Efficacy of sweet solutions for analgesia in infants between 1 and 12 months of age: A systematic review

Archives of Disease in Childhood

Volumn 95, Issue 6, 2010, Pages 406-413

  Harrison, Denise ^a,b,c   Stevens, Bonnie ^a,b   Bueno, Mariana ^b,d   Yamada, Janet ^a,b   Adams Webber, Thomasin ^a   Beyene, Joseph ^a,b   Ohlsson, Arne ^b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c ROYAL CHILDREN'S HOSPITAL   (Australia)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; HYDROCORTISONE; PLACEBO; SUCROSE; WATER;

ANALGESIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CRYING; DRUG EFFICACY; HEART RATE; HEART RATE VARIABILITY; HUMAN; IMMUNIZATION; INFANT; META ANALYSIS; PAIN ASSESSMENT; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REVIEW; SYSTEMATIC REVIEW;

ANALGESIA; CRYING; GLUCOSE; HUMANS; IMMUNIZATION; INFANT; PAIN; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SUCROSE;

EID: 77953715790     PISSN: 00039888     EISSN: 14682044     Source Type: Journal    
DOI: 10.1136/adc.2009.174227     Document Type: Review

References (44)

1. Stevens B, Yamada J, Ohlsson A. Sucrose for analgesia in newborn infants undergoing painful procedures. Cochrane Database Syst Rev 2004;3:CD001069.
2. Tsao JCI, Evans S, Meldrum M, et al. A Review of CAM for Procedural Pain in Infancy: Part I. Sucrose and Non-nutritive Sucking. Evid Based Complement Alternat Med 2008;5:371-81.
3. American Academy of Pediatrics, Committee on Psychosocial Aspects of Child and Family Health, Task Force on Pain in Infants Children and Adolescents. The assessment and management of acute pain in infants, children, and adolescents. Pediatrics 2001;108:793-7.
4. Anand KJ; International Evidence-Based Group for Neonatal Pain. Consensus statement for the prevention and management of pain in the newborn. Arch Pediatr Adolesc Med 2001;155:173-80.
5. Royal Australasian College of Physicians. Guideline Statement: Management of Procedure-related Pain in Neonates. Sydney: Paediatrics & Child Health Division, The Royal Australasian College of Physicians; 2005. http://www.racp.edu.au/page/health-policy-and-advocacy/paediatrics-and-child- health (accessed 19 January 2010).
6. Harrison D, Australian College of Neonatal Nurses. Management of pain in sick hospitalised infants. Neonat Paediatr Child Health Nurs 2006;9:27-9.
7. Henderson-Smart D, Australian & New Zealand Neonatal Network. Evidence Uptake Using Networks - Newborn Pain project. Sydney: National Institute of Clinical Studies, National Health & Medical Research Council. 2007
8. Harrison D. Oral sucrose for pain management in the paediatric emergency department; a review. Australa Emerg Nurs J 2008;11:72-9.
9. Higgins JPT, Green S (eds). Cochrane Handbook for Systematic Reviews of Interventions Version 5.0.1 [updated September 2008]. The Cochrane Collaboration, 2008. http://www.cochrane-handbook.org (accessed 6 April 2010).
10. The Nordic Cochrane Centre The Cochrane Collaboration. Review Manager (RevMan) 5.0 ed. Copenhagen; 2008.
11. Allen KD, White DD, Walburn JN. Sucrose as an analgesic agent for infants during immunization injections. Arch Pediatr Adolesc Med 1996;150:270-4.
12. Barr RG, Young SN, Wright JH, et al. "Sucrose analgesia" and diphtheria-tetanuspertussis immunizations at 2 and 4 months. J Dev Behav Pediatr 1995;16:220-5.
13. Dilli D, Küçük IG, Dallar Y. Interventions to reduce pain during vaccination in infancy. J Pediatr 2009;154:385-90.
14. Hatfield LA. Sucrose decreases infant biobehavioral pain response to immunizations: a randomized controlled trial. J Nurs Scholarsh 2008;40:219-25.
15. Hatfield LA, Gusic ME, Dyer AM, et al. Analgesic properties of oral sucrose during routine immunizations at 2 and 4 months of age. Pediatrics 2008;121:e327-34.
16. Lewindon PJ, Harkness L, Lewindon N. Randomised controlled trial of sucrose by mouth for the relief of infant crying after immunisation. Arch Dis Child 1998;78:453-6. (Pubitemid 28237387)
17. Lindh V, Wiklund U, Blomquist HK, et al. EMLA cream and oral glucose for immunization pain in 3-month-old infants. Pain 2003;104:381-8. (Pubitemid 36835906)
18. Mörelius E, Theodorsson E, Nelson N. Stress at three-month immunization: parents' and infants' salivary cortisol response in relation to the use of pacifier and oral glucose. Eur J Pain 2009;13:202-8.
19. Mowery B. Effects of sucrose on immunization injection pain in Hispanic infants. Unpublished thesis. Virginia: University of Virginia; 2007.
20. Poulsen M. Cane sugar unsuitable for use as analgesic in paediatric vaccination. Sygeplejersken/Danish Journal of Nursing 2009;106:54-7.
21. Ramenghi LA, Webb AV, Shevlin PM, et al. Intra-oral administration of sweettasting substances and infants' crying response to immunization: a randomized, placebo-controlled trial. Biol Neonate 2002;81:163-9.
22. Reis EC, Roth EK, Syphan JL, et al. Effective pain reduction for multiple immunization injections in young infants. Arch Pediatr Adolesc Med 2003;157:1115-20.
23. Soriano Faura J, Gomez Gil A. Controlled clinical study of sucrose administration to reduce the duration of crying in infants undergoing vaccination. Acta Pediatrica Espanola. 2003 May;61(5):234-8. (Pubitemid 36702369)
24. Thyr M, Sundholm A, Teeland L, et al. Oral glucose as an analgesic to reduce infant distress following immunization at the age of 3, 5 and 12 months. Acta Paediatr 2007;96:233-6. (Pubitemid 46307340)
25. Morelius E, Nelson N, Theodorsson E. Salivary cortisol and administration of concentrated oral glucose in newborn infants: improved detection limit and smaller sample volumes without glucose interference. Scand J Clin Lab Invest 2004;64:113-8. (Pubitemid 38491381)
26. Curtis SJ, Jou H, Ali S, et al. A randomized controlled trial of sucrose and/or pacifier as analgesia for infants receiving venipuncture in a pediatric emergency department. BMC Pediatr 2007;7:27. (Pubitemid 47322202)
27. Rogers AJ, Greenwald MH, Deguzman MA, et al. A randomized, controlled trial of sucrose analgesia in infants younger than 90 days of age who require bladder catheterization in the pediatric emergency department. Acad Emerg Med 2006;13:617-22.
28. Blass E, Fitzgerald E, Kehoe P. Interactions between sucrose, pain and isolation distress. Pharmacol Biochem Behav 1987;26:483-9. (Pubitemid 17047718)
29. Blass EM, Shah A. Pain-reducing properties of sucrose in human newborns. Chem Senses 1995;20:29-35.
30. Barr RG, Quek VS, Cousineau D, et al. Effects of intra-oral sucrose on crying, mouthing and hand-mouth contact in newborn and six-week-old infants. Dev Med Child Neurol 1994;36:608-18. (Pubitemid 24182767)
31. Harrison D, Loughnan P, Manias E, et al. Repeated doses of sucrose in infants continue to reduce procedural pain during prolonged hospitalizations. Nurs Res 2009;58:427-34.
32. Harrison D, Johnston L, Loughnan P. Oral sucrose for procedural pain in sick hospitalized infants: a randomized-controlled trial. J Paediatr Child Health 2003;39:591-7. (Pubitemid 37463941)
33. Johnston CC, Stremler R, Horton L, et al. Effect of repeated doses of sucrose during heel stick procedure in preterm neonates. Biol Neonate 1999;75:160-6. (Pubitemid 29067299)
34. Ramenghi LA, Griffith GC, Wood CM, et al. Effect of non-sucrose sweet tasting solution on neonatal heel prick responses. Arch Dis Child Fetal Neonatal Ed 1996;74:F129-31.
35. Blass EM, Smith BA. Differential effects of sucrose, fructose, glucose, and lactose on crying in 1- to 3-day-old human infants: qualitative and quantitative considerations. Dev Psychol 1992;28:804-10.
36. Lawrence J, Alcock D, McGrath P, et al. The development of a tool to assess neonatal pain. Neonatal Netw 1993;12:59-66.
37. Soetenga D, Frank J, Pellino TA. Assessment of the validity and reliability of the University of Wisconsin Children's Hospital Pain scale for Preverbal and Nonverbal Children. Pediatr Nurs 1999;25:670-6.
38. Duhn LJ, Medves JM. A systematic integrative review of infant pain assessment tools. Adv Neonatal Care 2004;4:126-40.
39. Taddio A, Nulman I, Koren BS, et al. A revised measure of acute pain in infants. J Pain Symptom Manage 1995;10:456-63.
40. Beyer JE, Denyes MJ, Villarruel AM. The creation, validation, and continuing development of the Oucher: a measure of pain intensity in children. J Pediatr Nurs 1992;7:335-46.
41. Stinson J, Yamada J, Dickson A, et al. Review of systematic reviews on acute procedural pain in children in the hospital setting. Pain Res Manag 2008;13:51-7. (Pubitemid 351513875)
42. Ipp M, Cohen E, Goldbach M, et al. Effect of choice of measles-mumps-rubella vaccine on immediate vaccination pain in infants. Arch Pediatr Adolesc Med 2004;158:323-6. (Pubitemid 38451557)
43. Ipp M, Taddio A, Sam J, et al. Vaccine-related pain: randomised controlled trial of two injection techniques. Arch Dis Child 2007;92:1105-8. (Pubitemid 350221456)
44. Uman LS, Chambers CT, McGrath PJ, et al. Psychological interventions for needle-related procedural pain and distress in children and adolescents. Cochrane Database Syst Rev. 2006;4:CD005179.