Ontogeny of taste preferences: Basic biology and implications for health1-5

American Journal of Clinical Nutrition

Volumn 99, Issue 3, 2014, Pages

  Mennella, Julie A ^a  

^a MONELL CHEMICAL SENSES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SODIUM CHLORIDE;

AMNION FLUID; ARTIFICIAL MILK; BITTER TASTE; BREAST MILK; CHILD NUTRITION; FACIAL EXPRESSION; FLAVOR; FRUIT; HUMAN; INFANCY; INFANT FEEDING; MATERNAL NUTRITION; NERVE CELL PLASTICITY; NONHUMAN; ONTOGENY; PERSONAL EXPERIENCE; REVIEW; SALTY TASTE; SMELL AND TASTE PARAMETERS; SWEETNESS; TASTE PREFERENCE; VEGETABLE;

ADULT; BREAST FEEDING; CHILD DEVELOPMENT; DIET; EVIDENCE-BASED MEDICINE; FEEDING METHODS; FEMALE; FETAL DEVELOPMENT; FOOD PREFERENCES; HEALTH PROMOTION; HUMANS; INFANT; INFANT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; INFANT, NEWBORN; MALE; MATERNAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; PARENTING; PREGNANCY; TASTE PERCEPTION;

EID: 84896811587     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.113.067694     Document Type: Review

References (114)

1. White House, Office of the First Lady. The First Lady Michele Obama launches "Let's Move": America's move to raise a healthier generation of kids. Version current 9 January 2014. Available from: http://www. whitehouse.gov/the-press-office/first-lady-michelle-obama-launches-lets-move- americas-move-raise-a-healthier-genera (cited 9 January 2014).
2. Gidding SS, Dennison BA, Birch LL, Daniels SR, Gillman MW, Lichtenstein AH, Rattay KT, Steinberger J, Stettler N, Van Horn L. Dietary recommendations for children and adolescents: a guide for practitioners: consensus statement from the American Heart Association. Circulation 2005;112:2061-75. (Pubitemid 41377427)
3. Lichtenstein AH, Appel LJ, Brands M, Carnethon M, Daniels S, Franch HA, Franklin B, Kris-Etherton P, Harris WS, Howard B, et al. Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation 2006;114:82-96. (Pubitemid 44305278)
4. US Department of Health and Human Services. Healthy People 2020: nutrition and weight status objectives. Washington, DC: US Department of Health and Human Services, 2010. Available from: www.healthypeople.gov/2020/ topicsobjectives2020/objectiveslist.aspx?topicid=29 (cited 9 January 2014).
5. Fox MK, Pac S, Devaney B, Jankowski L. Feeding infants and toddlers study: What foods are infants and toddlers eating? J Am Diet Assoc 2004;104:s22-30. (Pubitemid 40013714)
6. Mennella JA, Ziegler P, Briefel R, Novak T. Feeding Infants and Toddlers Study: the types of foods fed to Hispanic infants and toddlers. J Am Diet Assoc 2006;106:S96-106.
7. Siega-Riz AM, Deming DM, Reidy KC, Fox MK, Condon E, Briefel RR. Food consumption patterns of infants and toddlers: where are we now? J Am Diet Assoc 2010;110:S38-51.
8. Siega-Riz AM, Carson T, Popkin B. Three squares or mostly snacks - what do teens really eat? A sociodemographic study of meal patterns. J Adolesc Health 1998;22:29-36. (Pubitemid 28023028)
9. Nicklas TA, Demory-Luce D, Yang SJ, Baranowski T, Zakeri I, Berenson G. Children's food consumption patterns have changed over two decades (1973-1994): the Bogalusa Heart Study. J Am Diet Assoc 2004;104:1127-40. (Pubitemid 38802935)
10. Mannino ML, Lee Y, Mitchell DC, Smiciklas-Wright H, Birch LL. The quality of girls' diets declines and tracks across middle childhood. Int J Behav Nutr Phys Act 2004;1:5.
11. Schmidt M, Affenito SG, Striegel-Moore R, Khoury PR, Barton B, Crawford P, Kronsberg S, Schreiber G, Obarzanek E, Daniels S. Fastfood intake and diet quality in black and white girls: the National Heart, Lung, and Blood Institute Growth and Health Study. Arch Pediatr Adolesc Med 2005;159:626-31. (Pubitemid 41003083)
12. Mennella JA, Beauchamp GK. The role of early life experiences in flavor perception and delight. In: Dube L, Bechara A, Dagher A, Drewnowski A, LeBel J, James P, Richard D, Yada RY, eds. Obesity prevention: the role of society and brain on individual behavior. London, United Kingdom: Elsevier, 2010:203-18.
13. Trabulsi JC, Mennella JA. Diet, sensitive periods in flavour learning, and growth. Int Rev Psychiatry 2012;24:219-30.
14. Mennella JA, Ventura AK. Early feeding: setting the stage for healthy eating habits. Nestle Nutr Workshop Ser Pediatr Program 2011;68: 153-63; discussion 64-8.
15. Beauchamp GK, Mason JR. Comparative hedonics of taste. In: Bolles RC, ed. The hedonics of taste. Hillsdale, NJ: Lawrence Ealbaum Associates, Inc, 1991:159-83.
16. Glendinning JI. Is the bitter rejection response always adaptive? Physiol Behav 1994;56:1217-27. (Pubitemid 24374229)
17. Lindemann B. Taste reception. Physiol Rev 1996;76:718-66.
18. Glass TA, McAtee MJ. Behavioral science at the crossroads in public health: extending horizons, envisioning the future. Soc Sci Med 2006;62:1650-71. (Pubitemid 43243264)
19. Henney JE, Taylor CE, Boon CS. Strategies to reduce sodium intake in the United States. Washington, DC: Committee on Strategies to Reduce Sodium Intake; Institute of Medicine, 2010.
20. Gidding SS, Lichtenstein AH, Faith MS, Karpyn A, Mennella JA, Popkin B, Rowe J, Van Horn L, Whitsel L. Implementing American Heart Association pediatric and adult nutrition guidelines: a scientific statement from the American Heart Association Nutrition Committee of the Council on Nutrition, Physical Activity and Metabolism, Council on Cardiovascular Disease in the Young, Council on Arteriosclerosis, Thrombosis and Vascular Biology, Council on Cardiovascular Nursing, Council on Epidemiology and Prevention, and Council for High Blood Pressure Research. Circulation 2009;119:1161-75.
21. Ekelund U, Ong KK, Linne Y, Neovius M, Brage S, Dunger DB, Wareham NJ, Rossner S. Association of weight gain in infancy and early childhood with metabolic risk in young adults. J Clin Endocrinol Metab 2007;92:98-103. (Pubitemid 46067515)
22. Barker DJ. The developmental origins of adult disease. J Am Coll Nutr 2004;23:588S-95S. (Pubitemid 40096746)
23. Gluckman PD, Hanson MA. Developmental and epigenetic pathways to obesity: an evolutionary-developmental perspective. Int J Obes (Lond) 2008;32(suppl 7):S62-71.
24. Lucas A. The developmental origins of adult health and well-being. Adv Exp Med Biol 2005;569:13-5. (Pubitemid 43779602)
25. Roth T, Sweatt JD. Epigenetic mechanisms and enviromental shaping of the brain during sensitive periods of development. J Child Psychol Psychiatr 2011;52:398-408.
26. Mennella JA, Griffin CE, Beauchamp GK. Flavor programming during infancy. Pediatrics 2004;113:840-5. (Pubitemid 38437392)
27. Mennella JA, Castor SM. Sensitive period in flavor learning: effects of duration of exposure to formula flavors on food likes during infancy. Clin Nutr 2012;31:1022-5.
28. Mennella JA, Jagnow CP, Beauchamp GK. Prenatal and postnatal flavor learning by human infants. Pediatrics 2001;107:E88.
29. Mennella JA, Lukasewycz LD, Castor SM, Beauchamp GK. The timing and duration of a sensitive period in human flavor learning: a randomized trial. Am J Clin Nutr 2011;93:1019-24.
30. Mennella JA. The chemical senses and the development of flavor preferences in humans. In: Hale TW, Hartmann PE, eds. Textbook on human lactation. Amarillo, TX: Hale Publishing, 2007:403-14.
31. Skinner JD, Carruth BR, Wendy B, Ziegler PJ. Children's food preferences: a longitudinal analysis. J Am Diet Assoc 2002;102:1638-47. (Pubitemid 40434084)
32. Nicklaus S, Boggio V, Chabanet C, Issanchou S. A prospective study of food preferences in childhood. Food Qual Prefer 2004;15:805-18. (Pubitemid 39387049)
33. Singer MR, Moore LL, Garrahie EJ, Ellison RC. The tracking of nutrient intake in young children: the Framingham Children's Study. Am J Public Health 1995;85:1673-7. (Pubitemid 26002601)
34. Lioret S, McNaughton SA, Spence AC, Crawford D, Campbell KJ. Tracking of dietary intakes in early childhood: the Melbourne In-FANT Program. Eur J Clin Nutr 2013;67:275-81.
35. Northstone K, Emmett PM. Are dietary patterns stable throughout early and mid-childhood? A birth cohort study. Br J Nutr 2008;100:1069-76.
36. Kaikkonen JE, Mikkila V, Magnussen CG, Juonala M, Viikari JS, Raitakari OT. Does childhood nutrition influence adult cardiovascular disease risk? Insights from the Young Finns Study. Ann Med 2013;45:120-8.
37. Mikkilä V, Rasanen L, Raitakari OT, Pietinen P, Viikari J. Longitudinal changes in diet from childhood into adulthood with respect to risk of cardiovascular diseases: the Cardiovascular Risk in Young Finns Study. Eur J Clin Nutr 2004;58:1038-45. (Pubitemid 39077150)
38. Mikkilä V, Rasanen L, Raitakari OT, Marniemi J, Pietinen P, Ronnemaa T, Viikari J. Major dietary patterns and cardiovascular risk factors from childhood to adulthood: the Cardiovascular Risk in Young Finns Study. Br J Nutr 2007;98:218-25. (Pubitemid 47272168)
39. Lucas A. Programming by early nutrition: an experimental approach. J Nutr 1998;128(suppl):401S-6S. (Pubitemid 28090391)
40. Resnicow K, Smith M, Baranowski T, Baranowski J, Vaughan R, Davis M. 2-Year tracking of children's fruit and vegetable intake. J Am Diet Assoc 1998;98:785-9. (Pubitemid 28317483)
41. Skinner JD, Carruth BR, Bounds W, Ziegler P, Reidy K. Do food-related experiences in the first 2 years of life predict dietary variety in school-aged children? J Nutr Educ Behav 2002;34:310-5. (Pubitemid 36057186)
42. Cooke LJ, Wardle J, Gibson EL, Sapochnik M, Sheiham A, Lawson M. Demographic, familial and trait predictors of fruit and vegetable consumption by pre-school children. Public Health Nutr 2004;7:295-302. (Pubitemid 38419615)
43. Lioret S, Campbell KJ, Crawford D, Spence AC, Hesketh K, McNaughton SA. A parent focused child obesity prevention intervention improves some mother obesity risk behaviors: the Melbourne inFANT program. Int J Behav Nutr Phys Act 2012;9:100.
44. Wolfenden L, Wyse RJ, Britton BI, Campbell KJ, Hodder RK, Stacey FG, McElduff P, James EL. Interventions for increasing fruit and vegetable consumption in children aged 5 years and under. Cochrane Database Syst Rev 2012;11:CD008552.
45. Forestell CA, Mennella JA. The ontogeny of taste perception and preference throughout childhood. In: Doty RL, ed. Handbook of olfaction and gustation. 3rd ed. Wilmington, DE: John Wiley & Sons, 2013;823-46.
46. Sclafani A. Sweet taste signaling in the gut. Proc Natl Acad Sci USA 2007;104:14887-8. (Pubitemid 47619563)
47. Liedtke WB, McKinley MJ, Walker LL, Zhang H, Pfenning AR, Drago J, Hochendoner SJ, Hilton DL, Lawrence AJ, Denton DA. Relation of addiction genes to hypothalamic gene changes subserving genesis and gratification of a classic instinct, sodium appetite. Proc Natl Acad Sci USA 2011;108:12509-14.
48. Berridge KC. Pleasures of the brain. Brain Cogn 2003;52:106-28. (Pubitemid 36694049)
49. Steiner JE, Glaser D, Hawilo ME, Berridge KC. Comparative expression of hedonic impact: affective reactions to taste by human infants and other primates. Neurosci Biobehav Rev 2001;25:53-74. (Pubitemid 32098341)
50. Maone TR, Mattes RD, Bernbaum JC, Beauchamp GK. A new method for delivering a taste without fluids to preterm and term infants. Dev Psychobiol 1990;23:179-91. (Pubitemid 20338296)
51. Rosenstein D, Oster H. Differential facial responses to four basic tastes in newborns. Child Dev 1988;59:1555-68.
52. Maller O, Turner RE. Taste in acceptance of sugars by human infants. J Comp Physiol Psychol 1973;84:496-501.
53. Desor JA, Beauchamp GK. Longitudinal changes in sweet preferences in humans. Physiol Behav 1987;39:639-41.
54. Mennella JA. The sweet taste of childhood. In: Basbaum AI, Kaneko A, Shepherd CM, Westheimer G, eds. The senses: a comprehensive reference. Vol 4. Olfaction and taste. San Diego, CA: Academic Press, 2008:183-8.
55. Mennella JA, Lukasewycz LD, Griffith JW, Beauchamp GK. Evaluation of the Monell forced-choice, paired-comparison tracking procedure for determining sweet taste preferences across the lifespan. Chem Senses 2011;36:345-55.
56. Beauchamp GK, Moran M. Acceptance of sweet and salty tastes in 2-year-old children. Appetite 1984;5:291-305. (Pubitemid 15185579)
57. Pepino MY, Mennella JA. Sucrose-induced analgesia is related to sweet preferences in children but not adults. Pain 2005;119:210-8. (Pubitemid 41752981)
58. Mennella JA, Pepino MY, Reed DR. Genetic and environmental determinants of bitter perception and sweet preferences. Pediatrics 2005;115:e216-22. (Pubitemid 43193801)
59. Blass EM, Watt LB. Suckling- and sucrose-induced analgesia in human newborns. Pain 1999;83:611-23.
60. Harrison D, Stevens B, Bueno M, Yamada J, Adams-Webber T, Beyene J, Ohlsson A. Efficacy of sweet solutions for analgesia in infants between 1 and 12 months of age: a systematic review. Arch Dis Child 2010;95:406-13.
61. Miller A, Barr RG, Young SN. The cold pressor test in children: methodological aspects and the analgesic effect of intraoral sucrose. Pain 1994;56:175-83. (Pubitemid 24067846)
62. Mennella JA, Pepino MY, Lehmann-Castor SM, Yourshaw LM. Sweet preferences and analgesia during childhood: effects of family history of alcoholism and depression. Addiction 2010;105:666-75.
63. Beauchamp GK, Cowart BJ, Moran M. Developmental changes in salt acceptability in human infants. Dev Psychobiol 1986;19:17-25. (Pubitemid 17202552)
64. Bertino M, Beauchamp GK, Engelman K. Increasing dietary salt alters salt taste preference. Physiol Behav 1986;38:203-13. (Pubitemid 16028144)
65. Crystal SR, Bernstein IL. Morning sickness: impact on offspring salt preference. Appetite 1995;25:231-40. (Pubitemid 26031341)
66. Crystal SR, Bernstein IL. Infant salt preference and mother's morning sickness. Appetite 1998;30:297-307. (Pubitemid 28344684)
67. Stein LJ, Cowart BJ, Beauchamp GK. Salty taste acceptance by infants and young children is related to birth weight: longitudinal analysis of infants within the normal birth weight range. Eur J Clin Nutr 2006;60:272-9.
68. Kajiura H, Cowart BJ, Beauchamp GK. Early developmental change in bitter taste responses in human infants. Dev Psychobiol 1992;25:375-86.
69. Desor JA, Maller O, Andrews K. Ingestive responses of human newborns to salty, sour, and bitter stimuli. J Comp Physiol Psychol 1975;89:966-70.
70. Mangold JE, Hill DL. Extensive reorganization of primary afferent projections into the gustatory brainstem induced by feeding a sodium-restricted diet during development: less is more. J Neurosci 2007;27:4650-62. (Pubitemid 46663573)
71. Harder DB, Maggio JC, Whitney G. Assessing gustatory detection capabilities using preference procedures. Chem Senses 1989;14:547-64. (Pubitemid 19207232)
72. Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, Bufe B, Appendino G, Behrens M. The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 2010;35:157-70.
73. Lipchock SV, Mennella JA, Spielman AJ, Reed DR. Human bitter perception correlates with bitter receptor mRNA expression in taste cells. Am J Clin Nutr 2013;98:1136-43.
74. Mennella JA, Pepino MY, Duke FF, Reed DR. Age modifies the genotype-phenotype relationship for the bitter receptor TAS2R38. BMC Genet 2010;11:60.
75. Mennella JA, Pepino MY, Duke FF, Reed DR. Psychophysical dissection of genotype effects on human bitter perception. Chem Senses 2011;36:161-7.
76. Beauchamp GK, Cowart BJ. Congenital and experiential factors in the development of human flavor preferences. Appetite 1985;6:357-72.
77. Beauchamp GK, Moran M. Dietary experience and sweet taste preference in human infants. Appetite 1982;3:139-52. (Pubitemid 12024909)
78. Pepino MY, Mennella JA. Factors contributing to individual differences in sucrose preference. Chem Senses 2005;30(suppl 1):i319-20.
79. Liem DG, de Graaf C. Sweet and sour preferences in young children and adults: role of repeated exposure. Physiol Behav 2004;83:421-9. (Pubitemid 39586664)
80. Taras HL, Gage M. Advertised foods on children's television. Arch Pediatr Adolesc Med 1995;149:649-52.
81. Coon KA, Tucker KL. Television and children's consumption patterns: a review of the literature. Minerva Pediatr 2002;54:423-36.
82. Filer LJ. Studies of taste preference in infancy and childhood. Pediatric Basics 1978;12:5-9.
83. Ervin RB, Kit BK, Carroll MD, Ogden CL. Consumption of added sugar among U.S. children and adolescents, 2005-2008. NCHS Data Brief No. 87, 2012:1-8.
84. Mattes RD, Popkin BM. Nonnutritive sweetener consumption in humans: effects on appetite and food intake and their putative mechanisms. Am J Clin Nutr 2009;89:1-14.
85. Drewnowski A, Mennella JA, Johnson SL, Bellisle F. Sweetness and food preference. J Nutr 2012;142(suppl):1142S-8S.
86. Stein LJ, Cowart BJ, Beauchamp GK. The development of salty taste acceptance is related to dietary experience in human infants: a prospective study. Am J Clin Nutr 2012;95:123-9.
87. Harris G, Thomas A, Booth DA. Development of salt taste in infancy. Dev Psychol 1990;26:534-8.
88. Beauchamp GK, Engelman K. High salt intake: sensory and behavioral factors. Hypertension 1991;17:I176-81.
89. US Department of Health and Human Services; USDA; US Dietary Guidelines Advisory Committee. Dietary guidelines for Americans, 2010. 7th ed. Washington, DC: Government Printing Office, 2010.
90. Panel on Dietary Reference Intakes for Electrolytes and Water, Standing Committee on the Scientific Evaluation of Dietary Reference Intakes. Dietary Reference Intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: The National Academies Press, 2005. Available from: http://www.nap.edu/openbook.php?record-id=10925 (cited 9 January 2014).
91. Mattes RD, Donnelly D. Relative contributions of dietary sodium sources. J Am Coll Nutr 1991;10:383-93.
92. Institute of Medicine; Committee on Strategies to Reduce Sodium Intake; Food and Nutrition Board. In: Henney JE, Taylor CL, Boon CS, eds. Strategies to reduce sodium intake in the United States. Washington, DC: National Academic Press, 2010.
93. Provenza FD, Launchbauch KL. Foraging on the edge of chaos: grazing behavior of livestock and wildlife. In: Launchbaugh KL, Sanders KD, Mosley JC, eds. Grazing behavior of livestock and wildlife. Idaho Forest, Wildlife and Range Experiment Station, University of Iowa, Moscow, Idaho, 1999:1-12.
94. Todrank J, Heth G, Restrepo D. Effects of in utero odorant exposure on neuroanatomical development of the olfactory bulb and odour preferences. Proc Biol Sci 2011;278:1949-55.
95. Mennella JA, Beauchamp GK. Mothers' milk enhances the acceptance of cereal during weaning. Pediatr Res 1997;41:188-92. (Pubitemid 27066342)
96. Forestell CA, Mennella JA. Early determinants of fruit and vegetable acceptance. Pediatrics 2007;120:1247-54. (Pubitemid 350223675)
97. Galloway AT, Lee Y, Birch LL. Predictors and consequences of food neophobia and pickiness in young girls. J Am Diet Assoc 2003;103:692-8. (Pubitemid 38375906)
98. Mennella JA, Kennedy JM, Beauchamp GK. Vegetable acceptance by infants: effects of formula flavors. Early Hum Dev 2006;82:463-8. (Pubitemid 43963292)
99. Liem DG, Mennella JA. Sweet and sour preferences during childhood: role of early experiences. Dev Psychobiol 2002;41:388-95. (Pubitemid 35403403)
100. Mennella JA. The human infants' responses to vanilla flavors in human milk and formula. Infant Behav Dev 1996;19:13-9. (Pubitemid 126172680)
101. Mennella JA, Beauchamp GK. Flavor experiences during formula feeding are related to preferences during childhood. Early Hum Dev 2002;68:71-82. (Pubitemid 34756758)
102. Mennella JA, Forestell CA, Morgan LK, Beauchamp GK. Early milk feeding influences taste acceptance and liking during infancy. Am J Clin Nutr 2009;90:780S-8S.
103. Agostoni C, Carratu B, Boniglia C, Lammardo AM, Riva E, Sanzini E. Free glutamine and glutamic acid increase in human milk through a three-month lactation period. J Pediatr Gastroenterol Nutr 2000;31:508-12.
104. Grummer-Strawn LM, Scanlon KS, Fein SB. Infant feeding and feeding transitions during the first year of life. Pediatrics 2008;122(Suppl 2):S36-42.
105. Mennella JA, Ventura AK, Beauchamp GK. Differential growth patterns among healthy infants fed protein hydrolysate or cow-milk formulas. Pediatrics 2011;127:110-8.
106. Gerrish CJ, Mennella JA. Flavor variety enhances food acceptance in formula-fed infants. Am J Clin Nutr 2001;73:1080-5. (Pubitemid 32496948)
107. Mennella JA, Nicklaus S, Jagolino AL, Yourshaw LM. Variety is the spice of life: strategies for promoting fruit and vegetable acceptance during infancy. Physiol Behav 2008;94:29-38. (Pubitemid 351503583)
108. Birch LL, Gunder L, Grimm-Thomas K, Laing DG. Infants' consumption of a new food enhances acceptance of similar foods. Appetite 1998;30:283-95. (Pubitemid 28344683)
109. Lundy BFT, Carraway K, Hart S, Malphurs J, Rosenstein M, Pelaez-Nogueras M, Coletta F, Ott D, Hernandez-Reif M. Food texture preferences in infants versus toddlers. Early Child Dev Care 1998;146:69-85.
110. Caton SJ, Ahern SM, Remy E, Nicklaus S, Blundell P, Hetherington MM. Repetition counts: repeated exposure increases intake of a novel vegetable in UK pre-school children compared to flavour-flavour and flavour-nutrient learning. Br J Nutr 2013;109:2089-97.
111. Sullivan SA, Birch LL. Infant dietary experience and acceptance of solid foods. Pediatrics 1994;93:271-7. (Pubitemid 24047165)
112. Ong ZY, Muhlhausler BS. Maternal "junk-food" feeding of rat dams alters food choices and development of the mesolimbic reward pathway in the offspring. FASEB J 2011;25:2167-79.
113. Bayol SA, Macharia R, Farrington SJ, Simbi BH, Stickland NC. Evidence that a maternal "junk food" diet during pregnancy and lactation can reduce muscle force in offspring. Eur J Nutr 2009;48:62-5.
114. Korthals M. Coevolution of nutrigenomics and society: ethical considerations. Am J Clin Nutr 2011;94(suppl):2025S-9S.