Methylglyoxal increases cardiomyocyte ischemia-reperfusion injury via glycative inhibition of thioredoxin activity

American Journal of Physiology - Endocrinology and Metabolism

Volumn 299, Issue 2, 2010, Pages

  Wang, Xiao Liang ^a   Lau, Wayne B ^a   Yuan, Yue Xing ^a   Wang, Ya Jing ^a   Yi, Wei ^a   Christopher, Theodore A ^a   Lopez, Bernard L ^a   Liu, Hui Rong ^b   Ma, Xin Liang ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Hypoxia and reoxygenation

Indexed keywords

ADVANCED GLYCATION END PRODUCT; AMINOGUANIDINE; CASPASE 3; LACTATE DEHYDROGENASE; METHYLGLYOXAL; MITOGEN ACTIVATED PROTEIN KINASE P38; THIOREDOXIN; RECOMBINANT PROTEIN; TXN1 PROTEIN, RAT;

APOPTOSIS; ARTICLE; BLOOD VESSEL INJURY; CARDIOVASCULAR DISEASE; CELL CULTURE; CONTROLLED STUDY; DIABETES MELLITUS; GLYCATION; HEART INJURY; HEART MUSCLE ISCHEMIA; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TEMPERATURE; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REOXYGENATION; REPERFUSION INJURY; ANIMAL; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HEART MUSCLE CELL; IMMUNOHISTOCHEMISTRY; METABOLISM; PATHOLOGY; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELLS, CULTURED; GLYCOSYLATION END PRODUCTS, ADVANCED; IMMUNOHISTOCHEMISTRY; L-LACTATE DEHYDROGENASE; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRUVALDEHYDE; RATS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; THIOREDOXINS;

EID: 77954911547     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00215.2010     Document Type: Article

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