. Lippincott-Raven, Philadelphia
16. Chen CH, Lu J, Chen SH et al (2012) Effects of electronegative VLDL on endothelium damage in metabolic syndrome. Diabetes Care 35:648-653
17. Chen CH, Cartwright J Jr, Li Z et al (1997) Inhibitory effects of hypercholesterolemia and ox-LDL on angiogenesis-like endothelial growth in rabbit aortic explants. Essential role of basic fibroblast growth factor. Arterioscler Thromb Vasc Biol 17:1303-1312 (Pubitemid 27329853)
18. Institute of Laboratory Animal Research CoLS, National Research Council (1996) Guide for the use and care of laboratory animals. National Academy Press, Washington, DC
19. Wang GJ, Shan J, Pang PK, Yang MC, Chou CJ, Chen CF (1996) The vasorelaxing action of rutaecarpine: direct paradoxical effects on intracellular calcium concentration of vascular smooth muscle and endothelial cells. J Pharmacol Exp Ther 276:1016-1021 (Pubitemid 126660577)
20. Vanhecke TE, Kim R, Raheem SZ, McCullough PA (2010) Myocardial ischemia in patients with diastolic dysfunction and heart failure. Curr Cardiol Rep 12:216-222
21. Davani EY, Boyd JH, Dorscheid DR et al (2006) Cardiac ICAM-1 mediates leukocyte-dependent decreased ventricular contractility in endotoxemic mice. Cardiovasc Res 72:134-142 (Pubitemid 44310639)
22. Abe Y, Fornage M, Yang CY et al (2007) L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion. Atherosclerosis 192:56-66 (Pubitemid 46628805)
23. Oral H, Dorn GW II, Mann DL (1997) Sphingosine mediates the immediate negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian cardiac myocyte. J Biol Chem 272:4836-4842 (Pubitemid 27090030)
24. Cain BS, Meldrum DR, Dinarello CA et al (1999) Tumor necrosis factor-alpha and interleukin-1beta synergistically depress human myocardial function. Crit Care Med 27:1309-1318 (Pubitemid 29379369)
25. Chandrasekar B, Smith JB, Freeman GL (2001) Ischemia-reperfusion of rat myocardium activates nuclear factor-KappaB and induces neutrophil infiltration via lipopolysaccharide-induced CXC chemokine. Circulation 103:2296-2302 (Pubitemid 32433721)
26. Chandrasekar B, Mitchell DH, Colston JT, Freeman GL (1999) Regulation of CCAAT/Enhancer binding protein, interleukin-6, interleukin-6 receptor, and gp130 expression during myocardial ischemia/reperfusion. Circulation 99:427-433 (Pubitemid 29051270)
27. Chandrasekar B (2002) Chemokine-cytokine cross-talk. The ELR+CXC chemokine LIX (CXCL5) amplifies a proinflammatory cytokine response via a phosphatidylinositol 3-kinase-NF-kappa B pathway. J Biol Chem 278:4675-4686 (Pubitemid 36800967)
28. Bowie A, O'Neill LA (2000) Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries. Biochem Pharmacol 59:13-23
29. Mercurio F, Manning AM (1999) NF-kappaB as a primary regulator of the stress response. Oncogene 18:6163-6171
30. Yang M, Wu J, Martin CM, Kvietys PR, Rui T (2008) Important role of p38 MAP kinase/NF-kappaB signaling pathway in the sepsis-induced conversion of cardiac myocytes to a proinflammatory phenotype. Am J Physiol Heart Circ Physiol 294:H994-1001 (Pubitemid 351253313)
31. Yokoyama T, Vaca L, Rossen RD, Durante W, Hazarika P, Mann DL (1993) Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heart. J Clin Invest 92:2303-2312 (Pubitemid 23333536)