The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1)

Biochemical and Biophysical Research Communications

Volumn 440, Issue 3, 2013, Pages 443-448

  Courilleau, Delphine ^a   Bouyssou, Pascal ^b   Fischmeister, Rodolphe ^c   Lezoualc'h, Frank ^c   Blondeau, Jean Paul ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b UNIVERSITÉ D'ORLÉANS   (France)

^c INSERM   (France)

Author keywords

CAMP signaling; Drug enantiomers; Epac inhibitor; Rap1 GEF; Tetrahydroquinoline analogs

Indexed keywords

8 (4 CHLOROPHENYLTHIO) 2' O METHYLADENOSINE 3',5' CYCLIC MONOPHOSPHATE; CE 3F 4; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CYCLIC AMP ISOFORM 1 INHIBITOR; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CYCLIC AMP ISOFORM 2 INHIBITOR; PROTEIN INHIBITOR; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; 6 FLUORO 5,7 DIBROMO 2 METHYL 1 FORMYL 1,2,3,4 TETRAHYDROQUINOLINE; 6-FLUORO-5,7-DIBROMO-2-METHYL-1-FORMYL-1,2,3,4-TETRAHYDROQUINOLINE; CE3F4; CYCLIC AMP DEPENDENT PROTEIN KINASE; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CYCLIC AMP; GUANINE NUCLEOTIDE EXCHANGE FACTOR; ISOPROTEIN; RAPGEF3 PROTEIN, HUMAN;

ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG STRUCTURE; ENANTIOMER; ENANTIOSELECTIVITY; IC 50; IN VITRO STUDY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; 007; 8-(4-CHLORO-PHENYLTHIO)-2′-O-METHYL-CAMP; CAMP SIGNALING; CNB; CYCLIC NUCLEOTIDE BINDING; DEP; DISHEVELED/EGL-10/PLECKSTRIN; DRUG ANTAGONISM; DRUG ENANTIOMERS; EPAC; EPAC INHIBITOR; GEF; GUANINE-NUCLEOTIDE EXCHANGE FACTOR; HUMAN; ISOMERISM; PKA; RAP1 GEF; TETRAHYDROQUINOLINE ANALOGS; ANTAGONISTS AND INHIBITORS;

007; 6-FLUORO-5,7-DIBROMO-2-METHYL-1-FORMYL-1,2,3,4-TETRAHYDROQUINOLINE; 8-(4-CHLORO-PHENYLTHIO)-2′-O-METHYL-CAMP; CAMP SIGNALING; CE3F4; CNB; CYCLIC NUCLEOTIDE BINDING; DEP; DISHEVELED/EGL-10/PLECKSTRIN; DRUG ENANTIOMERS; EPAC; EPAC INHIBITOR; EXCHANGE PROTEIN DIRECTLY ACTIVATED BY CYCLIC AMP; GEF; GUANINE-NUCLEOTIDE EXCHANGE FACTOR; PKA; PROTEIN KINASE A; RAP1 GEF; TETRAHYDROQUINOLINE ANALOGS;

GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; ISOMERISM; PROTEIN ISOFORMS; QUINOLINES;

EID: 84888133964     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2013.09.107     Document Type: Article

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