Identification and validation of modulators of exchange protein activated by cAMP (Epac) activity: Structure-function implications for Epac activation and inhibition

Journal of Biological Chemistry

Volumn 289, Issue 12, 2014, Pages 8217-8230

  Brown, Loren M ^a   Rogers, Kathleen E ^a   McCammon, J Andrew ^a,b   Insel, Paul A ^a,c  

^a San Diego   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEOTIDES; PROTEINS;

ALLOSTERIC INHIBITOR; COMPUTATIONAL MOLECULAR MODELING; GUANINE NUCLEOTIDE EXCHANGE FACTORS; INTRAMOLECULAR MOVEMENT; LOW MOLECULAR WEIGHT; RESONANCE ENERGIES; SIGNALING MOLECULES; STRUCTURE FUNCTIONS;

CHEMICAL ACTIVATION;

8 (4 CHLOROPHENYLTHIO) CYCLIC AMP; 8 CHLOROPHENYLTHIO 2' O ME CYCLIC AMP; 8 METHOXYPHENYLTHIO 2' O ME CYCLIC AMP; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; EPAC1 PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; RAP1 PROTEIN; UNCLASSIFIED DRUG; VASODILATOR STIMULATED PHOSPHOPROTEIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CONFORMATIONAL TRANSITION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HYDROGEN BOND; LIGAND BINDING; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

BIOLUMINESCENCE RESONANCE ENERGY TRANSFER (BRET); CYCLIC AMP (CAMP); ENZYME INHIBITORS; EPAC1; GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF); MOLECULAR DOCKING; MOLECULAR PHARMACOLOGY;

ANIMALS; CELL LINE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUG DISCOVERY; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; LUMINESCENT MEASUREMENTS; MICE; MODELS, MOLECULAR; SIGNAL TRANSDUCTION; THIONUCLEOTIDES;

EID: 84896928348     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.548636     Document Type: Article

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