The anti-apoptotic Bcl-B protein inhibits BECN1-dependent autophagic cell death

Autophagy

Volumn 8, Issue 4, 2012, Pages 637-649

  Robert, Guillaume ^a,b,c   Gastaldi, Cecile ^a   Puissant, Alexandre ^a,b,c   Hamouda, Amine ^a,b,c   Jacquel, Arnaud ^a,b,c   Dufies, Maeva ^a,b,c   Belhacene, Nathalie ^a,b,c   Colosetti, Pascal ^a,b,c   Reed, John C ^d   Auberger, Patrick ^a,b,c   Luciano, Fréderic ^a,b,c  

^a UNIVERSITÉ CÔTE D'AZUR   (France)

^b CENTRE MÉDITERRANÉEN DE MÉDECINE MOLÉCULAIRE C3M   (France)

^c Equipe Labellisee Par la Ligue Nationale Contre le Cancer   (France)

^d BURNHAM INSTITUTE   (United States)

Author keywords

Amino acid starvation; Apoptosis; Autophagy; Bcl B; BECN1

Indexed keywords

AUTOPHAGY PROTEIN 5; BCL B PROTEIN; BECLIN 1; BH3 PROTEIN; CELL PROTEIN; LC3 PROTEIN; PEPTIDES AND PROTEINS; UNCLASSIFIED DRUG;

ARTICLE; AUTOPHAGY; CELL DEATH; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; KWASHIORKOR; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; STIMULUS RESPONSE;

EID: 84862275104     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.19084     Document Type: Article

References (38)

1. Kroemer G, Galluzzi L, Vandenabeele P, Abrams J, Alnemri ES, Baehrecke EH, et al & Nomenclature Committee on Cell Death 2009. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ 2009; 16:3-11; PMID:18846107; http://dx.doi.org/10.1038/cdd. 2008.150
2. Reed JC. Mechanisms of apoptosis. Am J Pathol 2000; 157:1415-30; PMID:11073801; http://dx.doi.org/10.1016/S0002-9440(10)64779-7
3. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100:57-70; PMID:10647931; http://dx.doi.org/10.1016/S0092-8674(00)81683-9
4. Konopleva M, Contractor R, Tsao T, Samudio I, Ruvolo PP, Kitada S, et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell 2006; 10:375-88. Write to the Help Desk NCBI | NLM | NIH Department of Health & Human Services Privacy Statement | Freedom of Information Act | Disclaimer Dec 18 2006 06:34:27.
5. Kondo Y, Kanzawa T, Sawaya R, Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 2005; 5:726-34; PMID: 16148885; http://dx.doi.org/10.1038/nrc1692
6. Shintani T, Klionsky DJ. Autophagy in health and disease: a double-edged sword. Science 2004; 306:990-5; PMID:15528435; http://dx.doi.org/10.1126/ science.1099993
7. Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 2007; 8:931-7; PMID:17712358; http://dx.doi.org/10.1038/nrm2245
8. Oberstein A, Jeffrey PD, Shi Y. Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J Biol Chem 2007; 282:13123-32; PMID:17337444; http://dx.doi.org/10.1074/jbc.M700492200
9. Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, et al. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122:927-39; PMID:16179260; http://dx.doi.org/10.1016/j.cell.2005.07.002
10. Maiuri MC, Le Toumelin G, Criollo A, Rain JC, Gautier F, Juin P, et al. Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J 2007; 26:2527-39; PMID: 17446862; http://dx.doi.org/10.1038/sj. emboj.7601689
11. Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, Berry G, et al. Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol 1998; 72:8586-96; PMID: 9765397
12. Levine B, Sinha S, Kroemer G. Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy 2008; 4:600-6; PMID:18497563
13. Ke N, Godzik A, Reed JC. Bcl-B, a novel Bcl-2 family member that differentially binds and regulates Bax and Bak. J Biol Chem 2001; 276:12481-4; PMID: 11278245; http://dx.doi.org/10.1074/jbc.C000871200
14. Zhang H, Holzgreve W, De Geyter C. Bcl2-L-10, a novel anti-apoptotic member of the Bcl-2 family, blocks apoptosis in the mitochondria death pathway but not in the death receptor pathway. Hum Mol Genet 2001; 10:2329-39; PMID:11689480; http://dx.doi.org/10.1093/hmg/10.21.2329
15. Zhai D, Ke N, Zhang H, Ladror U, Joseph M, Eichinger A, et al. Characterization of the anti-apoptotic mechanism of Bcl-B. Biochem J 2003; 376:229-36; PMID:12921534; http://dx.doi.org/10.1042/BJ20030374
16. Krajewska M, Kitada S, Winter JN, Variakojis D, Lichtenstein A, Zhai D, et al. Bcl-B expression in human epithelial and nonepithelial malignancies. Clin Cancer Res 2008; 14:3011-21; PMID:18483366; http://dx.doi.org/10.1158/1078- 0432.CCR-07-1955
17. Arsov I, Li X, Matthews G, Coradin J, Hartmann B, Simon AK, et al. BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte development. Cell Death Differ 2008; 15:1385-95; PMID:18451870; http://dx.doi.org/10.1038/cdd.2008.59
18. Zhong Y, Wang QJ, Li X, Yan Y, Backer JM, Chait BT, et al. Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol 2009; 11:468-76; PMID:19270693; http://dx.doi.org/10.1038/ncb1854
19. Luciano F, Krajewska M, Ortiz-Rubio P, Krajewski S, Zhai D, Faustin B, et al. Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma. Blood 2007; 109:3849-55; PMID: 17227826; http://dx.doi.org/10.1182/blood-2006-11-056879
20. Pattingre S, Bauvy C, Carpentier S, Levade T, Levine B, Codogno P. Role of JNK1-dependent Bcl-2 phosphorylation in ceramide-induced macroautophagy. J Biol Chem 2009; 284:2719-28; PMID:19029119; http://dx.doi.org/10.1074/jbc. M805920200
21. Puissant A, Auberger P. AMPK- and p62/SQSTM1-dependent autophagy mediate Resveratrol-induced cell death in chronic myelogenous leukemia. Autophagy 2010; 6:655-7; PMID:20458181; http://dx.doi.org/10.4161/auto.6.5.12126
22. He C, Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 2009; 43:67-93; PMID:19653858; http://dx.doi.org/10. 1146/annurev-genet-102808-114910
23. Puissant A, Robert G, Fenouille N, Luciano F, Cassuto JP, Raynaud S, et al. Resveratrol promotes autophagic cell death in chronic myelogenous leukemia cells via JNK-mediated p62/SQSTM1 expression and AMPK activation. Cancer Res 2010; 70:1042-52; PMID: 20103647; http://dx.doi.org/10.1158/0008-5472.CAN-09- 3537
24. Erlich S, Mizrachy L, Segev O, Lindenboim L, Zmira O, Adi-Harel S, et al. Differential interactions between Beclin 1 and Bcl-2 family members. Autophagy 2007; 3:561-8; PMID:17643073
25. Priault M, Hue E, Marhuenda F, Pilet P, Oliver L, Vallette FM. Differential dependence on Beclin 1 for the regulation of pro-survival autophagy by Bcl-2 and Bcl-xL in HCT116 colorectal cancer cells. PLoS One 2010; 5:e8755; PMID:20090905; http://dx.doi.org/10.1371/journal.pone.0008755
26. Mehrpour M, Esclatine A, Beau I, Codogno P. Overview of macroautophagy regulation in mammalian cells. Cell Res 2010; 20:748-62; PMID:20548331; http://dx.doi.org/10.1038/cr.2010.82
27. Høyer-Hansen M, Bastholm L, Szyniarowski P, Campanella M, Szabadkai G, Farkas T, et al. Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. Mol Cell 2007; 25:193-205; PMID:17244528; http://dx.doi.org/10.1016/j.molcel.2006.12.009
28. Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132:27-42; PMID:18191218; http://dx.doi.org/10.1016/j.cell.2007.12.018
29. Elgendy M, Sheridan C, Brumatti G, Martin SJ. Oncogenic Ras-Induced Expression of Noxa and Beclin-1 Promotes Autophagic Cell Death and Limits Clonogenic Survival. Mol Cell.
30. Kihara A, Kabeya Y, Ohsumi Y, Yoshimori T. Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep 2001; 2:330-5; PMID:11306555; http://dx.doi.org/10.1093/emboreports/kve061
31. Zeng X, Overmeyer JH, Maltese WA. Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking. J Cell Sci 2006; 119:259-70; PMID:16390869; http://dx.doi.org/10.1242/jcs.02735
32. Ciechomska IA, Goemans GC, Skepper JN, Tolkovsky AM. Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function. Oncogene 2009; 28:2128-41; PMID: 19347031; http://dx.doi.org/10.1038/onc.2009.60
33. Maiuri MC, Criollo A, Tasdemir E, Vicencio JM, Tajeddine N, Hickman JA, et al. BH3-only proteins and BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin 1 and Bcl-2/ Bcl-X(L). Autophagy 2007; 3:374-6; PMID:17438366
34. Djavaheri-Mergny M, Maiuri MC, Kroemer G. Cross talk between apoptosis and autophagy by caspase-mediated cleavage of Beclin 1. Oncogene 2010; 29:1717-9; PMID:20101204; http://dx.doi.org/10.1038/onc.2009.519
35. Zhai D, Jin C, Huang Z, Satterthwait AC, Reed JC. Differential regulation of Bax and Bak by anti-apoptotic Bcl-2 family proteins Bcl-B and Mcl-1. J Biol Chem 2008; 283:9580-6; PMID:18178565; http://dx.doi.org/10.1074/jbc.M708426200
36. Inohara N, Gourley TS, Carrio R, Muñiz M, Merino J, Garcia I, et al. Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death. J Biol Chem 1998; 273:32479-86; PMID: 9829980; http://dx.doi.org/10.1074/jbc.273.49.32479
37. Kim JH, Yoon S, Won M, Sim SH, Ko JJ, Han S, et al. HIP1R interacts with a member of Bcl-2 family, BCL2L10, and induces BAK-dependent cell death. Cell Physiol Biochem 2009; 23:43-52; PMID:19255499; http://dx.doi.org/10.1159/ 000204088
38. Zhai D, Jin C, Satterthwait AC, Reed JC. Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins. Cell Death Differ 2006; 13:1419-21; PMID: 16645636; http://dx.doi.org/10.1038/sj.cdd.4401937