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Volumn 14, Issue 4-5, 2014, Pages 412-425

The roles of extracellular vesicles in cancer biology: Toward the development of novel cancer biomarkers

Author keywords

Biomarker; Biomedicine; Cancer; Diagnosis; Exosome; Microvesicle

Indexed keywords

TUMOR MARKER;

EID: 84896777949     PISSN: 16159853     EISSN: 16159861     Source Type: Journal    
DOI: 10.1002/pmic.201300389     Document Type: Review
Times cited : (132)

References (144)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan, D., Weinberg, R. A., The hallmarks of cancer. Cell 2000, 100, 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 77952568396 scopus 로고    scopus 로고
    • Hallmarks of cancer: interactions with the tumor stroma
    • Pietras, K., Ostman, A., Hallmarks of cancer: interactions with the tumor stroma. Exp. Cell Res. 2010, 316, 1324-1331.
    • (2010) Exp. Cell Res. , vol.316 , pp. 1324-1331
    • Pietras, K.1    Ostman, A.2
  • 3
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan, D., Weinberg, R. A., Hallmarks of cancer: the next generation. Cell 2011, 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 4
    • 84949934993 scopus 로고    scopus 로고
    • As we wait: coping with an imperfect nomenclature for extracellular vesicles
    • Gould, S. J., Raposo, G., As we wait: coping with an imperfect nomenclature for extracellular vesicles. J. Extracell. Vesicles 2013, 2, 20389.
    • (2013) J. Extracell. Vesicles , vol.2 , pp. 20389
    • Gould, S.J.1    Raposo, G.2
  • 5
    • 0014332027 scopus 로고
    • An electronmicroscope study of themegacaryocyte of the rat bone marrow. I. The development of the demarcationmembrane system and the platelet surface coat
    • Behnke, O., An electronmicroscope study of themegacaryocyte of the rat bone marrow. I. The development of the demarcationmembrane system and the platelet surface coat. J. Ultrastruct. Res. 1968, 24, 412-433.
    • (1968) J. Ultrastruct. Res. , vol.24 , pp. 412-433
    • Behnke, O.1
  • 6
    • 79960096964 scopus 로고    scopus 로고
    • Exosomes: secreted vesicles and intercellular communications
    • Théry, C., Exosomes: secreted vesicles and intercellular communications. F1000 Biol. Rep. 2011, 3, 15.
    • (2011) F1000 Biol. Rep. , vol.3 , pp. 15
    • Théry, C.1
  • 7
    • 0020804037 scopus 로고
    • Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes
    • Harding, C., Heuser, J., Stahl, P., Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes. J. Cell Biol. 1983, 97, 329-339.
    • (1983) J. Cell Biol. , vol.97 , pp. 329-339
    • Harding, C.1    Heuser, J.2    Stahl, P.3
  • 8
    • 0020956787 scopus 로고
    • Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor
    • Pan, B. T., Johnstone, R. M., Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell 1983, 33, 967-978.
    • (1983) Cell , vol.33 , pp. 967-978
    • Pan, B.T.1    Johnstone, R.M.2
  • 9
    • 84874354368 scopus 로고    scopus 로고
    • Exosomes: looking back three decades and into the future
    • Harding, C. V., Heuser, J. E., Stahl, P. D., Exosomes: looking back three decades and into the future. J. Cell Biol. 2013, 200, 367-371.
    • (2013) J. Cell Biol. , vol.200 , pp. 367-371
    • Harding, C.V.1    Heuser, J.E.2    Stahl, P.D.3
  • 11
    • 0031863853 scopus 로고    scopus 로고
    • Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes
    • Zitvogel, L., Regnault, A., Lozier, A., Wolfers, J. et al., Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes. Nat. Med. 1998, 4, 594-600.
    • (1998) Nat. Med. , vol.4 , pp. 594-600
    • Zitvogel, L.1    Regnault, A.2    Lozier, A.3    Wolfers, J.4
  • 12
    • 43049139913 scopus 로고    scopus 로고
    • Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
    • Al-Nedawi, K., Meehan, B., Micallef, J., Lhotak, V. et al., Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat. Cell Biol. 2008, 10, 619-624.
    • (2008) Nat. Cell Biol. , vol.10 , pp. 619-624
    • Al-Nedawi, K.1    Meehan, B.2    Micallef, J.3    Lhotak, V.4
  • 13
    • 84862007577 scopus 로고    scopus 로고
    • Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
    • Peinado, H., Alečković, M., Lavotshkin, S., Matei, I. et al., Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat. Med. 2012, 18, 883-891.
    • (2012) Nat. Med. , vol.18 , pp. 883-891
    • Peinado, H.1    Alečković, M.2    Lavotshkin, S.3    Matei, I.4
  • 14
    • 0036172425 scopus 로고    scopus 로고
    • Shedding of the matrix metalloproteinases MMP-2, MMP-9, and MT1-MMP as membrane vesicle-associated components by endothelial cells
    • Taraboletti, G., D'Ascenzo, S., Borsotti, P., Giavazzi, R. et al., Shedding of the matrix metalloproteinases MMP-2, MMP-9, and MT1-MMP as membrane vesicle-associated components by endothelial cells. Am. J. Pathol. 2002, 160, 673-680.
    • (2002) Am. J. Pathol. , vol.160 , pp. 673-680
    • Taraboletti, G.1    D'Ascenzo, S.2    Borsotti, P.3    Giavazzi, R.4
  • 15
    • 57149087260 scopus 로고    scopus 로고
    • Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes
    • Hakulinen, J., Sankkila, L., Sugiyama, N., Lehti, K., Keski-Oja, J., Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes. J. Cell Biochem. 2008, 105, 1211-1228
    • (2008) J. Cell Biochem. , vol.105 , pp. 1211-1228
    • Hakulinen, J.1    Sankkila, L.2    Sugiyama, N.3    Lehti, K.4    Keski-Oja, J.5
  • 16
    • 84873688339 scopus 로고    scopus 로고
    • Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes
    • Katsuda, T., Tsuchiya, R., Kosaka, N., Yoshioka, Y. et al., Human adipose tissue-derived mesenchymal stem cells secrete functional neprilysin-bound exosomes. Sci. Rep. 2013, 3, 1197.
    • (2013) Sci. Rep. , vol.3 , pp. 1197
    • Katsuda, T.1    Tsuchiya, R.2    Kosaka, N.3    Yoshioka, Y.4
  • 17
    • 77957195392 scopus 로고    scopus 로고
    • Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling
    • Chairoungdua, A., Smith, D. L., Pochard, P., Hull, M., Caplan, M. J., Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling. J. Cell Biol. 2010, 190, 1079-1091.
    • (2010) J. Cell Biol. , vol.190 , pp. 1079-1091
    • Chairoungdua, A.1    Smith, D.L.2    Pochard, P.3    Hull, M.4    Caplan, M.J.5
  • 18
    • 79957925099 scopus 로고    scopus 로고
    • LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation
    • Verweij, F. J., van Eijndhoven, M. A., Hopmans, E. S., Vendrig, T. et al. LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation. EMBO J. 2011, 30, 2115-2129.
    • (2011) EMBO J. , vol.30 , pp. 2115-2129
    • Verweij, F.J.1    van Eijndhoven, M.A.2    Hopmans, E.S.3    Vendrig, T.4
  • 19
    • 33646146422 scopus 로고    scopus 로고
    • Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery
    • Ratajczak, J., Miekus, K., Kucia, M., Zhang, J. et al., Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia 2006, 20, 847-856.
    • (2006) Leukemia , vol.20 , pp. 847-856
    • Ratajczak, J.1    Miekus, K.2    Kucia, M.3    Zhang, J.4
  • 20
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M. et al., Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 2007, 9, 654-659.
    • (2007) Nat. Cell Biol. , vol.9 , pp. 654-659
    • Valadi, H.1    Ekström, K.2    Bossios, A.3    Sjöstrand, M.4
  • 22
    • 77954257796 scopus 로고    scopus 로고
    • Secreted monocytic miR-150 enhances targeted endothelial cell migration
    • Zhang, Y., Liu, D., Chen, X., Li, J. et al., Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol. Cell. 2010, 39, 133-144.
    • (2010) Mol. Cell. , vol.39 , pp. 133-144
    • Zhang, Y.1    Liu, D.2    Chen, X.3    Li, J.4
  • 23
    • 77952920881 scopus 로고    scopus 로고
    • Secretory mechanisms and intercellular transfer of microRNAs in living cells
    • Kosaka, N., Iguchi, H., Yoshioka, Y., Takeshita, F. et al., Secretory mechanisms and intercellular transfer of microRNAs in living cells. J. Biol. Chem. 2010, 285, 17442-17452.
    • (2010) J. Biol. Chem. , vol.285 , pp. 17442-17452
    • Kosaka, N.1    Iguchi, H.2    Yoshioka, Y.3    Takeshita, F.4
  • 25
    • 84878665716 scopus 로고    scopus 로고
    • The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles
    • Katsuda, T., Kosaka, N., Takeshita, F., Ochiya, T., The therapeutic potential of mesenchymal stem cell-derived extracellular vesicles. Proteomics 2013, 13, 1637-1653.
    • (2013) Proteomics , vol.13 , pp. 1637-1653
    • Katsuda, T.1    Kosaka, N.2    Takeshita, F.3    Ochiya, T.4
  • 26
    • 74049102373 scopus 로고    scopus 로고
    • Human villous trophoblasts express and secrete placenta-specific microRNAs into maternal circulation via exosomes
    • Luo, S. S., Ishibashi, O., Ishikawa, G., Ishikawa, T. et al., Human villous trophoblasts express and secrete placenta-specific microRNAs into maternal circulation via exosomes. Biol. Reprod. 2009, 81, 717-729.
    • (2009) Biol. Reprod. , vol.81 , pp. 717-729
    • Luo, S.S.1    Ishibashi, O.2    Ishikawa, G.3    Ishikawa, T.4
  • 27
    • 77957037314 scopus 로고    scopus 로고
    • microRNA as a new immune-regulatory agent in breast milk
    • Kosaka, N., Izumi, H., Sekine, K., Ochiya, T., microRNA as a new immune-regulatory agent in breast milk. Silence 2010, 1, 7.
    • (2010) Silence , vol.1 , pp. 7
    • Kosaka, N.1    Izumi, H.2    Sekine, K.3    Ochiya, T.4
  • 28
    • 20244390010 scopus 로고    scopus 로고
    • Cleavage of L1 in exosomes and apoptotic membrane vesicles released from ovarian carcinoma cells
    • Gutwein, P., Stoeck, A., Riedle, S., Gast, D. et al., Cleavage of L1 in exosomes and apoptotic membrane vesicles released from ovarian carcinoma cells. Clin. Cancer Res. 2005, 11, 2492-2501.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 2492-2501
    • Gutwein, P.1    Stoeck, A.2    Riedle, S.3    Gast, D.4
  • 29
    • 2442676505 scopus 로고    scopus 로고
    • Predominant expression of mutant EGFR (EGFRvIII) is rare in primary glioblastomas
    • Biernat, W., Huang, H., Yokoo, H., Kleihues, P., Ohgaki, H., Predominant expression of mutant EGFR (EGFRvIII) is rare in primary glioblastomas. Brain Pathol. 2004, 14, 131-136.
    • (2004) Brain Pathol , vol.14 , pp. 131-136
    • Biernat, W.1    Huang, H.2    Yokoo, H.3    Kleihues, P.4    Ohgaki, H.5
  • 32
    • 2942716692 scopus 로고    scopus 로고
    • Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness
    • Eustace, B. K., Sakurai, T., Stewart, J. K., Yimlamai, D. et al., Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness. Nat. Cell Biol. 2004, 6, 507-514.
    • (2004) Nat. Cell Biol. , vol.6 , pp. 507-514
    • Eustace, B.K.1    Sakurai, T.2    Stewart, J.K.3    Yimlamai, D.4
  • 33
    • 77953481684 scopus 로고    scopus 로고
    • Secretion of extracellular hsp90alpha via exosomes increases cancer cell motility: a role for plasminogen activation
    • McCready, J., Sims, J. D., Chan, D., Jay, D. G., Secretion of extracellular hsp90alpha via exosomes increases cancer cell motility: a role for plasminogen activation. BMC Cancer 2010, 10, 294.
    • (2010) BMC Cancer , vol.10 , pp. 294
    • McCready, J.1    Sims, J.D.2    Chan, D.3    Jay, D.G.4
  • 34
    • 57049103401 scopus 로고    scopus 로고
    • Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers
    • Skog, J., Würdinger, T., van Rijn, S., Meijer, D. H. et al., Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat. Cell Biol. 2008, 10, 1470-1476.
    • (2008) Nat. Cell Biol. , vol.10 , pp. 1470-1476
    • Skog, J.1    Würdinger, T.2    van Rijn, S.3    Meijer, D.H.4
  • 35
    • 80053309537 scopus 로고    scopus 로고
    • Intercellular nanovesicle-mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth
    • Kogure, T., Lin, W. L., Yan, I. K., Braconi, C., Patel, T., Intercellular nanovesicle-mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth. Hepatology 2011, 54, 1237-1248.
    • (2011) Hepatology , vol.54 , pp. 1237-1248
    • Kogure, T.1    Lin, W.L.2    Yan, I.K.3    Braconi, C.4    Patel, T.5
  • 36
    • 0036852241 scopus 로고    scopus 로고
    • Cancer immunoediting: from immuno-surveillance to tumor escape
    • Dunn, G. P., Bruce, A. T., Ikeda, H., Old, L. J., Schreiber, R. D., Cancer immunoediting: from immuno-surveillance to tumor escape. Nat. Immunol. 2002, 3, 991-998.
    • (2002) Nat. Immunol. , vol.3 , pp. 991-998
    • Dunn, G.P.1    Bruce, A.T.2    Ikeda, H.3    Old, L.J.4    Schreiber, R.D.5
  • 38
    • 20244373139 scopus 로고    scopus 로고
    • Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming
    • Wolfers, J., Lozier, A., Raposo, G., Regnault, A. et al., Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat. Med. 2001, 7, 297-303.
    • (2001) Nat. Med. , vol.7 , pp. 297-303
    • Wolfers, J.1    Lozier, A.2    Raposo, G.3    Regnault, A.4
  • 39
    • 27144529107 scopus 로고    scopus 로고
    • More efficient induction of HLA-A*0201-restricted and carcinoembryonic antigen (CEA)-specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumor cells
    • Dai, S., Wan, T., Wang, B., Zhou, X. et al., More efficient induction of HLA-A*0201-restricted and carcinoembryonic antigen (CEA)-specific CTL response by immunization with exosomes prepared from heat-stressed CEA-positive tumor cells. Clin. Cancer Res. 2005, 11, 7554-7563.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 7554-7563
    • Dai, S.1    Wan, T.2    Wang, B.3    Zhou, X.4
  • 40
    • 35848941965 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes stimulate stronger CD8+ CTL responses and antitumor immunity than tumor cell-derived exosomes
    • Hao, S., Bai, O., Yuan, J., Qureshi, M., Xiang, J., Dendritic cell-derived exosomes stimulate stronger CD8+ CTL responses and antitumor immunity than tumor cell-derived exosomes. Cell. Mol. Immunol. 2006, 3, 205-211.
    • (2006) Cell. Mol. Immunol. , vol.3 , pp. 205-211
    • Hao, S.1    Bai, O.2    Yuan, J.3    Qureshi, M.4    Xiang, J.5
  • 41
    • 33845677330 scopus 로고    scopus 로고
    • Mature dendritic cells pulsed with exosomes stimulate efficient cytotoxic T-lymphocyte responses and antitumour immunity
    • Hao, S., Bai, O., Li, F., Yuan, J. et al., Mature dendritic cells pulsed with exosomes stimulate efficient cytotoxic T-lymphocyte responses and antitumour immunity. Immunology 2007, 120, 90-102.
    • (2007) Immunology , vol.120 , pp. 90-102
    • Hao, S.1    Bai, O.2    Li, F.3    Yuan, J.4
  • 42
    • 39449101177 scopus 로고    scopus 로고
    • Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses
    • Zeelenberg, I. S., Ostrowski, M., Krumeich, S., Bobrie, A. et al., Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses. Cancer Res. 2008, 68, 1228-1235.
    • (2008) Cancer Res. , vol.68 , pp. 1228-1235
    • Zeelenberg, I.S.1    Ostrowski, M.2    Krumeich, S.3    Bobrie, A.4
  • 43
    • 20444431560 scopus 로고    scopus 로고
    • Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells
    • Gastpar, R., Gehrmann, M., Bausero, M. A., Asea, A. et al., Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells. Cancer Res. 2005, 65, 5238-5247.
    • (2005) Cancer Res. , vol.65 , pp. 5238-5247
    • Gastpar, R.1    Gehrmann, M.2    Bausero, M.A.3    Asea, A.4
  • 44
    • 0037141153 scopus 로고    scopus 로고
    • Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles
    • Andreola, G., Rivoltini, L., Castelli, C., Huber, V. et al., Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles. J. Exp. Med. 2002, 195, 1303-1316.
    • (2002) J. Exp. Med. , vol.195 , pp. 1303-1316
    • Andreola, G.1    Rivoltini, L.2    Castelli, C.3    Huber, V.4
  • 45
    • 24644524011 scopus 로고    scopus 로고
    • Tumor exosomes expressing Fas ligand mediate CD8 +T-cell apoptosis
    • Abusamra, A. J., Zhong, Z., Zheng, X., Li, M. et al., Tumor exosomes expressing Fas ligand mediate CD8 +T-cell apoptosis. Blood Cells Mol. Dis. 2005, 35, 169-173.
    • (2005) Blood Cells Mol. Dis. , vol.35 , pp. 169-173
    • Abusamra, A.J.1    Zhong, Z.2    Zheng, X.3    Li, M.4
  • 46
    • 12944329896 scopus 로고    scopus 로고
    • Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes
    • Kim, J. W., Wieckowski, E., Taylor, D. D., Reichert, T. E. et al., Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes. Clin. Cancer Res. 2005, 11, 1010-1020.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 1010-1020
    • Kim, J.W.1    Wieckowski, E.2    Taylor, D.D.3    Reichert, T.E.4
  • 47
    • 31144451576 scopus 로고    scopus 로고
    • Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function
    • Liu, C., Yu, S., Zinn, K., Wang, J. et al., Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function. J. Immunol. 2006, 176, 1375-1385.
    • (2006) J. Immunol. , vol.176 , pp. 1375-1385
    • Liu, C.1    Yu, S.2    Zinn, K.3    Wang, J.4
  • 48
    • 34547686145 scopus 로고    scopus 로고
    • Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2. Responses to interleukin-2
    • Clayton, A., Mitchell, J. P., Court, J., Mason, M. D., Tabi, Z., Human tumor-derived exosomes selectively impair lymphocyte responses to interleukin-2. Responses to interleukin-2. Cancer Res. 2007, 67, 7458-7466.
    • (2007) Cancer Res. , vol.67 , pp. 7458-7466
    • Clayton, A.1    Mitchell, J.P.2    Court, J.3    Mason, M.D.4    Tabi, Z.5
  • 49
    • 76549099879 scopus 로고    scopus 로고
    • Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes
    • Ashiru, O., Boutet, P., Fernández-Messina, L., Agüera-González, S. et al., Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes. Cancer Res. 2010, 70, 481-489.
    • (2010) Cancer Res. , vol.70 , pp. 481-489
    • Ashiru, O.1    Boutet, P.2    Fernández-Messina, L.3    Agüera-González, S.4
  • 50
    • 80052384534 scopus 로고    scopus 로고
    • Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor-beta1
    • Szczepanski, M. J., Szajnik, M., Welsh, A., Whiteside, T. L., Boyiadzis, M., Blast-derived microvesicles in sera from patients with acute myeloid leukemia suppress natural killer cell function via membrane-associated transforming growth factor-beta1. Haematologica 2011, 96, 1302-1309.
    • (2011) Haematologica , vol.96 , pp. 1302-1309
    • Szczepanski, M.J.1    Szajnik, M.2    Welsh, A.3    Whiteside, T.L.4    Boyiadzis, M.5
  • 51
    • 64249115813 scopus 로고    scopus 로고
    • Induction of myeloid-derived suppressor cells by tumor exosomes
    • Xiang, X., Poliakov, A., Liu, C., Liu, Y. et al., Induction of myeloid-derived suppressor cells by tumor exosomes. Int. J. Cancer. 2009, 124, 2621-2633.
    • (2009) Int. J. Cancer , vol.124 , pp. 2621-2633
    • Xiang, X.1    Poliakov, A.2    Liu, C.3    Liu, Y.4
  • 52
    • 76649097628 scopus 로고    scopus 로고
    • Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells
    • Chalmin, F., Ladoire, S., Mignot, G., Vincent, J. et al., Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells. J. Clin. Invest. 2010, 120, 457-471.
    • (2010) J. Clin. Invest , vol.120 , pp. 457-471
    • Chalmin, F.1    Ladoire, S.2    Mignot, G.3    Vincent, J.4
  • 53
    • 77952042113 scopus 로고    scopus 로고
    • Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells
    • Liu, Y., Xiang, X., Zhuang, X., Zhang, S. et al., Contribution of MyD88 to the tumor exosome-mediated induction of myeloid derived suppressor cells. Am. J. Pathol. 2010, 176, 2490-2499.
    • (2010) Am. J. Pathol. , vol.176 , pp. 2490-2499
    • Liu, Y.1    Xiang, X.2    Zhuang, X.3    Zhang, S.4
  • 54
    • 77955406553 scopus 로고    scopus 로고
    • Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg)
    • Szajnik, M., Czystowska, M., Szczepanski, M. J., Mandapathil, M., Whiteside, T. L., Tumor-derived microvesicles induce, expand and up-regulate biological activities of human regulatory T cells (Treg). PLoS One 2010, 5, e11469.
    • (2010) PLoS One , vol.5
    • Szajnik, M.1    Czystowska, M.2    Szczepanski, M.J.3    Mandapathil, M.4    Whiteside, T.L.5
  • 55
    • 85013312416 scopus 로고
    • Tumor angiogenesis: therapeutic implications
    • Folkman, J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 1971, 285, 1182-1186.
    • (1971) N. Engl. J. Med. , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 56
    • 0023157363 scopus 로고
    • Angiogenic factors
    • Folkman, J., Klagsbrun, M. Angiogenic factors. Science 1987, 235, 442-447.
    • (1987) Science , vol.235 , pp. 442-447
    • Folkman, J.1    Klagsbrun, M.2
  • 57
    • 51649123760 scopus 로고    scopus 로고
    • A review of Judah Folkman's remarkable achievements in biomedicine
    • Cao, Y., Langer, R. A review of Judah Folkman's remarkable achievements in biomedicine. Proc. Natl. Acad. Sci. USA 2008, 105, 13203-13205.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 13203-13205
    • Cao, Y.1    Langer, R.2
  • 58
    • 33746886963 scopus 로고    scopus 로고
    • Systemic induction of the angiogenesis switch by the tetra-spanin D6.1A/CO-029
    • Gesierich, S., Berezovskiy, I., Ryschich, E., Zöller, M., Systemic induction of the angiogenesis switch by the tetra-spanin D6.1A/CO-029. Cancer Res. 2006, 66, 7083-7094.
    • (2006) Cancer Res. , vol.66 , pp. 7083-7094
    • Gesierich, S.1    Berezovskiy, I.2    Ryschich, E.3    Zöller, M.4
  • 59
    • 76749106591 scopus 로고    scopus 로고
    • Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation
    • Nazarenko, I., Rana, S., Baumann, A., Mcalear, J. et al., Cell surface tetraspanin Tspan8 contributes to molecular pathways of exosome-induced endothelial cell activation. Cancer Res. 2010, 70, 1668-1678.
    • (2010) Cancer Res. , vol.70 , pp. 1668-1678
    • Nazarenko, I.1    Rana, S.2    Baumann, A.3    Mcalear, J.4
  • 60
    • 62649095692 scopus 로고    scopus 로고
    • Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR
    • Al-Nedawi, K., Meehan, B., Kerbel, R. S., Allison, A. C., Rak, J., Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR. Proc. Natl. Acad. Sci. USA 2009, 106, 3794-3799.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 3794-3799
    • Al-Nedawi, K.1    Meehan, B.2    Kerbel, R.S.3    Allison, A.C.4    Rak, J.5
  • 61
    • 82655164839 scopus 로고    scopus 로고
    • Dll4-Notch signaling as therapeutic target in tumor angiogenesis
    • Kuhnert, F., Kirshner, J. R., Thurston, G., Dll4-Notch signaling as therapeutic target in tumor angiogenesis. Vasc. Cell 2011, 3, 20.
    • (2011) Vasc. Cell , vol.3 , pp. 20
    • Kuhnert, F.1    Kirshner, J.R.2    Thurston, G.3
  • 62
    • 77957708340 scopus 로고    scopus 로고
    • New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes
    • Sheldon, H., Heikamp, E., Turley, H., Dragovic, R. et al., New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes. Blood 2010, 116, 2385-2394.
    • (2010) Blood , vol.116 , pp. 2385-2394
    • Sheldon, H.1    Heikamp, E.2    Turley, H.3    Dragovic, R.4
  • 63
    • 84876248584 scopus 로고    scopus 로고
    • Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis
    • Kosaka, N., Iguchi, H., Hagiwara, K., Yoshioka, Y. et al., Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis. J. Biol. Chem. 2013, 288, 10849-10859.
    • (2013) J. Biol. Chem. , vol.288 , pp. 10849-10859
    • Kosaka, N.1    Iguchi, H.2    Hagiwara, K.3    Yoshioka, Y.4
  • 64
    • 19944426500 scopus 로고    scopus 로고
    • Hypoxia is important in the biology and aggression of human glial brain tumors
    • Evans, S. M., Judy, K. D., Dunphy, I., Jenkins, W. T. et al., Hypoxia is important in the biology and aggression of human glial brain tumors. Clin. Cancer Res. 2004, 10, 8177-8184.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 8177-8184
    • Evans, S.M.1    Judy, K.D.2    Dunphy, I.3    Jenkins, W.T.4
  • 65
    • 65349121788 scopus 로고    scopus 로고
    • Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
    • Stupp, R., Hegi, M. E., Mason, W. P., van den Bent, M. J. et al., Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 2009, 10, 459-466.
    • (2009) Lancet Oncol. , vol.10 , pp. 459-466
    • Stupp, R.1    Hegi, M.E.2    Mason, W.P.3    van den Bent, M.J.4
  • 66
    • 23244432180 scopus 로고    scopus 로고
    • Signaling of the tissue factor coagulation pathway in angiogenesis and cancer
    • Belting, M., Ahamed, J., Ruf, W., Signaling of the tissue factor coagulation pathway in angiogenesis and cancer. Arterioscler. Thromb. Vasc. Biol. 2005, 25, 1545-1550.
    • (2005) Arterioscler. Thromb. Vasc. Biol. , vol.25 , pp. 1545-1550
    • Belting, M.1    Ahamed, J.2    Ruf, W.3
  • 67
    • 33845288991 scopus 로고    scopus 로고
    • Oncogenes, trousseau syndrome, and cancer-related changes in the coagulome of mice and humans
    • Rak, J., Yu, J. L., Luyendyk, J., Mackman, N., Oncogenes, trousseau syndrome, and cancer-related changes in the coagulome of mice and humans. Cancer Res. 2006, 66, 10643-10646.
    • (2006) Cancer Res. , vol.66 , pp. 10643-10646
    • Rak, J.1    Yu, J.L.2    Luyendyk, J.3    Mackman, N.4
  • 68
    • 80051971645 scopus 로고    scopus 로고
    • Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells
    • Svensson, K. J., Kucharzewska, P., Christianson, H. C., Sköld, S. et al., Hypoxia triggers a proangiogenic pathway involving cancer cell microvesicles and PAR-2-mediated heparin-binding EGF signaling in endothelial cells. Proc. Natl. Acad. Sci. USA 2011, 108, 13147-13152.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 13147-13152
    • Svensson, K.J.1    Kucharzewska, P.2    Christianson, H.C.3    Sköld, S.4
  • 69
    • 84876927914 scopus 로고    scopus 로고
    • Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development
    • Kucharzewska, P., Christianson, H. C., Welch, J. E., Svensson, K. J. et al., Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. Proc. Natl. Acad. Sci. USA 2013, 110, 7312-7317.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 7312-7317
    • Kucharzewska, P.1    Christianson, H.C.2    Welch, J.E.3    Svensson, K.J.4
  • 70
    • 77952111459 scopus 로고    scopus 로고
    • MiR-210-micromanager of the hypoxia pathway
    • Huang, X., Le, Q. T., Giaccia, A. J., MiR-210-micromanager of the hypoxia pathway. Trends Mol. Med. 2010, 16, 230-237.
    • (2010) Trends Mol. Med. , vol.16 , pp. 230-237
    • Huang, X.1    Le, Q.T.2    Giaccia, A.J.3
  • 71
    • 84866502787 scopus 로고    scopus 로고
    • Hypoxic enhancement of exosome release by breast cancer cells
    • King, H. W., Michael, M. Z., Gleadle, J. M., Hypoxic enhancement of exosome release by breast cancer cells. BMC Cancer 2012, 12, 421.
    • (2012) BMC Cancer , vol.12 , pp. 421
    • King, H.W.1    Michael, M.Z.2    Gleadle, J.M.3
  • 72
    • 84857640591 scopus 로고    scopus 로고
    • Cancer associated fibroblasts: the dark side of the coin
    • Cirri, P., Chiarugi, P., Cancer associated fibroblasts: the dark side of the coin. Am. J. Cancer Res. 2011, 1, 482-497.
    • (2011) Am. J. Cancer Res. , vol.1 , pp. 482-497
    • Cirri, P.1    Chiarugi, P.2
  • 73
    • 33645739790 scopus 로고    scopus 로고
    • Tumor stroma and regulation of cancer development
    • Tlsty, T. D., Coussens, L. M., Tumor stroma and regulation of cancer development. Annu. Rev. Pathol. 2006, 1, 119-150.
    • (2006) Annu. Rev. Pathol. , vol.1 , pp. 119-150
    • Tlsty, T.D.1    Coussens, L.M.2
  • 74
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery, J. P., Acloque, H., Huang, R. Y. J., Nieto, M. A., Epithelial-mesenchymal transitions in development and disease. Cell. 2009, 139, 871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.J.3    Nieto, M.A.4
  • 75
    • 84871563123 scopus 로고    scopus 로고
    • Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration
    • Luga, V., Zhang, L., Viloria-Petit, A. M., Ogunjimi, A. A. et al., Exosomes mediate stromal mobilization of autocrine Wnt-PCP signaling in breast cancer cell migration. Cell 2012, 151, 1542-1556.
    • (2012) Cell , vol.151 , pp. 1542-1556
    • Luga, V.1    Zhang, L.2    Viloria-Petit, A.M.3    Ogunjimi, A.A.4
  • 76
    • 62949144392 scopus 로고    scopus 로고
    • Bone marrow-derived cells and tumor growth: contribution of bone marrow-derived cells to tumor micro-environments with special focus on mesenchymal stem cells
    • Roorda, B. D., ter Elst, A., Kamps, W. A., de Bont, E. S., Bone marrow-derived cells and tumor growth: contribution of bone marrow-derived cells to tumor micro-environments with special focus on mesenchymal stem cells. Crit. Rev. Oncol. Hematol. 2009, 69, 187-198.
    • (2009) Crit. Rev. Oncol. Hematol. , vol.69 , pp. 187-198
    • Roorda, B.D.1    ter Elst, A.2    Kamps, W.A.3    de Bont, E.S.4
  • 77
    • 81955167406 scopus 로고    scopus 로고
    • Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo
    • Zhu, W., Huang, L., Li, Y., Zhang, X. et al., Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth in vivo. Cancer Lett. 2012, 315, 28-37.
    • (2012) Cancer Lett. , vol.315 , pp. 28-37
    • Zhu, W.1    Huang, L.2    Li, Y.3    Zhang, X.4
  • 78
    • 84875846330 scopus 로고    scopus 로고
    • BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression
    • Roccaro, A. M., Sacco, A., Maiso, P., Azab, A. K. et al., BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression. J. Clin. Invest. 2013, 123, 1542-1555.
    • (2013) J. Clin. Invest. , vol.123 , pp. 1542-1555
    • Roccaro, A.M.1    Sacco, A.2    Maiso, P.3    Azab, A.K.4
  • 79
    • 84855519096 scopus 로고    scopus 로고
    • Competitive interactions of cancer cells and normal cells via secretory microRNAs
    • Kosaka, N., Iguchi, H., Yoshioka, Y., Hagiwara, K. et al., Competitive interactions of cancer cells and normal cells via secretory microRNAs. J. Biol. Chem. 2011, 287, 1397-1405.
    • (2011) J. Biol. Chem. , vol.287 , pp. 1397-1405
    • Kosaka, N.1    Iguchi, H.2    Yoshioka, Y.3    Hagiwara, K.4
  • 80
    • 84866857904 scopus 로고    scopus 로고
    • The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells
    • Putz, U., Howitt, J., Doan, A., Goh, C. P. et al., The tumor suppressor PTEN is exported in exosomes and has phosphatase activity in recipient cells. Sci. Signal. 2012, 5, ra7.
    • (2012) Sci. Signal. , vol.5
    • Putz, U.1    Howitt, J.2    Doan, A.3    Goh, C.P.4
  • 81
    • 84880823162 scopus 로고    scopus 로고
    • Regulation of the tumor suppressor PTEN through exosomes: a diagnostic potential for prostate cancer
    • Gabriel, K., Ingram, A., Austin, R., Kapoor, A. et al., Regulation of the tumor suppressor PTEN through exosomes: a diagnostic potential for prostate cancer. PLoS One. 2013, 8, e70047.
    • (2013) PLoS One , vol.8
    • Gabriel, K.1    Ingram, A.2    Austin, R.3    Kapoor, A.4
  • 82
    • 84858592019 scopus 로고    scopus 로고
    • The role of stromal myofibroblast and extracellular matrix in tumor angiogenesis
    • Vong, S., Kalluri, R., The role of stromal myofibroblast and extracellular matrix in tumor angiogenesis. Genes Cancer 2011, 2, 1139-1145.
    • (2011) Genes Cancer , vol.2 , pp. 1139-1145
    • Vong, S.1    Kalluri, R.2
  • 83
    • 78649958307 scopus 로고    scopus 로고
    • Cancer exosomes trigger fibroblast to myofibroblast differentiation
    • Webber, J., Steadman, R., Mason, M. D., Tabi, Z., Clayton, A., Cancer exosomes trigger fibroblast to myofibroblast differentiation. Cancer Res. 2010, 70, 9621-9630.
    • (2010) Cancer Res. , vol.70 , pp. 9621-9630
    • Webber, J.1    Steadman, R.2    Mason, M.D.3    Tabi, Z.4    Clayton, A.5
  • 84
    • 80054717963 scopus 로고    scopus 로고
    • Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional characteristics of tumor-supporting myofibroblasts
    • Cho, J. A., Park, H., Lim, E. H., Kim, K. H. et al., Exosomes from ovarian cancer cells induce adipose tissue-derived mesenchymal stem cells to acquire the physical and functional characteristics of tumor-supporting myofibroblasts. Gynecol. Oncol. 2011, 123, 379-386.
    • (2011) Gynecol. Oncol. , vol.123 , pp. 379-386
    • Cho, J.A.1    Park, H.2    Lim, E.H.3    Kim, K.H.4
  • 85
    • 84455171408 scopus 로고    scopus 로고
    • Exosomes from breast cancer cells can convert adipose tissue-derived mesenchymal stem cells into myofibroblast-like cells
    • Cho, J. A., Park, H., Lim, E. H., Lee, K. W., Exosomes from breast cancer cells can convert adipose tissue-derived mesenchymal stem cells into myofibroblast-like cells. Int. J. Oncol. 2012, 40, 130-138.
    • (2012) Int. J. Oncol. , vol.40 , pp. 130-138
    • Cho, J.A.1    Park, H.2    Lim, E.H.3    Lee, K.W.4
  • 86
    • 70149123439 scopus 로고    scopus 로고
    • CD44v6 dependence of premetastatic niche preparation by exosomes
    • Jung, T., Castellana, D., Klingbeil, P., Cuesta Hernández, I. et al., CD44v6 dependence of premetastatic niche preparation by exosomes. Neoplasia 2009, 11, 1093-1105.
    • (2009) Neoplasia , vol.11 , pp. 1093-1105
    • Jung, T.1    Castellana, D.2    Klingbeil, P.3    Cuesta Hernández, I.4
  • 87
    • 84874637012 scopus 로고    scopus 로고
    • Exosomal tumor microRNA modulates premetastatic organ cells
    • Rana, S., Malinowska, K., Zöller, M. Exosomal tumor microRNA modulates premetastatic organ cells. Neoplasia 2013, 15, 281-295.
    • (2013) Neoplasia , vol.15 , pp. 281-295
    • Rana, S.1    Malinowska, K.2    Zöller, M.3
  • 88
    • 79960960417 scopus 로고    scopus 로고
    • Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche
    • Grange, C., Tapparo, M., Collino, F., Vitillo, L. et al., Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche. Cancer Res. 2011, 71, 5346-5356.
    • (2011) Cancer Res. , vol.71 , pp. 5346-5356
    • Grange, C.1    Tapparo, M.2    Collino, F.3    Vitillo, L.4
  • 89
    • 28644432204 scopus 로고    scopus 로고
    • VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
    • Kaplan, R. N., Riba, R. D., Zacharoulis, S., Bramley, A. H. et al., VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 2005, 438, 820-827.
    • (2005) Nature , vol.438 , pp. 820-827
    • Kaplan, R.N.1    Riba, R.D.2    Zacharoulis, S.3    Bramley, A.H.4
  • 90
    • 84871602943 scopus 로고    scopus 로고
    • Cancer cells induced to express mesenchymal phenotype release exosome-like extracellular vesicles carrying tissue factor
    • Garnier, D., Magnus, N., Lee, T. H., Bentley, V. et al., Cancer cells induced to express mesenchymal phenotype release exosome-like extracellular vesicles carrying tissue factor. J. Biol. Chem. 2012, 287, 43565-43572.
    • (2012) J. Biol. Chem. , vol.287 , pp. 43565-43572
    • Garnier, D.1    Magnus, N.2    Lee, T.H.3    Bentley, V.4
  • 91
    • 84885372620 scopus 로고    scopus 로고
    • Qualitative changes in the proteome of extracellular vesicles accompanying cancer cell transition to mesenchymal state
    • Garnier, D., Magnus, N., Meehan, B., Kislinger, T., Rak, J., Qualitative changes in the proteome of extracellular vesicles accompanying cancer cell transition to mesenchymal state. Exp. Cell Res. 2013, 319, 2747-2757.
    • (2013) Exp. Cell Res. , vol.319 , pp. 2747-2757
    • Garnier, D.1    Magnus, N.2    Meehan, B.3    Kislinger, T.4    Rak, J.5
  • 92
    • 84881102179 scopus 로고    scopus 로고
    • Oncogenic H-ras reprograms Madin-Darby canine kidney (MDCK) cell-derived exosomal proteins following epithelial-mesenchymal transition
    • Tauro, B. J., Mathias, R. A., Greening, D. W., Gopal, S. K. et al., Oncogenic H-ras reprograms Madin-Darby canine kidney (MDCK) cell-derived exosomal proteins following epithelial-mesenchymal transition. Mol. Cell. Proteomics 2013, 12, 2148-2159.
    • (2013) Mol. Cell. Proteomics , vol.12 , pp. 2148-2159
    • Tauro, B.J.1    Mathias, R.A.2    Greening, D.W.3    Gopal, S.K.4
  • 94
    • 84874600636 scopus 로고    scopus 로고
    • Two distinct populations of exosomes are released from LIM1863 colon carcinoma cell-derived organoids
    • Tauro, B. J., Greening, D. W., Mathias, R. A., Mathivanan, S. et al., Two distinct populations of exosomes are released from LIM1863 colon carcinoma cell-derived organoids. Mol. Cell. Proteomics 2013, 12, 587-598.
    • (2013) Mol. Cell. Proteomics , vol.12 , pp. 587-598
    • Tauro, B.J.1    Greening, D.W.2    Mathias, R.A.3    Mathivanan, S.4
  • 95
    • 84864399889 scopus 로고    scopus 로고
    • Medulloblastoma exosome proteomics yield functional roles for extracellular vesicles
    • Epple, L. M., Griffiths, S. G., Dechkovskaia, A. M., Dusto, N. L. et al., Medulloblastoma exosome proteomics yield functional roles for extracellular vesicles. PLoS One 2012, 7, e42064.
    • (2012) PLoS One , vol.7
    • Epple, L.M.1    Griffiths, S.G.2    Dechkovskaia, A.M.3    Dusto, N.L.4
  • 96
    • 85007427694 scopus 로고    scopus 로고
    • Quantitative proteomics of extracellular vesicles derived from human primary and metastatic colorectal cancer cells
    • Choi, D. S., Choi, D. Y., Hong, B. S., Jang, S. C. et al., Quantitative proteomics of extracellular vesicles derived from human primary and metastatic colorectal cancer cells. J. Extracell. Vesicles 2012, 1, 18704.
    • (2012) J. Extracell. Vesicles , vol.1 , pp. 18704
    • Choi, D.S.1    Choi, D.Y.2    Hong, B.S.3    Jang, S.C.4
  • 97
    • 84884379486 scopus 로고    scopus 로고
    • Proteome profiling of neuroblastoma-derived exosomes reveal the expression of proteins potentially involved in tumor progression
    • Marimpietri, D., Petretto, A., Raffaghello, L., Pezzolo, A. et al., Proteome profiling of neuroblastoma-derived exosomes reveal the expression of proteins potentially involved in tumor progression. PLoS One 2013, 8, e75054.
    • (2013) PLoS One , vol.8
    • Marimpietri, D.1    Petretto, A.2    Raffaghello, L.3    Pezzolo, A.4
  • 98
    • 84880630042 scopus 로고    scopus 로고
    • Identification and characterization of proteins isolated from microvesicles derived from human lung cancer pleural effusions
    • Park, J. O., Choi, D. Y., Choi, D. S., Kim, H. J. et al., Identification and characterization of proteins isolated from microvesicles derived from human lung cancer pleural effusions. Proteomics 2013, 13, 2125-2134.
    • (2013) Proteomics , vol.13 , pp. 2125-2134
    • Park, J.O.1    Choi, D.Y.2    Choi, D.S.3    Kim, H.J.4
  • 99
    • 0028086057 scopus 로고
    • Management of cancer of the prostate
    • Catalona, W. J., Management of cancer of the prostate. N. Engl. J. Med. 1994, 331, 996-1004.
    • (1994) N. Engl. J. Med. , vol.331 , pp. 996-1004
    • Catalona, W.J.1
  • 100
    • 45449093192 scopus 로고    scopus 로고
    • MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer
    • Taylor, D. D., Gercel-Taylor, C., MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol. Oncol. 2008, 110, 13-21.
    • (2008) Gynecol. Oncol. , vol.110 , pp. 13-21
    • Taylor, D.D.1    Gercel-Taylor, C.2
  • 101
    • 65449117971 scopus 로고    scopus 로고
    • High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients
    • Logozzi, M., De Milito, A., Lugini, L., Borghi, M. et al., High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients. PLoS One 2009, 4, e5219.
    • (2009) PLoS One , vol.4
    • Logozzi, M.1    De Milito, A.2    Lugini, L.3    Borghi, M.4
  • 102
    • 59849107900 scopus 로고    scopus 로고
    • Identification of extracellular delta-catenin accumulation for prostate cancer detection
    • Lu, Q., Zhang, J., Allison, R., Gay, H. et al., Identification of extracellular delta-catenin accumulation for prostate cancer detection. Prostate 2009, 69, 411-418.
    • (2009) Prostate , vol.69 , pp. 411-418
    • Lu, Q.1    Zhang, J.2    Allison, R.3    Gay, H.4
  • 103
    • 67349142591 scopus 로고    scopus 로고
    • Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer
    • Nilsson, J., Skog, J., Nordstrand, A., Baranov, V. et al., Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer. Br. J. Cancer 2009, 100, 1603-1607.
    • (2009) Br. J. Cancer , vol.100 , pp. 1603-1607
    • Nilsson, J.1    Skog, J.2    Nordstrand, A.3    Baranov, V.4
  • 105
    • 69249213928 scopus 로고    scopus 로고
    • Patient-derived tumor-reactive antibodies as diagnostic markers for ovarian cancer
    • Taylor, D. D., Gercel-Taylor, C., Parker, L. P., Patient-derived tumor-reactive antibodies as diagnostic markers for ovarian cancer. Gynecol. Oncol. 2009, 115, 112-120.
    • (2009) Gynecol. Oncol. , vol.115 , pp. 112-120
    • Taylor, D.D.1    Gercel-Taylor, C.2    Parker, L.P.3
  • 106
    • 79959740942 scopus 로고    scopus 로고
    • Proteomic analysis of microvesicles derived from human colorectal cancer ascites
    • Choi, D. S., Park, J. O., Jang, S. C., Yoon, Y. J. et al., Proteomic analysis of microvesicles derived from human colorectal cancer ascites. Proteomics 2011, 11, 2745-2751.
    • (2011) Proteomics , vol.11 , pp. 2745-2751
    • Choi, D.S.1    Park, J.O.2    Jang, S.C.3    Yoon, Y.J.4
  • 107
    • 79957673695 scopus 로고    scopus 로고
    • Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer
    • Tavoosidana, G., Ronquist, G., Darmanis, S., Yan, J. et al., Multiple recognition assay reveals prostasomes as promising plasma biomarkers for prostate cancer. Proc. Natl. Acad. Sci. USA 2011, 108, 8809-8814.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 8809-8814
    • Tavoosidana, G.1    Ronquist, G.2    Darmanis, S.3    Yan, J.4
  • 108
    • 84856812332 scopus 로고    scopus 로고
    • Changes in circulating microRNA levels associated with prostate cancer
    • Bryant, R. J., Pawlowski, T., Catto, J. W., Marsden, G. et al., Changes in circulating microRNA levels associated with prostate cancer. Br. J. Cancer 2012, 106, 768-774.
    • (2012) Br. J. Cancer , vol.106 , pp. 768-774
    • Bryant, R.J.1    Pawlowski, T.2    Catto, J.W.3    Marsden, G.4
  • 109
    • 84867602816 scopus 로고    scopus 로고
    • Plasma-derived exosomal survivin, a plausible biomarker for early detection of prostate cancer
    • Khan, S., Jutzy, J. M., Valenzuela, M. M., Turay, D. et al., Plasma-derived exosomal survivin, a plausible biomarker for early detection of prostate cancer. PLoS One 2012, 7, e46737.
    • (2012) PLoS One , vol.7
    • Khan, S.1    Jutzy, J.M.2    Valenzuela, M.M.3    Turay, D.4
  • 110
    • 84868268464 scopus 로고    scopus 로고
    • Comprehensive miRNA expression analysis in peripheral blood can diagnose liver disease
    • Murakami, Y., Toyoda, H., Tanahashi, T., Tanaka, J. et al., Comprehensive miRNA expression analysis in peripheral blood can diagnose liver disease. PLoS One 2012, 7, e48366.
    • (2012) PLoS One , vol.7
    • Murakami, Y.1    Toyoda, H.2    Tanahashi, T.3    Tanaka, J.4
  • 111
    • 84870931536 scopus 로고    scopus 로고
    • Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy
    • Shao, H., Chung, J., Balaj, L., Charest, A. et al., Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy. Nat. Med. 2012, 18, 1835-1840.
    • (2012) Nat. Med. , vol.18 , pp. 1835-1840
    • Shao, H.1    Chung, J.2    Balaj, L.3    Charest, A.4
  • 112
    • 84855784507 scopus 로고    scopus 로고
    • RNA expression patterns in serum microvesicles from patients with glioblastoma multiforme and controls
    • Noerholm, M., Balaj, L., Limperg, T., Salehi, A. et al., RNA expression patterns in serum microvesicles from patients with glioblastoma multiforme and controls. BMC Cancer 2012, 12, 22.
    • (2012) BMC Cancer , vol.12 , pp. 22
    • Noerholm, M.1    Balaj, L.2    Limperg, T.3    Salehi, A.4
  • 113
    • 84874755851 scopus 로고    scopus 로고
    • Clinical impact of serum exosomal microRNA-21 as a clinical biomarker in human esophageal squamous cell carcinoma
    • Tanaka, Y., Kamohara, H., Kinoshita, K., Kurashige, J. et al., Clinical impact of serum exosomal microRNA-21 as a clinical biomarker in human esophageal squamous cell carcinoma. Cancer 2013, 119, 1159-1167.
    • (2013) Cancer , vol.119 , pp. 1159-1167
    • Tanaka, Y.1    Kamohara, H.2    Kinoshita, K.3    Kurashige, J.4
  • 114
    • 84891636580 scopus 로고    scopus 로고
    • Role of pancreatic cancer-derived exosomes in salivary biomarker development
    • Lau, C, Kim, Y, Chia, D, Spielmann, N. et al., Role of pancreatic cancer-derived exosomes in salivary biomarker development. J. Biol. Chem. 2013, 288, 26888-26897.
    • (2013) J. Biol. Chem , vol.288 , pp. 26888-26897
    • Lau, C.1    Kim, Y.2    Chia, D.3    Spielmann, N.4
  • 115
    • 77957091969 scopus 로고    scopus 로고
    • Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis
    • Kosaka, N., Iguchi, H., Ochiya, T., Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis. Cancer Sci. 2010, 101, 2087-2092.
    • (2010) Cancer Sci , vol.101 , pp. 2087-2092
    • Kosaka, N.1    Iguchi, H.2    Ochiya, T.3
  • 116
    • 43449102192 scopus 로고    scopus 로고
    • Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma
    • Lawrie, C. H., Gal, S., Dunlop, H. M., Pushkaran, B. et al., Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br. J. Haematol. 2008, 141, 672-675.
    • (2008) Br. J. Haematol , vol.141 , pp. 672-675
    • Lawrie, C.H.1    Gal, S.2    Dunlop, H.M.3    Pushkaran, B.4
  • 117
    • 48749122914 scopus 로고    scopus 로고
    • Circulating microRNAs as stable blood-based markers for cancer detection
    • Mitchell, P. S., Parkin, R. K., Kroh, E. M., Fritz, B. R. et al., Circulating microRNAs as stable blood-based markers for cancer detection. Proc. Natl. Acad. Sci. USA 2008, 105, 10513-10518.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 10513-10518
    • Mitchell, P.S.1    Parkin, R.K.2    Kroh, E.M.3    Fritz, B.R.4
  • 118
    • 0023180716 scopus 로고
    • Immunohistochemical study of the expression of a Mr 34,000 human epithelium-specific surface glycoprotein in normal and malignant tissues
    • Momburg, F., Moldenhauer, G., Hämmerling, G. J., Möller, P., Immunohistochemical study of the expression of a Mr 34, 000 human epithelium-specific surface glycoprotein in normal and malignant tissues. Cancer Res. 1987, 47, 2883-2891.
    • (1987) Cancer Res. , vol.47 , pp. 2883-2891
    • Momburg, F.1    Moldenhauer, G.2    Hämmerling, G.J.3    Möller, P.4
  • 119
    • 84867417250 scopus 로고    scopus 로고
    • Profiling of microRNAs in exosomes released from PC-3 prostate cancer cells
    • Hessvik, N. P., Phuyal, S., Brech, A., Sandvig, K., Llorente, A., Profiling of microRNAs in exosomes released from PC-3 prostate cancer cells. Biochim. Biophys. Acta 2012, 1819, 1154-1163.
    • (2012) Biochim. Biophys. Acta , vol.1819 , pp. 1154-1163
    • Hessvik, N.P.1    Phuyal, S.2    Brech, A.3    Sandvig, K.4    Llorente, A.5
  • 120
    • 36348935057 scopus 로고    scopus 로고
    • Malignant ascites-derived exosomes of ovarian carcinoma patients contain CD24 and EpCAM
    • Runz, S., Keller, S., Rupp, C., Stoeck, A. et al., Malignant ascites-derived exosomes of ovarian carcinoma patients contain CD24 and EpCAM. Gynecol. Oncol. 2007, 107, 563-571.
    • (2007) Gynecol. Oncol. , vol.107 , pp. 563-571
    • Runz, S.1    Keller, S.2    Rupp, C.3    Stoeck, A.4
  • 121
    • 76649094917 scopus 로고    scopus 로고
    • Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature
    • Mathivanan, S., Lim, J. W., Tauro, B. J., Ji, H. et al., Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature. Mol. Cell. Proteomics 2010, 9, 197-208.
    • (2010) Mol. Cell. Proteomics , vol.9 , pp. 197-208
    • Mathivanan, S.1    Lim, J.W.2    Tauro, B.J.3    Ji, H.4
  • 122
    • 84878630476 scopus 로고    scopus 로고
    • Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components
    • Ji, H., Greening, D. W., Barnes, T. W., Lim, J. W. et al., Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components. Proteomics 2013, 13, 1672-1686.
    • (2013) Proteomics , vol.13 , pp. 1672-1686
    • Ji, H.1    Greening, D.W.2    Barnes, T.W.3    Lim, J.W.4
  • 123
    • 34548574823 scopus 로고    scopus 로고
    • YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts
    • Nakahara, T, Kita, A, Yamanaka, K, Mori, M. et al., YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts. Cancer Res. 2007, 67, 8014-8021.
    • (2007) Cancer Res. , vol.67 , pp. 8014-8021
    • Nakahara, T.1    Kita, A.2    Yamanaka, K.3    Mori, M.4
  • 124
    • 79951551519 scopus 로고    scopus 로고
    • Survivin is released from cancer cells via exosomes
    • Khan, S., Jutzy, J. M., Aspe, J. R., McGregor, D. W. et al., Survivin is released from cancer cells via exosomes. Apoptosis 2011, 16, 1-12.
    • (2011) Apoptosis , vol.16 , pp. 1-12
    • Khan, S.1    Jutzy, J.M.2    Aspe, J.R.3    McGregor, D.W.4
  • 125
    • 84868208632 scopus 로고    scopus 로고
    • Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease
    • Di Vizio, D., Morello, M., Dudley, A. C., Schow, P. W. et al., Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease. Am. J. Pathol. 2012, 181, 1573-1584.
    • (2012) Am. J. Pathol , vol.181 , pp. 1573-1584
    • Di Vizio, D.1    Morello, M.2    Dudley, A.C.3    Schow, P.W.4
  • 126
    • 67650481175 scopus 로고    scopus 로고
    • Oncosome formation in prostate cancer: association with a region of frequent chromosomal deletion in metastatic disease
    • Di Vizio, D., Kim, J., Hager, M. H., Morello, M. et al., Oncosome formation in prostate cancer: association with a region of frequent chromosomal deletion in metastatic disease. Cancer Res. 2009, 69, 5601-5609.
    • (2009) Cancer Res , vol.69 , pp. 5601-5609
    • Di Vizio, D.1    Kim, J.2    Hager, M.H.3    Morello, M.4
  • 127
    • 84874967621 scopus 로고    scopus 로고
    • Exosomal tumor-suppressive microRNAs as novel cancer therapy: "exocure" is another choice for cancer treatment
    • Kosaka, N., Takeshita, F., Yoshioka, Y., Hagiwara, K. et al., Exosomal tumor-suppressive microRNAs as novel cancer therapy: "exocure" is another choice for cancer treatment. Adv. Drug Deliv. Rev. 2013, 65, 376-382.
    • (2013) Adv. Drug Deliv. Rev. , vol.65 , pp. 376-382
    • Kosaka, N.1    Takeshita, F.2    Yoshioka, Y.3    Hagiwara, K.4
  • 128
    • 79953858598 scopus 로고    scopus 로고
    • Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
    • Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C. et al., Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat. Biotechnol. 2011, 29, 341-345.
    • (2011) Nat. Biotechnol. , vol.29 , pp. 341-345
    • Alvarez-Erviti, L.1    Seow, Y.2    Yin, H.3    Betts, C.4
  • 129
    • 84871923602 scopus 로고    scopus 로고
    • Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells
    • Ohno, S., Takanashi, M., Sudo, K., Ueda, S. et al., Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells. Mol. Ther. 2013, 21, 185-191.
    • (2013) Mol. Ther. , vol.21 , pp. 185-191
    • Ohno, S.1    Takanashi, M.2    Sudo, K.3    Ueda, S.4
  • 130
    • 40049112564 scopus 로고    scopus 로고
    • Ceramide triggers budding of exosome vesicles into multi-vesicular endosomes
    • Trajkovic, K., Hsu, C., Chiantia, S., Rajendran, L. et al., Ceramide triggers budding of exosome vesicles into multi-vesicular endosomes. Science 2008, 319, 1244-1247.
    • (2008) Science , vol.319 , pp. 1244-1247
    • Trajkovic, K.1    Hsu, C.2    Chiantia, S.3    Rajendran, L.4
  • 131
    • 79953136097 scopus 로고    scopus 로고
    • Rab27a and Rab27b control different steps of the exosome secretion pathway
    • Ostrowski, M., Carmo, N. B., Krumeich, S., Fanget, I. et al., Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat. Cell Biol. 2010, 12, 19-30.
    • (2010) Nat. Cell Biol. , vol.12 , pp. 19-30
    • Ostrowski, M.1    Carmo, N.B.2    Krumeich, S.3    Fanget, I.4
  • 132
    • 77951183654 scopus 로고    scopus 로고
    • Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C
    • Hsu, C., Morohashi, Y., Yoshimura, S., Manrique-Hoyos, N. et al., Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. J. Cell Biol. 2010, 189, 223-232.
    • (2010) J. Cell Biol. , vol.189 , pp. 223-232
    • Hsu, C.1    Morohashi, Y.2    Yoshimura, S.3    Manrique-Hoyos, N.4
  • 133
    • 84875994843 scopus 로고    scopus 로고
    • Heparanase regulates secretion, composition, and function of tumor cell-derived exosomes
    • Thompson, C. A., Purushothaman, A., Ramani, V. C., Vlodavsky, I., Sanderson, R. D., Heparanase regulates secretion, composition, and function of tumor cell-derived exosomes. J. Biol. Chem. 2013, 288, 10093-10099.
    • (2013) J. Biol. Chem. , vol.288 , pp. 10093-10099
    • Thompson, C.A.1    Purushothaman, A.2    Ramani, V.C.3    Vlodavsky, I.4    Sanderson, R.D.5
  • 134
    • 77956403452 scopus 로고    scopus 로고
    • Proteomics of colorectal cancer: overview of discovery studies and identification of commonly identified cancer-associated proteins and candidate CRC serum markers
    • Jimenez, C. R., Knol, J. C., Meijer, G. A., Fijneman, R. J., Proteomics of colorectal cancer: overview of discovery studies and identification of commonly identified cancer-associated proteins and candidate CRC serum markers. J. Proteomics 2010, 73, 1873-1895.
    • (2010) J. Proteomics , vol.73 , pp. 1873-1895
    • Jimenez, C.R.1    Knol, J.C.2    Meijer, G.A.3    Fijneman, R.J.4
  • 136
    • 84858661692 scopus 로고    scopus 로고
    • Breast cancer exosome-like microvesicles and salivary gland cells interplay alters salivary gland cell-derived exosome-like microvesicles in vitro
    • Lau, C. S., Wong, D. T., Breast cancer exosome-like microvesicles and salivary gland cells interplay alters salivary gland cell-derived exosome-like microvesicles in vitro. PLoS One 2012, 7, e33037.
    • (2012) PLoS One , vol.7
    • Lau, C.S.1    Wong, D.T.2
  • 137
    • 84858776611 scopus 로고    scopus 로고
    • Proteomic analysis of exosome-like vesicles derived from breast cancer cells
    • Palazzolo, G., Albanese, N. N., DI Cara, G., Gygax, D. et al., Proteomic analysis of exosome-like vesicles derived from breast cancer cells. Anticancer Res. 2012, 32, 847-860.
    • (2012) Anticancer Res. , vol.32 , pp. 847-860
    • Palazzolo, G.1    Albanese, N.N.2    DI Cara, G.3    Gygax, D.4
  • 138
    • 84878630476 scopus 로고    scopus 로고
    • Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components
    • Ji, H., Greening, D. W., Barnes, T. W., Lim, J. W. et al., Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components. Proteomics 2013, 13, 1672-1686.
    • (2013) Proteomics , vol.13 , pp. 1672-1686
    • Ji, H.1    Greening, D.W.2    Barnes, T.W.3    Lim, J.W.4
  • 139
    • 78149419143 scopus 로고    scopus 로고
    • Selective release of microRNA species from normal and malignant mammary epithelial cells
    • Pigati, L., Yaddanapudi, S. C., Iyengar, R., Kim, D. J. et al., Selective release of microRNA species from normal and malignant mammary epithelial cells. PLoS One 2010, 5, e13515.
    • (2010) PLoS One , vol.5
    • Pigati, L.1    Yaddanapudi, S.C.2    Iyengar, R.3    Kim, D.J.4
  • 140
    • 84867417250 scopus 로고    scopus 로고
    • Profiling of microRNAs in exosomes released from PC-3 prostate cancer cells
    • Hessvik, N. P., Phuyal, S., Brech, A., Sandvig, K., Llorente A., Profiling of microRNAs in exosomes released from PC-3 prostate cancer cells. Biochim. Biophys. Acta 2012, 1819, 1154-1163.
    • (2012) Biochim. Biophys. Acta , vol.1819 , pp. 1154-1163
    • Hessvik, N.P.1    Phuyal, S.2    Brech, A.3    Sandvig, K.4    Llorente, A.5
  • 141
    • 84870039629 scopus 로고    scopus 로고
    • A label-free electrical detection of exosomal microRNAs using microelectrode array
    • Goda, T., Masuno, K., Nishida, J., Kosaka, N. et al., A label-free electrical detection of exosomal microRNAs using microelectrode array. Chem. Commun. (Camb.) 2012, 48, 11942-11944.
    • (2012) Chem. Commun. (Camb.) , vol.48 , pp. 11942-11944
    • Goda, T.1    Masuno, K.2    Nishida, J.3    Kosaka, N.4
  • 142
    • 85013222187 scopus 로고    scopus 로고
    • Standardization of sample collection, isolation and analysis methods in extracellular vesicle research
    • Witwer, K. W., Buzás, E. I., Bemis, L. T., Bora, A. et al., Standardization of sample collection, isolation and analysis methods in extracellular vesicle research. J. Extracell. Vesicles 2013, 2, 20360.
    • (2013) J. Extracell. Vesicles , vol.2 , pp. 20360
    • Witwer, K.W.1    Buzás, E.I.2    Bemis, L.T.3    Bora, A.4
  • 143
    • 84874377202 scopus 로고    scopus 로고
    • Extracellular vesicles: exosomes, microvesicles, and friends
    • Raposo, G., Stoorvogel, W. Extracellular vesicles: exosomes, microvesicles, and friends. J. Cell Biol. 2013, 200, 373-383.
    • (2013) J. Cell Biol. , vol.200 , pp. 373-383
    • Raposo, G.1    Stoorvogel, W.2
  • 144
    • 85017356000 scopus 로고    scopus 로고
    • Comparative marker analysis of extracellular vesicles in different human cancer types
    • Yoshioka, Y., Konishi, Y., Kosaka, N., Katsuda et al., Comparative marker analysis of extracellular vesicles in different human cancer types. J. Extracell. Vesicles 2013, 2, 20424.
    • (2013) J. Extracell. Vesicles , vol.2 , pp. 20424
    • Yoshioka, Y.1    Konishi, Y.2    Kosaka, N.3    Katsuda4


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